Luke Baxter
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View article: Apnoea duration and changes in cardiorespiratory and cerebrovascular responses in preterm neonates: a systematic review and meta-analysis
Apnoea duration and changes in cardiorespiratory and cerebrovascular responses in preterm neonates: a systematic review and meta-analysis Open
Background Apnoea is a common respiratory complication in preterm neonates, leading to substantial changes in physiology. We conducted this systematic review and meta-analysis to examine the relationship between apnoea duration and changes…
View article: Exogenous Melatonin and Sleep Quality: A Scoping Review of Systematic Reviews
Exogenous Melatonin and Sleep Quality: A Scoping Review of Systematic Reviews Open
Melatonin is increasingly used to treat sleep disturbances, yet its overall efficacy remains unclear due to variability in existing evidence. This scoping review aimed to synthesize systematic reviews with meta‐analyses assessing the effec…
View article: Prevalence of clinically significant radiological abnormalities in people with first episode psychosis
Prevalence of clinically significant radiological abnormalities in people with first episode psychosis Open
View article: 412. TARGETING MICROGLIAL ACTIVATION IN SCHIZOPHRENIA: A LONGITUDINAL [18F]DPA-714 PET IMAGING STUDY INVESTIGATING THE EFFECTS OF A 3-MONTH TREATMENT WITH NATALIZUMAB
412. TARGETING MICROGLIAL ACTIVATION IN SCHIZOPHRENIA: A LONGITUDINAL [18F]DPA-714 PET IMAGING STUDY INVESTIGATING THE EFFECTS OF A 3-MONTH TREATMENT WITH NATALIZUMAB Open
Background Microglial activation is implicated in the pathophysiology of schizophrenia. The monoclonal antibody natalizumab antagonizes α4β1-integrins, and is known to suppress activation of microglia in neuroinflammatory disorders. Aims &…
View article: Is noxious stimulus-evoked electroencephalography response a reliable, valid, and interpretable outcome measure to assess analgesic efficacy in neonates? A systematic review and individual participant data (IPD) meta-analysis protocol
Is noxious stimulus-evoked electroencephalography response a reliable, valid, and interpretable outcome measure to assess analgesic efficacy in neonates? A systematic review and individual participant data (IPD) meta-analysis protocol Open
Background There are several major challenges limiting our ability to test analgesic efficacy for treatment of neonatal pain, and progress in analgesic drug studies in neonates has stalled. One significant issue is the reliance of clinical…
View article: 10 years of an advanced practice nurse-led chest pain clinic; the sustainable advantages of cardiology nurse-led advanced physical assessment
10 years of an advanced practice nurse-led chest pain clinic; the sustainable advantages of cardiology nurse-led advanced physical assessment Open
Background Internationally chest pain is a common presentation to Emergency Departments (ED), accounting for 8% of local ED visits annually. Of these many are non-acute coronary syndrome (ACS) and in 2012 an advanced nurse led chest pain s…
View article: Brain activity as a candidate biomarker for personalised caffeine treatment in premature neonates
Brain activity as a candidate biomarker for personalised caffeine treatment in premature neonates Open
Background Medication in hospitalised infants is often prescribed using a ‘one-size-fits-all’ approach due to lack of clinical biomarkers. Caffeine is one of the most frequently administered medicines in neonatology - prescribed for the ma…
View article: How to Peer Review a Systematic Review: A Peer‐Reviewer's Guide to Reviewing Reviews
How to Peer Review a Systematic Review: A Peer‐Reviewer's Guide to Reviewing Reviews Open
Systematic reviews hold significant academic weight, but poor execution can render them misleading and unreliable. To help improve the quality of systematic reviews, the peer review process plays a crucial role. Peer reviewing systematic r…
View article: Relationship between apnoea duration and changes in physiology in preterm neonates: a systematic review and meta-analysis
Relationship between apnoea duration and changes in physiology in preterm neonates: a systematic review and meta-analysis Open
Background Apnoea is a common respiratory complication in preterm neonates, leading to substantial changes in physiology. We conducted this systematic review and meta-analysis to examine the relationship between apnoea duration and changes…
View article: Physiological responses to retinopathy of prematurity screening: indirect ophthalmoscopy versus ultra-widefield retinal imaging
Physiological responses to retinopathy of prematurity screening: indirect ophthalmoscopy versus ultra-widefield retinal imaging Open
View article: VACCINE RESPONSE AND IMMUNITY IN PATIENTS WITH PSYCHOTIC DISORDERS: PROSPECTIVE STUDY OF SARS-COV-2 AND PNEUMOCOCCAL VACCINATION
VACCINE RESPONSE AND IMMUNITY IN PATIENTS WITH PSYCHOTIC DISORDERS: PROSPECTIVE STUDY OF SARS-COV-2 AND PNEUMOCOCCAL VACCINATION Open
Background Schizophrenia is associated with excess mortality compared to the general population for both COVID-19 and pneumonia (1,2). Immune dysfunction may play a role in poorer outcomes. Schizophrenia has been associated with altered se…
View article: Statistical analysis plan for the Petal trial: the effects of parental touch on relieving acute procedural pain in neonates
Statistical analysis plan for the Petal trial: the effects of parental touch on relieving acute procedural pain in neonates Open
Background Infants undergo multiple clinically-required painful procedures during their time in hospital, and there is an increasing desire from both parents and clinical staff to have parents directly involved in their newborn’s pain reli…
View article: Analgesia and sedation in premature infants receiving invasive ventilation: a systematic scoping review.
Analgesia and sedation in premature infants receiving invasive ventilation: a systematic scoping review. Open
The purpose of this scoping review is to assess the risks and benefits of providing analgesic and sedative drugs to ventilated premature infants. We sourced primary empirical research reporting outcomes related to the use of pharmacologica…
View article: Head circumference and intelligence, schooling, employment, and income: a systematic review
Head circumference and intelligence, schooling, employment, and income: a systematic review Open
Background No consensus exists about the role of head circumference in identifying children at risk of suboptimal development. The objective of this study was to evaluate the association between head circumference and intelligence, schooli…
View article: Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder Open
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects o…
View article: Statistical analysis plan for the Petal trial: the effects of parental touch on relieving acute procedural pain in neonates
Statistical analysis plan for the Petal trial: the effects of parental touch on relieving acute procedural pain in neonates Open
Background Infants undergo multiple clinically-required painful procedures during their time in hospital, and there is an increasing desire from both parents and clinical staff to have parents directly involved in their newborn’s pain reli…
View article: The association between ibuprofen administration in children and the risk of developing or exacerbating asthma: a systematic review and meta-analysis
The association between ibuprofen administration in children and the risk of developing or exacerbating asthma: a systematic review and meta-analysis Open
View article: Matched pair analysis of the effect of longer hypothermic machine perfusion time on kidney transplant outcomes
Matched pair analysis of the effect of longer hypothermic machine perfusion time on kidney transplant outcomes Open
BACKGROUND Hypothermic machine perfusion (HMP) has demonstrated benefits in terms of early kidney transplant function compared to static cold storage. While longer preservation times have shown detrimental effects, a previous paired study …
View article: Establishing a standardised approach for the measurement of neonatal noxious-evoked brain activity in response to an acute somatic nociceptive heel lance stimulus
Establishing a standardised approach for the measurement of neonatal noxious-evoked brain activity in response to an acute somatic nociceptive heel lance stimulus Open
View article: ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain
ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain Open
International audience
View article: A machine learning artefact detection method for single-channel infant event-related potential studies
A machine learning artefact detection method for single-channel infant event-related potential studies Open
Objective . Automated detection of artefact in stimulus-evoked electroencephalographic (EEG) data recorded in neonates will improve the reproducibility and speed of analysis in clinical research compared with manual identification of artef…
View article: Is noxious stimulus-evoked electroencephalography response a reliable, valid, and interpretable outcome measure to assess analgesic efficacy in neonates? A systematic review and individual participant data (IPD) meta-analysis protocol
Is noxious stimulus-evoked electroencephalography response a reliable, valid, and interpretable outcome measure to assess analgesic efficacy in neonates? A systematic review and individual participant data (IPD) meta-analysis protocol Open
Background: There are several major challenges limiting our ability to test analgesic efficacy for treatment of neonatal pain, and progress in analgesic drug studies in neonates has stalled. One significant issue is the reliance of clinica…
View article: Tripping into the unknown: Exploring the experiences of first-time LSD users through global drug survey insights
Tripping into the unknown: Exploring the experiences of first-time LSD users through global drug survey insights Open
Background: The recreational use of LSD, a synthetic psychedelic drug, has surged in recent years, coinciding with a renewed research focus on its potential psychotherapeutic properties. Aim: This study aims to describe the experiences and…
View article: Resting state electroencephalographic brain activity in neonates can predict age and is indicative of neurodevelopmental outcome
Resting state electroencephalographic brain activity in neonates can predict age and is indicative of neurodevelopmental outcome Open
View article: Identifying characteristics that enable resilient immunisation programmes: a scoping review
Identifying characteristics that enable resilient immunisation programmes: a scoping review Open
Objectives The COVID-19 pandemic highlighted the fragility of immunisation programmes and resulted in a significant reduction in vaccination rates, with increasing vaccine-preventable disease outbreaks consequently reported. These vulnerab…
View article: Identifying factors that can be used to assess a country’s readiness to deploy a new vaccine or improve uptake of an underutilised vaccine: a scoping review
Identifying factors that can be used to assess a country’s readiness to deploy a new vaccine or improve uptake of an underutilised vaccine: a scoping review Open
Objectives Identifying whether a country is ready to deploy a new vaccine or improve uptake of an existing vaccine requires knowledge of a diverse range of interdependent, context-specific factors. This scoping review aims to identify comm…
View article: Apnoea suppresses brain activity in infants
Apnoea suppresses brain activity in infants Open
Apnoea – the cessation of breathing – is commonly observed in premature infants. These events can reduce cerebral oxygenation and are associated with poorer neurodevelopmental outcomes. However, relatively little is known about how apnoea …
View article: Effect of parental touch on relieving acute procedural pain in neonates and parental anxiety (Petal): a multicentre, randomised controlled trial in the UK
Effect of parental touch on relieving acute procedural pain in neonates and parental anxiety (Petal): a multicentre, randomised controlled trial in the UK Open
View article: Immune response to vaccination in people with psychotic disorders relative to healthy controls: prospective study of SARS-CoV-2 vaccination
Immune response to vaccination in people with psychotic disorders relative to healthy controls: prospective study of SARS-CoV-2 vaccination Open
Summary This prospective study examines the immune response to SARS-CoV-2 vaccination in patients with psychotic disorders compared with healthy volunteers. Participants were recruited naturalistically as part of the UK's COVID-19 vaccinat…
View article: Global cross-sectional survey on neonatal pharmacologic sedation and analgesia practices and pain assessment tools: impact of the sociodemographic index (SDI)
Global cross-sectional survey on neonatal pharmacologic sedation and analgesia practices and pain assessment tools: impact of the sociodemographic index (SDI) Open