Lujia Guan
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View article: Blood Eosinophil Stability Predicts Clinical Outcomes in Hospitalized Patients with Acute Exacerbations of COPD
Blood Eosinophil Stability Predicts Clinical Outcomes in Hospitalized Patients with Acute Exacerbations of COPD Open
Blood eosinophil stability during hospitalization is associated with AECOPD prognosis and may help guide inpatient treatment and identify patients at higher risk of future readmission.
View article: Plasma Proteomic Profiling Yields a High-Performance Biomarker Panel for Predicting a Poor Prognosis in Patients with COVID-19
Plasma Proteomic Profiling Yields a High-Performance Biomarker Panel for Predicting a Poor Prognosis in Patients with COVID-19 Open
Background The coronavirus disease 2019 (COVID-19) pandemic increased the demand for reliable tests to predict disease severity and mortality. Methods In training cohort, we obtained traditional clinical data and plasma proteomics performe…
View article: A nomogram-based clinical prediction model for adverse clinical outcomes in non-HIV Pneumocystis jirovecii pneumonia patients
A nomogram-based clinical prediction model for adverse clinical outcomes in non-HIV Pneumocystis jirovecii pneumonia patients Open
Background Non-human immunodeficiency virus (HIV) immunocompromised patients with Pneumocystis jirovecii pneumonia (PJP) face rapid progression and high mortality, necessitating a predictive model to identify patients at risk of adverse cl…
View article: Clinical Characteristics and Treatment Efficacy in Patients With SARS‐CoV‐2 Positivity After Nirmatrelvir‐Ritonavir Therapy
Clinical Characteristics and Treatment Efficacy in Patients With SARS‐CoV‐2 Positivity After Nirmatrelvir‐Ritonavir Therapy Open
Nirmatrelvir‐ritonavir (NMV‐r) has been widely used to treat coronavirus disease 2019 (COVID‐19) for a standard period of 5‐days. However, there are increasing reports of patients with persistent severe acute respiratory syndrome coronavir…
View article: Longitudinal multi-omics analysis of convalescent individuals with respiratory sequelae 6–36 months after COVID-19
Longitudinal multi-omics analysis of convalescent individuals with respiratory sequelae 6–36 months after COVID-19 Open
These data provide insights concerning molecular sequelae among COVID-19 convalescents up to 3 years after hospital discharge, clarify mechanisms driving respiratory sequelae, and support the development of a novel model to predict reduced…
View article: Comparative Dosing of Adjunctive Corticosteroids Therapy for Pneumocystis Pneumonia with ARDS in Non-HIV Immunocompromised Patients
Comparative Dosing of Adjunctive Corticosteroids Therapy for Pneumocystis Pneumonia with ARDS in Non-HIV Immunocompromised Patients Open
The standard-dose steroid therapy significantly reduced 28-day and 60-day mortality without major complications in the non-HIV immunocompromised population with severe PCP with ARDS. These findings highlight the potential survival benefit …
View article: Dysregulated proteasome activity and steroid hormone biosynthesis are associated with mortality among patients with acute COVID-19
Dysregulated proteasome activity and steroid hormone biosynthesis are associated with mortality among patients with acute COVID-19 Open
The persistence of coronavirus disease 2019 (COVID-19)-related hospitalization severely threatens medical systems worldwide and has increased the need for reliable detection of acute status and prediction of mortality. We applied a systems…
View article: Adjunctive corticosteroids therapy for Pneumocystis pneumonia with ARDS in non-HIV immunocompromised patients：a retrospective cohort study
Adjunctive corticosteroids therapy for Pneumocystis pneumonia with ARDS in non-HIV immunocompromised patients：a retrospective cohort study Open
Background Adjuvant corticosteroids are effective in patients with human immunodeficiency virus (HIV)-associated Pneumocystis jirovecii pneumonia (PCP) patients, but the effectiveness of adjuvant corticosteroids in non-HIV PCP remained con…
View article: Two‐ and 3‐year outcomes in convalescent individuals with COVID‐19: A prospective cohort study
Two‐ and 3‐year outcomes in convalescent individuals with COVID‐19: A prospective cohort study Open
As the long‐term consequences of coronavirus disease 2019 (COVID‐19) have not been defined, it is necessary to explore persistent symptoms, long‐term respiratory impairment, and impact on quality of life over time in COVID‐19 survivors. In…
View article: Comparison of Relapsing Polychondritis Patients with and Without Respiratory Involvement Based on Chest Computed Tomography: A Retrospective Cohort Study
Comparison of Relapsing Polychondritis Patients with and Without Respiratory Involvement Based on Chest Computed Tomography: A Retrospective Cohort Study Open
Background Relapsing polychondritis (RP) patients with tracheal cartilage involvement are different from other patients. The objectives of this study were to compare the clinical features and disease patterns between respiratory involvemen…
View article: Clinical characteristics and disease patterns of patients with relapsing polychondritis: a retrospective cohort
Clinical characteristics and disease patterns of patients with relapsing polychondritis: a retrospective cohort Open
Background Relapsing polychondritis (RP) is a rare autoimmune disease affected various cartilage, Patients with tracheal cartilage involvement are different from other patients. The objectives of this study were to allocated RP patients in…