Lukas Junk
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View article: Total Synthesis of Mycoplanecin A
Total Synthesis of Mycoplanecin A Open
The first total synthesis of mycoplanecin A, a potent antitubercular macrocyclic depsipeptide natural product targeting the DnaN sliding clamp, is described. Interesting key steps are the synthesis of the two trans-4-alkylated-l-prolines v…
View article: Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria
Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria Open
Antimicrobial resistance is a global health threat that requires the development of new treatment concepts. These should not only overcome existing resistance but be designed to slow down the emergence of new resistance mechanisms. Targete…
View article: Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria
Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria Open
Antimicrobial resistance is a global health threat that requires development of new treatment concepts. These should not only overcome existing resistance, but be designed to slow down emergence of new resistance mechanisms. Targeted prote…
View article: Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival
Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival Open
The ClpC1:ClpP1P2 protease is a core component of the proteostasis system in mycobacteria. To improve the efficacy of antitubercular agents targeting the Clp protease, we characterized the mechanism of the antibiotics cyclomarin A and ecum…
View article: BacPROTAC-induced degradation of ClpC1 as a new strategy against drug-resistant mycobacteria
BacPROTAC-induced degradation of ClpC1 as a new strategy against drug-resistant mycobacteria Open
Antimicrobial resistance (AMR) is a global public health threat that urgently requires development of new treatment concepts. In general, these treatments should not only be able to overcome existing resistance, but designed to slow down o…
View article: BacPROTACs mediate targeted protein degradation in bacteria
BacPROTACs mediate targeted protein degradation in bacteria Open
Hijacking the cellular protein degradation system offers unique opportunities for drug discovery, as exemplified by proteolysis-targeting chimeras. Despite their great promise for medical chemistry, so far, it has not been possible to repr…
View article: Recent Developments on the Synthesis and Bioactivity of Ilamycins/Rufomycins and Cyclomarins, Marine Cyclopeptides That Demonstrate Anti-Malaria and Anti-Tuberculosis Activity
Recent Developments on the Synthesis and Bioactivity of Ilamycins/Rufomycins and Cyclomarins, Marine Cyclopeptides That Demonstrate Anti-Malaria and Anti-Tuberculosis Activity Open
Ilamycins/rufomycins and cyclomarins are marine cycloheptapeptides containing unusual amino acids. Produced by Streptomyces sp., these compounds show potent activity against a range of mycobacteria, including multidrug-resistant strains of…
View article: The Allylic Alkylation of Ketone Enolates
The Allylic Alkylation of Ketone Enolates Open
The palladium‐catalyzed allylic alkylation of non‐stabilized ketone enolates was thought for a long time to be not as efficient as the analogous reactions of stabilized enolates, e. g. of malonates and β‐ketoesters. The field has experienc…
View article: CCDC 1471766: Experimental Crystal Structure Determination
CCDC 1471766: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1484690: Experimental Crystal Structure Determination
CCDC 1484690: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1471765: Experimental Crystal Structure Determination
CCDC 1471765: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1471767: Experimental Crystal Structure Determination
CCDC 1471767: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …