Lujuan Wang
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View article: Immunological role and prognostic value of ITGA3 and ITGA5 in oral squamous cell carcinoma
Immunological role and prognostic value of ITGA3 and ITGA5 in oral squamous cell carcinoma Open
View article: SRSF3 undergoes phase separation in lung cancer and is associated with immunity and ferroptosis
SRSF3 undergoes phase separation in lung cancer and is associated with immunity and ferroptosis Open
As one of the most deadly malignant tumours, lung cancer has been increasing in incidence and mortality worldwide. The incidence and mortality rates of lung cancer are increasing annually. A deeper understanding of the development of lung …
View article: Pre-harvest melatonin treatment alleviates post-harvest deterioration in Volvariella volvacea (Chinese mushroom) by improving its antioxidant activity
Pre-harvest melatonin treatment alleviates post-harvest deterioration in Volvariella volvacea (Chinese mushroom) by improving its antioxidant activity Open
View article: SRSF9 mediates oncogenic RNA splicing of SLC37A4 via liquid–liquid phase separation to promote oral cancer progression
SRSF9 mediates oncogenic RNA splicing of SLC37A4 via liquid–liquid phase separation to promote oral cancer progression Open
This study elucidates the mechanism by which SRSF9 phase separation mediates splicing in oral cancer, thereby establishing a basis for considering SRSF9 and its associated SLC37A4-S isoforms as potential therapeutic targets for oral cancer…
View article: Molecular Mechanism During Mycelium Subculture Degeneration of Volvariella volvacea
Molecular Mechanism During Mycelium Subculture Degeneration of Volvariella volvacea Open
Periodic mycelial subculture is a method commonly used for the storage of edible mushrooms, but excessive subculturing can lead to the degeneration of strains. In this study, the Volvariella volvacea strain V971(M0) was successively subcul…
View article: Girls play basketball too? A study of the mechanisms of traditional social gender consciousness on female participation in contact leisure sports
Girls play basketball too? A study of the mechanisms of traditional social gender consciousness on female participation in contact leisure sports Open
Background With the development of women’s sports, the mechanism of barriers to women’s leisure sports participation has attracted extensive attention from the academic community. Despite its significant impact, there are few empirical stu…
View article: Identification of protein methyltransferases 5 associated with ferroptosis and immune cell infiltration of head and neck squamous cell carcinoma
Identification of protein methyltransferases 5 associated with ferroptosis and immune cell infiltration of head and neck squamous cell carcinoma Open
Head and neck tumors are malignant tumors that appear in the head and neck. Although much progress has been made in the treatment of head and neck tumors, many challenges remain. The prognosis of some advanced cases remains poor and surviv…
View article: LRP6 is a potential biomarker of kidney clear cell carcinoma related to prognosis and immune infiltration
LRP6 is a potential biomarker of kidney clear cell carcinoma related to prognosis and immune infiltration Open
Renal cell carcinoma is the most common and most lethal genitourinary tumor. The causes of renal clear cell carcinoma are complex and the heterogeneity of the tumor tissue is high, so patient outcomes are not very satisfactory. Exploring b…
View article: Splicing inhibition mediated by reduced splicing factors and helicases is associated with the cellular response of lung cancer cells to cisplatin
Splicing inhibition mediated by reduced splicing factors and helicases is associated with the cellular response of lung cancer cells to cisplatin Open
View article: Exosomal ITGB6 from dormant lung adenocarcinoma cells activates cancer-associated fibroblasts by KLF10 positive feedback loop and the TGF-β pathway
Exosomal ITGB6 from dormant lung adenocarcinoma cells activates cancer-associated fibroblasts by KLF10 positive feedback loop and the TGF-β pathway Open
In all, we demonstrated that CAFs were activated by exosomes from dormant lung cancer cells and reconstruct ECM. ITGB6 may be a critical molecule for activating the TGF-β pathway and remodeling ECM.
View article: EphA2 as a phase separation protein associated with ferroptosis and immune cell infiltration in colorectal cancer
EphA2 as a phase separation protein associated with ferroptosis and immune cell infiltration in colorectal cancer Open
Colorectal cancer is one of the most common malignant tumors in the digestive system, and its high incidence and metastasis rate make it a terrible killer that threatens human health. In-depth exploration of the targets affecting the progr…
View article: N6-methyladenosine modification—a key player in viral infection
N6-methyladenosine modification—a key player in viral infection Open
View article: The Eph/Ephrin system in primary bone tumor and bone cancer pain
The Eph/Ephrin system in primary bone tumor and bone cancer pain Open
The family of Eph receptor tyrosine kinases and their Ephrin ligands system constitutes a bidirectional signaling pathway. Eph/Ephrin system coordinate a wide spectrum of pathologic processes during development, metastasis, prognosis, drug…
View article: Exosomes from cisplatin-induced dormant cancer cells facilitate the formation of premetastatic niche in bone marrow through activating glycolysis of BMSCs
Exosomes from cisplatin-induced dormant cancer cells facilitate the formation of premetastatic niche in bone marrow through activating glycolysis of BMSCs Open
Introduction Lung cancer is the leading cause of cancer-related deaths worldwide. Chemotherapy kills most cancer cells; however, residual cells enter a dormant state. The dormant cancer cells can be reactivated under specific circumstances…
View article: Cell-cell contact-driven EphB1 cis- and trans- signalings regulate cancer stem cells enrichment after chemotherapy
Cell-cell contact-driven EphB1 cis- and trans- signalings regulate cancer stem cells enrichment after chemotherapy Open
Reactivation of chemotherapy-induced dormant cancer cells is the main cause of relapse and metastasis. The molecular mechanisms underlying remain to be elucidated. In this study, we introduced a cellular model that mimics the process of ci…
View article: Proteomic profiling of extracellular vesicles and particles reveals the cellular response to cisplatin in <scp>NSCLC</scp>
Proteomic profiling of extracellular vesicles and particles reveals the cellular response to cisplatin in <span>NSCLC</span> Open
Background Cisplatin‐based chemotherapy is a therapeutic strategy against non‐small cell lung cancer (NSCLC). However, cancers relapse after chemotherapy due to a dormant state of residual cancer cells. Extracellular vesicles and particles…
View article: Chromatin accessibility regulates chemotherapy-induced dormancy and reactivation
Chromatin accessibility regulates chemotherapy-induced dormancy and reactivation Open
View article: Epstein–Barr virus EBNA2 phase separation regulates cancer‐associated alternative RNA splicing patterns
Epstein–Barr virus EBNA2 phase separation regulates cancer‐associated alternative RNA splicing patterns Open
Alternative splicing of pre-mRNAs is a significant mRNA maturation process that increases RNA and protein diversity in eukaryotes.1-3 The Epstein–Barr Virus (EBV)-encoded nuclear antigen 2 (EBNA2) is a multifunctional transcriptional activ…
View article: Lung microbiome alterations in NSCLC patients
Lung microbiome alterations in NSCLC patients Open
View article: Proteomic profiling of extracellular vesicles and particles reveals the cellular response to cisplatin in NSCLC
Proteomic profiling of extracellular vesicles and particles reveals the cellular response to cisplatin in NSCLC Open
Background Cisplatin-based chemotherapy is a first-line therapeutic strategy against Non Small Cell Lung Cancer. However, cancers relapse months or years after chemotherapy due to a dormant state of residual cancer cells. Great efforts hav…
View article: Microbiome Related Cytotoxically Active CD8+ TIL Are Inversely Associated With Lung Cancer Development
Microbiome Related Cytotoxically Active CD8+ TIL Are Inversely Associated With Lung Cancer Development Open
Lung cancer is the most common cancer type around the world. Although major advances in cancer therapy, lung cancer has been the largest proportion of all cancer-related deaths. The respiratory tract contains many types of bacteria and a d…
View article: Phase Separation of Epstein-Barr Virus EBNA2 and Its Coactivator EBNALP Controls Gene Expression
Phase Separation of Epstein-Barr Virus EBNA2 and Its Coactivator EBNALP Controls Gene Expression Open
Protein condensates can be assembled via liquid-liquid phase separation (LLPS), a process involving the concentration of molecules in a confined liquid-like compartment. LLPS allows for the compartmentalization and sequestration of materia…
View article: Ligand-independent EphB1 signaling mediates TGF-β-activated CDH2 and promotes lung cancer cell invasion and migration
Ligand-independent EphB1 signaling mediates TGF-β-activated CDH2 and promotes lung cancer cell invasion and migration Open
Purpose: The initial step of cancer metastasis is that cancer cells acquire the capability to migrate and invade. Eph receptors comprise the largest family of receptor tyrosine and display dual role in tumor progression due to uniqu…
View article: Serine/arginine-rich splicing factors: the bridge linking alternative splicing and cancer
Serine/arginine-rich splicing factors: the bridge linking alternative splicing and cancer Open
The serine/arginine-rich splicing factors (SRs) belong to the serine arginine-rich protein family, which plays an extremely important role in the splicing process of precursor RNA. The SRs recognize the splicing elements on precursor RNA, …
View article: Cancer-educated mesenchymal stem cells promote the survival of cancer cells at primary and distant metastatic sites via the expansion of bone marrow-derived-PMN-MDSCs
Cancer-educated mesenchymal stem cells promote the survival of cancer cells at primary and distant metastatic sites via the expansion of bone marrow-derived-PMN-MDSCs Open
View article: A Stable Pep2-proapoptotic Peptide Inducing Apoptosis of Acute Myeloid Leukemia Cells by Down-Regulating EZH2
A Stable Pep2-proapoptotic Peptide Inducing Apoptosis of Acute Myeloid Leukemia Cells by Down-Regulating EZH2 Open
View article: BMSC-derived leptin and IGFBP2 promote erlotinib resistance in lung adenocarcinoma cells through IGF-1R activation in hypoxic environment
BMSC-derived leptin and IGFBP2 promote erlotinib resistance in lung adenocarcinoma cells through IGF-1R activation in hypoxic environment Open
EGFR-TKIs such as erlotinib and gefitinib have been introduced into the first-line treatment for patients having a mutation of deletion in exon 19 or L858R missense mutations in exon 21. Almost all patients who respond to EGFR-TKIs at firs…
View article: Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT
Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT Open
Exosome-mediated transfer of miR-193a-3p, miR-210-3p and miR-5100, could promote invasion of lung cancer cells by activating STAT3 signalling-induced EMT. These exosomal miRNAs may be promising noninvasive biomarkers for cancer progression.
View article: Correction to: miR-18a reactivates the Epstein-Barr virus through defective DNA damage response and promotes genomic instability in EBV-associated lymphomas
Correction to: miR-18a reactivates the Epstein-Barr virus through defective DNA damage response and promotes genomic instability in EBV-associated lymphomas Open
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View article: miR-18a reactivates the Epstein-Barr virus through defective DNA damage response and promotes genomic instability in EBV-associated lymphomas
miR-18a reactivates the Epstein-Barr virus through defective DNA damage response and promotes genomic instability in EBV-associated lymphomas Open