Luke A. Downey
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View article: Effects of Cannabidiol on Social Relating, Anxiety, and Parental Stress in Autistic Children: A Randomized Controlled Crossover Trial
Effects of Cannabidiol on Social Relating, Anxiety, and Parental Stress in Autistic Children: A Randomized Controlled Crossover Trial Open
Cannabidiol (CBD), a non‐intoxicating compound derived from the cannabis plant, has garnered increasing attention as a potential pharmacological therapeutic for autism. We conducted a randomized, double‐blind, placebo‐controlled, crossover…
View article: A Systematic Review of the Impact of the Alcohol Hangover Upon Negative Affect
A Systematic Review of the Impact of the Alcohol Hangover Upon Negative Affect Open
Issue Alcohol hangovers can occur after a single episode of drinking and begin as blood alcohol concentration returns to zero. While hangovers are widely known for their physical symptoms, they also include psychological symptoms such as a…
View article: Cannabidiol Modulates Right Fronto-Parietal Connectivity in Autistic Children: A Secondary EEG Analysis from a Randomised Placebo-Controlled Crossover Trial
Cannabidiol Modulates Right Fronto-Parietal Connectivity in Autistic Children: A Secondary EEG Analysis from a Randomised Placebo-Controlled Crossover Trial Open
Autistic children often show altered brain network connectivity, including circuitry implicated in social cognition. Cannabidiol (CBD) has emerged as a potential therapy for autism, but its neural mechanisms remain under-researched. Here, …
View article: Same-Day Sedative and Night-Time Sleep Effects Following Combined Cannabinoid Formulations: A Randomised-Controlled Trial
Same-Day Sedative and Night-Time Sleep Effects Following Combined Cannabinoid Formulations: A Randomised-Controlled Trial Open
ACTRN12622001539729, 13 December 2022, prospectively registered.
View article: Analgesic and Hemodynamic Effects of Dexmedetomidine–Ketamine vs Fentanyl–Ketamine in Healthy Volunteers: A Randomized Trial
Analgesic and Hemodynamic Effects of Dexmedetomidine–Ketamine vs Fentanyl–Ketamine in Healthy Volunteers: A Randomized Trial Open
https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=372916.
View article: Acute Administration of 10 mg Methylphenidate on Cognitive Performance and Visual Scanning in Healthy Adults: Randomised, Double‐Blind, Placebo‐Controlled Study
Acute Administration of 10 mg Methylphenidate on Cognitive Performance and Visual Scanning in Healthy Adults: Randomised, Double‐Blind, Placebo‐Controlled Study Open
Objective To examine the effect of a low dose (10 mg) of methylphenidate on cognitive performance, visuospatial working memory (VSWM) and gaze behaviour capabilities in healthy adults. Methods This randomised, double‐blind, placebo‐control…
View article: Driving performance and ocular activity following acute administration of 10 mg methylphenidate: A randomised, double-blind, placebo-controlled study
Driving performance and ocular activity following acute administration of 10 mg methylphenidate: A randomised, double-blind, placebo-controlled study Open
Background: Methylphenidate is a routinely prescribed treatment for attention-deficit/hyperactivity disorder with misuse potential owing to its perceived performance-enhancing and euphoric properties. Although clinically effective, there i…
View article: The effect of nightly use of 150 mg cannabidiol on daytime neurocognitive performance in primary insomnia: a randomized controlled pilot trial
The effect of nightly use of 150 mg cannabidiol on daytime neurocognitive performance in primary insomnia: a randomized controlled pilot trial Open
Rationale Cannabidiol (CBD) is increasingly used as a sleep aid for insomnia; yet neurocognitive and subjective state effects following daily therapeutic use are unclear. Objectives To measure the effect of daily CBD use on neurocognitive …
View article: Acute methamphetamine and alcohol usage alters gaze behaviour during driving: A randomised, double-blind, placebo-controlled study
Acute methamphetamine and alcohol usage alters gaze behaviour during driving: A randomised, double-blind, placebo-controlled study Open
Background: Methamphetamine is frequently co-consumed with alcohol, yet combined effects on visually guided behaviours have not been experimentally assessed. This study examined whether methamphetamine and alcohol-induced changes in gaze b…
View article: Effects of Cannabidiol on Social Relating, Anxiety, and Parental Stress in Autistic Children: A Randomized Controlled Crossover Trial
Effects of Cannabidiol on Social Relating, Anxiety, and Parental Stress in Autistic Children: A Randomized Controlled Crossover Trial Open
Cannabidiol (CBD), a non-intoxicating compound derived from the cannabis plant, has garnered increasing attention as a potential pharmacological therapeutic for autism. We conducted a randomized, double-blind, placebo-controlled, crossover…
View article: Trait anger as a predictor of dangerous driving behaviour amongst people who use methamphetamine
Trait anger as a predictor of dangerous driving behaviour amongst people who use methamphetamine Open
Trait anger is a strong predictor of risky driving among road users who use methamphetamine. Interactions between stable negative-emotional and situational traffic and driving-related factors may increase risk of harm through greater engag…
View article: Producing Altered States of Consciousness, Reducing Substance Misuse: A Review of Psychedelic-Assisted Psychotherapy, Transcendental Meditation and Hypnotherapy
Producing Altered States of Consciousness, Reducing Substance Misuse: A Review of Psychedelic-Assisted Psychotherapy, Transcendental Meditation and Hypnotherapy Open
A set of interventions that can produce altered states of consciousness (ASC) have shown utility in the treatment of substance misuse. In this review, we examine addiction-related outcomes associated with three common interventions that pr…
View article: A randomised, placebo-controlled, double blind, crossover trial on the effect of a 20:1 cannabidiol: Δ9-tetrahydrocannabinol medical cannabis product on neurocognition, attention, and mood
A randomised, placebo-controlled, double blind, crossover trial on the effect of a 20:1 cannabidiol: Δ9-tetrahydrocannabinol medical cannabis product on neurocognition, attention, and mood Open
As cannabinoid-based medications gain popularity in the treatment of refractory medical conditions, it is crucial to examine the neurocognitive effects of commonly prescribed products to ensure associated safety profiles. The present study…
View article: A semi-naturalistic open-label study examining the effect of prescribed medical cannabis use on simulated driving performance
A semi-naturalistic open-label study examining the effect of prescribed medical cannabis use on simulated driving performance Open
Background: Despite increasing medical cannabis use, research has yet to establish whether and to what extent products containing delta-9-tetrahydrocannabinol (THC) impact driving performance among patients. Stable doses of prescribed cann…
View article: The psychological determinants of rugby union player performance
The psychological determinants of rugby union player performance Open
The performance of professional sportspeople attracts great interest from the viewing public, team management, coaches, and athletes alike. Contributors to elite performance have been explored across a wide variety of sports, but have gene…
View article: A systematic review of oculomotor deficits associated with acute and chronic cannabis use
A systematic review of oculomotor deficits associated with acute and chronic cannabis use Open
Driving is a critical everyday task necessitating the rapid and seamless integration of dynamic visually derived information to guide neurobehaviour. Biological markers are frequently employed to detect Δ9‐tetrahydrocannabinol (THC) consum…
View article: A Semi-Naturalistic, Open-Label Trial Examining the Effect of Prescribed Medical Cannabis on Neurocognitive Performance
A Semi-Naturalistic, Open-Label Trial Examining the Effect of Prescribed Medical Cannabis on Neurocognitive Performance Open
These findings suggest that prescribed medical cannabis may have minimal acute impact on cognitive function among patients with chronic health conditions, although larger and controlled trials are needed.
View article: P102 Sleep Quality, Depression, and Anxiety in People with Spinal Cord Injury and Traumatic Brain Injury Undergoing Inpatient Rehabilitation.
P102 Sleep Quality, Depression, and Anxiety in People with Spinal Cord Injury and Traumatic Brain Injury Undergoing Inpatient Rehabilitation. Open
Introduction Poor sleep, depression, and anxiety are prevalent secondary complications of spinal cord injury (SCI) and traumatic brain injury (TBI), and may interfere with recovery. This observational, exploratory study aimed to describe s…
View article: P030 Understanding the relationships between sleep quality, and depression and anxiety in neurotrauma: A scoping review.
P030 Understanding the relationships between sleep quality, and depression and anxiety in neurotrauma: A scoping review. Open
Introduction Sleep problems, depression, and anxiety are highly prevalent following a spinal cord injury (SCI) and traumatic brain injury (TBI) and may worsen functional outcomes and quality of life. This scoping review examined the existi…
View article: Acute administration of alprazolam, alcohol and their combination on cognitive performance and mood: A randomised, double-blind, placebo-controlled study
Acute administration of alprazolam, alcohol and their combination on cognitive performance and mood: A randomised, double-blind, placebo-controlled study Open
Background: Recreational co-consumption of benzodiazepines and alcohol is a common practise; yet, the cognitive effects of this combination remain poorly understood. This study aimed to investigate the acute cognitive effects of combining …
View article: Improved depressive symptoms, and emotional regulation and reactivity, in individuals with obstructive sleep apnea after short- and long-term CPAP therapy use
Improved depressive symptoms, and emotional regulation and reactivity, in individuals with obstructive sleep apnea after short- and long-term CPAP therapy use Open
Obstructive Sleep Apnoea (OSA) is associated with high rates of depression; however, if and how treatment of OSA improves depressive symptoms is unclear. To further understand this link we considered the role of emotional regulation - the …
View article: Driving impairment and altered ocular activity under the effects of alprazolam and alcohol: A randomized, double-blind, placebo-controlled study
Driving impairment and altered ocular activity under the effects of alprazolam and alcohol: A randomized, double-blind, placebo-controlled study Open
Alprazolam and alcohol, alone and in combination, impaired select aspects of vehicle control over time. GTE, microsleeps, and fixation rate show potential as real-time indicators of driving impairment and crash risk associated with alcohol…
View article: Acute neurocognitive and subjective effects of oral methamphetamine with low doses of alcohol: A randomised controlled trial
Acute neurocognitive and subjective effects of oral methamphetamine with low doses of alcohol: A randomised controlled trial Open
Background: Methamphetamine is often recreationally co-consumed with alcohol due to desirable off-target effects; however, the acute neurocognitive and subjective consequences of combined use are unclear. Methods: In a randomised, placebo-…
View article: Assessment of Medical Cannabis and Health-Related Quality of Life
Assessment of Medical Cannabis and Health-Related Quality of Life Open
Importance The use of cannabis as a medicine is becoming increasingly prevalent. Given the diverse range of conditions being treated with medical cannabis, as well as the vast array of products and dose forms available, clinical evidence i…
View article: Effect of CannEpil<sup>®</sup> on simulated driving performance and co-monitoring of ocular activity: A randomised controlled trial
Effect of CannEpil<sup>®</sup> on simulated driving performance and co-monitoring of ocular activity: A randomised controlled trial Open
Background: Medicinal cannabis products containing Δ9-tetrahydrocannabinol (THC) are increasingly accessible. Yet, policy guidelines regarding fitness to drive are lacking, and cannabinoid-specific indexations of impairment are underdevelo…
View article: Default Mode Network Modulation by Psychedelics: A Systematic Review
Default Mode Network Modulation by Psychedelics: A Systematic Review Open
Psychedelics are a unique class of drug that commonly produce vivid hallucinations as well as profound psychological and mystical experiences. A grouping of interconnected brain regions characterized by increased temporal coherence at rest…