Explanipedia

Eomesodermin expressing CD4 Th cells and association with multiple sclerosis progression and brain atrophy Open

Marielena Bongert, Emelie Schönauer, Paulina Trendelenburg, Ulaş Ceylan, Theodoros Ladopoulos , et al. · 2025

Multiple sclerosis is a chronic inflammatory disease affecting the central nervous system. While treatment made huge advances, progression remains a challenge. Eomesodermin+ Th cells are associated with cytotoxicity, neuroinflammation, and…

Multiple Sclerosis Relapse Treatment During Pregnancy and Offspring Functional and Structural Neurodevelopment Open

Valeska Kozik, Michelle Dreiling, D.R. Muller, Oliver Tiedge, Ruth Schneider , et al. · 2025

In spite of theoretical concerns that MP exposure during pregnancy might lead to alterations in neurodevelopment, this was not found to be the case in this cohort, with most exposures occurring during the second trimester. However, this st…

Cortical thinning and white matter alterations in myotonic dystrophy type 2 over a 10-year period Open

Britta Krieger, Christiane Schneider‐Gold, Erhan Genç, Onur Güntürkün, Christian Prehn , et al. · 2025

Deep Learning Modeling to Differentiate Multiple Sclerosis From MOG Antibody–Associated Disease Open

Rosa Cortese, Francesco Sforazzini, Giordano Gentile, A. Mauro, Ludovico Luchetti , et al. · 2025

This study provides Class III evidence that both a clinical/MRI algorithm and an MRI-based DL model accurately distinguish RRMS from MOGAD.

Middle Meningeal Artery Embolization for the Treatment of Chronic Subdural Hematomas—a German Nationwide Multi-center Study On 718 Embolizations Open

Dominik F. Vollherbst, Ansgar Berlis, Mahmoud Zaki, Christoph J. Maurer, Christina Onyinzo , et al. · 2025

Background Embolization of the middle meningeal artery (EMMA) is a promising novel technique for the treatment of patients with chronic subdural hematomas (cSDH). Methods After a nationwide query in Germany, patients with cSDH, treated wit…

MRI-based human brain atlases of R1, R2, proton density, and myelin volume fraction using synthetic quantitative imaging at 1.5 T Open

Hasan Sbaihat, Katharina Roenneke, Dajana Müller, Theodoros Ladopoulos, Ruth Schneider , et al. · 2025

Quantitative MRI (qMRI) enables objective, reproducible measurement of tissue-specific MR properties, offering improved diagnostic accuracy and deeper insight into disease mechanisms compared to conventional MRI. Parameters such as proton …

Endovascular treatment in ischemic stroke with active cancer: retrospective analysis of university stroke center data Open

Athina‐Maria Aloizou, David‐Dimitris Chlorogiannis, Daniel Richter, Theodorοs Mavridis, Dimitra Aloizou , et al. · 2025

Introduction Active cancer (AC) associates strongly with ischemic stroke (IS). Intravenous thrombolysis (IVT) is often contraindicated in AC, and endovascular treatment (EVT) is considered the gold treatment standard, although data on its …

RECLAIM—A retrospective, multicenter observational study aimed at enabling the development of artificial intelligence-driven prognostic models for disease progression in multiple sclerosis Open

Jelle Praet, Lina Anderhalten, Cristoforo Comi, Dana Horáková, Tjalf Ziemssen , et al. · 2025

Multiple sclerosis (MS) is characterized by a progressive worsening of disability over time. As many regulatory-cleared disease-modifying treatments aiming to slow down this progression are now available, a clear need has arisen for a pers…

Relevance of choroid plexus volumes in multiple sclerosis Open

Britta Krieger, Barbara Bellenberg, Anna Katharina Roenneke, Ruth Schneider, Theodoros Ladopoulos , et al. · 2025

Neurological disability and brain grey matter atrophy in primary progressive multiple sclerosis are determined by microstructural lesional changes, but not by lesion load Open

Theodoros Ladopoulos, Zainab Abbas, Britta Krieger, Barbara Bellenberg, Jeyanthan Charles James , et al. · 2025

Lesion assessment in multiple sclerosis: a comparison between synthetic and conventional fluid-attenuated inversion recovery imaging Open

Roald Ruwen Essel, Britta Krieger, Barbara Bellenberg, Dajana Müller, Theodoros Ladopoulos , et al. · 2025

Background and purpose Magnetic resonance imaging (MRI)-based lesion quantification is essential for the diagnosis of and prognosis in multiple sclerosis (MS). This study compares an established software's performance for automated volumet…

The Impact of Spinal Manipulation on Lumbar Proprioception and its Link to Pain Relief: A Randomized Controlled Trial Open

Nyirö Luana, D. Monika, Suter Magdalena, Carsten Lukas, Vogel Noemi , et al. · 2024

Manual therapy, such as spinal manipulation (SM), is commonly used to treat non-specific chronic low back pain (CLBP), although its mechanisms remain poorly understood. It has been hypothesized that the mechanical forces applied during spi…

Disentangling Neurodegeneration From Aging in Multiple Sclerosis Using Deep Learning Open

Giuseppe Pontillo, Ferrán Prados, Jordan Colman, Baris Kanber, Omar Abdel‐Mannan , et al. · 2024

The brain-predicted DD gap is sensitive to MS-related lesions and brain atrophy, adds to the brain-age paradigm in explaining physical disability both cross-sectionally and longitudinally, and may be used as an MS-specific biomarker of dis…

Cognitive Impairment, Associated Clinical Factors, and MR Volumetric Measures in Myelin Oligodendrocyte Glycoprotein-IgG–Associated Disease Open

Ann‐Kathrin Kogel, Theodoros Ladopoulos, Carolin Schwake, Ingo Kleiter, Bianca Teegen , et al. · 2024

Despite a low overall disability, every 5th patient with MOGAD experiences cognitive impairment. Cognitive impairment is associated with a higher number of relapses and particularly ADEM/ADEM-like attacks. Although both WM and DGM atrophie…

Aseptic meningitis with recurrent headache episodes, vomiting, and central fever as first manifestation of isolated neurosarcoidosis: a case report Open

Athina‐Maria Aloizou, Theresa Anne Gabriel, Carsten Lukas, Ralf Gold, Jeremias Motte · 2024

Background Neurosarcoidosis is a rare entity, usually within the context of systematic sarcoidosis. Isolated neurosarcoidosis and especially a manifestation with pachymeningitis is a notable rarity. Case Report A 26-year-old patient presen…

A future of AI-driven personalized care for people with multiple sclerosis Open

Jelle Praet, Lina Anderhalten, Cristoforo Comi, Dana Horáková, Tjalf Ziemssen , et al. · 2024

Multiple sclerosis (MS) is a devastating immune-mediated disorder of the central nervous system resulting in progressive disability accumulation. As there is no cure available yet for MS, the primary therapeutic objective is to reduce rela…

Cortical atrophy patterns in myelin oligodendrocyte glycoprotein antibody‐associated disease Open

Ruth Schneider, Ann‐Kathrin Kogel, Theodoros Ladopoulos, Nadine Siems, Britta Krieger , et al. · 2024

Objectives Global brain volume changes in patients with myelin oligodendrocyte glycoprotein antibody‐associated disease compared with healthy controls (HC) could be revealed by magnetic resonance imaging, but specific atrophy patterns of c…

Greater cortical thinning and microstructural integrity loss in myotonic dystrophy type 1 compared to myotonic dystrophy type 2 Open

Britta Krieger, Christiane Schneider‐Gold, Erhan Genç, Onur Güntürkün, Christian Prehn , et al. · 2024

Background Myotonic dystrophy is a multisystem disorder characterized by widespread organic involvement including central nervous system symptoms. Although myotonic dystrophy disease types 1 (DM1) and 2 (DM2) cover a similar spectrum of sy…

Grey Matter Atrophy and its Relationship with White Matter Lesions in Patients with Myelin Oligodendrocyte Glycoprotein Antibody‐associated Disease, Aquaporin‐4 Antibody‐Positive Neuromyelitis Optica Spectrum Disorder, and Multiple Sclerosis Open

Rosa Cortese, Marco Battaglini, Ferrán Prados, Giordano Gentile, Ludovico Luchetti , et al. · 2024

Objective To evaluate: (1) the distribution of gray matter (GM) atrophy in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), aquaporin‐4 antibody‐positive neuromyelitis optica spectrum disorder (AQP4+NMOSD), and rela…

Disentangling neurodegeneration from ageing in multiple sclerosis: the brain-predicted disease duration gap Open

Giuseppe Pontillo, Ferrán Prados, Jordan Colman, Baris Kanber, Omar Abdel‐Mannan , et al. · 2024

Disentangling brain ageing from disease-related neurodegeneration in patients with multiple sclerosis (PwMS) is increasingly topical. The brain-age paradigm offers a window into this problem but may miss disease-specific effects. Here, we …

Akutes vestibuläres Syndrom mit cochleärer Beteiligung – ein neurologischer Notfall? Open

David Bächinger, Alexander A. Tarnutzer, Ralf Gold, Carsten Lukas, Stefan Dazert , et al. · 2024

Computed tomography hypoperfusion-hypodensity mismatch vs. automated perfusion mismatch to identify stroke patients eligible for thrombolysis Open

Peter B. Sporns, André Kemmling, Lennart Meyer, Christos Krogias, Volker Puetz , et al. · 2023

Background and purpose Automated perfusion imaging can detect stroke patients with unknown time of symptom onset who are eligible for thrombolysis. However, the availability of this technique is limited. We, therefore, established the nove…

Automatic estimation of brain parenchymal fraction in patients with multple sclerosis: a comparison between synthetic MRI and an established automated brain segmentation software based on FSL Open

Ilyas Yazici, Britta Krieger, Barbara Bellenberg, Theodoros Ladopoulos, Ralf Gold , et al. · 2023

Purpose We aimed to validate the estimation of the brain parenchymal fraction (BPF) in patients with multiple sclerosis (MS) using synthetic magnetic resonance imaging (SyMRI) by comparison with software tools of the FMRIB Software Library…

Prognostic value of single-subject grey matter networks in early multiple sclerosis Open

Vinzenz Fleischer, Gabriel González‐Escamilla, Deborah Pareto, Àlex Rovira, Jaume Sastre‐Garriga , et al. · 2023

The identification of prognostic markers in early multiple sclerosis (MS) is challenging and requires reliable measures that robustly predict future disease trajectories. Ideally, such measures should make inferences at the individual leve…

Diffusion-based structural connectivity patterns of multiple sclerosis phenotypes Open

Eloy Martínez‐Heras, Elisabeth Solana, Francesc Vivó, Elisabet López-Soley, Alberto Calvi , et al. · 2023

Background We aimed to describe the severity of the changes in brain diffusion-based connectivity as multiple sclerosis (MS) progresses and the microstructural characteristics of these networks that are associated with distinct MS phenotyp…

Diagnosis behind the mask: A rare case of infected Charcot's spine Open

Giedre Kučinskaite, Theodor Lutz, Sönke P. Frey, Mark Wetterkamp, Tobias L. Schulte , et al. · 2023

Menière's Syndrome Associated With Fibrous Dysplasia of the Temporal Bone Open

Nora M. Weiss, Tabita Breitsprecher, Julia Dlugaiczyk, Felix Kämmerer, Carsten Lukas , et al. · 2023

BACKGROUND Pathologies of the endolymphatic sac (ES) most likely diminish the inner ear's capability to maintain normal ion and fluid homeostasis and, more recently, have been systematically linked to the pathogenesis of Menière's symptoms…

Diffusion-based structural connectivity patterns of multiple sclerosis phenotypes Open

Eloy Martínez‐Heras, Elisabeth Solana, Francesc Vivó, Elisabet López-Soley, Alberto Calvi , et al. · 2023

Background We aimed to describe the severity of the changes in brain diffusion-based connectivity as multiple sclerosis (MS) progresses and the microstructural characteristics of these networks that are associated with distinct MS phenotyp…

Greater Cortical Thinning and Microstructural Integrity Loss in Myotonic Dystrophy Type 1 Compared to Type 2 Open

Britta Krieger, Christiane Schneider‐Gold, Erhan Genç, Onur Güntürkün, Christian Prehn , et al. · 2023

Factors associated with depressive mood at the onset of multiple sclerosis - an analysis of 781 patients of the German NationMS cohort Open

Anke Salmen, Robert Hoepner, Vinzenz Fleischer, M.B. Oefinger T. Heldt, Barbara Gisevius , et al. · 2023

Background: Depression has a major impact on the disease burden of multiple sclerosis (MS). Analyses of overlapping MS and depression risk factors [smoking, vitamin D (25-OH-VD) and Epstein-Barr virus (EBV) infection] and sex, age, disease…

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