Lüjun Yang
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View article: Human umbilical cord mesenchymal stem cells improve the survial of flaps by promoting angiogenesis in mice
Human umbilical cord mesenchymal stem cells improve the survial of flaps by promoting angiogenesis in mice Open
Improved cell incubation conditions can enhance its utility. The application of HuMSCs and their conditioned medium promoted the survival of the flap by inducing neovasculogenesis.
View article: Human Umbilical Cord Mesenchymal Stem Cells Improve the Survial of Flaps by Promoting Angiogenesis in Mice
Human Umbilical Cord Mesenchymal Stem Cells Improve the Survial of Flaps by Promoting Angiogenesis in Mice Open
Background Flap necrosis post-operation disturbs surgeons during plastic and reconstructive surgery. This is caused by hypoperfusion and subsequent ischemia-reperfusion injury, where restricted blood flow followed by restored circulation p…
View article: Green Synthesis and Antimicrobial Performance Assessment of Mgo Nanoparticles Using Plant Extracts: Moringa Oleifera, Cotonier, Black Tea
Green Synthesis and Antimicrobial Performance Assessment of Mgo Nanoparticles Using Plant Extracts: Moringa Oleifera, Cotonier, Black Tea Open
View article: A Study on the Mechanisms by Which AGEs and RAG Promote Wound Healing in Patients with Second-Degree Burns undergoing Eschar Grinding Combined with Drug Therapy
A Study on the Mechanisms by Which AGEs and RAG Promote Wound Healing in Patients with Second-Degree Burns undergoing Eschar Grinding Combined with Drug Therapy Open
View article: Promotion of hair growth by a conditioned medium from human umbilical cord mesenchymal stem cells cultivated in a 3D scaffold of gelatin sponge
Promotion of hair growth by a conditioned medium from human umbilical cord mesenchymal stem cells cultivated in a 3D scaffold of gelatin sponge Open
View article: An investigation of a self-assembled cell-extracellular complex and its potentials in improving wound healing
An investigation of a self-assembled cell-extracellular complex and its potentials in improving wound healing Open
Background: To maintain and enhance the wound healing effects of mesenchymal stem cells (MSCs), a scaffold for hosting MSCs is needed, which ought to be completely biocompatible, durable, producible, and of human source. Objective: To buil…
View article: Effects of caloric overload before caloric restriction in the murine heart
Effects of caloric overload before caloric restriction in the murine heart Open
The beneficial effects of caloric restriction (CR) against cardiac aging and for prevention of cardiovascular diseases are numerous. However, to our knowledge, there is no scientific evidence about how a high-calorie diet (HCD) background …
View article: Protective effects of MSC-conditioned medium on DFO-induced mimetic-hypoxia injury of renal tubular epithelial cells
Protective effects of MSC-conditioned medium on DFO-induced mimetic-hypoxia injury of renal tubular epithelial cells Open
Background: Acute kidney injury (AKI) is mainly characterized by inflammatory infiltration, the damage and death of renal tubular epithelial cells (RTECs), in which hypoxia plays an important role. Deferoxamine (DFO) inducing cells’ mimeti…
View article: The consequences of a high-calorie diet background before calorie restriction on skeletal muscles in a mouse model
The consequences of a high-calorie diet background before calorie restriction on skeletal muscles in a mouse model Open
The beneficial effects of calorie restriction (CR) are numerous. However, there is no scientific evidence about how a high-calorie diet (HCD) background influences the mechanisms underlying CR on skeletal muscles in an experimental mouse m…
View article: Characteristics and clinical potential of a cellularly modified gelatin sponge
Characteristics and clinical potential of a cellularly modified gelatin sponge Open
Background: Human umbilical cord mesenchymal stem cells (HuMSCs) injected directly have been proven effective for improving chronic wounds. However, HuMSCs largely die within 14 days. The aim of study is to establish a cellularly modified …
View article: Articular chondrocyte-derived extracellular vesicles promote cartilage differentiation of human umbilical cord mesenchymal stem cells by activation of autophagy
Articular chondrocyte-derived extracellular vesicles promote cartilage differentiation of human umbilical cord mesenchymal stem cells by activation of autophagy Open
View article: Articular chondrocyte derived exosomes promote cartilage differentiation of human umbilical cord mesenchymal stem cells by activation of autophagy
Articular chondrocyte derived exosomes promote cartilage differentiation of human umbilical cord mesenchymal stem cells by activation of autophagy Open
Background Umbilical cord mesenchymal stem cells (HUCMSCs)-based therapies were previously predicated in cartilage regeneration due to the chondrogenic potential of MSCs. However, chondrogenic differentiation of HUMSCs is limited by admini…
View article: Overexpression of retinoblastoma‑binding protein 4 contributes to the radiosensitivity of AGS gastric cancer cells via phosphoinositide3‑kinase/protein kinase B pathway suppression
Overexpression of retinoblastoma‑binding protein 4 contributes to the radiosensitivity of AGS gastric cancer cells via phosphoinositide3‑kinase/protein kinase B pathway suppression Open
In the present study, the effects and underlying mechanism of RbAp48 on the radiosensitivity of AGS gastric cancer cells was investigated. Cell proliferation was determined with an MTT assay. Flow cytometry was performed to evaluate the ce…
View article: Genome-Wide DNA Methylation Analysis During Palatal Fusion Reveals the Potential Mechanism of Enhancer Methylation Regulating Epithelial Mesenchyme Transformation
Genome-Wide DNA Methylation Analysis During Palatal Fusion Reveals the Potential Mechanism of Enhancer Methylation Regulating Epithelial Mesenchyme Transformation Open
Epithelial mesenchyme transformation (EMT) of the medial edge epithelium (MEE) is the crucial process during palatal fusion. This work is aimed to elucidate the enhancer regulatory mechanism by genome-wide DNA methylation analysis of EMT d…
View article: [Application of amniotic membrane-living skin equivalent in repairing skin defect after removal of congenital giant nevus].
[Application of amniotic membrane-living skin equivalent in repairing skin defect after removal of congenital giant nevus]. Open
The cultivated AM-LSE with autologous cells can repair skin defect and survive for a long term without rejection.
View article: Human umbilical cord Wharton jelly cells promote extra-pancreatic insulin formation and repair of renal damage in STZ-induced diabetic mice
Human umbilical cord Wharton jelly cells promote extra-pancreatic insulin formation and repair of renal damage in STZ-induced diabetic mice Open
We confirmed the potential of IP administration of hUCWJCs and the capability of these cells to migrate to damaged tissues and promote insulin secretion from non-pancreatic local cells and to improve renal damage. These findings confer uni…
View article: Platelet poor plasma gel combined with amnion improves the therapeutic effects of human umbilical cord-derived mesenchymal stem cells on wound healing in rats
Platelet poor plasma gel combined with amnion improves the therapeutic effects of human umbilical cord-derived mesenchymal stem cells on wound healing in rats Open
The aim of the present study was to investigate the efficacy of human umbilical cord‑derived mesenchymal stem cell (HUMSCs) embedded in platelet poor plasma (PPP) gel combined with amnion (PPPA) in improving wound healing on Sprague‑Dawley…
View article: Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms
Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms Open
The T-cell lymphoproliferative neoplasms (T-LPN) are characterized by a poor clinical outcome. Current therapeutics are mostly non-selective and may induce harmful side effects. It has been reported that NOTCH1 activation mutations frequen…