Jörg R. Aschenbach
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View article: Peptide Barcodes for miRNA activity assessment in mammalian cells
Peptide Barcodes for miRNA activity assessment in mammalian cells Open
Summary Studies of gene regulation require measurements of mRNA and protein levels of a regulated gene. Recently, parallel reporter assays have been introduced to study the regulation of multiple genes at once. While transcriptional regula…
View article: Changes in Ruminal Fermentation and Growth Performance in Calves After Increasing Ruminal Undegradable Protein at Two Different Time Points Pre-Weaning
Changes in Ruminal Fermentation and Growth Performance in Calves After Increasing Ruminal Undegradable Protein at Two Different Time Points Pre-Weaning Open
The cost-effective rearing of heifers depends on the provision of adequate nutrients at an appropriate age to meet nutrient requirements for growth and production. The objective of the present study was to investigate how the time of switc…
View article: Transport of Neutral Amino Acids in the Jejunum of Pigs with Special Consideration of L-Methionine
Transport of Neutral Amino Acids in the Jejunum of Pigs with Special Consideration of L-Methionine Open
Background: Methionine (Met) is a popular nutritional supplement in humans and animals. It is routinely supplemented to pigs as L-Met, DL-Met, or DL-2-hydroxy-4-(methylthio) butanoic acid (DL-HMTBA). Methods: We investigated the effect of …
View article: Response to Incremental Replacement of Palm Oil with Fish Oil in Starter Diet on Growth Performance, Plasma Metabolites, Ruminal Fermentation, and Behavior of Dairy Calves
Response to Incremental Replacement of Palm Oil with Fish Oil in Starter Diet on Growth Performance, Plasma Metabolites, Ruminal Fermentation, and Behavior of Dairy Calves Open
The objective of this study was to evaluate the effects of the incremental levels of n-3 fatty acids (FA) in starter feed (SF) on growth and metabolic performance of milk-fed calves. From day 3 of age, 30 female calves (39.4 ± 3.1 kg of bo…
View article: Low Magnesium Concentration Enforces Bone Calcium Deposition Irrespective of 1,25-Dihydroxyvitamin D3 Concentration
Low Magnesium Concentration Enforces Bone Calcium Deposition Irrespective of 1,25-Dihydroxyvitamin D3 Concentration Open
Efficient coordination between Mg2+ and vitamin D maintains adequate Ca2+ levels during lactation. This study explored the possible interaction between Mg2+ (0.3, 0.8, and 3 mM) and 1,25-dihydroxyvitamin D3 (1,25D; 0.05 and 5 nM) during os…
View article: Multilineage Differentiation Potential of Equine Adipose-Derived Stromal/Stem Cells from Different Sources
Multilineage Differentiation Potential of Equine Adipose-Derived Stromal/Stem Cells from Different Sources Open
The investigation of multipotent stem/stromal cells (MSCs) in vitro represents an important basis for translational studies in large animal models. The study’s aim was to examine and compare clinically relevant in vitro properties of equin…
View article: Blood calcium concentration and performance in periparturient and early lactating dairy cows is influenced by plant bioactive lipid compounds
Blood calcium concentration and performance in periparturient and early lactating dairy cows is influenced by plant bioactive lipid compounds Open
Previous studies ex vivo suggested that plant bioactive lipid compounds (PBLC) can increase ruminal calcium absorption. Therefore, we hypothesized that PBLC feeding around calving may potentially counteract hypocalcemia and support perform…
View article: Dietary fiber and its role in performance, welfare, and health of pigs
Dietary fiber and its role in performance, welfare, and health of pigs Open
Dietary fiber (DF) is receiving increasing attention, and its importance in pig nutrition is now acknowledged. Although DF for pigs was frowned upon for a long time because of reductions in energy intake and digestibility of other nutrient…
View article: Growth performance, nutrient digestibility, and ruminal fermentation of dairy calves fed starter diets with alfalfa hay versus corn silage as forage and soybean oil versus palm fatty acids as fat source
Growth performance, nutrient digestibility, and ruminal fermentation of dairy calves fed starter diets with alfalfa hay versus corn silage as forage and soybean oil versus palm fatty acids as fat source Open
The present study was intended to evaluate the effect of forage source (alfalfa hay; ALF vs. corn silage; CS) along with a supplemental fat source (soybean oil; SO vs. rumen-inert palm fatty acids; PF) on growth performance, nutrient diges…
View article: Effects of Oil Supplements on Growth Performance, Eating Behavior, Ruminal Fermentation, and Ruminal Morphology in Lambs during Transition from a Low- to a High-Grain Diet
Effects of Oil Supplements on Growth Performance, Eating Behavior, Ruminal Fermentation, and Ruminal Morphology in Lambs during Transition from a Low- to a High-Grain Diet Open
The objectives of this study were to investigate the effect of a maximum recommended oil supplementation on growth performance, eating behavior, ruminal fermentation, and ruminal morphological characteristics in growing lambs during transi…
View article: Comparison of Sources and Methods for the Isolation of Equine Adipose Tissue-Derived Stromal/Stem Cells and Preliminary Results on Their Reaction to Incubation with 5-Azacytidine
Comparison of Sources and Methods for the Isolation of Equine Adipose Tissue-Derived Stromal/Stem Cells and Preliminary Results on Their Reaction to Incubation with 5-Azacytidine Open
Physiological particularities of the equine heart justify the development of an in vitro model suitable for investigations of the species-specific equine cardiac electrophysiology. Adipose tissue-derived stromal/stem cells (ASCs) could be …
View article: Growth Performance, Eating Behavior, Digestibility, Blood Metabolites, and Carcass Traits in Growing-Finishing Fat-Tailed Lambs Fed Different Levels of Dietary Neutral Detergent Fiber with High Rumen Undegradable Protein
Growth Performance, Eating Behavior, Digestibility, Blood Metabolites, and Carcass Traits in Growing-Finishing Fat-Tailed Lambs Fed Different Levels of Dietary Neutral Detergent Fiber with High Rumen Undegradable Protein Open
This study was conducted to investigate the effect of decreasing concentrations of dietary neutral detergent fiber (NDF) at high rumen undegradable protein (RUP) on performance, digestibility, chewing activity, blood attributes, and carcas…
View article: Expression of proposed methionine transporters along the gastrointestinal tract of pigs and their regulation by dietary methionine sources
Expression of proposed methionine transporters along the gastrointestinal tract of pigs and their regulation by dietary methionine sources Open
Background Given the key role of methionine (Met) in biological processes like protein translation, methylation, and antioxidant defense, inadequate Met supply can limit performance. This study investigated the effect of different dietary …
View article: The Combined Influence of Magnesium and Insulin on Central Metabolic Functions and Expression of Genes Involved in Magnesium Homeostasis of Cultured Bovine Adipocytes
The Combined Influence of Magnesium and Insulin on Central Metabolic Functions and Expression of Genes Involved in Magnesium Homeostasis of Cultured Bovine Adipocytes Open
At the onset of lactation, dairy cows suffer from insulin resistance, insulin deficiency or both, similar to human diabetes, resulting in lipolysis, ketosis and fatty liver. This work explored the combined effects of different levels of ma…
View article: Changes in the Relationship between Ionized and Total Calcium in Clinically Healthy Dairy Cows in the Period around Calving
Changes in the Relationship between Ionized and Total Calcium in Clinically Healthy Dairy Cows in the Period around Calving Open
We aimed to establish a model for prediction of iCa from tCa, using multivariable regressions with diverse blood constituents. Blood was taken from 14 cows at days −2, 0, 2, 4, 7, and 14 relative to parturition. Cows were clinically health…
View article: Establishment of a novel probe-based RT-qPCR approach for detection and quantification of tight junctions reveals age-related changes in the gut barriers of broiler chickens
Establishment of a novel probe-based RT-qPCR approach for detection and quantification of tight junctions reveals age-related changes in the gut barriers of broiler chickens Open
Tight junctions (TJs) play a dominant role in gut barrier formation, therefore, resolving the structures of TJs in any animal species is crucial but of major importance in fast growing broilers. They are regulated in molecular composition,…
View article: Menthol stimulates calcium absorption in the rumen but not in the jejunum of sheep
Menthol stimulates calcium absorption in the rumen but not in the jejunum of sheep Open
Stimulation of Ca2+ absorption can counteract hypocalcemia at the onset of lactation. The plant bioactive lipid compound (PBLC) menthol is an agonist for nonselective cation channels of the transient receptor potential (TRP) family. It acu…
View article: Functional Changes of the Community of Microbes With Ni-Dependent Enzyme Genes Accompany Adaptation of the Ruminal Microbiome to Urea-Supplemented Diets
Functional Changes of the Community of Microbes With Ni-Dependent Enzyme Genes Accompany Adaptation of the Ruminal Microbiome to Urea-Supplemented Diets Open
Urea is an inexpensive non-protein nitrogen source commonly supplemented to the diets of ruminants. It is cleaved to ammonia by bacterial ureases, which require Ni as a catalyst for ureolysis. The key event in the changes of the ruminal mi…
View article: Dietary Mg2+ Intake and the Na+/Mg2+ Exchanger SLC41A1 Influence Components of Mitochondrial Energetics in Murine Cardiomyocytes
Dietary Mg2+ Intake and the Na+/Mg2+ Exchanger SLC41A1 Influence Components of Mitochondrial Energetics in Murine Cardiomyocytes Open
Cardiomyocytes are among the most energy-intensive cell types. Interplay between the components of cellular magnesium (Mg) homeostasis and energy metabolism in cardiomyocytes is poorly understood. We have investigated the effects of dietar…
View article: Effects of lipopolysaccharide exposure in primary bovine ruminal epithelial cells
Effects of lipopolysaccharide exposure in primary bovine ruminal epithelial cells Open
The objective of this study was to investigate whether cultured ruminal epithelial cells (REC) responded to lipopolysaccharide (LPS) stimulation and determine whether LPS induced a proinflammatory response. Primary bovine REC were isolated…
View article: Erratum to “The GadX regulon affects virulence gene expression and adhesion of porcine enteropathogenic Escherichia coli in vitro” [Vet. Anim. Sci. 3C (2017) 10–17]
Erratum to “The GadX regulon affects virulence gene expression and adhesion of porcine enteropathogenic Escherichia coli in vitro” [Vet. Anim. Sci. 3C (2017) 10–17] Open
[This corrects the article DOI: 10.1016/j.vas.2017.04.001.].
View article: Relationship between intracellular free magnesium concentration and the degree of insulin resistance in horses with equine metabolic syndrome
Relationship between intracellular free magnesium concentration and the degree of insulin resistance in horses with equine metabolic syndrome Open
Magnesium metabolism, especially the intracellular magnesium concentration [Mg 2+ ]i, plays an important role in human diabetes mellitus.The aim of this study was to evaluate [Mg 2+ ]i in horses with insulin resistance and to examine a pos…
View article: Optimizing adipogenic transdifferentiation of bovine mesenchymal stem cells: a prominent role of ascorbic acid in <i>FABP4</i> induction
Optimizing adipogenic transdifferentiation of bovine mesenchymal stem cells: a prominent role of ascorbic acid in <i>FABP4</i> induction Open
Adipocyte differentiation of bovine adipose-derived stem cells (ASC) was induced by foetal bovine serum (FBS), biotin, pantothenic acid, insulin, rosiglitazone, dexamethasone and 3-isobutyl-1-methylxanthine, followed by incubation in diffe…