Lukas Scheef
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View article: Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study
Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study Open
Physical activity (PA) plays an important role in affect processing. Studies describe the orbitofrontal cortex (OFC) as a major hub for emotion processing and the pathophysiology of affective disorders. Subregions of the OFC show diverse f…
View article: Regional cortical perfusion increases induced by a 6-month endurance training in young sedentary adults
Regional cortical perfusion increases induced by a 6-month endurance training in young sedentary adults Open
Physical inactivity is documented as a health risk factor for chronic diseases, accelerated aging, and cognitive impairment. Physical exercise, on the other hand, plays an important role in healthy aging by promoting positive muscular, car…
View article: Coherent Structural and Functional Network Changes after Thalamic Lesions in Essential Tremor
Coherent Structural and Functional Network Changes after Thalamic Lesions in Essential Tremor Open
Background Magnetic resonance–guided focused ultrasound of the ventral intermediate nucleus is a novel incisionless ablative treatment for essential tremor (ET). Objective The aim was to study the structural and functional network changes …
View article: Effects of a 6-Month Aerobic Exercise Intervention on Mood and Amygdala Functional Plasticity in Young Untrained Subjects
Effects of a 6-Month Aerobic Exercise Intervention on Mood and Amygdala Functional Plasticity in Young Untrained Subjects Open
Acute exercise has beneficial effects on mood and is known to induce modulations in functional connectivity (FC) within the emotional network. However, the long-term effects of exercise on affective brain circuits remain largely unknown. H…
View article: Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study
Cortical representation of experimental periodontal pain: a functional magnetic resonance imaging study Open
The aim of this study was to investigate central pain representations during loading of the periodontium induced by orthodontic and occlusal stress. Nineteen healthy male volunteers (25.7 ± 2.8 years) were tested on two consecutive days: a…
View article: Hippocampal subfield volumes are nonspecifically reduced in premature‐born adults
Hippocampal subfield volumes are nonspecifically reduced in premature‐born adults Open
Reduced global hippocampus volumes have been demonstrated in premature‐born individuals, from newborns to adults; however, it is unknown whether hippocampus subfield (HCSF) volumes are differentially affected by premature birth and how rel…
View article: Decreased cortical thickness mediates the relationship between premature birth and cognitive performance in adulthood
Decreased cortical thickness mediates the relationship between premature birth and cognitive performance in adulthood Open
Cortical thickness (CTh) reflects cortical properties such as dendritic complexity and synaptic density, which are not only vulnerable to developmental disturbances caused by premature birth but also highly relevant for cognitive performan…
View article: Sequelae of Premature Birth in Young Adults
Sequelae of Premature Birth in Young Adults Open
Background and Purpose Qualitative studies about the abnormalities appreciated on routine magnetic resonance imaging (MRI) sequences in prematurely born adults are lacking. This article aimed at filling this knowledge gap by (1) qualitativ…
View article: Basal forebrain atrophy along the Alzheimer’s disease spectrum and its relevance for subjective cognitive decline
Basal forebrain atrophy along the Alzheimer’s disease spectrum and its relevance for subjective cognitive decline Open
Background There is growing evidence in the literature that the cholinergic basal forebrain might be one of the earliest affected structures in Alzheimer’s disease (AD). Recent data suggest that individuals with preclinical Alzheimer’s pat…
View article: Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status
Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status Open
Background: While cerebral beta-amyloid accumulation was found in many studies to alter precuneus-based functional connectivity (FC) in mild cognitive impairment and demented Alzheimer’s disease (AD) patients, its impact is less well under…
View article: Prominent White Matter Involvement in Multiple System Atrophy of Cerebellar Type
Prominent White Matter Involvement in Multiple System Atrophy of Cerebellar Type Open
Background Sporadic degenerative ataxia patients fall into 2 major groups: multiple system atrophy with predominant cerebellar ataxia (MSA‐C) and sporadic adult‐onset ataxia (SAOA). Both groups have cerebellar volume loss, but little is kn…
View article: IC‐P‐028: PATTERNS OF INCREASED AND DECREASED PRECUNEUS FUNCTIONAL CONNECTIVITY IN SCD DEPENDING ON AMYLOID STATUS
IC‐P‐028: PATTERNS OF INCREASED AND DECREASED PRECUNEUS FUNCTIONAL CONNECTIVITY IN SCD DEPENDING ON AMYLOID STATUS Open
The precuneus/posterior cingulate (PCC) is a hub region of the default-mode network (DMN) and a prominent target of amyloid-beta (Aß) deposition in MCI and AD causing subsequent disruptions of DMN functional connectivity (FC). In subjectiv…
View article: IC‐P‐016: CORTICAL AMYLOID BURDEN CORRELATES WITH ATROPHY OF THE POSTERIOR PART OF THE NUCLEUS BASALIS MEYNERT IN AMYLOID‐POSITIVE SCD
IC‐P‐016: CORTICAL AMYLOID BURDEN CORRELATES WITH ATROPHY OF THE POSTERIOR PART OF THE NUCLEUS BASALIS MEYNERT IN AMYLOID‐POSITIVE SCD Open
One of the earliest brain regions affected during the development of Alzheimer's disease (AD) is the cholinergic basal forebrain (BF). Especially the posterior part of the Nucleus basalis Meynert (Ch4p) seems to be affected already during …
View article: Effects of low- and high-intensity exercise on emotional face processing: an fMRI face-matching study
Effects of low- and high-intensity exercise on emotional face processing: an fMRI face-matching study Open
Physical exercise has positive effects on mood and it reduces clinical depression and states of anxiety. While previous work mostly used subjective measures to study the effect of exercise upon emotions, this study for the first time emplo…
View article: Aberrant gyrification contributes to the link between gestational age and adult IQ after premature birth
Aberrant gyrification contributes to the link between gestational age and adult IQ after premature birth Open
Gyrification is a hallmark of human brain development, starting in the second half of gestation in primary cortices, followed by unimodal and then transmodal associative cortices. Alterations in gyrification have been noted in premature-bo…
View article: Achilles tendon mechanosensitivity is preserved in old age: In vivo evidence from a 1.5 years long resistance training intervention
Achilles tendon mechanosensitivity is preserved in old age: In vivo evidence from a 1.5 years long resistance training intervention Open
Introduction Ageing deteriorates musculoskeletal system structure and function and limits its adaptability to mechanical loading. Medium-term (12-14 weeks) exercise interventions in older adults have been shown to increase tendon stiffness…
View article: Achilles tendon is mechanosensitive in old adults: a 1.5 year resistance training intervention
Achilles tendon is mechanosensitive in old adults: a 1.5 year resistance training intervention Open
INTRODUCTION The aging tendon experiences general degeneration in its structure and function, which is usually described through a diminished ability to adapt to environmental stress as a consequence of deteriorated tissue homeostasis. Ten…
View article: The Achilles tendon is mechanosensitive in older adults: adaptations following 14 weeks versus 1.5 years of cyclic strain exercise
The Achilles tendon is mechanosensitive in older adults: adaptations following 14 weeks versus 1.5 years of cyclic strain exercise Open
The aging musculoskeletal system experiences a general decline in structure and function, characterized by a reduced adaptability to environmental stress. We investigated whether the older human Achilles tendon (AT) demonstrates mechanosen…
View article: Functional Laterality of Task-Evoked Activation in Sensorimotor Cortex of Preterm Infants: An Optimized 3 T fMRI Study Employing a Customized Neonatal Head Coil
Functional Laterality of Task-Evoked Activation in Sensorimotor Cortex of Preterm Infants: An Optimized 3 T fMRI Study Employing a Customized Neonatal Head Coil Open
Our findings strengthen the importance of using optimized coil settings for neonatal fMRI, yielding robust and reproducible SMC activation at the single subject level. We conclude that functional lateralization of SMC activation, as found …
View article: Central Pain Processing in Early-Stage Parkinson's Disease: A Laser Pain fMRI Study
Central Pain Processing in Early-Stage Parkinson's Disease: A Laser Pain fMRI Study Open
Our data during pain processing extend previous findings suggesting default mode network dysfunction in Parkinson's disease. On the other hand, they argue against a genuine pain-specific processing abnormality in early-stage Parkinson's di…