Lukas Uebbing
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View article: Direct structural investigation of pH responsiveness in mRNA lipid nanoparticles: Refining paradigms
Direct structural investigation of pH responsiveness in mRNA lipid nanoparticles: Refining paradigms Open
Using small angle X-ray scattering measurements, structural coherencies in lipid nanoparticle (LNP) formulations comprising messenger RNA (mRNA) were elucidated in response to pH changes and as a function of RNA to lipid ratio. Formulation…
View article: Polysarcosine-Functionalized mRNA Lipid Nanoparticles Tailored for Immunotherapy
Polysarcosine-Functionalized mRNA Lipid Nanoparticles Tailored for Immunotherapy Open
Lipid nanoparticles (LNPs) have gained great attention as carriers for mRNA-based therapeutics, finding applications in various indications, extending beyond their recent use in vaccines for infectious diseases. However, many aspects of LN…
View article: Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA
Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA Open
Hybrid nanoparticles from lipidic and polymeric components were assembled to serve as vehicles for the transfection of messenger RNA (mRNA) using different portions of the cationic lipid DOTAP (1,2-Dioleoyl-3-trimethylammonium-propane) and…
View article: Justification of disintegration testing beyond current FDA criteria using in vitro and in silico models
Justification of disintegration testing beyond current FDA criteria using in vitro and in silico models Open
Drug product performance testing is an important part of quality-by-design approaches, but this process often lacks the underlying mechanistic understanding of the complex interactions between the disintegration and dissolution processes i…