Lukas Frontzkowski
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View article: A systematic comparison of ATN biomarkers for monitoring longitudinal cognitive changes in Alzheimer's disease
A systematic comparison of ATN biomarkers for monitoring longitudinal cognitive changes in Alzheimer's disease Open
INTRODUCTION With anti‐amyloid beta (Aβ) therapies approved for Alzheimer's disease (AD), surrogate biomarkers are needed to monitor clinical treatment efficacy. Therefore, we systematically compared longitudinal changes in A/T/N biomarker…
View article: Localized network damage related to white matter hyperintensities is linked to worse outcome after severe stroke
Localized network damage related to white matter hyperintensities is linked to worse outcome after severe stroke Open
White matter hyperintensities of presumed vascular origin (WMH) are associated with various clinical sequelae. In stroke patients, the total WMH burden is linked to recurrent cerebrovascular events and worse clinical outcomes. As WMH also …
View article: Brain Networks Route Neurodegeneration Patterns in Patients with Progressive Supranuclear Palsy
Brain Networks Route Neurodegeneration Patterns in Patients with Progressive Supranuclear Palsy Open
Background Progressive supranuclear palsy (PSP) is a neurodegenerative disease driven by 4‐repeat τ pathology, which is thought to propagate across interconnected neurons. Objectives We hypothesized that interconnected brain regions exhibi…
View article: Developing a novel reference region for [18F]PI-2620-PET imaging to facilitate the assessment of 4-repeat tauopathies
Developing a novel reference region for [18F]PI-2620-PET imaging to facilitate the assessment of 4-repeat tauopathies Open
View article: Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer’s disease
Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer’s disease Open
Background Aggregated alpha-Synuclein (αSyn) is a hallmark pathology in Parkinson’s disease but also one of the most common co-pathologies in Alzheimer’s disease (AD). Preclinical studies suggest that αSyn can exacerbate tau aggregation, i…
View article: Exploring the origins of frequent tau-PET signal in vermal and adjacent regions
Exploring the origins of frequent tau-PET signal in vermal and adjacent regions Open
View article: Assessment and staging of A/T/N with a single dynamic [<sup>18</sup>F]PI-2620 recording
Assessment and staging of A/T/N with a single dynamic [<sup>18</sup>F]PI-2620 recording Open
Patients with Alzheimer’s disease (AD) and clinically overlapping neurodegenerative diseases are classified molecularly using the A/T/N classification system. Apart from fluid biomarkers and structural MRI, the three-dimensional A/T/N syst…
View article: Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer’s disease
Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer’s disease Open
In Alzheimer’s disease (AD), Aβ triggers p-tau secretion, which drives tau aggregation. Therefore, it is critical to characterize modulators of Aβ-related p-tau increases which may alter AD trajectories. Here, we assessed whether factors k…
View article: Human cortical high‐gamma power scales with movement rate in healthy participants and stroke survivors
Human cortical high‐gamma power scales with movement rate in healthy participants and stroke survivors Open
Motor cortical high‐gamma oscillations (60–90 Hz) occur at movement onset and are spatially focused over the contralateral primary motor cortex. Although high‐gamma oscillations are widely recognized for their significance in human motor c…
View article: Feasibility and potential diagnostic value of [18F]PI-2620 PET in patients with down syndrome and Alzheimer’s disease: a case series
Feasibility and potential diagnostic value of [18F]PI-2620 PET in patients with down syndrome and Alzheimer’s disease: a case series Open
Purpose of the report Adults with Down Syndrome (DS) have a substantially increased risk for Alzheimer’s disease (AD) due to the triplicated amyloid-precursor-protein gene on chromosome 21, resulting in amyloid and tau accumulation. Howeve…
View article: Frontoparietal Structural Network Disconnections Correlate With Outcome After a Severe Stroke
Frontoparietal Structural Network Disconnections Correlate With Outcome After a Severe Stroke Open
Structural disconnectome analyses have provided valuable insights into how a stroke lesion results in widespread network disturbances and how these relate to deficits, recovery patterns, and outcomes. Previous analyses have primarily focus…
View article: Cortical microstructure and hemispheric specialization—A diffusion‐imaging analysis in younger and older adults
Cortical microstructure and hemispheric specialization—A diffusion‐imaging analysis in younger and older adults Open
Characterizing cortical plasticity becomes increasingly important for identifying compensatory mechanisms and structural reserve in the ageing population. While cortical thickness (CT) largely contributed to systems neuroscience, it incomp…
View article: Localized network damage related to white matter hyperintensities is linked to worse outcome after severe stroke
Localized network damage related to white matter hyperintensities is linked to worse outcome after severe stroke Open
White matter hyperintensities of presumed vascular origin (WMH), a manifestation of cerebral small vessel disease, are associated with various clinical sequelae. In stroke patients, total WMH burden is linked to recurrent cerebrovascular e…
View article: Frontoparietal structural network disconnections correlate with outcome after a severe stroke
Frontoparietal structural network disconnections correlate with outcome after a severe stroke Open
Structural disconnectome analyses have provided valuable insights into how a stroke lesion results in widespread network disturbances and how these relate to deficits, recovery patterns, and outcome. Previous analyses have primarily focuse…
View article: Dopaminergic mesolimbic structural reserve is positively linked to better outcome after severe stroke
Dopaminergic mesolimbic structural reserve is positively linked to better outcome after severe stroke Open
The concept of brain reserve capacity has emerged in stroke recovery research in recent years. Imaging-based biomarkers of brain health have helped to better understand outcome variability in clinical cohorts. Still, outcome inferences are…
View article: Preserved Corticospinal Tract Revealed by Acute Perfusion Imaging Relates to Better Outcome After Thrombectomy in Stroke
Preserved Corticospinal Tract Revealed by Acute Perfusion Imaging Relates to Better Outcome After Thrombectomy in Stroke Open
BACKGROUND: The indication for mechanical thrombectomy (MT) in stroke patients with large vessel occlusion has been constantly expanded over the past years. Despite remarkable treatment effects at the group level in clinical trials, many p…
View article: Human cortical high-gamma power relates to movement speed and is disproportionately reduced after stroke
Human cortical high-gamma power relates to movement speed and is disproportionately reduced after stroke Open
Motor cortical high-gamma oscillations (60 to 90 Hz) occur at the onset of movement and are spatially focused over the contralateral primary motor cortex. Although high-gamma oscillations are widely recognized for their significance in hum…
View article: Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading
Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading Open
View article: Tau deposition patterns are associated with functional connectivity in primary tauopathies
Tau deposition patterns are associated with functional connectivity in primary tauopathies Open
Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread prion-like across connected neurons, but the mechanisms of …
View article: Tau spreading is driven by neuronal connectivity in primary tauopathies - evidence from tau-PET and histopathology
Tau spreading is driven by neuronal connectivity in primary tauopathies - evidence from tau-PET and histopathology Open
Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies (4RT), including cortico-basal degeneration and progressive supranuclear palsy (PSP). Tau is assumed to spread prion-like across connected neurons, but the me…
View article: Segregation of functional networks is associated with cognitive resilience in Alzheimer’s disease
Segregation of functional networks is associated with cognitive resilience in Alzheimer’s disease Open
Cognitive resilience is an important modulating factor of cognitive decline in Alzheimer’s disease, but the functional brain mechanisms that support cognitive resilience remain elusive. Given previous findings in normal ageing, we tested t…
View article: Lower cerebral perfusion is associated with tau-PET in the entorhinal cortex across the Alzheimer's continuum
Lower cerebral perfusion is associated with tau-PET in the entorhinal cortex across the Alzheimer's continuum Open
View article: Modeling patient‐specific tau spreading patterns in Alzheimer’s disease: Towards precision medicine
Modeling patient‐specific tau spreading patterns in Alzheimer’s disease: Towards precision medicine Open
Background In Alzheimer’s disease (AD), tau pathology spreads from the temporal lobe throughout the brain, ensuing cognitive decline. PET‐assessed tau‐spreading patterns are, however, heterogeneous across patients, posing challenges for as…
View article: Global system segregation enhances reserve in normal aging and Alzheimer’s disease
Global system segregation enhances reserve in normal aging and Alzheimer’s disease Open
Background Epidemiological studies suggest that reserve capacity is associated with a significant delay of cognitive decline by up to 4 years in aging and dementia. Identifying brain substrates of reserve is a pivotal step to define potent…
View article: Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer’s disease
Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer’s disease Open
In Alzheimer’s disease, PET-assessed tau pathology emerges locally and spreads throughout functionally connected regions.
View article: Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration
Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration Open
Background The Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). TREM2 (i.e. Triggering receptor expressed on myeloid cells 2) is a microglial transmembrane protein brain th…
View article: Left frontal hub connectivity enhances task‐related brain network segregation and cognition in aging: Implications for reserve: Neuroimaging/Normal brain aging
Left frontal hub connectivity enhances task‐related brain network segregation and cognition in aging: Implications for reserve: Neuroimaging/Normal brain aging Open
Background: Global connectivity of the left frontal cortex (LFC), a hub of the cognitive control network, is associated with higher fluid intelligence and relatively preserved cognition despite age‐ and Alzheimer’s disease (AD)‐related bra…