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View article: Lumen charge governs gated ion transport in β-barrel nanopores
Lumen charge governs gated ion transport in β-barrel nanopores Open
β-Barrel nanopores are involved in crucial biological processes, from ATP export in mitochondria to bacterial resistance, and represent a promising platform for emerging sequencing technologies. However, in contrast to ion channels, the un…
View article: Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology
Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology Open
Multiple-system atrophy (MSA) is a rapidly progressive neurodegenerative disease of unknown cause, typically affecting individuals aged 50-60 years and leading to death within a decade1-3. It is characterized by glial cytoplasmic inclusion…
View article: Lumen charge governs gated ion transport in β-barrel nanopores
Lumen charge governs gated ion transport in β-barrel nanopores Open
β-barrel nanopores are involved in crucial biological processes, from ATP export in mitochondria to bacterial resistance, and represent a promising platform for emerging sequencing technologies. However, in contrast to ion channels, the un…
View article: Ultrastructural diversity of alpha-Synuclein pathology in the post-mortem brain of Parkinson patients: implications for Lewy Body formation
Ultrastructural diversity of alpha-Synuclein pathology in the post-mortem brain of Parkinson patients: implications for Lewy Body formation Open
Lewy bodies, the major pathological hallmark of Parkinson’s disease, are intraneuronal inclusions rich in aggregated alpha-synuclein (aSyn). To understand the cellular mechanisms behind the formation of Lewy bodies and the aggregation of a…
View article: Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology
Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology Open
Summary Paragraph Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disease of unknown cause, typically affecting individuals aged 50–60 and leading to death within a decade 1–3 . It is characterized by glial cytopla…
View article: Correlative light and electron microscopy for human brain and other biological models
Correlative light and electron microscopy for human brain and other biological models Open
Correlative light and electron microscopy (CLEM) combines light microscopy, for identifying a target via genetic labels, dyes, antibodies, and morphological features, with electron microscopy, for analyzing high-resolution subcellular ultr…
View article: A workcell 1.0 for programmable and controlled operation of multiple fluidic chips in parallel
A workcell 1.0 for programmable and controlled operation of multiple fluidic chips in parallel Open
We developed a versatile lab-on-chip (LOC) workcell that enables the design and automatic execution of experiments on LOC devices, improving how we establish, optimize, and productionalize LOC processes. Key features include direct docking…
View article: allie-burns/2021_Silva_NatureNeuroscience: Code Repository Release for Silva et al., 2021, Nature Neuroscience
allie-burns/2021_Silva_NatureNeuroscience: Code Repository Release for Silva et al., 2021, Nature Neuroscience Open
Publication of the code used for the analysis found in Silva et al., 2021, Nature Neuroscience.