Luke Slind
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View article: HCMV promotes viral reactivation through the coordinated regulation of Notch signaling by UL8 and miR-UL36
HCMV promotes viral reactivation through the coordinated regulation of Notch signaling by UL8 and miR-UL36 Open
Human cytomegalovirus (HCMV) establishes latency in CD34 + hematopoietic progenitor cells (HPCs), where reactivation is intimately linked to cellular differentiation. We demonstrate that the Notch signaling pathway, a key regulator of stem…
View article: The HCMV chemokine receptor UL78 is required for efficient viral reactivation from latent infection in CD34+ HPCs 4278
The HCMV chemokine receptor UL78 is required for efficient viral reactivation from latent infection in CD34+ HPCs 4278 Open
Description Human cytomegalovirus (HCMV) is a ubiquitous pathogen that persists throughout the host’s lifetime. Despite a robust immune response against HCMV, viral clearance cannot be achieved due to the establishment of viral latency wit…
The HCMV chemokine receptor UL78 is required for efficient viral reactivation from latent infection in CD34+ HPCs 4278 Open
Description Human cytomegalovirus (HCMV) is a ubiquitous pathogen that persists throughout the host’s lifetime. Despite a robust immune response against HCMV, viral clearance cannot be achieved due to the establishment of viral latency wit…
View article: Human cytomegalovirus UL78 is a nuclear-localized GPCR necessary for efficient reactivation from latent infection in CD34 <sup>+</sup> hematopoietic progenitor cells
Human cytomegalovirus UL78 is a nuclear-localized GPCR necessary for efficient reactivation from latent infection in CD34 <sup>+</sup> hematopoietic progenitor cells Open
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that persists throughout the lifetime of the host due to the establishment of latency. HCMV encodes four putative G protein-coupled receptors (GPCRs): US27, US28, UL33, and UL78. A defi…
View article: Human Cytomegalovirus UL78 is a Nuclear-Localized GPCR Necessary for Efficient Reactivation from Latent Infection in CD34 <sup>+</sup> Hematopoietic Progenitor Cells
Human Cytomegalovirus UL78 is a Nuclear-Localized GPCR Necessary for Efficient Reactivation from Latent Infection in CD34 <sup>+</sup> Hematopoietic Progenitor Cells Open
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that persists throughout the lifetime of the host due in part to the establishment of latency in CD34 + hematopoietic progenitor cells (HPCs) and CD14 + monocytes. HCMV encodes four put…
Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34+ hematopoietic progenitor cells and humanized mice Open
Human cytomegalovirus (HCMV) actively manipulates cellular signaling pathways to benefit viral replication. Phosphatidyl-inositol 3-kinase (PI3K)/Akt signaling is an important negative regulator of HCMV replication, and during lytic infect…
View article: Third intracellular loop of HCMV US28 is necessary for signaling and viral reactivation
Third intracellular loop of HCMV US28 is necessary for signaling and viral reactivation Open
The human cytomegalovirus (HCMV) encoded chemokine receptor US28 plays a critical role in viral pathogenesis, mediating several processes such as cellular migration, differentiation, transformation, and viral latency and reactivation. Desp…
Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34 <sup>+</sup> hematopoietic progenitor cells and humanized mice Open
Human cytomegalovirus (HCMV) actively manipulates cellular signaling pathways to benefit viral replication. Phosphatidyl-inositol 3-kinase (PI3K)/Akt signaling is an important negative regulator of HCMV replication, and during lytic infect…