Explanipedia

Cost-effectiveness analysis of molecular testing for cytologically indeterminate thyroid nodules Open

Navjit Dharampal, Kristine A. Smith, Adrian Harvey, Ralf Paschke, Luke Rudmik , et al. · 2022

Background Thyroid nodules affect up to 65% of the population. Although fine needle aspirate (FNA) cytology is the gold standard for diagnosis, 15–30% of results are indeterminate. Molecular testing may aid in the diagnosis of nodules and …

International consensus statement on allergy and rhinology: rhinosinusitis 2021 Open

Richard R. Orlandi, Todd T. Kingdom, Timothy L. Smith, Benjamin S. Bleier, Adam S. DeConde , et al. · 2020

I. Executive Summary Background The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of r…

Issue Information Open

David N. Kennedy, Timothy L. Smith, Benjamin S. Bleier, Noam A. Cohen, Jan Gosepath , et al. · 2020

Socioeconomic status impacts postoperative productivity loss and health utility changes in refractory chronic rhinosinusitis Open

Daniel M. Beswick, Jess C. Mace, Zachary M. Soler, Luke Rudmik, Jeremiah A. Alt , et al. · 2019

Background Social determinants of health can have a substantial impact on treatment outcomes. Prior study has shown that socioeconomic status influences the likelihood of improvement in quality‐of‐life (QOL) following endoscopic sinus surg…

Symptom importance, patient expectations, and satisfaction in chronic rhinosinusitis Open

José L. Mattos, Luke Rudmik, Rodney J. Schlosser, Timothy L. Smith, Jess C. Mace , et al. · 2019

Background Sinonasal symptoms and poor quality of life (QOL) prompt chronic rhinosinusitis (CRS) patients to undergo sinus surgery (ESS). However, little is known regarding the symptoms most important to patients and how these impact expec…

Appropriateness Criteria for Surgery in the Management of Adult Recurrent Acute Rhinosinusitis Open

Luke Rudmik, Daniel M. Beswick, Jeremiah A. Alt, Neil Bhattacharyya, Alexander C. Chester , et al. · 2018

Objectives/Hypothesis Endoscopic sinus surgery (ESS) is frequently performed for recurrent acute rhinosinusitis (RARS). Appropriate indications for surgery among patients with RARS have not yet been rigorously determined. The objective of …

Appropriateness criteria predict outcomes for sinus surgery and may aid in future patient selection Open

Daniel M. Beswick, Jess C. Mace, Zachary M. Soler, Noel Ayoub, Luke Rudmik , et al. · 2018

Objectives Appropriateness criteria to determine surgical candidacy for chronic rhinosinusitis (CRS) have recently been described. This study stratified patients who underwent endoscopic sinus surgery (ESS) according to these new appropria…

Airway management changes associated with rising radiologic incidence of external laryngotracheal injury Open

Derrick R. Randall, Luke Rudmik, Chad G. Ball, J. Douglas Bosch · 2018

Management of ELTIs shifted from predominantly conservative airway monitoring to endotracheal tube intubation over the study period in spite of no clinically significant change in injury severity or operative intervention frequency. The lo…

CHronic Rhinosinusitis Outcome MEasures (CHROME), developing a core outcome set for trials of interventions in chronic rhinosinusitis Open

Claire Hopkins, R. Hettige, A. Soni-Jaiswal, Ruchi JainAlisha Lakhani, S. Carrie , et al. · 2018

Evaluating the effectiveness of treatments in chronic rhinosinusitis (CRS) have been limited by both a paucity of high quality randomised trials, and the heterogeneity of outcomes in those that have been reported. Core outcome sets (COS) a…

International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis Open

Sarah K. Wise, Sandra Y. Lin, Elina Toskala, Richard R. Orlandi, Cezmi A. Akdiş , et al. · 2018

Background Critical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate …

国际过敏与鼻科学共识声明 : 变应性鼻炎 Open

Sarah K. Wise, Sandra Y. Lin, Elina Toskala, Richard R. Orlandi, Cezmi A. Akdiş , et al. · 2018

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Evaluating Surgeon-Specific Performance for Endoscopic Sinus Surgery Open

Luke Rudmik, Yuan Xu, Jeremiah A. Alt, Adam S. DeConde, Timothy L. Smith , et al. · 2017

Evaluating surgeon-specific performance for ESS may provide information to assist in quality improvement. Although most surgeons had comparable risk-adjusted, 5-year ESS revision rates, 16% of surgeons had lower-than-expected performance, …

What drives productivity loss in chronic rhinosinusitis? A SNOT‐22 subdomain analysis Open

Naweed I. Chowdhury, Jess C. Mace, Timothy L. Smith, Luke Rudmik · 2017

Objectives/Hypothesis Previous studies have shown declines in productivity due to chronic rhinosinusitis (CRS) are correlated with disease‐specific quality‐of‐life (QOL) measures. However, it is unclear which symptom domains contribute pri…

Mortality risk in patients with chronic rhinosinusitis and its association to asthma Open

Jeremiah A. Alt, Andrew J. Thomas, Karen Curtin, Jathine Wong, Luke Rudmik , et al. · 2017

Background Chronic rhinosinusitis (CRS) is a highly prevalent inflammatory condition, with significant effects on morbidity and quality of life. Given that other chronic inflammatory conditions have been associated with increased mortality…

CHronic Rhinosinusitis Outcome MEasures (CHROME), developing a core outcome set for trials of interventions in chronic rhinosinusitis Open

Claire Hopkins, Roland Hettige, Archana Soni‐Jaiswal, Raj Lakhani, Sean Carrie , et al. · 2017

The authors hope inclusion of these core outcomes in future trials will increase the value of research on interventions for CRS in adults. It was felt important to make recommendations regarding how these outcomes should be measured, altho…

Masthead ‐ Editorial Board And Table of Contents Open

Jeremiah A. Alt, Vijay R. Ramakrishnan, Michael P. Platt, Preeti Kohli, Kristina A. Storck , et al. · 2017

ABOUT THE COVER: The cover illustrations represent hematoxylin-eosin stains (left) and immunocytochemistry stains (right) using a CD45 antibody of olfactory mucosa from the same mouse pirsturbinates to demarcate the inflammatory cell infil…

Table of contents Open

Michael Stewart, Daniel Clayburgh, Daniel Brickman, Randall A. Bly, Jonathan A. Perkins , et al. · 2016

Prevalence of polyp recurrence after endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis Open

Adam S. DeConde, Jess C. Mace, Joshua M. Levy, Luke Rudmik, Jeremiah A. Alt , et al. · 2016

Objectives/Hypothesis Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a disease process that is driven, in part, by intrinsic mucosal inflammation. Surgery plus continued medical therapy is commonly elected by medically recalcitran…

Prevalence and Incidence of Diagnosed Chronic Rhinosinusitis in Alberta, Canada Open

Yuan Xu, Hude Quan, Peter Faris, Stephanie Garies, Mingfu Liu , et al. · 2016

Although the incidence and prevalence rates of diagnosed CRS were lower compared with earlier published estimates obtained from population-based survey analysis, outcomes from this study may more accurately reflect the disease burden of CR…

Association of olfactory dysfunction in chronic rhinosinusitis with economic productivity and medication usage Open

Rodney J. Schlosser, Kristina A. Storck, Luke Rudmik, Timothy L. Smith, Jess C. Mace , et al. · 2016

Background Chronic rhinosinusitis (CRS) has significant impacts upon productivity, economic metrics, and medication usage; however, factors that are associated with these economic outcomes are unknown. Methods We evaluated olfactory dysfun…

Contemporary management of chronic rhinosinusitis with nasal polyposis in aspirin‐exacerbated respiratory disease: an evidence‐based review with recommendations Open

Joshua M. Levy, Luke Rudmik, Anju T. Peters, Sarah K. Wise, Brian Rotenberg , et al. · 2016

Background Chronic rhinosinusitis (CRS) in aspirin‐exacerbated respiratory disease (AERD) represents a recalcitrant form of sinonasal inflammation for which a multidisciplinary consensus on patient management has not been reached. Several …

Low 22‐item sinonasal outcome test scores in chronic rhinosinusitis: Why do patients seek treatment? Open

Joshua M. Levy, Jess C. Mace, Luke Rudmik, Zachary M. Soler, Timothy L. Smith · 2016

Objectives/Hypothesis Patients with chronic rhinosinusitis (CRS) who experience minimal reductions in quality of life (QoL) may present for treatment despite QoL scores comparable to controls without CRS. This study seeks to identify cofac…

Health utility values for patients with recurrent acute rhinosinusitis undergoing endoscopic sinus surgery: a nested case control study Open

Toby O. Steele, Jess C. Mace, Raj D. Dedhia, Luke Rudmik, Timothy L. Smith , et al. · 2016

Background Health utility scores quantify an individual's valuation of particular health states and are vital components of health economic studies and cost‐effectiveness research. We sought to characterize health utility values for patien…

Comparing surgeon outcomes in endoscopic sinus surgery for chronic rhinosinusitis Open

Timothy L. Smith, Jess C. Mace, Luke Rudmik, Rodney J. Schlosser, Peter H. Hwang , et al. · 2016

Objectives/Hypothesis The objective of this investigation was to evaluate endoscopic sinus surgery (ESS) outcomes for chronic rhinosinusitis (CRS) between medical centers to determine if differences in quality‐of‐life outcomes were detecta…

Defining appropriateness criteria for endoscopic sinus surgery during management of uncomplicated adult chronic rhinosinusitis: a RAND/UCLA appropriateness study Open

Luke Rudmik, Zachary M. Soler, Claire Hopkins, Rodney J. Schlosser, Anju T. Peters , et al. · 2016

Introduction: Appropriate indications for endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) are currently poorly defined. The lack of clear surgical indications for ESS likely contributes to the large geographic variation in …

Using postoperative SNOT-22 to help predict the probability of revision sinus surgery Open

Luke Rudmik, Zachary M. Soler, Claire Hopkins · 2016

Background: There is a need to develop a patient-level strategy to identify those at higher risk of requiring revision ESS since this may assist clinicians in tailoring their postoperative management. This study evaluated whether identifyi…

Depression-Specific Outcomes After Treatment of Chronic Rhinosinusitis Open

Rodney J. Schlosser, J. Madison Hyer, Timothy L. Smith, Jess C. Mace, Bernadette M. Cortese , et al. · 2016

Depression is a common comorbidity in patients with CRS and affects numerous quality-of-life and health care outcomes. There are few objective baseline factors to aid physicians in identifying depression in patients with CRS. Medical and s…

Depression in Chronic Rhinosinusitis: A Controlled Cohort Study Open

Rodney J. Schlosser, Kristina A. Storck, Bernadette M. Cortese, Thomas W. Uhde, Luke Rudmik , et al. · 2016

Background Depression in patients with chronic rhinosinusitis (CRS) is underdiagnosed but significantly impacts treatment outcomes and health care utilization. Objective To compare undiagnosed depression in a CRS cohort with a healthy, non…

Outcomes of chronic frontal sinusitis treated with ethmoidectomy: a prospective study Open

Waleed M. Abuzeid, Jess C. Mace, Milena L. Costa, Luke Rudmik, Zachary M. Soler , et al. · 2016

Background In medically refractory chronic frontal sinusitis, ethmoidectomy without instrumentation of the frontal ostium may resolve frontal disease. Our aim was to determine the efficacy of ethmoidectomy alone for the treatment of chroni…

Patient‐centered decision making: the role of the baseline SNOT‐22 in predicting outcomes for medical management of chronic rhinosinusitis Open

Toby O. Steele, Luke Rudmik, Jess C. Mace, Adam S. DeConde, Jeremiah A. Alt , et al. · 2016

Background For patients with chronic rhinosinusitis (CRS), the decision to elect continued medical management vs surgery is complex and involves tradeoffs between benefits, risks, and overall effectiveness of each therapy. The purpose of t…

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