Lukas Semmler
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View article: Effects of mavacamten on the cellular response to beta adrenergic and frequency dependent stress in an HFpEF mouse model
Effects of mavacamten on the cellular response to beta adrenergic and frequency dependent stress in an HFpEF mouse model Open
Background Heart failure with preserved ejection fraction is characterized by reduced exercise tolerance and has been associated with increased myofilament sensitivity in the heart. Our recent findings have shown that adrenergic functional…
View article: Impairment of the adrenergic reserve associated with exercise intolerance in a murine model of heart failure with preserved ejection fraction
Impairment of the adrenergic reserve associated with exercise intolerance in a murine model of heart failure with preserved ejection fraction Open
Aim Exercise intolerance is the central symptom in patients with heart failure with preserved ejection fraction. In the present study, we investigated the adrenergic reserve both in vivo and in cardiomyocytes of a murine cardiometabolic HF…
View article: Lung-to-Heart Nano-in-Micro Peptide Promotes Cardiac Recovery in a Pig Model of Chronic Heart Failure
Lung-to-Heart Nano-in-Micro Peptide Promotes Cardiac Recovery in a Pig Model of Chronic Heart Failure Open
The overall tolerability of LungToHeartNIM along with the beneficial effects of the LTCC modulator point toward a game-changing treatment for HFrEF patients, also demonstrating the effective delivery of a therapeutic peptide to the disease…
View article: Nitro-oxidative stress impairs single cardiomyocyte adrenergic reserve in a murine model of HFpEF
Nitro-oxidative stress impairs single cardiomyocyte adrenergic reserve in a murine model of HFpEF Open
Background Exercise intolerance is the central symptom of patients with heart failure and preserved ejection fraction (HFpEF). Underlying reduced cardiac functional reserve in response to adrenergic stimuli (stress testing) has been sugges…
View article: COVID19-associated cardiomyocyte dysfunction, arrhythmias and the effect of Canakinumab
COVID19-associated cardiomyocyte dysfunction, arrhythmias and the effect of Canakinumab Open
Background Cardiac injury associated with cytokine release frequently occurs in SARS-CoV-2 mediated coronavirus disease (COVID19) and mortality is particularly high in these patients. The mechanistic role of the COVID19 associated cytokine…
View article: Implications of SGLT Inhibition on Redox Signalling in Atrial Fibrillation
Implications of SGLT Inhibition on Redox Signalling in Atrial Fibrillation Open
Atrial fibrillation (AF) is the most common sustained (atrial) arrhythmia, a considerable global health burden and often associated with heart failure. Perturbations of redox signalling in cardiomyocytes provide a cellular substrate for th…
View article: Dual SGLT-1 and SGLT-2 inhibition improves left atrial dysfunction in HFpEF
Dual SGLT-1 and SGLT-2 inhibition improves left atrial dysfunction in HFpEF Open
View article: BRCA1 and Breast Cancer: a Review of the Underlying Mechanisms Resulting in the Tissue-Specific Tumorigenesis in Mutation Carriers
BRCA1 and Breast Cancer: a Review of the Underlying Mechanisms Resulting in the Tissue-Specific Tumorigenesis in Mutation Carriers Open
Since the first cloning of BRCA1 in 1994, many of its cellular interactions have been elucidated. However, its highly specific role in tumorigenesis in the breast tissue-carriers of BRCA1 mutations are predisposed to life-tim…
View article: The effects of 2-hydroxyglutarate on the tumorigenesis of gliomas
The effects of 2-hydroxyglutarate on the tumorigenesis of gliomas Open
Mutation of the isocitrate-dehydrogenase (IDH) enzymes is one of the central research topics regarding gliomagenesis. Indeed, 70% of gliomas are associated with a gain-of-function IDH mutation and consequently synthesize the oncometabolite…