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View article: An explorative analysis of plasma biomarkers associated with cerebral amyloid angiopathy
An explorative analysis of plasma biomarkers associated with cerebral amyloid angiopathy Open
Background Cerebral amyloid angiopathy (CAA) remains diagnostically challenging, particularly in asymptomatic individuals. While CAA often co-exists with Alzheimer’s disease (AD), it may even have a direct impact on AD pathophysiology and …
View article: Linking latent trajectories of ageing-related atrophy, white matter hyperintensities, and cognitive ageing over four years: Insights into brain maintenance
Linking latent trajectories of ageing-related atrophy, white matter hyperintensities, and cognitive ageing over four years: Insights into brain maintenance Open
Introduction We studied brain maintenance, examining the co-evolution of ageing-related atrophy, white matter hyperintensities (WMH), and cognition, alongside domain-specific and domain-general contributions of lifestyle and personality. M…
View article: Disrupted Forward Connectivity in Parieto-temporal Network Impairs Memory Performance in Alzheimer’s Disease
Disrupted Forward Connectivity in Parieto-temporal Network Impairs Memory Performance in Alzheimer’s Disease Open
Alzheimer’s disease (AD) is characterised by the accumulation of beta-amyloid (Aβ) and tau proteins, leading to neurodegeneration and cognitive decline. While Aβ and tau are known to disrupt synaptic function, the mechanisms linking these …
View article: An Unsupervised XAI Framework for Dementia Detection with Context Enrichment
An Unsupervised XAI Framework for Dementia Detection with Context Enrichment Open
Introduction Explainable Artificial Intelligence (XAI) methods enhance the diagnostic efficiency of clinical decision support systems by making the predictions of a convolutional neural network’s (CNN) on brain imaging more transparent and…
View article: A computational ontology framework for the synthesis of multi-level pathology reports from brain MRI scans
A computational ontology framework for the synthesis of multi-level pathology reports from brain MRI scans Open
Background Convolutional neural network (CNN) based volumetry of MRI data can help differentiate Alzheimer's disease (AD) and the behavioral variant of frontotemporal dementia (bvFTD) as causes of cognitive decline and dementia. However, e…
View article: CSF biomarkers are differentially linked to brain areas high and low in noradrenaline, dopamine and serotonin across the Alzheimer’s disease spectrum
CSF biomarkers are differentially linked to brain areas high and low in noradrenaline, dopamine and serotonin across the Alzheimer’s disease spectrum Open
Neurotransmitter systems of noradrenaline, dopamine, serotonin and acetylcholine are implicated in cognitive functions such as memory, learning and attention and are known to be altered in neurodegenerative diseases like Alzheimer’s diseas…
View article: Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects
Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects Open
Background Quantification of Amyloid beta (Aβ) oligomers in plasma enables early diagnosis of Alzheimer’s Disease (AD) and improves our understanding of underlying pathologies. However, quantification necessitates an extremely sensitive an…
View article: A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting
A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting Open
Background Memory clinic patients are a heterogeneous population representing various aetiologies of pathological aging. It is unknown if divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer’…
View article: A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting
A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting Open
Background Memory clinic patients are a heterogeneous population representing various aetiologies of pathological aging. It is unknown if divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer’…
View article: Cognitive reserve against Alzheimer’s pathology is linked to brain activity during memory formation
Cognitive reserve against Alzheimer’s pathology is linked to brain activity during memory formation Open
The cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration. Here, we test this hypothesis in the continuum from cognitively nor…
View article: SMAS: Structural MRI-Based AD Score using Bayesian VAE
SMAS: Structural MRI-Based AD Score using Bayesian VAE Open
This study introduces the Structural MRI-based Alzheimer’s Disease Score (SMAS), a novel index intended to quantify Alzheimer’s Disease (AD)-related morphometric patterns using a deep learning Bayesian-supervised Variational Autoencoder (B…
View article: Perivascular space enlargement accelerates in ageing and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study
Perivascular space enlargement accelerates in ageing and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study Open
Background Perivascular space (PVS) enlargement in ageing and Alzheimer’s disease (AD) and the drivers of such a structural change in humans require longitudinal investigation. Elucidating the effects of demographic factors, hypertension, …
View article: Association of Neurogranin and BACE1 With Clinical Cognitive Decline in Individuals With Subjective Cognitive Decline
Association of Neurogranin and BACE1 With Clinical Cognitive Decline in Individuals With Subjective Cognitive Decline Open
Our findings suggest that CSF neurogranin and BACE1 begin to change in the preclinical stage of AD and they are associated with clinical progression in individuals with SCD.
View article: Assessing blood-brain barrier dysfunction and its association with Alzheimer’s pathology, cognitive impairment and neuroinflammation
Assessing blood-brain barrier dysfunction and its association with Alzheimer’s pathology, cognitive impairment and neuroinflammation Open
Background Blood-brain barrier (BBB) alterations may contribute to AD pathology through various mechanisms, including impaired amyloid-β (Aβ) clearance and neuroinflammation. Soluble platelet-derived growth factor receptor beta (sPDGFRβ) h…
View article: Single-value brain activity scores reflect both severity and risk across the Alzheimer’s continuum
Single-value brain activity scores reflect both severity and risk across the Alzheimer’s continuum Open
Single-value scores reflecting the deviation from (FADE score) or similarity with (SAME score) prototypical novelty-related and memory-related functional MRI activation patterns in young adults have been proposed as imaging biomarkers of h…
View article: Short communication: Lifetime musical activity and resting-state functional connectivity in cognitive networks
Short communication: Lifetime musical activity and resting-state functional connectivity in cognitive networks Open
Background Participation in multimodal leisure activities, such as playing a musical instrument, may be protective against brain aging and dementia in older adults (OA). Potential neuroprotective correlates underlying musical activity rema…
View article: Inferior Frontal Sulcal Hyperintensities on Brain MRI Are Associated with Amyloid Positivity beyond Age—Results from the Multicentre Observational DELCODE Study
Inferior Frontal Sulcal Hyperintensities on Brain MRI Are Associated with Amyloid Positivity beyond Age—Results from the Multicentre Observational DELCODE Study Open
Inferior frontal sulcal hyperintensities (IFSHs) on fluid-attenuated inversion recovery (FLAIR) sequences have been proposed to be indicative of glymphatic dysfunction. Replication studies in large and diverse samples are nonetheless neede…
View article: A generalizable data-driven model of atrophy heterogeneity and progression in memory clinic settings
A generalizable data-driven model of atrophy heterogeneity and progression in memory clinic settings Open
Memory clinic patients are a heterogeneous population representing various aetiologies of pathological ageing. It is not known whether divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer’s d…
View article: Aβ oligomers peak in early stages of Alzheimer's disease preceding tau pathology
Aβ oligomers peak in early stages of Alzheimer's disease preceding tau pathology Open
INTRODUCTION Soluble amyloid beta (Aβ) oligomers have been suggested as initiating Aβ related neuropathologic change in Alzheimer's disease (AD) but their quantitative distribution and chronological sequence within the AD continuum remain …
View article: Reduced expression of fMRI subsequent memory effects with increasing severity across the Alzheimer’s disease risk spectrum
Reduced expression of fMRI subsequent memory effects with increasing severity across the Alzheimer’s disease risk spectrum Open
In functional magnetic resonance imaging (fMRI) studies, episodic memory is commonly investigated with the subsequent memory paradigm in which brain activity is recorded during encoding and analyzed as a function of subsequent remembering …
View article: A multicenter validation study on the diagnostic and prognostic value of CSF Neurogranin and BACE1
A multicenter validation study on the diagnostic and prognostic value of CSF Neurogranin and BACE1 Open
Background Cerebrospinal fluid (CSF) biomarkers have immense diagnostic and prognostic potential for Alzheimer disease (AD). Currently, AD is still mostly diagnosed relatively late in the disease process, sometimes even years after the ini…
View article: Fronto-striatal alterations correlate with apathy severity in behavioral variant frontotemporal dementia
Fronto-striatal alterations correlate with apathy severity in behavioral variant frontotemporal dementia Open
Structural and functional changes in cortical and subcortical regions have been reported in behavioral variant frontotemporal dementia (bvFTD), however, a multimodal approach may provide deeper insights into the neural correlates of neurop…
View article: Cognitive Reserve Against Alzheimer’s Pathology Is Linked to Brain Activity During Memory Formation
Cognitive Reserve Against Alzheimer’s Pathology Is Linked to Brain Activity During Memory Formation Open
The cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration. Here, we tested this hypothesis in the Alzheimer’s disease continuu…
View article: Single-value fMRI scores reflect both stage and risk across the Alzheimer’s disease continuum
Single-value fMRI scores reflect both stage and risk across the Alzheimer’s disease continuum Open
Single-value scores reflecting the deviation from (FADE score) or similarity with (SAME score) prototypical novelty-related and memory-related functional magnetic resonance imaging (fMRI) activation patterns in young adults have been propo…
View article: Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline
Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline Open
Our results suggest that MNPD are a risk factor for AD-related clinical progression in cognitively normal patients seeking medical counseling because of SCD. As such, the assessment of MNPD could be useful for individual clinical predictio…
View article: Perivascular space enlargement accelerates with hypertension, white matter hyperintensities, chronic inflammation, and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study
Perivascular space enlargement accelerates with hypertension, white matter hyperintensities, chronic inflammation, and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study Open
Background Perivascular space (PVS) enlargement in ageing and Alzheimer’s disease (AD) and its exacerbators require further investigation. Methods We studied centrum semiovale (CSO) and basal ganglia (BG) PVS computationally over three to …
View article: Reduced expression of fMRI subsequent memory effects with increasing severity across the Alzheimer’s disease risk spectrum
Reduced expression of fMRI subsequent memory effects with increasing severity across the Alzheimer’s disease risk spectrum Open
In functional magnetic resonance imaging (fMRI) studies, episodic memory is commonly investigated with the subsequent memory paradigm in which brain activity is recorded during encoding and analyzed as a function of subsequent remembering …
View article: Cognitive Trajectories in Preclinical and Prodromal Alzheimer’s Disease Related to Amyloid Status and Brain Atrophy: A Bayesian Approach
Cognitive Trajectories in Preclinical and Prodromal Alzheimer’s Disease Related to Amyloid Status and Brain Atrophy: A Bayesian Approach Open
Background: Cognitive decline is a key outcome of clinical studies in Alzheimer’s disease (AD). Objective: To determine effects of global amyloid load as well as hippocampus and basal forebrain volumes on longitudinal rates and practice ef…
View article: Gaussian Process-based prediction of memory performance and biomarker status in ageing and Alzheimer’s disease—A systematic model evaluation
Gaussian Process-based prediction of memory performance and biomarker status in ageing and Alzheimer’s disease—A systematic model evaluation Open
View article: Arterial hypertension and β-amyloid accumulation have spatially overlapping effects on posterior white matter hyperintensity volume: a cross-sectional study
Arterial hypertension and β-amyloid accumulation have spatially overlapping effects on posterior white matter hyperintensity volume: a cross-sectional study Open