Luiz Guilherme Darrigo
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View article: Hematopoietic stem cell transplantation in children with thalassemia: Brazilian Society of Bone Marrow Transplantation Consensus
Hematopoietic stem cell transplantation in children with thalassemia: Brazilian Society of Bone Marrow Transplantation Consensus Open
Allogeneic hematopoietic cell transplantation (HCT) represents a critical therapeutic option for patients with transfusiondependent thalassemia (TDT), with thalassemia-free survival rates exceeding 90% in cases involving HLA-matched siblin…
View article: Sickle cell disease
Sickle cell disease Open
Sickle cell disease (SCD) is known as the most common hemoglobin disorder, with severe forms of thalassemia syndromes following closely. Current standard treatments, including transfusions, hydroxyurea, and L-glutamine, still do not signif…
View article: Management of pediatric acute leukemias relapse after hematopoietic cell transplantation
Management of pediatric acute leukemias relapse after hematopoietic cell transplantation Open
Prevention is the best way to avoid relapse after hematopoietic cell transplantation (HCT). Immunomodulation can enhance graft-versus-leukemia effect and, if graft-versus-host disease (GVHD) is absent, prophylactic donor lymphocyte infusio…
View article: Hematopoietic cell transplantation in inherited bone marrow failure syndromes
Hematopoietic cell transplantation in inherited bone marrow failure syndromes Open
Inherited bone marrow failure syndromes (IBMFS) comprise a heterogeneous group of rare genetic disorders characterized by defective hematopoiesis, congenital anomalies, and a predisposition to clonal evolution and malignancies. Hematopoiet…
View article: Molecular Profile and Dynamics of Commensal Viruses in Brazilian Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation
Molecular Profile and Dynamics of Commensal Viruses in Brazilian Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation Open
Background Commensal viruses are typically well‐tolerated by healthy individuals, but their behavior in immunocompromised patients is not fully understood. Methods This study investigated the prevalence, molecular dynamics, and circulating…
View article: Viral Metagenomics in Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation (HSCT): A Brazilian Experience
Viral Metagenomics in Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation (HSCT): A Brazilian Experience Open
Viral infections are one of the most important causes of morbidity and mortality among patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Immunosuppression may lead to the reactivation of latent viruses or the a…
View article: HEMATOPOIETIC CELL TRANSPLANTATION (HCT) FOR ALL: A report from the 2024 Congress of the Brazilian Bone Marrow Transplantation and Cellular Therapy Society (SBTMO)
HEMATOPOIETIC CELL TRANSPLANTATION (HCT) FOR ALL: A report from the 2024 Congress of the Brazilian Bone Marrow Transplantation and Cellular Therapy Society (SBTMO) Open
This article analyzes current data, and the main challenges faced in Hematopoietic cell Transplantation (HCT) in Brazil, as presented at the SBTMO 2024 meeting, with the aim of guiding future actions. Topics discussed included the waiting …
View article: The Role of Smartphone-Based Applications and Artificial Intelligence Aiding in Screening, Faster Diagnosis and Prevention in Skin Cancer: A Systematic Mini-Review
The Role of Smartphone-Based Applications and Artificial Intelligence Aiding in Screening, Faster Diagnosis and Prevention in Skin Cancer: A Systematic Mini-Review Open
Background: Skin cancer, especially melanoma, is one of the most common cancers in humans. According to the WHO, it causes a significant burden on modern health services. Currently, diagnostics are painful and invasive for patients and hea…
View article: HLA-identical sibling hematopoietic stem cell transplantation following reduced-toxicity myeloablative conditioning regimen in sickle cell disease
HLA-identical sibling hematopoietic stem cell transplantation following reduced-toxicity myeloablative conditioning regimen in sickle cell disease Open
Allogeneic hematopoietic stem cell transplantation (HSCT) is the only widely available curative treatment for sickle cell disease (SCD). Myeloablative conditioning regimens are associated with excellent outcomes in children with HLA-identi…
View article: HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR HEMOGLOBINOPATHIES
HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR HEMOGLOBINOPATHIES Open
In 2021 the Brazilian society of stem cell transplantation and cell therapy published the consensus guidelines regarding hematopoietic stem cell transplantation (HSCT) for hemoglobinopathies. No changes have been added for thalassemia. HSC…
View article: Effects of nandrolone decanoate on telomere length and clinical outcome in patients with telomeropathies: a prospective trial
Effects of nandrolone decanoate on telomere length and clinical outcome in patients with telomeropathies: a prospective trial Open
Androgens have been reported to elongate telomeres in retrospective and prospective trials with patients with telomeropathies, mainly with bone marrow failure. In our single-arm prospective clinical trial (clinicaltrials gov. Identifier: N…
View article: Epidemiological profile and clinical characteristics of 491 Brazilian patients with neurofibromatosis type 1
Epidemiological profile and clinical characteristics of 491 Brazilian patients with neurofibromatosis type 1 Open
Background Neurofibromatosis type 1 (NF1) is a chronic and progressive autosomal dominant genetic and sporadic disease characterized by cutaneous and neurological abnormalities. Plexiform neurofibroma (PN), a significant cause of clinical …
View article: Guidelines on sickle cell disease: secondary stroke prevention in children and adolescents. Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular guidelines project: Associação Médica Brasileira - 2022
Guidelines on sickle cell disease: secondary stroke prevention in children and adolescents. Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular guidelines project: Associação Médica Brasileira - 2022 Open
View article: Allogeneic haematopoietic stem cell transplantation resets T‐ and B‐cell compartments in sickle cell disease patients
Allogeneic haematopoietic stem cell transplantation resets T‐ and B‐cell compartments in sickle cell disease patients Open
Objectives Allogeneic haematopoietic stem cell transplantation (allo‐HSCT) is the only currently available curative treatment for sickle cell disease (SCD). Here, we comprehensively evaluated the reconstitution of T‐ and B‐cell compartment…
View article: Brazilian Consensus Meeting on Pediatric Hematopoietic Stem Cell Transplantation for Acquired Aplastic Anemia and Inherited Bone Marrow Failure Syndromes
Brazilian Consensus Meeting on Pediatric Hematopoietic Stem Cell Transplantation for Acquired Aplastic Anemia and Inherited Bone Marrow Failure Syndromes Open
THE BRAZILIAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION (SBTMO) PRESENTS THE BRAZILIAN GUIDELINES ON HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR ACQUIRED APLASTIC ANEMIA AND INHERITED BONE MARROW FAILURE SYNDROMES
View article: HEMATOPOIETIC STEM CELL TRANSPLANTATION IN CHILDREN WITH HEMOGLOBINOPATHIES: BRAZILIAN SOCIETY OF BONE MARROW TRANSPLANTATION CONSENSUS
HEMATOPOIETIC STEM CELL TRANSPLANTATION IN CHILDREN WITH HEMOGLOBINOPATHIES: BRAZILIAN SOCIETY OF BONE MARROW TRANSPLANTATION CONSENSUS Open
THE BRAZILIAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION (SBTMO) PRESENTS THE BRAZILIAN GUIDELINES ON HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR CHILDREN WITH HEMOGLOBINOPATHIES
View article: Consenso Brasileiro de Nutrição em Transplante de Células-Tronco Hematopoiéticas: crianças e adolescentes
Consenso Brasileiro de Nutrição em Transplante de Células-Tronco Hematopoiéticas: crianças e adolescentes Open
RESUMO O Consenso Brasileiro de Nutricao em Transplante de Celulas-Tronco Hematopoieticas: criancas e adolescentes foi elaborado com a participacao de nutricionistas, medicos nutrologos e medicos hematologistas pediatricos de 10 centros br…
View article: Guidelines on sickle cell disease: primary stroke prevention in children and adolescents. Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Guidelines project: Associação Médica Brasileira - 2021
Guidelines on sickle cell disease: primary stroke prevention in children and adolescents. Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Guidelines project: Associação Médica Brasileira - 2021 Open
View article: Hematopoietic stem cell transplantation reverses white matter injury measured by diffusion-tensor imaging (DTI) in sickle cell disease patients
Hematopoietic stem cell transplantation reverses white matter injury measured by diffusion-tensor imaging (DTI) in sickle cell disease patients Open
View article: HSCT FOR ACQUIRED BONE MARROW FAILURE SYNDROMES
HSCT FOR ACQUIRED BONE MARROW FAILURE SYNDROMES Open
THE BRAZILIAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION (SBTMO) PRESENTS THE BRAZILIAN GUIDELINES ON HEMATOPOIETIC STEM CELL TRANSPLANTATION
View article: HSCT FOR INHERITED BONE MARROW FAILURE SYNDROMES
HSCT FOR INHERITED BONE MARROW FAILURE SYNDROMES Open
THE BRAZILIAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION (SBTMO) PRESENTS THE BRAZILIAN GUIDELINES ON HEMATOPOIETIC STEM CELL TRANSPLANTATION
View article: HSCT FOR HEMOGLOBINOPATHIES
HSCT FOR HEMOGLOBINOPATHIES Open
THE BRAZILIAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION (SBTMO) PRESENTS THE BRAZILIAN GUIDELINES ON HEMATOPOIETIC STEM CELL TRANSPLANTATION
View article: HSCT FOR PEDIATRIC DISEASES
HSCT FOR PEDIATRIC DISEASES Open
THE BRAZILIAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION (SBTMO) PRESENTS THE BRAZILIAN GUIDELINES ON HEMATOPOIETIC STEM CELL TRANSPLANTATION
View article: Clinical assessment of the use of topical liquid diclofenac following laser microporation of cutaneous neurofibromas in individuals with neurofibromatosis type 1
Clinical assessment of the use of topical liquid diclofenac following laser microporation of cutaneous neurofibromas in individuals with neurofibromatosis type 1 Open
ClinicalTrials.gov (NCT03090971) retrospectively registered March 27, 2017.
View article: Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: children and adolescents
Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: children and adolescents Open
The Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Children and Adolescents was developed by dietitians, physicians, and pediatric hematologists from 10 Brazilian reference centers in hematopoietic stem cell tr…
View article: <p>Treatment of Recurrent Urinary Tract Infection Symptoms with Urinary Antiseptics Containing Methenamine and Methylene Blue: Analysis of Etiology and Treatment Outcomes</p>
Treatment of Recurrent Urinary Tract Infection Symptoms with Urinary Antiseptics Containing Methenamine and Methylene Blue: Analysis of Etiology and Treatment Outcomes Open
Both treatments were effective in reducing UTI symptoms assessed by UTISA questionnaire after 3 days of treatment. The two regimens were comparable in incidence of adverse events, but the combination of methenamine + methylene blue resulte…
View article: RECENT ADVANCES IN HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR INHERITED BONE MARROW FAILURE SYNDROMES
RECENT ADVANCES IN HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR INHERITED BONE MARROW FAILURE SYNDROMES Open
The inherited bone marrow failure syndromes (IBMFS) are a heterogeneous group of genetic disorders characterized by the inadequate production of at least one of the hematopoietic lineages, leading to the development of both isolated cytope…
View article: Issue Information
Issue Information Open
Non-myeloablative matched sibling stem cell transplantation with the optional reinforced stem cell infusion for patients with hemoglobinopathies Application of comprehensive geriatric assessment in predicting early mortality among elder pa…
View article: Blood transfusion support for sickle cell patients during haematopoietic stem cell transplantation: a single‐institution experience
Blood transfusion support for sickle cell patients during haematopoietic stem cell transplantation: a single‐institution experience Open
Sickle cell disease (SCD) is the most prevalent monogenic disease in the world.1 In Brazil, SCD affects approximately 30 000 people, with 3 500 new patients born each year.2 SCD is characterized by haemolytic anaemia and organ injury. Trea…
View article: Outcome of patients with Fanconi anemia developing myelodysplasia and acute leukemia who received allogeneic hematopoietic stem cell transplantation: A retrospective analysis on behalf of <scp>EBMT</scp> group
Outcome of patients with Fanconi anemia developing myelodysplasia and acute leukemia who received allogeneic hematopoietic stem cell transplantation: A retrospective analysis on behalf of <span>EBMT</span> group Open
Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is curative for bone marrow failure in patients with Fanconi anemia (FA), but the presence of a malignant transformation is associated with a poor prognosis and the management …