Luisa Ugedo
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View article: Preferential Modulatory Action of 5-HT<sub>2A</sub>Receptors on the Dynamic Regulation of Basal Ganglia Circuits
Preferential Modulatory Action of 5-HT<sub>2A</sub>Receptors on the Dynamic Regulation of Basal Ganglia Circuits Open
In rodents, cortical information is transferred to the substantia nigra pars reticulata (SNr) through motor and medial prefrontal (mPF) basal ganglia (BG) circuits implicated in motor and cognitive/motivational behaviors, respectively. The…
View article: Motor cortico-nigral and cortico-entopeduncular information transmission and its modulation by buspirone in control and after dopaminergic denervation
Motor cortico-nigral and cortico-entopeduncular information transmission and its modulation by buspirone in control and after dopaminergic denervation Open
Cortical information is transferred to the substantia nigra pars reticulata (SNr) and the entopeduncular nucleus (EP), the output structures of the basal ganglia (BG), through three different pathways: the hyperdirect trans-subthalamic and…
View article: The effect of 5‐HT<sub>1A</sub> receptor agonists on the entopeduncular nucleus is modified in 6‐hydroxydopamine‐lesioned rats
The effect of 5‐HT<sub>1A</sub> receptor agonists on the entopeduncular nucleus is modified in 6‐hydroxydopamine‐lesioned rats Open
Background and Purpose l ‐DOPA prolonged treatment leads to disabling motor complications as dyskinesia that could be decreased by drugs acting on 5‐HT 1A receptors. Since the internal segment of the globus pallidus , homologous to the ent…
View article: Dopaminergic denervation impairs cortical motor and associative/limbic information processing through the basal ganglia and its modulation by the CB1 receptor
Dopaminergic denervation impairs cortical motor and associative/limbic information processing through the basal ganglia and its modulation by the CB1 receptor Open
View article: Changes in Day/Night Activity in the 6-OHDA-Induced Experimental Model of Parkinson’s Disease: Exploring Prodromal Biomarkers
Changes in Day/Night Activity in the 6-OHDA-Induced Experimental Model of Parkinson’s Disease: Exploring Prodromal Biomarkers Open
The search for experimental models mimicking an early stage of Parkinson's disease (PD) before motor manifestations is fundamental in order to explore early signs and get a better prognosis. Interestingly, our previous studies have indicat…
View article: Changes in day/night activity in the 6-OHDA-induced experimental model of Parkinson´s disease: Exploring prodromal biomarkers
Changes in day/night activity in the 6-OHDA-induced experimental model of Parkinson´s disease: Exploring prodromal biomarkers Open
The authors have withdrawn this preprint due to author disagreement.
View article: Changes in day/night activity in the 6-OHDA-induced experimental model of Parkinson´s disease: Exploring prodromal biomarkers
Changes in day/night activity in the 6-OHDA-induced experimental model of Parkinson´s disease: Exploring prodromal biomarkers Open
Background : Parkinson’s disease (PD) is a prevalent neurodegenerative disorder for which there is not currently a cure and when it is clinically diagnosed is likely too late. The search for experimental models mimicking an early stage of …
View article: 6‐Hydroxydopamine lesion and levodopa treatment modify the effect of buspirone in the <i>substantia nigra pars reticulata</i>
6‐Hydroxydopamine lesion and levodopa treatment modify the effect of buspirone in the <i>substantia nigra pars reticulata</i> Open
Background and Purpose l ‐DOPA‐induced dyskinesia (LID) is considered a major complication in the treatment of Parkinson's disease (PD). Buspirone (5‐HT 1A partial agonist) have shown promising results in the treatment of PD and LID, howev…
View article: Acute L-DOPA administration reverses changes in firing pattern and low frequency oscillatory activity in the entopeduncular nucleus from long term L-DOPA treated 6-OHDA-lesioned rats
Acute L-DOPA administration reverses changes in firing pattern and low frequency oscillatory activity in the entopeduncular nucleus from long term L-DOPA treated 6-OHDA-lesioned rats Open
The pathophysiology of Parkinson's disease (PD) and L-DOPA-induced dyskinesia (LID) is associated with aberrant neuronal activity and abnormal high levels of oscillatory activity and synchronization in several basal ganglia nuclei and the …
View article: Effects of adult enriched environment on cognition, hippocampal-prefrontal plasticity and NMDAR subunit expression in MK-801-induced schizophrenia model
Effects of adult enriched environment on cognition, hippocampal-prefrontal plasticity and NMDAR subunit expression in MK-801-induced schizophrenia model Open
Schizophrenia is a mental disorder characterized by psychosis, negative symptoms and cognitive impairment. Cognitive deficits are enduring and represent the most disabling symptom but are currently poorly treated. N-methyl D-aspartate rece…
View article: Cannabinoids differentially modulate cortical information transmission through the sensorimotor or medial prefrontal basal ganglia circuits
Cannabinoids differentially modulate cortical information transmission through the sensorimotor or medial prefrontal basal ganglia circuits Open
Background and Purpose In the sensorimotor (SM) and medial prefrontal (mPF) basal ganglia (BG) circuits, the cortical information is transferred to the substantia nigra pars reticulata (SNr) through the hyperdirect trans‐subthalamic pathwa…
View article: Beneficial effects of n-3 polyunsaturated fatty acids administration in a partial lesion model of Parkinson's disease: The role of glia and NRf2 regulation
Beneficial effects of n-3 polyunsaturated fatty acids administration in a partial lesion model of Parkinson's disease: The role of glia and NRf2 regulation Open
View article: Opioid Activity in the Locus Coeruleus Is Modulated by Chronic Neuropathic Pain
Opioid Activity in the Locus Coeruleus Is Modulated by Chronic Neuropathic Pain Open
Pain affects both sensory and emotional aversive responses, often provoking depression and anxiety-related conditions when it becomes chronic. As the opioid receptors in the locus coeruleus (LC) have been implicated in pain, stress respons…
View article: Impairment of Serotonergic Transmission by the Antiparkinsonian Drug L-DOPA: Mechanisms and Clinical Implications
Impairment of Serotonergic Transmission by the Antiparkinsonian Drug L-DOPA: Mechanisms and Clinical Implications Open
The link between the anti-Parkinsonian drug L-3,4-dihydroxyphenylalanine (L-DOPA) and the serotonergic (5-HT) system has been long established and has received increased attention during the last decade. Most studies have focused on the fa…
View article: The role of <scp>NMDA</scp> receptor‐dependent activity of noradrenergic neurons in attention, impulsivity and exploratory behaviors
The role of <span>NMDA</span> receptor‐dependent activity of noradrenergic neurons in attention, impulsivity and exploratory behaviors Open
Activity of the brain's noradrenergic (NA) neurons plays a major role in cognitive processes, including the ability to adapt behavior to changing environmental circumstances. Here, we used the NR1 DbhCre transgenic mouse strain to test how…
View article: Inactivation of <scp>GIRK</scp> channels weakens the pre‐ and postsynaptic inhibitory activity in dorsal raphe neurons
Inactivation of <span>GIRK</span> channels weakens the pre‐ and postsynaptic inhibitory activity in dorsal raphe neurons Open
The serotonergic tone of the dorsal raphe ( DR ) is regulated by 5‐ HT 1A receptors, which negatively control serotonergic activity via the activation of G protein‐coupled inwardly rectifying K + ( GIRK ) channels. In addition, DR activity…
View article: Activation of Extracellular Signal-Regulated Kinases (ERK 1/2) in the Locus Coeruleus Contributes to Pain-Related Anxiety in Arthritic Male Rats
Activation of Extracellular Signal-Regulated Kinases (ERK 1/2) in the Locus Coeruleus Contributes to Pain-Related Anxiety in Arthritic Male Rats Open
As phosphorylated extracellular signal-regulated kinase 1/2 blockade in the Locus Coeruleus relieved anxiety and counteracted altered LC function, we propose that phosphorylated extracellular signal-regulated kinase 1/2 activation in the L…
View article: Zergatik egiten digu alkoholak kalte?
Zergatik egiten digu alkoholak kalte? Open
Gaur egun, alkohol-kontsumoa oso hedatua dago gure gizartean. Nahiz eta gizartearen aldetik oso onartua egon, iradoki izan da batetik efektu euforikoak eragiten dituela, eta bestetik asaldura fisiko zein psikiko kaltegarriak eragin diezazk…
View article: Cannabinoids and Motor Control of the Basal Ganglia: Therapeutic Potential in Movement Disorders
Cannabinoids and Motor Control of the Basal Ganglia: Therapeutic Potential in Movement Disorders Open
Cannabinoid receptors in the brain appear to be intimately involved in the motor control. Cannabinoid CB1 receptors are densely located in the basal ganglia (BG), a forebrain system that integrates cortical information to coordinate motor …
View article: Chronic L-DOPA administration increases the firing rate but does not reverse enhanced slow frequency oscillatory activity and synchronization in substantia nigra pars reticulata neurons from 6-hydroxydopamine-lesioned rats
Chronic L-DOPA administration increases the firing rate but does not reverse enhanced slow frequency oscillatory activity and synchronization in substantia nigra pars reticulata neurons from 6-hydroxydopamine-lesioned rats Open
The pathophysiology of Parkinson's disease (PD) and of L-DOPA-induced dyskinesia (LID) is associated with dysfunctional neuronal activity in several nuclei of the basal ganglia. Moreover, high levels of oscillatory activity and synchroniza…
View article: The acute and long‐term L‐DOPA effects are independent from changes in the activity of dorsal raphe serotonergic neurons in 6‐OHDA lesioned rats
The acute and long‐term L‐DOPA effects are independent from changes in the activity of dorsal raphe serotonergic neurons in 6‐OHDA lesioned rats Open
Background and Purpose L‐DOPA is still the most efficacious pharmacological treatment for Parkinson's disease. However, in the majority of patients receiving long‐term therapy with L‐DOPA, its efficacy is compromised by motor complications…
View article: Buspirone requires the intact nigrostriatal pathway to reduce the activity of the subthalamic nucleus via 5-HT1A receptors
Buspirone requires the intact nigrostriatal pathway to reduce the activity of the subthalamic nucleus via 5-HT1A receptors Open
The most effective treatment for Parkinson's disease (PD), l-DOPA, induces dyskinesia after prolonged use. We have previously shown that in 6-hydroxydopamine (6-OHDA) lesioned rats rendered dyskinetic by prolonged l-DOPA administration, le…
View article: Depressive-like behavior observed with a minimal loss of locus coeruleus (LC) neurons following administration of 6-hydroxydopamine is associated with electrophysiological changes and reversed with precursors of norepinephrine
Depressive-like behavior observed with a minimal loss of locus coeruleus (LC) neurons following administration of 6-hydroxydopamine is associated with electrophysiological changes and reversed with precursors of norepinephrine Open
View article: Deletion of GIRK2 Subunit of GIRK Channels Alters the 5-HT<sub>1A</sub>Receptor-Mediated Signaling and Results in a Depression-Resistant Behavior
Deletion of GIRK2 Subunit of GIRK Channels Alters the 5-HT<sub>1A</sub>Receptor-Mediated Signaling and Results in a Depression-Resistant Behavior Open
Our results indicate that GIRK channels formed by GIRK2 subunits determine depression-related behaviors as well as basal and 5-HT1A receptor-mediated dorsal raphe neuronal activity, becoming alternative therapeutic targets for psychiatric …
View article: Dysfunctional Inhibitory Mechanisms in Locus Coeruleus Neurons of the Wistar Kyoto Rat
Dysfunctional Inhibitory Mechanisms in Locus Coeruleus Neurons of the Wistar Kyoto Rat Open
These results point out that in WKY rats the inhibitory control exerted by α2-adrenoceptors and GABAergic input onto LC neurons is dysregulated. Overall, this study supports in this animal model the hypothesis that claims an imbalance betw…