Li Deng
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View article: Succinate-driven PKM2 succinylation and dimerization accelerates age-associated cardiac fibrosis
Succinate-driven PKM2 succinylation and dimerization accelerates age-associated cardiac fibrosis Open
Age-related cardiac fibrosis is a key driver of heart failure and hallmark of aging whose mechanisms remain incompletely understood. Here we show elevated succinate levels in aged mice and humans drive cardiac fibrosis by enhancing fibrobl…
View article: Global and regional burden of kidney cancer from 1990 to 2021: analysis and future predictions based on global burden of disease study
Global and regional burden of kidney cancer from 1990 to 2021: analysis and future predictions based on global burden of disease study Open
Background The incidence and mortality of kidney cancer vary widely globally. This study aims to examine the global burden and trends of kidney cancer from 1990 to 2021 and its associations with various factors. Methods Data on kidney canc…
View article: [Retracted] Peritumoral activated hepatic stellate cells are associated with hepatic recurrence for resectable colorectal adenocarcinoma liver metastasis following resection
[Retracted] Peritumoral activated hepatic stellate cells are associated with hepatic recurrence for resectable colorectal adenocarcinoma liver metastasis following resection Open
[This retracts the article DOI: 10.3892/ol.2020.12150.].
View article: Integrated data mining and network pharmacology to explore the prescription patterns from a senior TCM oncologist’s clinical practice in treating chemotherapy-induced hand-foot syndrome
Integrated data mining and network pharmacology to explore the prescription patterns from a senior TCM oncologist’s clinical practice in treating chemotherapy-induced hand-foot syndrome Open
Hand-foot syndrome (HFS) is a common and refractory adverse effect of chemotherapy lacking specific therapeutic strategies currently. Traditional Chinese medicine (TCM) has shown empirical efficacy in clinical HFS management. This study in…
View article: Application Research of SBL in Developing Evidence-Based Pharmacy Competencies Among Clinical Pharmacy Students
Application Research of SBL in Developing Evidence-Based Pharmacy Competencies Among Clinical Pharmacy Students Open
To reform traditional internship teaching in Introduction to Clinical Pharmacy and enhance its quality, this study explores the impact of scenario-based learning (SBL)on cultivating Evidence-Based Pharmacy (EBP) competencies among clinical…
View article: Design and Parameter Optimization of Quasi-Zero-Stiffness Structures Based on Cosine-Curve Compliant Beams
Design and Parameter Optimization of Quasi-Zero-Stiffness Structures Based on Cosine-Curve Compliant Beams Open
Quasi-zero-stiffness (QZS) structures can provide a near constant force output in a certain range of displacement without force sensors and controllers. Therefore, they can be used in overload protection, vibration isolation, and biomedica…
View article: Adipocyte-derived IL6 and triple-negative breast cancer cell-derived CXCL1 co-activate STAT3/NF-κB pathway to mediate the crosstalk between adipocytes and triple-negative breast cancer cells
Adipocyte-derived IL6 and triple-negative breast cancer cell-derived CXCL1 co-activate STAT3/NF-κB pathway to mediate the crosstalk between adipocytes and triple-negative breast cancer cells Open
Triple-negative breast cancer (TNBC) is correlated to a poor prognosis, especially in the context of obesity. The interaction between adipocytes and TNBC cellsplay a key role in the progression of TNBC. This study aims to investigate the m…
View article: Worldwide trends and future projections of fungal skin disease burden: a comprehensive analysis from the Global Burden of Diseases study 2021
Worldwide trends and future projections of fungal skin disease burden: a comprehensive analysis from the Global Burden of Diseases study 2021 Open
Background Fungal skin diseases represent pervasive global health concerns, predominantly arising from dermatophytes, yeasts, and molds. Objective This study aimed to estimate the disease burden associated with fungal skin diseases in 2021…
View article: SysLLMatic: Large Language Models are Software System Optimizers
SysLLMatic: Large Language Models are Software System Optimizers Open
Automatic software system optimization can improve software speed and save energy. Traditional approaches to optimization rely on manual tuning and compiler heuristics, limiting their ability to generalize across diverse codebases. Recent …
View article: Artesunate alleviates cerebral ischemia/reperfusion injury by suppressing FUNDC1-mediated excessive mitophagy
Artesunate alleviates cerebral ischemia/reperfusion injury by suppressing FUNDC1-mediated excessive mitophagy Open
Cerebral ischemia-reperfusion (I/R) injury represents a debilitating neurological disorder with significant morbidity. Artesunate, a water-soluble hemisuccinate derivative, has emerged as a potential therapeutic agent for cerebral I/R inju…
View article: Temporal trend in non-melanoma skin cancer mortality in China, 1992–2021: an analysis for the global burden of disease study 2021
Temporal trend in non-melanoma skin cancer mortality in China, 1992–2021: an analysis for the global burden of disease study 2021 Open
Introduction Non - melanoma skin cancer (NMSC) is a widespread malignant neoplasm affecting the skin globally. In China, over the past 30 years, the prevalence and incidence of NMSC have changed significantly, yet mortality rate (MR) data …
View article: Sex differences in outcomes in patients with acute myocardial infarction
Sex differences in outcomes in patients with acute myocardial infarction Open
This Trial was registered in the Chinese clinical trials registry: ChiCTR1800014583. Registered 22 January 2018 ( http://www.chictr.org.cn/searchproj.aspx ).
View article: NCR as a biomarker for nutritional status and inflammation in predicting outcomes in patients with cancer cachexia: a prospective, multicenter study
NCR as a biomarker for nutritional status and inflammation in predicting outcomes in patients with cancer cachexia: a prospective, multicenter study Open
Background Systemic inflammation and nutritional status are key factors affecting the prognosis of patients with cancer cachexia. This study aims to evaluate the prognostic value of a new nutritional and inflammatory index, Prognostic Nutr…
View article: A Novel Definition and Grading Diagnostic Criteria for Tumour‐Type‐Specific Comprehensive Cachexia Risk
A Novel Definition and Grading Diagnostic Criteria for Tumour‐Type‐Specific Comprehensive Cachexia Risk Open
Background The existing diagnostic criteria for cancer cachexia do not meet clinical needs. We aimed to establish novel comprehensive evaluation scales for cachexia specific to patients with solid tumours. Methods This study included 12 65…
View article: Characterization of T-Cell Receptor Profiles Predicts Survival Situation in Patients with Hepatocellular Carcinoma
Characterization of T-Cell Receptor Profiles Predicts Survival Situation in Patients with Hepatocellular Carcinoma Open
Purpose Hepatocellular carcinoma (HCC) is the most common liver malignancy in the world, and tumor-infiltrating T cells have been shown to be closely related to the prognosis of HCC. This study investigated the potential and efficacy of T …
View article: IL17A/F secreted by ASCT2-overexpression ovarian cancer cells contributes to immune escape through the suppression of natural killer (NK) cells cytotoxicity by the activation of c-JUN/ PTGS2 pathway
IL17A/F secreted by ASCT2-overexpression ovarian cancer cells contributes to immune escape through the suppression of natural killer (NK) cells cytotoxicity by the activation of c-JUN/ PTGS2 pathway Open
Ovarian cancer (OC) is a deadly gynecologic cancer associated with metastasis, recurrence, and treatment resistance. The expression of the alanine-serine-cysteine transporter 2 (ASCT2) has been linked to poor prognosis and immune cell infi…
View article: Endothelial cells under disturbed flow release extracellular vesicles to promote inflammatory polarization of macrophages and accelerate atherosclerosis
Endothelial cells under disturbed flow release extracellular vesicles to promote inflammatory polarization of macrophages and accelerate atherosclerosis Open
Taken together, targeting the MAPK signaling pathway holds potential as a novel therapeutic strategy for inhibiting the secretion of EC-derived EVs and mitigating the inflammatory polarization of macrophages, ultimately ameliorating the pr…
View article: Electroacupuncture for recovery of gastrointestinal function after laparoscopic hysterectomy surgery: a prospective, randomized, controlled trial
Electroacupuncture for recovery of gastrointestinal function after laparoscopic hysterectomy surgery: a prospective, randomized, controlled trial Open
EA demonstrates promising effects in accelerating the recovery of GI function and has potential for widespread adoption across diverse healthcare systems globally. However, its exact mechanism requires further in-depth research.
View article: Body Roundness Index Trajectories and the Risk of Cancer: A Cohort Study
Body Roundness Index Trajectories and the Risk of Cancer: A Cohort Study Open
Background The body rounds index (BRI), an innovative obesity indicator integrating waist circumference (WC) and height, offers a two‐dimensional assessment of obesity. The relationship between BRI trajectories and cancer has been overlook…
View article: Interstitial Fluid Shear Stress Induces the Synthetic Phenotype Switching of VSMCs to Release Pro-calcified Extracellular Vesicles via EGFR-MAPK-KLF5 Pathway
Interstitial Fluid Shear Stress Induces the Synthetic Phenotype Switching of VSMCs to Release Pro-calcified Extracellular Vesicles via EGFR-MAPK-KLF5 Pathway Open
Phenotypic switching (from contractile to synthetic) of vascular smooth muscle cells (VSMCs) is essential in the progression of atherosclerosis. The damaged endothelium in the atherosclerotic artery exposes VSMCs to increased interstitial …