Luiz H. M. Bozi
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View article: The human zinc-binding cysteine proteome
The human zinc-binding cysteine proteome Open
Zinc is an essential micronutrient that regulates a wide range of physiological processes, most often through zinc binding to protein cysteine residues. Despite being critical for modulation of protein function, the cysteine sites in the m…
View article: Author Correction: A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats
Author Correction: A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats Open
View article: A comprehensive landscape of the zinc-regulated human proteome
A comprehensive landscape of the zinc-regulated human proteome Open
Summary Zinc is an essential micronutrient that regulates a wide range of physiological processes, principally through Zn 2+ binding to protein cysteine residues. Despite being critical for modulation of protein function, for the vast majo…
View article: Lactate regulates cell cycle by remodelling the anaphase promoting complex
Lactate regulates cell cycle by remodelling the anaphase promoting complex Open
View article: Architecture of the outbred brown fat proteome defines regulators of metabolic physiology
Architecture of the outbred brown fat proteome defines regulators of metabolic physiology Open
View article: Exercise preserves fitness capacity during aging through AMPK and mitochondrial dynamics
Exercise preserves fitness capacity during aging through AMPK and mitochondrial dynamics Open
Exercise is a nonpharmacological intervention that improves health during aging, and a valuable tool in the diagnostics of aging-related diseases. In muscle, exercise transiently alters mitochondrial functionality and metabolism. Mitochond…
View article: pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise
pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise Open
View article: Mitochondrial Unfolded Protein Response (UPRmt) Activation in Cardiac Diseases
Mitochondrial Unfolded Protein Response (UPRmt) Activation in Cardiac Diseases Open
View article: A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats
A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats Open
View article: Exercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy
Exercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy Open
Increased proteolytic activity has been widely associated with skeletal muscle atrophy. However, elevated proteolysis is also critical for the maintenance of cellular homeostasis by disposing cytotoxic proteins and non-functioning organell…
View article: Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure
Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure Open
We previously reported that facilitating the clearance of damaged mitochondria through macroautophagy/autophagy protects against acute myocardial infarction. Here we characterize the impact of exercise, a safe strategy against cardiovascul…
View article: Mitochondrial‐derived vesicles: a new player in cardiac mitochondrial quality control
Mitochondrial‐derived vesicles: a new player in cardiac mitochondrial quality control Open
Mitochondria are critical organelles involved in adenosine triphosphate (ATP) synthesis, reactive oxygen species generation, ion homeostasis, aldehyde metabolism and programmed cell death. Loss of mitochondrial integrity is sufficient to e…
View article: Lactate Up-Regulates the Expression of Lactate Oxidation Complex-Related Genes in Left Ventricular Cardiac Tissue of Rats
Lactate Up-Regulates the Expression of Lactate Oxidation Complex-Related Genes in Left Ventricular Cardiac Tissue of Rats Open
Our results provide evidence for lactate-induced up-regulation of lactate oxidation complex associated with increased NADH oxidase activity and cardiac O2●-/H2O2 driving to an anti-oxidant response. These results unveil lactate as an impor…
View article: Caracterização da disfunção cardíaca induzida pelo estresse do retículo endoplasmático: papel do treinamento físico aeróbico
Caracterização da disfunção cardíaca induzida pelo estresse do retículo endoplasmático: papel do treinamento físico aeróbico Open
\n As doenças cardiovasculares são a principal causa de morte no mundo, sendo a cardiomiopatia isquêmica a mais prevalente. Independente da sua etiologia, a via final comum da maioria das doenças cardiovasculares é a insuficiência cardíaca…
View article: Impact of Leucine Supplementation on Exercise Training Induced Anti-Cardiac Remodeling Effect in Heart Failure Mice
Impact of Leucine Supplementation on Exercise Training Induced Anti-Cardiac Remodeling Effect in Heart Failure Mice Open
Leucine supplementation potentiates the effects of aerobic exercise training (AET) on skeletal muscle; however, its potential effects associated with AET on cardiac muscle have not been clarified yet. We tested whether leucine supplementat…
View article: Resistance Training Regulates Cardiac Function through Modulation of miRNA-214
Resistance Training Regulates Cardiac Function through Modulation of miRNA-214 Open
Aims: To determine the effects of resistance training (RT) on the expression of microRNA (miRNA)-214 and its target in sarcoplasmic reticulum Ca2+-ATPase (SERCA2a), and on the morphological and mechanical properties of isolated left ventri…