Lukas Leder
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Identification and characterization of binders to a cryptic and functional pocket in KRAS Open
RAS proteins control cell proliferation and activating mutations are collectively the most frequent oncogenic event observed in cancer patients, justifying investments into multiple drug discovery efforts. While RAS-directed therapeutic ag…
View article: Identification and characterization of binders to a novel cryptic and functional pocket in KRAS
Identification and characterization of binders to a novel cryptic and functional pocket in KRAS Open
RAS proteins control cell proliferation and activating mutations are collectively the most frequent oncogenic event observed in cancer patients, justifying investments into multiple drug discovery efforts. While RAS-directed therapeutic ag…
View article: Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches
Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches Open
Human interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a critical role in the regulation of the immune response and the development of various inflammatory diseases. In this publication, we disclose our efforts toward the d…
mRNA Display Identifies Potent, Paralog-Selective Peptidic Ligands for ARID1B Open
The ARID1A and ARID1B subunits are mutually exclusive components of the BAF variant of SWI/SNF chromatin remodeling complexes. Loss of function mutations in ARID1A are frequently observed in various cancers, resulting in a dependency on th…
View article: Encoded Library Technologies as Integrated Lead Finding Platforms for Drug Discovery
Encoded Library Technologies as Integrated Lead Finding Platforms for Drug Discovery Open
The scope of targets investigated in pharmaceutical research is continuously moving into uncharted territory. Consequently, finding suitable chemical matter with current compound collections is proving increasingly difficult. Encoded libra…