Explanipedia

Avaliação do percentual de gordura corporal em relação à esteatose hepática Open

Irineu da Silva, Matheus Gabriel de Oliveira, João Luís Neto, Josilda Ferreira Cruz · 2025

A DHGNA é uma doença multifatorial caracterizada pelo acúmulo de gordura no fígado quando ultrapassado 5% do peso do fígado e não tem relação com o consumo de álcool. Atualmente, a doença é considerada como o principal distúrbio hepático. …

A importância das enzimas ALT, AST e GGT na gravidade da esteatose hepática não alcoólica Open

Matheus Gabriel de Oliveira, Irineu da Silva, João Luís Neto, Josilda Ferreira Cruz · 2025

Introdução: A Doença Hepática Gordurosa Não Alcoólica (DHGNA) é caracterizada pelo acúmulo excessivo de lipídios nos hepatócitos e acomete indivíduos que não apresentam consumo significativo de álcool. É considerada um dos principais probl…

Entre a Margem e o Essencial: A Inserção do Ensino de Algas nos Cursos de Biologia nas Universidades Estaduais Open

João Luís Neto, Francisco de Assis Ribeiro dos Santos · 2025

Comparative analysis of mortality trends from meningioma across regions of Brazil from 2012 to 2022 Open

Giulia Di Credico Paranhos, Letícia Bezerra de Almeida, João Luís Neto, Luana Araújo Duarte, Lucas Lucena , et al. · 2025

RESÍDUOS E CONSCIÊNCIA: TRANSFORMANDO DESAFIOS EM SUSTENTABILIDADE NO INTERIOR PIAUIENSE Open

Edmundo Sousa, Fabiana Paiva Coelho Santos, Iza Marielly de Araújo Nobre, João Luís Neto, Ana Lima · 2025

A PREVALÊNCIA DE FLUOROSE EM CRIANÇAS E ADOLESCENTES Open

João Luís Neto, Lidiane dos Santos Carvalho, Lívia dos Santos Pinto, Maria C. F. de Oliveira, Márcia Regina Soares Cruz · 2024

O flúor, um mineral natural, é reconhecido como um dos ametais mais reativos da tabela periódica, e sua presença é significativa na crosta terrestre. Comum em alimentos como arroz, feijão e frutos do mar (HAGMANN, 2008). Na odontologia, su…

Analytical validation and algorithm improvement of HepatoPredict kit to assess hepatocellular carcinoma prognosis before a liver transplantation Open

Maria Gonçalves-Reis, Daniela Proença, Laura P. Frazão, João Luís Neto, Sílvia Silva , et al. · 2024

The use of neural networks to predict stroke diagnosis: a systematic review Open

V. Silva, Kael Costa Santana, João Luís Neto, Miguel Lira, Marcela Vasconcelos Montenegro , et al. · 2024

Background: Stroke is a syndrome of acute neurological deficit attributed to vascular damage to the Nervous System (NS). The Artificial Intelligence (AI) techniques in Medicine – such as Artificial Neural Networks algorithms (ANNs) – have …

CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia Open

Bruno A. Cardoso, Mafalda Duque, Ana Gírio, Rita Fragoso, Mariana L. Oliveira , et al. · 2023

CASZ1 is a conserved transcription factor involved in neural development, blood vessel assembly and heart morphogenesis. CASZ1 has been implicated in cancer, either suppressing or promoting tumor development depending on the tissue. Howeve…

Orientação em campus universitário: um estudo sobre abordagens de aplicativos de localização por meio de revisão sistemática Open

Elizandro André Brasil CARNEIRO Carneiro, Eduardo Jorge Lira Antunes da SILVA Silva, João Luís Neto · 2023

A mobilidade é um fator importante em diversos ambientes, pois orienta e guia os usuários evitando possíveis constrangimentos. O design como subsídio para o estudo se torna um diferencial ao ampliar sua importância nas estratégias de inova…

Analytical validation of HepatoPredict kit to assess hepatocellular carcinoma prognosis prior to a liver transplantation Open

Maria Gonçalves-Reis, Daniela Proença, Laura P. Frazão, João Luís Neto, Sílvia Silva , et al. · 2023

Background The best curative treatment for hepatocellular carcinoma (HCC) is liver transplant (LT), but the limited number of organs available for LT dictates strict eligibility criteria. Despite this patient selection stringency, current …

LIPOMA INTRA-ABDOMINAL EM CÃO (RELATO DE CASO) Open

Bruno Alcântara Buzato, Bárbara Aparecida Moraes da Silva, Leandro Luís Martins, João Luís Neto, Carmen Lúcia Scortecci Hilst · 2022

Lipoma é uma neoplasia mesenquimal benigna de adipócitos, com grande frequência nas formas subcutânea ou dérmica e de maior ocorrência ligada à espécie canina. Caracteriza por apresentar massa única, arredondada, bem circunscrita de cresci…

A Gene Expression Signature to Select Hepatocellular Carcinoma Patients for Liver Transplantation Open

Hugo P. Marques, Joana Cardoso, Sílvia Silva, João Luís Neto, Maria Gonçalves-Reis , et al. · 2022

Objective: To propose a new decision algorithm combining biomarkers measured in a tumor biopsy with clinical variables, to predict recurrence after liver transplantation (LT). Background: Liver cancer is one of the most frequent causes of …

Molecular Characterization of Portuguese Patients with Hereditary Cerebellar Ataxia Open

Mariana Santos, Joana Damásio, Susana Carmona, João Luís Neto, Nadia Dehghani , et al. · 2022

Hereditary cerebellar ataxia (HCA) comprises a clinical and genetic heterogeneous group of neurodegenerative disorders characterized by incoordination of movement, speech, and unsteady gait. In this study, we performed whole-exome sequenci…

Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia Open

Afonso R. M. Almeida, João Luís Neto, Ana Cachucho, Mayara Ferreira Euzébio, Xiangyu Meng , et al. · 2021

Interleukin-7 receptor α (encoded by IL7R ) is essential for lymphoid development. Whether acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger leukemogenesis remains unclear. Here, we demonstrate that lym…

CD44v6 High Membranous Expression Is a Predictive Marker of Therapy Response in Gastric Cancer Patients Open

Gabriela M. Almeida, Carla Pereira, Ji‐Hyeon Park, Carolina Lemos, Sofia Campelos , et al. · 2021

In gastric cancer (GC), biomarkers that define prognosis and predict treatment response remain scarce. We hypothesized that the extent of CD44v6 membranous tumor expression could predict prognosis and therapy response in GC patients. Two G…

A genetic interaction of NRXN2 with GABRE, SYT1 and CASK in migraine patients: a case-control study Open

Miguel Alves‐Ferreira, Marlene Quintas, Jorge Sequeiros, Alda Sousa, José Pereira‐Monteiro , et al. · 2021

Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma Open

Ana Silva, Afonso R. M. Almeida, Ana Cachucho, João Luís Neto, Sofie Demeyer , et al. · 2021

Tight regulation of IL-7Rα expression is essential for normal T-cell development. IL-7Rα gain-of-function mutations are known drivers of T-cell acute lymphoblastic leukemia (T-ALL). Although a subset of patients with T-ALL display high IL7…

Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice Open

Marina Kovalenko, Serkan Erdin, Marissa A Andrew, Jason St. Claire, Melissa Shaughnessey , et al. · 2020

Somatic expansion of the Huntington’s disease (HD) CAG repeat drives the rate of a pathogenic process ultimately resulting in neuronal cell death. Although mechanisms of toxicity are poorly delineated, transcriptional dysregulation is a li…

Author response: Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice Open

Marina Kovalenko, Serkan Erdin, Marissa A Andrew, Jason St. Claire, Melissa Shaughnessey , et al. · 2020

Heritability and genetic variance of dementia with Lewy bodies Open

Rita Guerreiro, Valentina Escott‐Price, Dena Hernandez, Célia Kun‐Rodrigues, Owen A. Ross , et al. · 2019

LRP10 in α-synucleinopathies Open

Rita Guerreiro, Tatiana Orme, João Luís Neto, José Brás, Rita Guerreiro , et al. · 2018

Heritability and genetic variance of dementia with Lewy bodies Open

Rita Guerreiro, Valentina Escott‐Price, Dena G. Hernandez, Célia Kun‐Rodrigues, Owen A. Ross , et al. · 2018

Recent large-scale genetic studies have allowed for the first glimpse of the effects of common genetic variability in dementia with Lewy bodies (DLB), identifying risk variants with appreciable effect sizes. However, it is currently well e…

MARCADORES DO ESTRESSE OXIDATIVO EM CRIANÇAS INFECTADAS COM H.PYLORI RESIDENTES EM COMUNIDADE URBANA NO NORDESTE DO BRASIL Open

Nívea Silva, Michelle Soeiro de Oliveira, Ana Viana, Flávia Roberta dos Santos, Tiago Gomes da Silva Benígno , et al. · 2017

RESULTADOS DA ESOFAGECTOMIA POR VIDEOTORACOSCOPIA EM PACIENTES COM CÂNCER DE ESÔFAGO Open

Fábio Henrique Mendonça Chaim, Valdir Junior, João Luís Neto, Luiz Roberto Lopes, Nelson Adami Andreollo · 2017

CAG repeat instability in Huntington's disease: insights from HD patients and mouse models Open

João Luís Neto · 2017

Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington’s Disease Knock-In Mice Open

João Luís Neto, Jong‐Min Lee, Ali Afridi, Tammy Gillis, Jolene R. Guide , et al. · 2016

Huntington’s disease (HD) is a neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in exon 1 of the HTT gene. Longer repeat sizes are associated with increased disease penetrance and earlier ages of onset. Inte…

Green Ocean Amazon 2014/15 High-Volume Filter Sampling: Atmospheric Particulate Matter of an Amazon Tropical City and its Relationship to Population Health Field Campaign Report Open

Cristine M. D. Machado, Erickson Oliveira dos Santos, Karenn Silveira Fernandes, João Luís Neto, Rodrigo Augusto Ferreira De Souza · 2016

Manaus, the capital of the Brazilian state of Amazonas, is developing very rapidly. Its pollution plume contains aerosols from fossil fuel combustion mainly due to vehicular emission, industrial activity, and a thermal power plant. Soil re…

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