Lukas Zanders
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View article: Decoding heart failure subtypes with neural networks via differential explanation analysis
Decoding heart failure subtypes with neural networks via differential explanation analysis Open
Single-cell transcriptomics offers critical insights into the molecular mechanisms of heart failure (HF) with reduced or preserved ejection fraction. However, understanding these mechanisms is hindered by the growing complexity of single-c…
View article: Vascular Niches Are the Primary Hotspots in Cardiac Aging
Vascular Niches Are the Primary Hotspots in Cardiac Aging Open
BACKGROUND: Aging is a major, yet unmodifiable, cardiovascular risk factor and is associated with vascular alterations, increased cardiac fibrosis, and inflammation, all of which contribute to impaired cardiac function. However, the microe…
View article: Immunoregulatory Endothelial Cells Interact With T Cells After Myocardial Infarction
Immunoregulatory Endothelial Cells Interact With T Cells After Myocardial Infarction Open
BACKGROUND: Endothelial cells (ECs) play pivotal roles in maintaining cardiac blood supply and regulating inflammation by acting as gatekeepers for immune cell activity. This study unveils a novel immunomodulatory function of cardiac ECs f…
View article: Decoding heart failure subtypes with neural networks via differential explanation analysis
Decoding heart failure subtypes with neural networks via differential explanation analysis Open
Single-cell transcriptomics offers critical insights into the molecular mechanisms of heart failure with reduced or preserved ejection fraction. However, understanding these mechanisms is hindered by the growing complexity of single-cell d…
View article: Extracellular Matrix Proteins Improve Risk Prediction in Patients Undergoing Transcatheter Aortic Valve Replacement
Extracellular Matrix Proteins Improve Risk Prediction in Patients Undergoing Transcatheter Aortic Valve Replacement Open
Background Cardiac fibrosis is common in patients with severe aortic stenosis and an independent predictor of death. Therefore, we examined the additional value of circulating fibrosis markers as a putative biomarker platform to identify p…
View article: Mosaic loss of Y chromosome and mortality after coronary angiography
Mosaic loss of Y chromosome and mortality after coronary angiography Open
Background and Aims Acquired somatic mutations emerged as important drivers of adverse cardiovascular disease outcomes. Recently, mosaic loss of Y chromosome (LOY) in haematopoietic cells was identified to induce diffuse cardiac fibrosis i…
View article: Loss of Y-chromosomal genes in macrophages induces paracrine phenotypic alterations in cardiac cells
Loss of Y-chromosomal genes in macrophages induces paracrine phenotypic alterations in cardiac cells Open
Background At the intersection of gender medicine and ageing, mosaic loss of the Y chromosome (mLoY) in hematopoietic cells has emerged as a novel cardiovascular risk factor. As the most prevalent chromosomal aberration in men, mLoY is age…
View article: Loss of IDH1 and IDH2 in macrophages induces pathological phenotypes in cardiomyocytes
Loss of IDH1 and IDH2 in macrophages induces pathological phenotypes in cardiomyocytes Open
Introduction The clonal expansion of hematopoietic stem cells can be induced by a variety of age-related somatic mutations, a phenomenon known as "clonal hematopoiesis of indeterminate potential" (CHIP). CHIP is associated with an increase…
View article: Prognostic impact of fractional flow reserve measurements in patients with acute coronary syndromes: a subanalysis of the FLORIDA study
Prognostic impact of fractional flow reserve measurements in patients with acute coronary syndromes: a subanalysis of the FLORIDA study Open
Randomized trials suggest benefits for fractional flow reserve (FFR)-guided vs. angiography-guided treatment strategies in well-defined and selected patient cohorts with acute coronary syndromes (ACS). The long-term prognostic value of FFR…
View article: The Transcription Factor EB (TFEB) Sensitizes the Heart to Chronic Pressure Overload
The Transcription Factor EB (TFEB) Sensitizes the Heart to Chronic Pressure Overload Open
The transcription factor EB (TFEB) promotes protein degradation by the autophagy and lysosomal pathway (ALP) and overexpression of TFEB was suggested for the treatment of ALP-related diseases that often affect the heart. However, TFEB-medi…
View article: Teleproctoring for Training in Structural Heart Interventions: Initial Real‐World Experience During the COVID‐19 Pandemic
Teleproctoring for Training in Structural Heart Interventions: Initial Real‐World Experience During the COVID‐19 Pandemic Open
Background Proctoring represents a cornerstone in the acquisition of state‐of‐the‐art cardiovascular interventions. Yet, travel restrictions and containment measures during the COVID‐19 pandemic limited on‐site proctoring for training and …
View article: Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting
Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting Open
Background Sepsis and inflammation can cause intensive care unit‐acquired weakness (ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 signalling involves the glycoprotein 130 (gp130) receptor and the JA…