Luke Hounsome
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View article: Plasmid conjugation drives within–patient plasmid diversity
Plasmid conjugation drives within–patient plasmid diversity Open
Plasmids are well-known vehicles of antimicrobial resistance (AMR) gene dissemination. Through conjugation, plasmid-encoded AMR genes are spread among neighbouring bacteria, irrespective of their strain or even their species. This process …
View article: Review GIDE -- Restaurant Review Gastrointestinal Illness Detection and Extraction with Large Language Models
Review GIDE -- Restaurant Review Gastrointestinal Illness Detection and Extraction with Large Language Models Open
Foodborne gastrointestinal (GI) illness is a common cause of ill health in the UK. However, many cases do not interact with the healthcare system, posing significant challenges for traditional surveillance methods. The growth of publicly a…
View article: Plasmid conjugation drives within-patient plasmid diversity
Plasmid conjugation drives within-patient plasmid diversity Open
Plasmids are well known vehicles of antimicrobial resistance (AMR) genes dissemination. Through conjugation, plasmid–encoded AMR genes are spread among neighbouring bacteria, irrespective of their strain or even their species. This process…
View article: Evaluating Large Language Models for Public Health Classification and Extraction Tasks
Evaluating Large Language Models for Public Health Classification and Extraction Tasks Open
Advances in Large Language Models (LLMs) have led to significant interest in their potential to support human experts across a range of domains, including public health. In this work we present automated evaluations of LLMs for public heal…
View article: Prostate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality
Prostate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality Open
Importance The Cluster Randomized Trial of PSA Testing for Prostate Cancer (CAP) reported no effect of prostate-specific antigen (PSA) screening on prostate cancer mortality at a median 10-year follow-up (primary outcome), but the long-ter…
View article: Epidemiological impact of a large number of false negative SARS-CoV-2 test results in South West England during September and October 2021
Epidemiological impact of a large number of false negative SARS-CoV-2 test results in South West England during September and October 2021 Open
During September and October 2021, a substantial number of Polymerase Chain Reaction (PCR) tests in England processed at a single laboratory were incorrectly reported as negative. We estimate the number of false negative test results issue…
View article: Responsive modelling of the mpox epidemic in England as a cross-government and academia collaboration: the process, challenges, and lessons learned
Responsive modelling of the mpox epidemic in England as a cross-government and academia collaboration: the process, challenges, and lessons learned Open
On May 7, 2022, mpox (formerly known as monkeypox) was detected in a traveller returning to the UK from Nigeria. Before this outbreak, the UK had three mpox cases in September, 2018, with the index case also from Nigeria,1Petersen E Abubak…
View article: Epidemiological impact of a large number of incorrect negative SARS-CoV-2 test results in South West England during September and October 2021
Epidemiological impact of a large number of incorrect negative SARS-CoV-2 test results in South West England during September and October 2021 Open
Background In England, free testing for COVID-19 was widely available from early in the pandemic until 1 April 2022. Based on apparent differences in the rate of positive PCR tests at a single laboratory compared to the rest of the laborat…
View article: Diffuse large B cell lymphoma (DLBCL) in patients older than 65 years: analysis of 3 year Real World data of practice patterns and outcomes in England
Diffuse large B cell lymphoma (DLBCL) in patients older than 65 years: analysis of 3 year Real World data of practice patterns and outcomes in England Open
Background We wished to examine treatment and outcome patterns in older diffuse large B-cell lymphoma (DLBCL) patients, with a focus on the effect of route-to-diagnosis to outcome. Methods Data were extracted from Public Health England’s N…
View article: Treatable but not curable cancer in England: a retrospective cohort study using cancer registry data and linked data sets
Treatable but not curable cancer in England: a retrospective cohort study using cancer registry data and linked data sets Open
Objectives This study estimates the prevalence of cancers that are categorised as treatable but not curable (TbnC) in England. It provides a quantification of the population and a framework to aid identification of this group to enable the…
View article: Decision regret in men living with and beyond nonmetastatic prostate cancer in the United Kingdom: A population‐based patient‐reported outcome study
Decision regret in men living with and beyond nonmetastatic prostate cancer in the United Kingdom: A population‐based patient‐reported outcome study Open
Objective Clinical options for managing nonmetastatic prostate cancer (PCa) vary. Each option has side effects associated with it, leading to difficulty in decision‐making. This study aimed to assess the relationship between patient involv…
View article: Cancer-related symptoms, mental well-being, and psychological distress in men diagnosed with prostate cancer treated with androgen deprivation therapy
Cancer-related symptoms, mental well-being, and psychological distress in men diagnosed with prostate cancer treated with androgen deprivation therapy Open
While the majority of men treated with ADT did not report poor psychological outcomes, a small proportion reported severe problems. Clinically significant fatigue was demonstrated as a possible indicator of poor outcomes. Healthcare system…
View article: Key factors associated with social distress after prostate cancer: Results from the United Kingdom Life after Prostate Cancer diagnosis study
Key factors associated with social distress after prostate cancer: Results from the United Kingdom Life after Prostate Cancer diagnosis study Open
Most men following PCa are socially resilient. A simple checklist could help clinicians identify men at risk of social distress.
View article: Regional Variations in Quality of Survival Among Men with Prostate Cancer Across the United Kingdom
Regional Variations in Quality of Survival Among Men with Prostate Cancer Across the United Kingdom Open
We conducted a UK-wide survey of patient's quality of life after treatment for prostate cancer. Outcomes were found to vary depending upon where patients live. Different service providers need to ensure that all prostate cancer patients re…
View article: Is age a barrier to chemotherapy? Rates of treatment in older patients with breast, colon or lung cancer in England in 2014: A national registry study
Is age a barrier to chemotherapy? Rates of treatment in older patients with breast, colon or lung cancer in England in 2014: A national registry study Open
Background: Survival from cancer in older patients is poorer in the UK than other countries with similar health systems and wealth possibly due to undertreatment and increased toxicities in this specific population. This population-based o…
View article: What Proportion of Cancers in the UK and Its Constituent Countries Could Be Prevented? An Updated Analysis
What Proportion of Cancers in the UK and Its Constituent Countries Could Be Prevented? An Updated Analysis Open
Background: Understanding population-level exposure to cancer risk factors is vital when devising risk-reduction policies. By reducing exposure to cancer risk factors, many cancers could be prevented. But what impact on cancer incidence do…
View article: The fraction of cancer attributable to modifiable risk factors in England, Wales, Scotland, Northern Ireland, and the United Kingdom in 2015
The fraction of cancer attributable to modifiable risk factors in England, Wales, Scotland, Northern Ireland, and the United Kingdom in 2015 Open
Tobacco and overweight/obesity remain the top contributors of attributable cancer cases. Tobacco smoking has the highest PAF because it greatly increases cancer risk and has a large number of cancer types associated with it. Overweight/obe…
View article: Urinary, bowel and sexual health in older men from Northern Ireland
Urinary, bowel and sexual health in older men from Northern Ireland Open
Objectives To provide data on the prevalence of urinary, bowel and sexual dysfunction in Northern Ireland ( NI ), to act as a baseline for studies of prostate cancer outcomes and to aid service provision within the general population. Subj…
View article: The British Association of Urological Surgeons ( <scp>BAUS</scp> ) radical prostatectomy audit 2014/2015 – an update on current practice and outcomes by centre and surgeon case‐volume
The British Association of Urological Surgeons ( <span>BAUS</span> ) radical prostatectomy audit 2014/2015 – an update on current practice and outcomes by centre and surgeon case‐volume Open
Objectives To describe contemporary radical prostatectomy ( RP ) practice using the British Association of Urological Surgeons ( BAUS ) data and audit project and to observe differences in practice in relation to surgeon or centre case‐vol…
View article: ‘The mum has to live with the decision much more than the dad’; a qualitative study of men’s perceptions of their influence on breastfeeding decision-making
‘The mum has to live with the decision much more than the dad’; a qualitative study of men’s perceptions of their influence on breastfeeding decision-making Open
The key themes emerging from the interviews are suggestive of an impact on breastfeeding interventions that use the father as an intermediary. If they do not feel that they are 'permitted' to comment on their partner's breastfeeding, then …
View article: 'The mum has to live with the decision much more than the dad'. Men's perceptions of their influence on breastfeeding decision making: A qualitative study
'The mum has to live with the decision much more than the dad'. Men's perceptions of their influence on breastfeeding decision making: A qualitative study Open
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\nAlthough breastfeeding is widely acknowledged as the normal method of infant feeding, there are large variations in rates of initiation and duration. Several factors are linked to the likelihood of breastfeeding initia…
View article: Cross-sectional study evaluating data quality of the National Cancer Registration and Analysis Service (NCRAS) prostate cancer registry data using the Cluster randomised trial of PSA testing for Prostate cancer (CAP)
Cross-sectional study evaluating data quality of the National Cancer Registration and Analysis Service (NCRAS) prostate cancer registry data using the Cluster randomised trial of PSA testing for Prostate cancer (CAP) Open
Objectives To compare the completeness and agreement of prostate cancer data recorded by the National Cancer Registration and Analysis Service (NCRAS) with research-level data specifically abstracted from medical records from the Cluster r…
View article: P38 Decision regret in men treated for localised prostate cancer: results from the life after prostate cancer diagnosis study
P38 Decision regret in men treated for localised prostate cancer: results from the life after prostate cancer diagnosis study Open
Background Men with localised prostate cancer have a number of treatment options. Treatments carry associated benefits and side- and late-effects. The Life After Prostate Cancer Diagnosis study is a UK-wide survey of men 18–42 months post-…