Lukas Kater
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View article: Tandem association of CLOCK:BMAL1 complexes on DNA enables recruitment of CBP/p300 through multivalent interactions
Tandem association of CLOCK:BMAL1 complexes on DNA enables recruitment of CBP/p300 through multivalent interactions Open
The basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) transcription factor CLOCK:BMAL1 interacts with E-box motifs in the context of nucleosomes to elicit a circadian pattern of gene expression that oscillates with approximately 24 hour perio…
View article: Nucleosomes specify co-factor access to p53
Nucleosomes specify co-factor access to p53 Open
Pioneer transcription factors (TFs) engage chromatinized DNA motifs. However, it is unclear how the resultant TF-nucleosome complexes are decoded by co-factors. In humans, the TF p53 regulates cell-cycle progression, apoptosis, and the DNA…
View article: Designing Rigid DNA Origami Templates for Molecular Visualization Using Cryo-EM
Designing Rigid DNA Origami Templates for Molecular Visualization Using Cryo-EM Open
DNA origami, a method for constructing nanostructures from DNA, offers potential for diverse scientific and technological applications due to its ability to integrate various molecular functionalities in a programmable manner. In this stud…
View article: Structural insights into viral hijacking of p53 by E6 and E6AP
Structural insights into viral hijacking of p53 by E6 and E6AP Open
The E3-ubiquitin ligase E6AP degrades p53 when complexed with the viral protein E6 from human papilloma virus (HPV), which contributes to the transformation of cells in HPV-related cancers. Previous crystal structures of the E6AP-E6-p53 te…
View article: Orphan quality control shapes network dynamics and gene expression
Orphan quality control shapes network dynamics and gene expression Open
(Cell 186, 3460–3475.e1–e23; August 3, 2023) In the originally published version of this article, due to a copy-paste error, Figure 1B inadvertently showed the blot for MYC instead of BUBR1. This has since been corrected online. The author…
View article: Orphan quality control shapes network dynamics and gene expression
Orphan quality control shapes network dynamics and gene expression Open
All eukaryotes require intricate protein networks to translate developmental signals into accurate cell fate decisions. Mutations that disturb interactions between network components often result in disease, but how the composition and dyn…
View article: UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability
UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability Open
Nuclear hormone receptors (NRs) are ligand-binding transcription factors that are widely targeted therapeutically. Agonist binding triggers NR activation and subsequent degradation by unknown ligand-dependent ubiquitin ligase machinery. NR…
View article: Clearing of ribosome collisions by the ribosome quality control trigger complex RQT
Clearing of ribosome collisions by the ribosome quality control trigger complex RQT Open
After translational stalls, colliding eukaryotic ribosomes are cleared through dissociation into subunits by the ribosome quality control trigger complex, RQT, by an unknown mechanism. Here we show that RQT requires accessible mRNA and the…
View article: SAP domain forms a flexible part of DNA aperture in Ku70/80
SAP domain forms a flexible part of DNA aperture in Ku70/80 Open
Nonhomologous end joining (NHEJ) is a DNA repair mechanism that religates double‐strand DNA breaks to maintain genomic integrity during the entire cell cycle. The Ku70/80 complex recognizes DNA breaks and serves as an essential hub for rec…
View article: Structural studies of eukaryotic ribosome biogenesis and the sec and Bcs1 protein translocation systems
Structural studies of eukaryotic ribosome biogenesis and the sec and Bcs1 protein translocation systems Open
Three publications of this cumulative dissertation use cryo-electron microscopy (cryo-EM) to dissect the assembly pathway of the eukaryotic large ribosomal subunit (LSU). This pathway commences with freshly transcribed and initially unfold…
View article: The Protease ClpXP and the PAS Domain Protein DivL Regulate CtrA and Gene Transfer Agent Production in Rhodobacter capsulatus
The Protease ClpXP and the PAS Domain Protein DivL Regulate CtrA and Gene Transfer Agent Production in Rhodobacter capsulatus Open
Several members of the Rhodobacterales ( Alphaproteobacteria ) produce a conserved horizontal gene transfer vector, called the gene transfer agent (GTA), that appears to have evolved from a bacteriophage. The model system used to study GTA…