Explanipedia

Distinct Cellular Phenotypes of Language and Executive Decline in Amyotrophic Lateral Sclerosis Open

Joana Petrescu, Cláudio Gouveia Roque, Christopher A. Jackson, Aidan C. Daly, Kristy Kang , et al. · 2025

Cognitive manifestations, including impairment in language and executive functions, are seen in amyotrophic lateral sclerosis (ALS), but the mechanisms that underlie these deficits remain unclear. To address this, we mapped prefrontal cort…

A fully automated FAIMS-DIA mass spectrometry-based proteomic pipeline Open

Luke Reilly, E. C. Lara, Daniel M. Ramos, Ziyi Li, Caroline B. Pantazis , et al. · 2023

iNDI Transcription Factor-NGN2 differentiation of human iPSC into cortical neurons Version 2 v1 Open

E. Flores, Andy Qi, Luke Reilly, Marianita Santiana, Mark Cookson · 2023

Induced pluripotent stem cell (iPSC)-derived neurons are an important tool for studying diverse types of neurodegenerative disorders, including Alzheimer’s Disease, Parkinson’s disease, and related dementias. Understanding the molecular an…

Variant biomarker discovery using mass spectrometry-based proteogenomics Open

Luke Reilly, Sahba Seddighi, Andrew Singleton, Mark Cookson, Michael E. Ward , et al. · 2023

Genomic diversity plays critical roles in risk of disease pathogenesis and diagnosis. While genomic variants—including single nucleotide variants, frameshift variants, and mis-splicing isoforms—are commonly detected at the DNA or RNA level…

Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis Open

Luke Reilly, Evan R. Semenza, George Koshkaryan, Subrata H. Mishra, Sujan Chatterjee , et al. · 2023

A Fully Automated FAIMS-DIA Mass Spectrometry-Based Proteomic Pipeline Open

Luke Reilly, E. C. Lara, Daniel M. Ramos, Ziyi Li, Caroline B. Pantazis , et al. · 2023

A reference human induced pluripotent stem cell line for large-scale collaborative studies Open

Caroline B. Pantazis, Andrian Yang, Erika Lara, Justin A. McDonough, Cornelis Blauwendraat , et al. · 2022

A reference induced pluripotent stem cell line for large-scale collaborative studies Open

Caroline B. Pantazis, Andrian Yang, Erika Lara, Justin A. McDonough, Cornelis Blauwendraat , et al. · 2021

Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying development and disease, but the considerable phenotypic variation between lines makes it challenging to replicate key findings and integrate data across res…

A fully automated FAIMS-DIA proteomic pipeline for high-throughput characterization of iPSC-derived neurons Open

Luke Reilly, Lirong Peng, Erika Lara, Daniel M. Ramos, Michael S. Fernandopulle , et al. · 2021

Fully automated proteomic pipelines have the potential to achieve deep coverage of cellular proteomes with high throughput and scalability. However, it is important to evaluate performance, including both reproducibility and ability to pro…

Cocaine-induced locomotor stimulation involves autophagic degradation of the dopamine transporter Open

Maged M. Harraz, Prasun Guha, In Guk Kang, Evan R. Semenza, Adarsha P. Malla , et al. · 2021

Loss of PI3-kinase activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration and intestinal homeostasis Open

Prasun Guha, Luke Reilly, Evan R. Semenza, Efrat Abramson, Subrata H. Mishra , et al. · 2020

Inositol polyphosphate multikinase (IPMK) is a rate-limiting enzyme in the inositol phosphate (IP) pathway which converts IP3 to IP4 and IP5. In mammalian cells, IPMK can also act as a phosphoinositol-3-kinase (PI3-kinase). We previously f…

IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration Open

Prasun Guha, Richa Tyagi, Sayan Mullick Chowdhury, Luke Reilly, Chenglai Fu , et al. · 2019

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