Luiz Fernando Ferraz da Silva
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View article: STARComm Scalably Detects Emergent Modules of Spatial Cell-Cell Communication in Inflammation and Cancer.
STARComm Scalably Detects Emergent Modules of Spatial Cell-Cell Communication in Inflammation and Cancer. Open
In humans, cell-cell communication orchestrates tissue organization, immune coordination, and repair, yet spatially mapping these interactions remains a challenge for biology. We introduce STARComm, a scalable-interpretable computational m…
View article: Ageing and dysregulated lung immune responses in fatal COVID-19
Ageing and dysregulated lung immune responses in fatal COVID-19 Open
Elderly individuals were disproportionally affected during the COVID-19 pandemic, and more than 80% of the global COVID-19-related deaths between 2020 and 2021 occurred among people aged 60 years or older. Several cellular modifications in…
View article: Heightened Innate Immune and Inflammatory Gene Expression in the Skin of Severe COVID-19 Cases
Heightened Innate Immune and Inflammatory Gene Expression in the Skin of Severe COVID-19 Cases Open
The results revealed cutaneous alterations in the expression of genes associated with innate immunity and inflammation factors. This suggests that, unlike tissues with viral tropism, the skin is enriched with antiviral factors to defend ag…
View article: Type I Interferons in SARS-CoV-2 Cutaneous Infection: Is There a Role in Antiviral Defense?
Type I Interferons in SARS-CoV-2 Cutaneous Infection: Is There a Role in Antiviral Defense? Open
SARS-CoV-2, a β-coronavirus, primarily affects the lungs, with non-specific lesions and no cytopathic viral effect in the skin. Cutaneous antiviral mechanisms include activation of TLR/IRF pathways and production of type I IFN. We evaluate…
View article: Deconvolution of cell types and states in spatial multiomics utilizing TACIT
Deconvolution of cell types and states in spatial multiomics utilizing TACIT Open
View article: 7,12-Dimethylbenz(a)anthracene as a Model for Ovarian Cancer Induction in Rats
7,12-Dimethylbenz(a)anthracene as a Model for Ovarian Cancer Induction in Rats Open
Ovarian cancer has the highest mortality rate of all gynecological cancers. Animal models using 7,12-dimethylbenz(a)anthracene (DMBA) have been developed to investigate the mechanisms of ovarian carcinogenesis. The present study is a syste…
View article: The Respiratory Tract Plays a Pivotal Role in the Pathogenesis of Fatal Yellow Fever: An Autopsy Study from the 2017-2019 Yellow Fever Epidemic
The Respiratory Tract Plays a Pivotal Role in the Pathogenesis of Fatal Yellow Fever: An Autopsy Study from the 2017-2019 Yellow Fever Epidemic Open
View article: Nipah virus infection: preparedness for the pathological diagnosis of an emerging Paramyxoviridae disease with epidemic potential
Nipah virus infection: preparedness for the pathological diagnosis of an emerging Paramyxoviridae disease with epidemic potential Open
View article: Inflammation Exacerbates Congenital Zika Virus Infection and Naringenin Provides Protective Effects
Inflammation Exacerbates Congenital Zika Virus Infection and Naringenin Provides Protective Effects Open
View article: Osteomyelitis and aortic arteritis with thrombosis as primary manifestations of severe paracoccidioidomycosis: a case report.
Osteomyelitis and aortic arteritis with thrombosis as primary manifestations of severe paracoccidioidomycosis: a case report. Open
Paracoccidioidomycosis (PCM) configures a deep mycosis caused by Paracoccidioides spp., a neglected tropical disease. We describe a fatal case of PCM that manifested itself as osteomyelitis with thrombosis in the iliac artery in a man with…
View article: The role of hormone dosages in the assessment of cervical lesions by FNA: A descriptive analysis of 762 cases
The role of hormone dosages in the assessment of cervical lesions by FNA: A descriptive analysis of 762 cases Open
View article: Spatial Deconvolution of Cell Types and Cell States at Scale Utilizing TACIT
Spatial Deconvolution of Cell Types and Cell States at Scale Utilizing TACIT Open
Identifying cell types and states remains a time-consuming and error-prone challenge for spatial biology. While deep learning is increasingly used, it is difficult to generalize due to variability at the level of cells, neighborhoods, and …
View article: Lung tissue expression of epithelial injury markers is associated with acute lung injury severity but does not discriminate sepsis from ARDS
Lung tissue expression of epithelial injury markers is associated with acute lung injury severity but does not discriminate sepsis from ARDS Open
View article: Neuron-specific enolase at admission as a predictor for stroke volume, severity and outcome in ischemic stroke patients: a prognostic biomarker review
Neuron-specific enolase at admission as a predictor for stroke volume, severity and outcome in ischemic stroke patients: a prognostic biomarker review Open
An ideal blood biomarker for stroke should provide reliable results, enable fast diagnosis, and be readily accessible for practical use. Neuron-specific enolase (NSE), an enzyme released after neuronal damage, has been studied as a marker …
View article: Postmortem chest computed tomography in COVID-19: A minimally invasive autopsy method
Postmortem chest computed tomography in COVID-19: A minimally invasive autopsy method Open
View article: Osteomyelitis and Aortic Arteritis with thrombosis as primary manifestations of systemic paracoccidioidomycosis: a case report
Osteomyelitis and Aortic Arteritis with thrombosis as primary manifestations of systemic paracoccidioidomycosis: a case report Open
Background Paracoccidioidomycosis (PCM) is a neglected deep mycosis caused by Paracoccidioides sp. We describe a fatal PCM case, presenting as osteomyelitis, in a man having frequent contact with an endemic region of São Paulo, Brazil. Cas…
View article: Younger age is associated with cardiovascular pathological phenotype of severe COVID-19 at autopsy
Younger age is associated with cardiovascular pathological phenotype of severe COVID-19 at autopsy Open
Introduction COVID-19 affects patients of all ages. There are few autopsy studies focusing on the younger population. We assessed an autopsy cohort aiming to understand how age influences pathological outcomes in fatal COVID-19. Methods Th…
View article: Importance of the Return of Nimodipine to Brazil: pharmacological options for cerebral vasospasm after subarachnoid hemorrhage. Literature review
Importance of the Return of Nimodipine to Brazil: pharmacological options for cerebral vasospasm after subarachnoid hemorrhage. Literature review Open
View article: Targeting Students of Nonhealth Academic Fields for Basic Life Support: They Need to Know Why, What and How to Do CPR
Targeting Students of Nonhealth Academic Fields for Basic Life Support: They Need to Know Why, What and How to Do CPR Open
View article: Willingness and skills among students from non-health academic fields in providing efficient basic life support
Willingness and skills among students from non-health academic fields in providing efficient basic life support Open
View article: COVID-19 induces more pronounced extracellular matrix deposition than other causes of ARDS
COVID-19 induces more pronounced extracellular matrix deposition than other causes of ARDS Open
Background Lung fibrosis is a major concern in severe COVID-19 patients undergoing mechanical ventilation (MV). Lung fibrosis frequency in post-COVID syndrome is highly variable and even if the risk is proportionally small, many patients c…
View article: Implantação e impacto da disciplina de medicina culinária no quarto ano do curso de medicina na Universidade de São Paulo, USP, Brasil
Implantação e impacto da disciplina de medicina culinária no quarto ano do curso de medicina na Universidade de São Paulo, USP, Brasil Open
Introdução: A medicina culinária tornou-se área em expansão no mundo e no Brasil nos últimos 5 anos. Os primeiros passos como disciplina eletiva e optativa feitos em 2018, em 2023 consolida-se como disciplina obrigatória. Objetivo: Relatar…
View article: Implantação da disciplina de medicina de estilo de vida no currículo obrigatório na USP - Bauru
Implantação da disciplina de medicina de estilo de vida no currículo obrigatório na USP - Bauru Open
Introdução: A medicina do estilo de vida tem por objetivo a promoção e manutenção de hábitos de vida saudáveis levando a prevenção, reversão e redução das doenças crônicas não transmissíveis (DCNTs), principalmente doenças cardiovasculares…
View article: Pediatric postmortem CT angiography: validation of vascular access for PMCT angiography in stillbirths, babies and toddlers
Pediatric postmortem CT angiography: validation of vascular access for PMCT angiography in stillbirths, babies and toddlers Open
View article: Understanding yellow fever-associated myocardial injury: an autopsy study
Understanding yellow fever-associated myocardial injury: an autopsy study Open
This study was funded by Fundação de Amparo à Pesquisa do Estado de São Paulo, Bill and Melinda Gates Foundation, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
View article: Methotrexate for refractory adult atopic dermatitis leads to alterations in cutaneous IL-31 and IL-31RA expression
Methotrexate for refractory adult atopic dermatitis leads to alterations in cutaneous IL-31 and IL-31RA expression Open
View article: Neuron-Specific Enolase as a predictor for outcomes in ischemic stroke: a prognostic biomarker review
Neuron-Specific Enolase as a predictor for outcomes in ischemic stroke: a prognostic biomarker review Open
Recent studies have investigated the role of neuron-specific enolase (NSE) as a potential predictor for outcomes in acute ischemic stroke patients. However, up to date, the current body of research has yielded inconclusive results, as its …
View article: Um estudo da prevalência e da caracterização da mortalidade em crianças e adolescentes por leucemia no Brasil
Um estudo da prevalência e da caracterização da mortalidade em crianças e adolescentes por leucemia no Brasil Open
Este artigo tem por objetivo caracterizar a prevalência da mortalidade por leucemias em crianças e adolescentes no Brasil. Trata-se de um estudo epidemiológico, do tipo ecológico, cujas unidades de análise de área foram as regiões do Brasi…
View article: The need for integrated research autopsies in the era of precision oral medicine
The need for integrated research autopsies in the era of precision oral medicine Open
View article: Obesity Induces an Impaired Placental Antiviral Immune Response in Pregnant Women Infected with Zika Virus
Obesity Induces an Impaired Placental Antiviral Immune Response in Pregnant Women Infected with Zika Virus Open
Obesity is increasing in incidence worldwide, especially in women, which can affect the outcome of pregnancy. During this period, viral infections represent a risk to the mother, the placental unit, and the fetus. The Zika virus (ZIKV) out…