Lukman Owolabi
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View article: Law Versus What People Want: Stroke Neurobiobanking and Genomics Research in Nigeria and Ghana
Law Versus What People Want: Stroke Neurobiobanking and Genomics Research in Nigeria and Ghana Open
Research on strokes using genetics and neurobiobanking has highlighted some ethical, legal and social implications. Blood donation, brain donation, blood storage, re-use and sample sharing, data sharing, return of individual results, discl…
View article: Large-scale genetic characterization of Parkinson’s disease in the African and African admixed populations
Large-scale genetic characterization of Parkinson’s disease in the African and African admixed populations Open
Elucidating the genetic contributions to Parkinson’s disease (PD) etiology across diverse ancestries is a critical priority for the development of targeted therapies in a global context. We conducted the largest sequencing characterization…
View article: Cost-effectiveness of different tuberculosis diagnostic approaches in Nigeria based on decision analytical modelling
Cost-effectiveness of different tuberculosis diagnostic approaches in Nigeria based on decision analytical modelling Open
Background Tuberculosis (TB) remains a leading cause of morbidity and mortality in Nigeria, particularly among people living with HIV (PLWH), who face significantly higher risks of developing active TB. Conventional diagnostic methods such…
View article: Predicting stroke with machine learning techniques in a sub-Saharan African population
Predicting stroke with machine learning techniques in a sub-Saharan African population Open
View article: Communicating the ethical, legal, and social issues in neurobiobanking and stroke genomic research in Africa: Project intervention tools development and evaluation procedures
Communicating the ethical, legal, and social issues in neurobiobanking and stroke genomic research in Africa: Project intervention tools development and evaluation procedures Open
The overall reviewers' reports and evaluation scores indicate that the intervention tools are generally suitable for community deployment in sub-Saharan Africa. Clinical researchers must partner with key stakeholders, define policy objecti…
View article: Research participants’ perception of ethical issues in stroke genomics and neurobiobanking research in Africa
Research participants’ perception of ethical issues in stroke genomics and neurobiobanking research in Africa Open
Background There is a growing interest in stroke genomics and neurobiobanking research in Africa. These raise several ethical issues, such as consent, re-use, data sharing, storage, and incidental result of biological samples. Despite the …
View article: Large-scale genetic characterization of Parkinson’s disease in the African and African admixed populations
Large-scale genetic characterization of Parkinson’s disease in the African and African admixed populations Open
Elucidating the genetic contributions to Parkinson’s disease (PD) etiology across diverse ancestries is a critical priority for the development of targeted therapies in a global context. We conducted the largest sequencing characterization…
View article: Interventions That Improve the Uptake of Antenatal Care Services in Sub-saharan Africa: a Systematic Review and Meta-analysis
Interventions That Improve the Uptake of Antenatal Care Services in Sub-saharan Africa: a Systematic Review and Meta-analysis Open
Introduction: Despite 70% of global maternal deaths occurring in sub-Saharan Africa (SSA), antenatal care (ANC) still remains underutilized with diverse, inconsistent impact from interventions. This systematic review identifies the most ef…
View article: Distribution Patterns of Neurography in Diabetic Neuropathy
Distribution Patterns of Neurography in Diabetic Neuropathy Open
Background Diabetic neuropathy (DN), a prevalent complication of diabetes, significantly impacts nerve function. Utilizing nerve conduction studies (NCS), this investigation delves into the intricate patterns of neuropathy in diabetic pati…
View article: Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans
Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans Open
Background African ancestry populations have the highest burden of stroke worldwide, yet the genetic basis of stroke in these populations is obscure. The Stroke Investigative Research and Educational Network (SIREN) is a multicenter study …
View article: Clinical and neuroimaging factors associated with 30-day fatality among indigenous West Africans with spontaneous intracerebral hemorrhage
Clinical and neuroimaging factors associated with 30-day fatality among indigenous West Africans with spontaneous intracerebral hemorrhage Open
View article: Non-cigarette Tobacco Use and Stroke Among West Africans: Evidence From the SIREN Study
Non-cigarette Tobacco Use and Stroke Among West Africans: Evidence From the SIREN Study Open
Introduction Non-cigarette tobacco (NCT) represents a form of tobacco use with a misperceived significance in chronic disease events. Whether NCT use is sufficient to promote stroke events, especially among Africans, is yet to be understoo…
View article: Risk Assessment Score and Chi-Square Automatic Interaction Detection Algorithm for Hypertension Among Africans: Models From the SIREN Study
Risk Assessment Score and Chi-Square Automatic Interaction Detection Algorithm for Hypertension Among Africans: Models From the SIREN Study Open
BACKGROUND: This study aimed to develop a risk-scoring model for hypertension among Africans. METHODS: In this study, 4413 stroke-free controls were used to develop the risk-scoring model for hypertension. Logistic regression models were a…
View article: Research participants’ perception of ethical issues in stroke genomics and neurobiobanking research in Africa
Research participants’ perception of ethical issues in stroke genomics and neurobiobanking research in Africa Open
Background There is a growing interest in stroke genomics and neurobiobanking research in Africa. These raise several ethical issues, such as consent, re-use, data sharing, storage, and incidental result of biological samples. Despite the …
View article: Patient-level and system-level determinants of stroke fatality across 16 large hospitals in Ghana and Nigeria: a prospective cohort study
Patient-level and system-level determinants of stroke fatality across 16 large hospitals in Ghana and Nigeria: a prospective cohort study Open
For the Twi, Yoruba and Hausa translations of the abstract see Supplementary Materials section.
View article: Are there differences in perceptions, preferences and attitudes towards disclosure of genetic testing for Stroke? A qualitative study among stroke-free SIREN-SIBS genomics study participants
Are there differences in perceptions, preferences and attitudes towards disclosure of genetic testing for Stroke? A qualitative study among stroke-free SIREN-SIBS genomics study participants Open
View article: Secondhand smoke exposure is independently associated with stroke among non-smoking adults in West Africa
Secondhand smoke exposure is independently associated with stroke among non-smoking adults in West Africa Open
View article: Magnitude of diabetic peripheral neuropathy in Saudi Arabia: a systematic review and meta-analysis
Magnitude of diabetic peripheral neuropathy in Saudi Arabia: a systematic review and meta-analysis Open
View article: Differential associations between pre-diabetes, diabetes and stroke occurrence among West Africans
Differential associations between pre-diabetes, diabetes and stroke occurrence among West Africans Open
View article: Frequent vegetable consumption is inversely associated with hypertension among indigenous Africans
Frequent vegetable consumption is inversely associated with hypertension among indigenous Africans Open
Aims The relationship between vegetable consumption and hypertension occurrence remains poorly characterized in sub-Saharan Africa. This study assessed the association of vegetable consumption with odds of hypertension among indigenous Afr…
View article: Biological sample donation and informed consent for neurobiobanking: Evidence from a community survey in Ghana and Nigeria
Biological sample donation and informed consent for neurobiobanking: Evidence from a community survey in Ghana and Nigeria Open
Introduction Genomic research and neurobiobanking are expanding globally. Empirical evidence on the level of awareness and willingness to donate/share biological samples towards the expansion of neurobiobanking in sub-Saharan Africa is lac…
View article: Capacity-Building for Stroke Genomic Research Data Collection: The African Neurobiobank Ethical, Legal, and Social Implications Project Experience
Capacity-Building for Stroke Genomic Research Data Collection: The African Neurobiobank Ethical, Legal, and Social Implications Project Experience Open
Background: The fields of stroke genomics, biobanking, and precision medicine are rapidly expanding in sub-Saharan Africa. However, the ethical, legal, and social implications (ELSI) of emerging neurobiobanking and genomic da…
View article: Legal Implications of Stroke Biobanking and Genomics Research in Sub-Saharan Africa.
Legal Implications of Stroke Biobanking and Genomics Research in Sub-Saharan Africa. Open
Stroke is a major cause of death in Sub-Saharan Africa (SSA) and genetic factors appear to play a part. This has led to stroke biobanking and genomics research in SSA. Existing stroke studies have focused on causes, incidence rates, fatali…
View article: Disease-specific quality of life in patients with diabetic neuropathy
Disease-specific quality of life in patients with diabetic neuropathy Open
D+DN participants had a worse HRQoL compared with D-DN and healthy counterparts. NDS, NNS, physical inactivity, abnormal NCS, and duration of DM independently predicted poor HRQoL in D+DN participants.
View article: Magnitude of Diabetic Neuropathy in Saudi Arabia: A Systematic Review and Meta-Analysis
Magnitude of Diabetic Neuropathy in Saudi Arabia: A Systematic Review and Meta-Analysis Open
Background: Diabetic peripheral neuropathy (DPN), due to its potential for causing morbidity and disability from foot ulcers and amputations, is increasingly becoming a source of concern in Saudi Arabia and worldwide. However, wide variabi…
View article: Motor Function Test Protocol for Parkinsonian Triad in Rodent Model of Parkinson's Disease
Motor Function Test Protocol for Parkinsonian Triad in Rodent Model of Parkinson's Disease Open
Over the years, there has been an increase in research on parkinsonism in basic and translational neuroscience. Parkinson's disease (PD) is a progressive neurodegenerative disorder vehemently associated with motor function deficits and oth…
View article: Normative Data for Ulnar Nerve Conduction and the Influence of Gender and Height on Ulnar Nerve Conduction Velocity in Healthy Nigerians
Normative Data for Ulnar Nerve Conduction and the Influence of Gender and Height on Ulnar Nerve Conduction Velocity in Healthy Nigerians Open
Background: Despite the usefulness of ulnar nerve conduction studies in identifying disorders of ulnar nerves, there is a lack of normative values for the ulnar nerve in Nigerian population. Objective: The objective of the study was to gen…
View article: Patient- and Health Facility-Level Determinants of Stroke Fatality Across 15 Large Hospitals in Ghana & Nigeria
Patient- and Health Facility-Level Determinants of Stroke Fatality Across 15 Large Hospitals in Ghana & Nigeria Open
View article: Symbolic legislation and the regulation of stroke biobanking and genomics research in Sub-Saharan Africa
Symbolic legislation and the regulation of stroke biobanking and genomics research in Sub-Saharan Africa Open
Stroke is a major cause of death in Sub-Saharan Africa (SSA) and genetic factors appear to play a part. This led to the development of stroke bio-banking and genomics research in SSA. Existing stroke studies have focused on causes, inciden…
View article: A Novel Afrocentric Stroke Risk Assessment Score: Models from the Siren Study
A Novel Afrocentric Stroke Risk Assessment Score: Models from the Siren Study Open