Luiz Henrique Agra Cavalcante‐Silva
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View article: From hormonal immunomodulation to glioblastoma therapy: the emerging role of Ouabain
From hormonal immunomodulation to glioblastoma therapy: the emerging role of Ouabain Open
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, characterized by rapid proliferation, diffuse infiltration, and resistance to conventional therapies. Despite advances in surgery, radiotherapy, and chemotherapy, the…
View article: Cardiotonic Steroids as a Potential Novel Approach for Immunomodulation in Inflammatory Bowel Disease
Cardiotonic Steroids as a Potential Novel Approach for Immunomodulation in Inflammatory Bowel Disease Open
Inflammatory bowel disease (IBD) is a chronic condition that significantly impairs the quality of life of millions of individuals. The pathogenesis of IBD is closely linked to dysbiosis of microbiota and the activation of various inflammat…
View article: MiR-9-3 hypermethylation is associated with stages of diabetic retinopathy
MiR-9-3 hypermethylation is associated with stages of diabetic retinopathy Open
View article: T Cell Response in Tuberculosis-Infected Patients Vaccinated against COVID-19
T Cell Response in Tuberculosis-Infected Patients Vaccinated against COVID-19 Open
Many studies have focused on SARS-CoV-2 and Mycobacterium tuberculosis (Mtb) co-infection consequences. However, after a vaccination plan against COVID-19, the cases of severe disease and death are consistently controlled, although cases o…
View article: Vacinação em pessoas vivendo com HIV/AIDS: uma revisão integrativa
Vacinação em pessoas vivendo com HIV/AIDS: uma revisão integrativa Open
View article: COVID-19: papel de células T na doença e na proteção
COVID-19: papel de células T na doença e na proteção Open
View article: Papel dos neutrófilos na tuberculose
Papel dos neutrófilos na tuberculose Open
View article: Aspectos neuroimunológicos do microambiente tumoral de Glioblastomas Multiforme (GBM)
Aspectos neuroimunológicos do microambiente tumoral de Glioblastomas Multiforme (GBM) Open
View article: Vigilância epidemiológica da tuberculose na Paraíba, nordeste do Brasil: correlações com a COVID-19
Vigilância epidemiológica da tuberculose na Paraíba, nordeste do Brasil: correlações com a COVID-19 Open
View article: Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis
Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis Open
Mycobacterium tuberculosis complex causes tuberculosis (TB), a disease that causes pulmonary inflammation but can also affect other tissues. Despite macrophages having a defined role in TB immunopathogenesis, other innate immune cells, suc…
View article: <em>Mycobacterium tuberculosis</em> in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis
<em>Mycobacterium tuberculosis</em> in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis Open
Mycobacterium tuberculosis complex causes tuberculosis (TB), a disease that causes pulmonary inflammation but can also affect other tissues. Despite macrophages having a defined role in TB immunopathogenesis, other innate immune cells, suc…
View article: Leishmaniasis: Immune Cells Crosstalk in Macrophage Polarization
Leishmaniasis: Immune Cells Crosstalk in Macrophage Polarization Open
Leishmaniasis is a complex infectious parasitic disease caused by protozoa of the genus Leishmania, belonging to a group of neglected tropical diseases. It establishes significant global health challenges, particularly in socio-economicall…
View article: Leishmaniasis: Immune Cells Crosstalk in Macrophage Polarization
Leishmaniasis: Immune Cells Crosstalk in Macrophage Polarization Open
Leishmaniasis is a complex infectious parasitic disease caused by protozoa of the genus Leishmania, belonging to a group of neglected tropical diseases. It poses significant global health challenges, particularly in socio-economically disa…
View article: Leishmanicidal Activity of Guanidine Derivatives against Leishmania infantum
Leishmanicidal Activity of Guanidine Derivatives against Leishmania infantum Open
Leishmaniasis is a neglected tropical infectious disease with thousands of cases annually; it is of great concern to global health, particularly the most severe form, visceral leishmaniasis. Visceral leishmaniasis treatments are minimal an…
View article: Neuroinflammation and Neutrophils: Modulation by Ouabain
Neuroinflammation and Neutrophils: Modulation by Ouabain Open
Cardiotonic steroids are natural compounds that present many physiological and pharmacological functions. They bind Na + /K + -ATPase (NKA) modifying cellular ion concentration and trigger cell signaling mechanisms without altering ion bal…
View article: Determinação fitoquímica e avaliação do fator de proteção solar das espécies Acmella oleracea e Cipura paludosa / Phytochemical determination and sun protection factor evaluation of the species Acmella oleracea and Cipura paludosa
Determinação fitoquímica e avaliação do fator de proteção solar das espécies Acmella oleracea e Cipura paludosa / Phytochemical determination and sun protection factor evaluation of the species Acmella oleracea and Cipura paludosa Open
Os metabólitos secundários produzidos pelas plantas são responsáveis por suas atividades farmacológicas e a produção destes metabólitos representa também uma interação química entre a planta e o ambiente em que as envolve. Logo, tal produç…
View article: Ouabain Modulates Airway Remodeling Caused by Th2-High Asthma in Mice
Ouabain Modulates Airway Remodeling Caused by Th2-High Asthma in Mice Open
View article: Patulin inhibits LPS-induced nitric oxide production by suppressing MAPKs signaling pathway
Patulin inhibits LPS-induced nitric oxide production by suppressing MAPKs signaling pathway Open
Patulin (PAT) is a natural product isolated from several species of fungi. Here, we evaluated the effect of PAT (62.5–4,000 ng/ml) in lipopolysaccharide (LPS)-activated murine peritoneal macrophages. Cell viability assay showed that PAT at…
View article: Ouabain inhibits p38 activation in mice neutrophils
Ouabain inhibits p38 activation in mice neutrophils Open
View article: Neutrophils and COVID-19: The road so far
Neutrophils and COVID-19: The road so far Open
View article: Marinobufagenin Inhibits Neutrophil Migration and Proinflammatory Cytokines
Marinobufagenin Inhibits Neutrophil Migration and Proinflammatory Cytokines Open
Cardiotonic steroids, such as ouabain and digoxin, are known to bind to Na + /K + -ATPase and to promote several biological activities, including anti-inflammatory activity. However, there are still no reports in the literature about infla…
View article: 2-Allylphenol Reduces IL-1<i>β</i>and TNF-<i>α</i>, Promoting Antinociception through Adenosinergic, Anti-Inflammatory, and Antioxidant Mechanisms
2-Allylphenol Reduces IL-1<i>β</i>and TNF-<i>α</i>, Promoting Antinociception through Adenosinergic, Anti-Inflammatory, and Antioxidant Mechanisms Open
2-Allylphenol (2-AP) is a synthetic phenylpropanoid, structurally related to cardanol, thymol, and ortho-eugenol. Phenylpropanoids are described in the literature as being capable of promoting biological activity. Due to the similarity bet…
View article: Author Correction: Ouabain attenuates ovalbumin-induced airway inflammation
Author Correction: Ouabain attenuates ovalbumin-induced airway inflammation Open
View article: Corrigendum: Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain
Corrigendum: Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain Open
[This corrects the article on p. 895 in vol. 8, PMID: 29176951.].
View article: Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain
Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain Open
Since the discovery of ouabain as a cardiotonic steroid hormone present in higher mammals, research about it has progressed rapidly and several of its physiological and pharmacological effects have been described. Ouabain can behave as a s…
View article: Anti-inflammatory Effect of Discretamine, a Protoberberine Alkaloid Isolated from <i>Duguetia moricandiana</i>
Anti-inflammatory Effect of Discretamine, a Protoberberine Alkaloid Isolated from <i>Duguetia moricandiana</i> Open
Discretamine is a tetrahydroprotoberberine alkaloid isolated from Duguetia moricandiana (Annonaceae). In the present study, anti-inflammatory ability of discretamine in a lipopolysaccharide (LPS) stimulated macrophages model was investigat…
View article: Involvement of β adrenergic receptors in spasmolytic effect of caulerpine on guinea pig ileum
Involvement of β adrenergic receptors in spasmolytic effect of caulerpine on guinea pig ileum Open
Previously, we demonstrated that caulerpine has spasmolytic effect on guinea pig ileum. The aim of this study was to investigate pathways of its spasmolytic action. We test caulerpine against phasic contractions induced by carbachol in the…
View article: Obesity-Driven Gut Microbiota Inflammatory Pathways to Metabolic Syndrome
Obesity-Driven Gut Microbiota Inflammatory Pathways to Metabolic Syndrome Open
The intimate interplay between immune system, metabolism, and gut microbiota plays an important role in controlling metabolic homeostasis and possible obesity development. Obesity involves impairment of immune response affecting both innat…
View article: Efeito Antinociceptivo e Anti-inflamatório de Caulerpa kempfii (Caulerpaceae)
Efeito Antinociceptivo e Anti-inflamatório de Caulerpa kempfii (Caulerpaceae) Open
Os organismos marinhos sao uma fonte rica para a pesquisa de novos prototipos de farmacos, entre eles, as algas sao um grupo muito diverso, com diferentes caracteristicas morfologicas, estruturais e metabolicas. O presente trabalho teve co…
View article: Antinociceptive and Anti-inflammatory Effects of Caulerpa kempfii (Caulerpaceae)
Antinociceptive and Anti-inflammatory Effects of Caulerpa kempfii (Caulerpaceae) Open