Lujuan Xu
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View article: An aptamer-drug conjugate for promising cancer therapy with comprehensive evaluation from rodents to non-human primates
An aptamer-drug conjugate for promising cancer therapy with comprehensive evaluation from rodents to non-human primates Open
Aptamers serve as unique targeting ligands, making aptamer-drug conjugates (ApDCs) an attractive strategy for targeted cancer therapy. This study performs a comprehensive evaluation from rodents to non-human primates (NHP) of a protein tyr…
View article: Chemoselective dual functionalization of proteins via 1,6-addition of thiols to trifunctional N-alkylpyridinium
Chemoselective dual functionalization of proteins via 1,6-addition of thiols to trifunctional N-alkylpyridinium Open
View article: 1,6-Thiol Addition of Trifunctional N-Alkylpyridinium for Site-selective Dual Functionalization of Proteins
1,6-Thiol Addition of Trifunctional N-Alkylpyridinium for Site-selective Dual Functionalization of Proteins Open
We report N-alkylpyridinium reagents for site-selective dual modification of proteins via a regioselective 1,6-thiol addition reaction. The N-alkylpyridinium derivatives can be syn-thesized in two reaction steps and demonstrate high labell…
View article: Peptide-Decorated Degradable Polycarbonate Nanogels for Eliciting Antigen-Specific Immune Responses
Peptide-Decorated Degradable Polycarbonate Nanogels for Eliciting Antigen-Specific Immune Responses Open
For successful therapeutic interventions in cancer immunotherapy, strong antigen-specific immune responses are required. To this end, immunostimulating cues must be combined with antigens to simultaneously arrive at antigen-presenting cell…
View article: In Situ Assembly of Platinum(II)-Metallopeptide Nanostructures Disrupts Energy Homeostasis and Cellular Metabolism
In Situ Assembly of Platinum(II)-Metallopeptide Nanostructures Disrupts Energy Homeostasis and Cellular Metabolism Open
Nanostructure-based functions are omnipresent in nature and essential for the diversity of life. Unlike small molecules, which are often inhibitors of enzymes or biomimetics with established methods of elucidation, we show that functions o…
View article: In Situ Assembly of Platinum (II)-Metallopeptide Nanostructures Inhibits Energy Homeostasis and Cellular Metabolism
In Situ Assembly of Platinum (II)-Metallopeptide Nanostructures Inhibits Energy Homeostasis and Cellular Metabolism Open
Nanostructure-based functions are omnipresent in nature and essential for the diversity of life. Unlike small molecules, which are often inhibitors of enzymes or biomimetics with established methods of elucidation, we show that functions o…
View article: Platinum (II) Nanofibers as Assembly-driven Inhibitors of Metabolic Adaptation in Cancer Cells
Platinum (II) Nanofibers as Assembly-driven Inhibitors of Metabolic Adaptation in Cancer Cells Open
Nanostructure-based functions are omnipresent in biology and essential for the diversity of life. Despite their importance, it is difficult to establish mechanisms that define their bioactivity and rationalize them through synthetic design…
View article: Chloromethyl Acryl Reagents for Simple and Site-Selective Cysteine and Disulfide Modification
Chloromethyl Acryl Reagents for Simple and Site-Selective Cysteine and Disulfide Modification Open
The generation of protein biotherapeutics with improved features compared to the synthetic drugs has received emerging interest. The conjugation of various synthetic functionalities to proteins provides access to new classes of protein con…
View article: Chloromethyl Acryl Reagents for Simple and Site-Selective Cysteine and Disulfide Modification
Chloromethyl Acryl Reagents for Simple and Site-Selective Cysteine and Disulfide Modification Open
The generation of protein biotherapeutics with improved features compared to the synthetic drugs has received emerging interest. The conjugation of various synthetic functionalities to proteins provides access to new classes of protein con…
View article: Chemoselective cysteine or disulfide modification <i>via</i> single atom substitution in chloromethyl acryl reagents
Chemoselective cysteine or disulfide modification <i>via</i> single atom substitution in chloromethyl acryl reagents Open
2-Chloromethyl acryl derivatives (acrylamides and acrylates) can serve as simple and versatile bioconjugation reagents to achieve site-selective cysteine and disulfide modification on demand and with high efficiency.
View article: Contemporary Approaches for Site‐Selective Dual Functionalization of Proteins
Contemporary Approaches for Site‐Selective Dual Functionalization of Proteins Open
Site‐selective protein functionalization serves as an invaluable tool for investigating protein structures and functions in complicated cellular environments and accomplishing semi‐synthetic protein conjugates such as traceable therapeutic…
View article: Contemporary Approaches for Site‐Selective Dual Functionalization of Proteins
Contemporary Approaches for Site‐Selective Dual Functionalization of Proteins Open
Site‐selective protein functionalization serves as an invaluable tool for investigating protein structures and functions in complicated cellular environments and accomplishing semi‐synthetic protein conjugates such as traceable therapeutic…
View article: Site-selective protein modification <i>via</i> disulfide rebridging for fast tetrazine/<i>trans</i>-cyclooctene bioconjugation
Site-selective protein modification <i>via</i> disulfide rebridging for fast tetrazine/<i>trans</i>-cyclooctene bioconjugation Open
Site-selective incorporation of a reactive tetrazine tag into therapeutically relevant peptides and proteins via disulfide rebridging allows fast preparation of stable bioconjugates “on-demand”.