Lukas Wirth
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View article: GPR3 ligands discovered through combined virtual and conformational biosensor-based screening
GPR3 ligands discovered through combined virtual and conformational biosensor-based screening Open
GPR3 belongs to the protein superfamily of G protein-coupled receptors (GPCRs) and plays a central role in both benign and malignant physiological processes, such as energy expenditure in adipocytes and Alzheimer’s disease pathology, respe…
View article: Novel water-soluble and highly efficient dual type I/II next generation inhibitors of FMS-like tyrosine kinase 3 (FLT3)
Novel water-soluble and highly efficient dual type I/II next generation inhibitors of FMS-like tyrosine kinase 3 (FLT3) Open
Mutations of the FMS-like tyrosine kinase (FLT3) occur in acute myeloid leukemia (AML) and are associated with very poor prognosis. Available FLT3 inhibitors are potent but either show a lack of selectivity regarding other tyrosine kinases…
View article: ApOL-Application Oriented Workload Model for Digital Human Models for the Development of Human-Machine Systems
ApOL-Application Oriented Workload Model for Digital Human Models for the Development of Human-Machine Systems Open
Since musculoskeletal disorders are one of the most common work-related diseases for assemblers and machine operators, it is crucial to find new ways to alleviate the physical load on workers. Support systems such as exoskeletons or handhe…
View article: Meteorology-Aware Multi-Goal Path Planning for Large-Scale Inspection Missions with Long-Endurance Solar-Powered Aircraft
Meteorology-Aware Multi-Goal Path Planning for Large-Scale Inspection Missions with Long-Endurance Solar-Powered Aircraft Open
Solar-powered aircraft promise significantly increased flight endurance over conventional aircraft. While this makes them promising candidates for large-scale aerial inspection missions, their structural fragility necessitates that adverse…