Luke Riggan YOU? Author Swipe

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Author Correction: MEF2C regulates NK cell effector functions through control of lipid metabolism Open

Joey H. Li, Adalia Zhou, Cassidy D. Lee, Siya N. Shah, Jeong Hyun Ji , et al. · 2024

MEF2C is a critical regulator of human NK cell metabolism Open

Joey H. Li, Vignesh Senthilkumar, Siya N. Shah, Eddie T. Padilla, Luke Riggan , et al. · 2023

Natural killer (NK) cells are critical for the first line of defense against viral infection and malignancy. While the transcriptional and epigenetic regulation of activated NK cells is well characterized in mice, these processes are not y…

Supplementary Table from Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155 Open

Michael D. Nyquist, Alexandra Corella, John W. Burns, Ilsa M. Coleman, Shuai Gao , et al. · 2023

Correlation of tumor androgen levels with SLC35F2 transcript expression in PDX models

Fig S1 from Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155 Open

Michael D. Nyquist, Alexandra Corella, John W. Burns, Ilsa M. Coleman, Shuai Gao , et al. · 2023

Fig S1. Androgen Mediated Growth Suppression in LnCaP

Fig S3 from Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155 Open

Michael D. Nyquist, Alexandra Corella, John W. Burns, Ilsa M. Coleman, Shuai Gao , et al. · 2023

Fig S3. Tumor Androgen Levels Correlate with SLC35F2 Expression

Fig S2 from Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155 Open

Michael D. Nyquist, Alexandra Corella, John W. Burns, Ilsa M. Coleman, Shuai Gao , et al. · 2023

Fig S2. SLC35F2 Expression Determines Sensitivity to YM155

Fig S2 from Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155 Open

Michael D. Nyquist, Alexandra Corella, John W. Burns, Ilsa M. Coleman, Shuai Gao , et al. · 2023

Fig S2. SLC35F2 Expression Determines Sensitivity to YM155

Supplementary Table from Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155 Open

Michael D. Nyquist, Alexandra Corella, John W. Burns, Ilsa M. Coleman, Shuai Gao , et al. · 2023

Correlation of tumor androgen levels with SLC35F2 transcript expression in PDX models

Fig S3 from Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155 Open

Michael D. Nyquist, Alexandra Corella, John W. Burns, Ilsa M. Coleman, Shuai Gao , et al. · 2023

Fig S3. Tumor Androgen Levels Correlate with SLC35F2 Expression

Data from Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155 Open

Michael D. Nyquist, Alexandra Corella, John W. Burns, Ilsa M. Coleman, Shuai Gao , et al. · 2023

Androgen receptor (AR) signaling is fundamental to prostate cancer and is the dominant therapeutic target in metastatic disease. However, stringent androgen deprivation therapy regimens decrease quality of life and have been largely unsucc…

Fig S1 from Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155 Open

Michael D. Nyquist, Alexandra Corella, John W. Burns, Ilsa M. Coleman, Shuai Gao , et al. · 2023

Fig S1. Androgen Mediated Growth Suppression in LnCaP

Data from Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155 Open

Michael D. Nyquist, Alexandra Corella, John W. Burns, Ilsa M. Coleman, Shuai Gao , et al. · 2023

Androgen receptor (AR) signaling is fundamental to prostate cancer and is the dominant therapeutic target in metastatic disease. However, stringent androgen deprivation therapy regimens decrease quality of life and have been largely unsucc…

The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences Open

Mandy I. Cheng, Joey H. Li, Luke Riggan, Bryan Chen, Rana Yakhshi Tafti , et al. · 2023

Lentiviral gene therapy for X-linked chronic granulomatous disease recapitulates endogenous<i>CYBB</i>regulation and expression Open

Ryan L. Wong, Sarah Sackey, Devin Brown, Shantha Senadheera, Katelyn E. Masiuk , et al. · 2022

X-linked chronic granulomatous disease (X-CGD) is a primary immunodeficiency caused by mutations in the CYBB gene, resulting in the inability of phagocytic cells to eliminate infections. To design a lentiviral vector (LV) capable of recapi…

Mechanisms Behind Hypoxia-Driven Resistance to Immunotherapy in the Tumor Microenvironment Open

Alexandra Meyer, Luke Riggan · 2022

Tumor formation requires rapid proliferation of malignant cells which consume large amounts of oxygen from the microenvironment to meet metabolic demands. The resulting tumor microenvironment (TME) is usually low in oxygen compared to heal…

Mifepristone Increases Life Span in Female Drosophila Without Detectable Antibacterial Activity Open

Gary N. Landis, Luke Riggan, Hans S. Bell, William Vu, Tianyi Wang , et al. · 2022

Mifepristone dramatically increases the life span of mated female Drosophila while reducing the expression of innate immune response genes. Previous results indicated that mifepristone also reduced the load of aero-tolerant bacteria in mat…

Sex differences in NK cells mediated by the X-linked epigenetic regulator UTX Open

Mandy I. Cheng, Luke Riggan, Joey H. Li, Rana Yakhshi Tafti, Scott Chin , et al. · 2022

Viral infection outcomes are sex-biased, with males generally more susceptible than females. Paradoxically, the numbers of anti-viral natural killer (NK) cells are increased in males compared to females. Using samples from mice and humans,…

The transcription factor Fli1 restricts the formation of memory precursor NK cells during viral infection Open

Luke Riggan, Feiyang Ma, Joey H. Li, Elizabeth Fernández, David A. Nathanson , et al. · 2022

Arrested development: suppression of NK cell function in the tumor microenvironment Open

Luke Riggan, Siya N. Shah, Timothy E. O’Sullivan · 2021

Natural killer (NK) cells are cytotoxic innate lymphocytes that protect against viral infection and tumor metastasis. Despite their inherent ability to kill a broad range of virally infected, stressed and transformed cells, low numbers of …

Reciprocal Induction of MDM2 and MYCN in Neural and Neuroendocrine Cancers Open

Hung N. Tran, Hardeep Singh, Wenxuan Guo, Linda Cambier, Luke Riggan , et al. · 2020

MYC family oncoproteins MYC, MYCN, and MYCL are deregulated in diverse cancers and via diverse mechanisms. Recent studies established a novel form of MYCN regulation in MYCN-overexpressing retinoblastoma and neuroblastoma cells in which th…

CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Primary Innate Immune Cells Open

Andrew D. Hildreth, Luke Riggan, Timothy E. O’Sullivan · 2020

CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Mature Primary Innate Immune Cells Open

Luke Riggan, Andrew D. Hildreth, Marion Rolot, Yung-Yu Wong, William Satyadi , et al. · 2020

Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes Open

Tsukasa Nabekura, Luke Riggan, Andrew D. Hildreth, Timothy E. O’Sullivan, Akira Shibuya · 2019

Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12 Open

Orr-El Weizman, Eric Song, Nicholas M. Adams, Andrew D. Hildreth, Luke Riggan , et al. · 2019

Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155 Open

Michael D. Nyquist, Alexandra Corella, John Burns, Ilsa M. Coleman, Shuai Gao , et al. · 2017

Androgen receptor (AR) signaling is fundamental to prostate cancer and is the dominant therapeutic target in metastatic disease. However, stringent androgen deprivation therapy regimens decrease quality of life and have been largely unsucc…

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