Lianbo Yu
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View article: The independent association of social isolation and loneliness with cognitive frailty in Chinese older adults: a cross-sectional study
The independent association of social isolation and loneliness with cognitive frailty in Chinese older adults: a cross-sectional study Open
Social isolation and loneliness are independently associated with CF in Chinese older adults, highlighting the necessity of implementing effective and feasible interventions to concurrently address both factors in the prevention of CF amon…
View article: Prevalence and biological impact of clinically relevant gene fusions in head and neck cancers
Prevalence and biological impact of clinically relevant gene fusions in head and neck cancers Open
Head and neck cancer (HNC) is the seventh most common cancer worldwide. Currently-approved systemic therapies include chemotherapy, anti-EGFR antibodies, and PD-1 immunotherapy, with few genomic-based targeted therapies. Gene fusions invol…
View article: Circulating extracellular vesicles protein expression for early prediction of platinum-resistance in high-grade serous ovarian cancer
Circulating extracellular vesicles protein expression for early prediction of platinum-resistance in high-grade serous ovarian cancer Open
Platinum resistance in high-grade serous ovarian carcinoma (HGSOC) portends a poor prognosis. Although initial platinum-based chemotherapy response rates are high, 15-20% of patients demonstrate primary resistance to platinum therapy and a…
View article: Prognostic significance of serum MUC5AC in resected pancreatic ductal adenocarcinoma: initial insights
Prognostic significance of serum MUC5AC in resected pancreatic ductal adenocarcinoma: initial insights Open
Background We investigated the association between serum MUC5AC (sMUC5AC) levels and patient outcomes in individuals who underwent resection for pancreatic ductal adenocarcinoma (PDA), including those treated with neoadjuvant therapy (NAT)…
View article: Supplementary Figure S6 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Supplementary Figure S6 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
Supplementary Figure S6
View article: Figure 1 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Figure 1 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
IL-12 and trabectedin treatment increases human NK-cell activation in vitro. A, NK-cell viability after 48-hour treatment with DMSO (control), 10 ng/mL IL-12, 2.5 nmol/L trabectedin, or IL-12 plus trabectedin (n = 5 do…
View article: Supplementary Table S4 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Supplementary Table S4 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
Supplementary Table S4
View article: Figure 3 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Figure 3 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
Combination IL-12 and trabectedin selectively reduces immunosuppressive myeloid cells while increasing intratumoral CD8+ T cells. Mass cytometry analysis of splenic and tumor-infiltrating immune cells from 4T1 tumor–bearing mice…
View article: Supplementary Figure S5 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Supplementary Figure S5 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
Supplementary Figure S5
View article: Supplementary Figure S1 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Supplementary Figure S1 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
Supplementary Figure S1
View article: Supplementary Table S2 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Supplementary Table S2 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
Supplementary Table S2
View article: Supplementary Figure S3 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Supplementary Figure S3 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
Supplementary Figure S3
View article: Figure 7 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Figure 7 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
Anti–PD-L1 therapy improves response to combination IL-12 and trabectedin treatment. Mice bearing ∼50 mm3 4T1 tumors were treated with 0.5 μg IL-12 i.p. 3×/week and 0.15 mg/kg trabectedin i.v. 1×/week for 7 days with either αPD-…
View article: Supplementary Figure S2 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Supplementary Figure S2 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
Supplementary Figure S2
View article: Supplementary Table S1 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Supplementary Table S1 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
Supplementary Table S1
View article: Data from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Data from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
IL-12 is a potent NK cell–stimulating cytokine, but the presence of immunosuppressive myeloid cells such as myeloid-derived suppressor cells (MDSC) can inhibit IL-12–induced NK-cell cytotoxicity. Thus, we hypothesized that trabectedin, a m…
View article: Supplementary Figure S8 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Supplementary Figure S8 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
Supplementary Figure S8
View article: Supplementary Table S3 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Supplementary Table S3 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
Supplementary Table S3
View article: Supplementary Figure S7 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Supplementary Figure S7 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
Supplementary Figure S7
View article: Supplementary Figure S4 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Supplementary Figure S4 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
Supplementary Figure S4
View article: Figure 2 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Figure 2 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
Combination IL-12 and trabectedin effectively reduces TNBC tumor burden. A, General treatment schema for murine studies. PBS was used as the control. IL-12 (0.5 μg) was given intraperitoneally 3×/week and 0.15 mg/kg trabectedin was …
View article: Figure 6 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Figure 6 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
CD8a depletion abrogates IL-12/trabectedin-induced tumor control. BALB/c mice were inoculated with 4T1 cells. Once tumors reached ∼50 mm3, mice were either depleted of CD8a+ cells using α-CD8a antibody (n = 7) …
View article: Figure 5 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Figure 5 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
NK-cell depletion reduces combination-induced efficacy and reduces intratumoral CD8a. BALB/c mice were inoculated with 4T1 cells and divided into one of two groups once tumors reached ∼50 mm3. Mice were either depleted of NK cel…
View article: Figure 4 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Figure 4 from Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
Digital spatial profiling reveals areas of enhanced and activated immune cell infiltration in combination-treated tumors. A, Schematic detailing the digital spatial profiling workflow. 4T1 tumors were harvested and mice treated for …
View article: Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer Open
IL-12 is a potent NK cell–stimulating cytokine, but the presence of immunosuppressive myeloid cells such as myeloid-derived suppressor cells (MDSC) can inhibit IL-12–induced NK-cell cytotoxicity. Thus, we hypothesized that trabectedin, a m…
View article: Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity
Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity Open
Extracellular vesicles (EVs) are associated with intercellular communications, immune responses, viral pathogenicity, cardiovascular diseases, neurological disorders, and cancer progression. EVs deliver proteins, metabolites, and nucleic a…
View article: depower: Power Analysis for Differential Expression Studies
depower: Power Analysis for Differential Expression Studies Open
View article: Amino Acid Compound 2 (AAC2) Treatment Counteracts Insulin-Induced Synaptic Gene Expression and Seizure-Related Mortality in a Mouse Model of Alzheimer’s Disease
Amino Acid Compound 2 (AAC2) Treatment Counteracts Insulin-Induced Synaptic Gene Expression and Seizure-Related Mortality in a Mouse Model of Alzheimer’s Disease Open
Diabetes is a major risk factor for Alzheimer’s disease (AD). Amino acid compound 2 (AAC2) improves glycemic and cognitive functions in diabetic mouse models through mechanisms distinct from insulin. Our goal was to compare the effects of …
View article: HTLV‐1 infected T cells cause bone loss via small extracellular vesicles
HTLV‐1 infected T cells cause bone loss via small extracellular vesicles Open
Adult T cell leukaemia (ATL), caused by infection with human T‐ lymphotropic virus type 1 (HTLV‐1), is often complicated by hypercalcemia and osteolytic lesions. Therefore, we studied the communication between patient‐derived ATL cells (AT…
View article: Analytic validation of an<i>FGFR</i>-focused cell-free DNA liquid biopsy assay (FGFR-Dx)
Analytic validation of an<i>FGFR</i>-focused cell-free DNA liquid biopsy assay (FGFR-Dx) Open
Commercial liquid biopsy assays are routinely used by oncologists to monitor disease response and resistance to therapy. Additionally, in cases where tumor tissue is not available, clinicians may rely on cell-free DNA (cfDNA) testing as a …