Lukas Hingerl
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View article: Myo‐Inositol Deficiency, Structural Brain Changes, and Cerebral Perfusion Alterations in Classic Galactosemia: Preliminary Insights From a Multiparametric <scp>MRI</scp> Study
Myo‐Inositol Deficiency, Structural Brain Changes, and Cerebral Perfusion Alterations in Classic Galactosemia: Preliminary Insights From a Multiparametric <span>MRI</span> Study Open
Classic galactosemia is a rare metabolic disorder resulting from galactose‐1‐phosphate uridylyltransferase deficiency, which disrupts normal galactose metabolism, leading to toxic accumulation of galactose‐1‐phosphate and galactitol. Despi…
View article: EP03.02 IMAGING-BASED PREDICTION OF 5-ALA FLUORESCENCE IN GLIOMAS USING PREOPERATIVE 7T MRSI COMPARED TO T1W MRI AND PET
EP03.02 IMAGING-BASED PREDICTION OF 5-ALA FLUORESCENCE IN GLIOMAS USING PREOPERATIVE 7T MRSI COMPARED TO T1W MRI AND PET Open
BACKGROUND Maximizing the extent of safe tumor resection is a critical factor influencing survival outcomes in glioma patients. The use of 5-aminolevulinic acid (5-ALA) fluorescence has proven effective in enhancing resection, particularly…
View article: A Deep Autoencoder for Fast Spectral-Temporal Fitting of Dynamic Deuterium Metabolic Imaging Data at 7T
A Deep Autoencoder for Fast Spectral-Temporal Fitting of Dynamic Deuterium Metabolic Imaging Data at 7T Open
Deuterium metabolic imaging (DMI) is a non-invasive magnetic resonance spectroscopic imaging technique enabling in vivo mapping of glucose metabolism. Dynamic DMI provides time-resolved metabolite maps and allows spatially resolved fitting…
View article: Feasibility of High‐Resolution Deuterium Metabolic Imaging of the Human Kidney Using Concentric Ring Trajectory Sampling at 7T
Feasibility of High‐Resolution Deuterium Metabolic Imaging of the Human Kidney Using Concentric Ring Trajectory Sampling at 7T Open
The human kidneys play a pivotal role in regulating blood pressure, water, and salt homeostasis, but assessment of renal function typically requires invasive methods. Deuterium metabolic imaging (DMI) is a novel, noninvasive technique for …
View article: From a Voxel to Maps: A Comparative Study of sLASER SVS and 3D-CRT-FID-MRSI at 3 T and 7 T
From a Voxel to Maps: A Comparative Study of sLASER SVS and 3D-CRT-FID-MRSI at 3 T and 7 T Open
Magnetic resonance spectroscopy (MRS) enables non-invasive assessment of brain metabolites and is commonly implemented using single-voxel spectroscopy (SVS) or magnetic resonance spectroscopic imaging (MRSI). This study directly compares t…
View article: Glutamine Metabolism and Metabolic Profiling Using <scp>7 T CRT</scp>‐<scp>FID MRSI</scp> in Focal Epilepsy
Glutamine Metabolism and Metabolic Profiling Using <span>7 T CRT</span>‐<span>FID MRSI</span> in Focal Epilepsy Open
Background Approximately one‐third of people with epilepsy (PWE) remain drug‐resistant. In these cases, surgical resection of the epileptogenic zone may significantly reduce or eliminate seizures. Surgery necessitates precise delineation o…
View article: High-Resolution Mapping of Tumor and Peritumoral Glutamate and Glutamine in Gliomas Using 7-T MRSI
High-Resolution Mapping of Tumor and Peritumoral Glutamate and Glutamine in Gliomas Using 7-T MRSI Open
The 7-T MR spectroscopic imaging revealed increased glutamate and glutamine metabolic ratios within the peritumoral region compared with normal-appearing white matter in patients with glioma distinct from intratumoral changes, suggesting i…
View article: Comparison of Low‐Rank Denoising Methods for Dynamic Deuterium MRSI at 7 T
Comparison of Low‐Rank Denoising Methods for Dynamic Deuterium MRSI at 7 T Open
Dynamic deuterium ( 2 H)‐MRSI enables mapping of metabolic fluxes in vivo, but its sensitivity is hampered by the low 2 H gyromagnetic ratio and 2 H‐labelled metabolite concentrations. Low‐rank denoising can enhance MRSI sensitivity by sep…
View article: The relationship of glutamate and glutamine and metabolic profiling in focal epilepsy using 7T CRT-FID-MRSI
The relationship of glutamate and glutamine and metabolic profiling in focal epilepsy using 7T CRT-FID-MRSI Open
Approximately one-third of people with epilepsy (PWE) remain drug-resistant. In these cases, surgical resection of the epileptogenic zone may significantly reduce or eliminate seizures. Surgery necessitates precise delineation of the epile…
View article: Balanced steady state free precession enables high-resolution dynamic 3D Deuterium Metabolic Imaging of the human brain at 7T
Balanced steady state free precession enables high-resolution dynamic 3D Deuterium Metabolic Imaging of the human brain at 7T Open
Objectives Deuterium ( 2 H) Metabolic Imaging (DMI) is an emerging magnetic resonance technique to non-invasively map human brain glucose (Glc) uptake and downstream metabolism following oral or intravenous administration of 2 H-labeled Gl…
View article: Topographical mapping of metabolic abnormalities in multiple sclerosis using rapid echo-less 3D-MR spectroscopic imaging at 7T
Topographical mapping of metabolic abnormalities in multiple sclerosis using rapid echo-less 3D-MR spectroscopic imaging at 7T Open
This study highlights the ability of 3D-MRSI at 7T to map widespread metabolic abnormalities in MS, with NAA reductions in prefrontal, motor, and sensory areas, linked to neuroaxonal damage and disability progression, and elevated mI in pe…
View article: Exploring in vivo human brain metabolism at 10.5 T: Initial insights from MR spectroscopic imaging
Exploring in vivo human brain metabolism at 10.5 T: Initial insights from MR spectroscopic imaging Open
These preliminary findings highlight the potential of 10.5 T MRSI as a powerful imaging tool for probing cerebral metabolism. By providing unprecedented spatial and spectral resolution, this technology could offer a unique view into the me…
View article: Concentric Ring Trajectory Sampling With k‐Space Reordering Enables Assessment of Tissue‐Specific <i>T</i><sub>1</sub> and <i>T</i><sub>2</sub> Relaxation for <sup>2</sup>H‐Labeled Substrates in the Human Brain at 7 T
Concentric Ring Trajectory Sampling With k‐Space Reordering Enables Assessment of Tissue‐Specific <i>T</i><sub>1</sub> and <i>T</i><sub>2</sub> Relaxation for <sup>2</sup>H‐Labeled Substrates in the Human Brain at 7 T Open
Deuterium metabolic imaging (DMI) is an emerging Magnetic Resonance technique providing valuable insight into the dynamics of cellular glucose (Glc) metabolism of the human brain in vivo using deuterium‐labeled ( 2 H) glucose as non‐invasi…
View article: Proton‐free induction decay <scp>MRSI</scp> at <scp>7 T</scp> in the human brain using an egg‐shaped modified rosette K‐space trajectory
Proton‐free induction decay <span>MRSI</span> at <span>7 T</span> in the human brain using an egg‐shaped modified rosette K‐space trajectory Open
Purpose Proton ( 1 H)‐MRSI via spatial‐spectral encoding poses high demands on gradient hardware at ultra‐high fields and high‐resolutions. Rosette trajectories help alleviate these problems, but at reduced SNR‐efficiency because of their …
View article: Imaging of increased peritumoral glutamate and glutamine in gliomas using 7T MRSI
Imaging of increased peritumoral glutamate and glutamine in gliomas using 7T MRSI Open
Objectives Diffuse gliomas, due to their infiltrative properties, still lack effective treatment options. Recent research indicates that infiltration, malignancy, and symptoms such as epilepsy are related to synaptic connections between in…
View article: 7 Tesla magnetic resonance spectroscopic imaging predicting IDH status and glioma grading
7 Tesla magnetic resonance spectroscopic imaging predicting IDH status and glioma grading Open
Introduction With the application of high-resolution 3D 7 Tesla Magnetic Resonance Spectroscopy Imaging (MRSI) in high-grade gliomas, we previously identified intratumoral metabolic heterogeneities. In this study, we evaluated the potentia…
View article: Whole‐brain deuterium metabolic imaging via concentric ring trajectory readout enables assessment of regional variations in neuronal glucose metabolism
Whole‐brain deuterium metabolic imaging via concentric ring trajectory readout enables assessment of regional variations in neuronal glucose metabolism Open
Deuterium metabolic imaging (DMI) is an emerging magnetic resonance technique, for non‐invasive mapping of human brain glucose metabolism following oral or intravenous administration of deuterium‐labeled glucose. Regional differences in gl…
View article: Proton Free Induction Decay MRSI at 7T in the Human Brain Using an Egg-Shaped Modified Rosette K-Space Trajectory
Proton Free Induction Decay MRSI at 7T in the Human Brain Using an Egg-Shaped Modified Rosette K-Space Trajectory Open
1. Abstract 1.1 Purpose Proton ( 1 H)-MRSI via spatial-spectral encoding poses high demands on gradient hardware at ultra-high fields and high-resolutions. Rosette trajectories help alleviate these problems, but at reduced SNR-efficiency d…
View article: A Comparison of 7 Tesla MR Spectroscopic Imaging and 3 Tesla MR Fingerprinting for Tumor Localization in Glioma Patients
A Comparison of 7 Tesla MR Spectroscopic Imaging and 3 Tesla MR Fingerprinting for Tumor Localization in Glioma Patients Open
This paper investigated the correlation between magnetic resonance spectroscopic imaging (MRSI) and magnetic resonance fingerprinting (MRF) in glioma patients by comparing neuro-oncological markers obtained from MRSI to T1/T2 maps from MRF…
View article: Predicting dynamic, motion‐related changes in <scp><i>B</i><sub>0</sub></scp> field in the brain at a 7T <scp>MRI</scp> using a subject‐specific fine‐trained U‐net
Predicting dynamic, motion‐related changes in <span><i>B</i><sub>0</sub></span> field in the brain at a 7T <span>MRI</span> using a subject‐specific fine‐trained U‐net Open
Purpose Subject movement during the MR examination is inevitable and causes not only image artifacts but also deteriorates the homogeneity of the main magnetic field ( B 0 ), which is a prerequisite for high quality data. Thus, characteriz…
View article: ECCENTRIC: A fast and unrestrained approach for high-resolution in vivo metabolic imaging at ultra-high field MR
ECCENTRIC: A fast and unrestrained approach for high-resolution in vivo metabolic imaging at ultra-high field MR Open
A novel method for fast and high-resolution metabolic imaging, called ECcentric Circle ENcoding TRajectorIes for Compressed sensing (ECCENTRIC), has been developed at 7 Tesla MRI. ECCENTRIC is a non-Cartesian spatial-spectral encoding meth…
View article: Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct (2H) and indirect (1H) detection of deuterium labeled compounds at 7T and clinical 3T
Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct (2H) and indirect (1H) detection of deuterium labeled compounds at 7T and clinical 3T Open
View article: ECCENTRIC: a fast and unrestrained approach for high-resolution in vivo metabolic imaging at ultra-high field MR
ECCENTRIC: a fast and unrestrained approach for high-resolution in vivo metabolic imaging at ultra-high field MR Open
A novel method for fast and high-resolution metabolic imaging, called ECcentric Circle ENcoding TRajectorIes for Compressed sensing (ECCENTRIC), has been developed and implemented at 7 Tesla MRI. ECCENTRIC is a non-Cartesian spatial-spectr…
View article: 1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain
1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain Open
View article: Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct (<sup>2</sup>H) and indirect (<sup>1</sup>H) detection of deuterium labeled compounds at 7T and clinical 3T
Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct (<sup>2</sup>H) and indirect (<sup>1</sup>H) detection of deuterium labeled compounds at 7T and clinical 3T Open
Introduction Deuterium metabolic imaging (DMI) and quantitative exchange label turnover (QELT) are novel MR spectroscopy techniques for non-invasive imaging of human brain glucose and neurotransmitter metabolism with high clinical potentia…
View article: Predicting dynamic, motion-related changes in B0 field in the brain at a 7 T MRI using a subject-specific fine-tuned U-net
Predicting dynamic, motion-related changes in B0 field in the brain at a 7 T MRI using a subject-specific fine-tuned U-net Open
Subject movement during the magnetic resonance examination is inevitable and causes not only image artefacts but also deteriorates the homogeneity of the main magnetic field (B0), which is a prerequisite for high quality data. Thus, charac…
View article: A comparison of 7 Tesla MR spectroscopic imaging and 3 Tesla MR fingerprinting for tumor localization in glioma patients
A comparison of 7 Tesla MR spectroscopic imaging and 3 Tesla MR fingerprinting for tumor localization in glioma patients Open
This paper investigates the correlation between magnetic resonance spectroscopic imaging (MRSI) and magnetic resonance fingerprinting (MRF) in glioma patients by comparing neuro-oncological markers obtained from MRSI to T1/T2 maps from MRF…
View article: Metabolic Insights into Iron Deposition in Relapsing-Remitting Multiple Sclerosis via 7T Magnetic Resonance Spectroscopic Imaging
Metabolic Insights into Iron Deposition in Relapsing-Remitting Multiple Sclerosis via 7T Magnetic Resonance Spectroscopic Imaging Open
Objective To investigate the metabolic pattern of different types of iron accumulation in multiple sclerosis (MS) lesions, and compare metabolic alterations within and at the periphery of lesions and newly emerging lesions in vivo accordin…
View article: Noninvasive 3-Dimensional 1H-Magnetic Resonance Spectroscopic Imaging of Human Brain Glucose and Neurotransmitter Metabolism Using Deuterium Labeling at 3T
Noninvasive 3-Dimensional 1H-Magnetic Resonance Spectroscopic Imaging of Human Brain Glucose and Neurotransmitter Metabolism Using Deuterium Labeling at 3T Open
Objectives Noninvasive, affordable, and reliable mapping of brain glucose metabolism is of critical interest for clinical research and routine application as metabolic impairment is linked to numerous pathologies, for example, cancer, deme…
View article: Metabolic Insights into Iron Deposition in Relapsing-Remitting Multiple Sclerosis via 7 T Magnetic Resonance Spectroscopic Imaging
Metabolic Insights into Iron Deposition in Relapsing-Remitting Multiple Sclerosis via 7 T Magnetic Resonance Spectroscopic Imaging Open