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View article: Latent Cytomegalovirus Infection Is Associated With Impaired Left Ventricular Function After ST‐Segment–Elevation Myocardial Infarction
Latent Cytomegalovirus Infection Is Associated With Impaired Left Ventricular Function After ST‐Segment–Elevation Myocardial Infarction Open
Background Human cytomegalovirus is a herpes virus that affects most individuals globally and may increase the risk of cardiovascular disease. Whether cytomegalovirus influences outcomes after ST‐segment–elevation myocardial infarction (ST…
View article: Cardiovascular inflammaging: Mechanisms, consequences, and therapeutic perspectives
Cardiovascular inflammaging: Mechanisms, consequences, and therapeutic perspectives Open
Both aging and systemic inflammation are major risk factors for cardiovascular disease. This review summarizes the interrelationship of aging and inflammation-known as inflammaging-and the consequences for cardiovascular health. We discuss…
View article: How to measure and model cardiovascular aging
How to measure and model cardiovascular aging Open
Most acquired cardiovascular diseases are more common in older people, and the biological mechanisms and manifestations of aging provide insight into cardiovascular pathophysiology. Measuring aging within the cardiovascular system may help…
View article: The role of arginine vasopressin in the pathophysiology of microvascular dysfunction after ST-elevation myocardial infarction
The role of arginine vasopressin in the pathophysiology of microvascular dysfunction after ST-elevation myocardial infarction Open
Background Coronary microvascular dysfunction (CMD) after ST-elevation myocardial infarction (STEMI), in part due to impaired vasomotor tone, predicts heart failure and mortality at one year. Arginine vasopressin (AVP) may be implicated in…
View article: Arginine Vasopressin Plays a Role in Microvascular Dysfunction After ST‐Elevation Myocardial Infarction
Arginine Vasopressin Plays a Role in Microvascular Dysfunction After ST‐Elevation Myocardial Infarction Open
Background Coronary microvascular dysfunction (CMD) predicts mortality after ST‐elevation–myocardial infarction (STEMI). Arginine vasopressin (AVP) may be implicated, but data in humans are lacking, and no study has investigated the link b…
View article: Modification of the GRACE Risk Score for Risk Prediction in Patients With Acute Coronary Syndromes
Modification of the GRACE Risk Score for Risk Prediction in Patients With Acute Coronary Syndromes Open
Importance The Global Registry of Acute Coronary Events (GRACE) risk score, a guideline-recommended risk stratification tool for patients presenting with acute coronary syndromes (ACS), does not consider the extent of myocardial injury. Ob…
View article: Fractalkine Signalling (CX3CL1/CX3CR1 Axis) as an Emerging Target in Coronary Artery Disease
Fractalkine Signalling (CX3CL1/CX3CR1 Axis) as an Emerging Target in Coronary Artery Disease Open
Acute myocardial infarction (MI) is the most common and dramatic complication of atherosclerosis, which, despite successful reperfusion therapy, can lead to incident heart failure (HF). HF occurs when the healing process is impaired due to…
View article: Effector T cell chemokine IP-10 predicts cardiac recovery and clinical outcomes post-myocardial infarction
Effector T cell chemokine IP-10 predicts cardiac recovery and clinical outcomes post-myocardial infarction Open
Background and aims Preclinical data suggest that activation of the adaptive immune system is critical for myocardial repair processes in acute myocardial infarction. The aim of the present study was to determine the clinical value of base…
View article: Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction
Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction Open
Myocardial infarction (MI) accelerates immune ageing characterised by lymphopenia, expansion of terminally differentiated CD8 + T-lymphocytes (CD8 + T EMRA ) and inflammation. Pre-clinical data showed that TA-65, an oral telomerase activat…
View article: Activation of mitochondrial telomerase reverses relative lymphopenia post myocardial infarction: results from the randomised, double-blinded TACTIC phase IIa pilot trial
Activation of mitochondrial telomerase reverses relative lymphopenia post myocardial infarction: results from the randomised, double-blinded TACTIC phase IIa pilot trial Open
Background Immune ageing is a phenomenon which includes lymphopenia, expansion of pro-inflammatory T-lymphocyte subsets and telomere shortening. While lymphopenia predicts mortality after myocardial infarction (MI), MI itself leads to both…
View article: Relative monocytosis predicts the presence and severity of coronary artery disease on CT coronary angiography in patients with stable angina symptoms
Relative monocytosis predicts the presence and severity of coronary artery disease on CT coronary angiography in patients with stable angina symptoms Open
Background Monocytes, among other leucocytes, are crucially involved in the pathogenesis of atherosclerosis, but the value of peripheral blood leucocyte counts in predicting the presence or absence of atherosclerotic coronary artery diseas…
View article: The Fractalkine Receptor CX3CR1 Links Lymphocyte Kinetics in CMV-Seropositive Patients and Acute Myocardial Infarction With Adverse Left Ventricular Remodeling
The Fractalkine Receptor CX3CR1 Links Lymphocyte Kinetics in CMV-Seropositive Patients and Acute Myocardial Infarction With Adverse Left Ventricular Remodeling Open
Aims Latent cytomegalovirus (CMV) infection is associated with adverse cardiovascular outcomes. Virus-specific CX 3 CR1 + effector memory T-cells may be instrumental in this process due to their pro-inflammatory properties. We investigated…
View article: Rapid fall in circulating non‐classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury
Rapid fall in circulating non‐classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury Open
Myocardial infarction leads to a rapid innate immune response that is ultimately required for repair of damaged heart tissue. We therefore examined circulating monocyte dynamics immediately after reperfusion of the culprit coronary vessel …
View article: Rapid fall in circulating non-classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury
Rapid fall in circulating non-classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury Open
Objective Myocardial infarction leads to a rapid innate immune response that is ultimately required for repair of damaged heart tissue. We therefore examined circulating monocyte dynamics immediately after reperfusion of the culprit corona…
View article: Role of CMV-serostatus and CX3CR1 on lymphocyte kinetics and left ventricular remodelling in patients with acute myocardial infarction
Role of CMV-serostatus and CX3CR1 on lymphocyte kinetics and left ventricular remodelling in patients with acute myocardial infarction Open
Background Patients with latent cytomegalovirus (CMV) infection have higher rates of adverse cardiovascular outcomes, but the reasons for this remain elusive. CMV-induced changes to T-lymphocyte populations, with a proliferation of CMV-spe…
View article: P187 Not a headache clinic: giant cell arteritis fast track pathways (GCA-FTP) need not be overwhelming
P187 Not a headache clinic: giant cell arteritis fast track pathways (GCA-FTP) need not be overwhelming Open
Background False positive and negative GCA diagnoses lead to significant morbidity. GCA Fast Track Pathways (GCA-FTP) are advocated in the NHS. Concern that these become ‘headache clinics’, lack of access to temporal artery ultrasound (TAU…
View article: P167 Pulmonary hypertension in patients with systemic sclerosis: an audit of screening practices, incidence and cost over 10 years
P167 Pulmonary hypertension in patients with systemic sclerosis: an audit of screening practices, incidence and cost over 10 years Open
Background Patients with systemic sclerosis (SSc) are at risk of developing pulmonary arterial hypertension (PAH), a subtype of pulmonary hypertension (PH) which is not due to left-heart disease, chronic hypoxia or pulmonary arterial throm…