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View article: HBV DNA integration gene CCDC91 is oncogenic and a potential therapeutic target for hepatocellular carcinoma
HBV DNA integration gene CCDC91 is oncogenic and a potential therapeutic target for hepatocellular carcinoma Open
Hepatitis B virus (HBV) integration is strongly associated with hepatocellular carcinoma (HCC). However, the genetic alterations and pathogenesis mechanisms remain significantly unexplored, especially for HBV-inserted cancer-related genes.…
View article: An AI method to predict pregnancy loss by extracting biological indicators from embryo ultrasound recordings in early pregnancy
An AI method to predict pregnancy loss by extracting biological indicators from embryo ultrasound recordings in early pregnancy Open
View article: An ingenious design from nature to accelerate the repair of long-bone critical defects: the longitudinal tubular transverse interconnection structure of deer antlers
An ingenious design from nature to accelerate the repair of long-bone critical defects: the longitudinal tubular transverse interconnection structure of deer antlers Open
View article: The resistance of litchi fruit to Peronophythora litchii is associated with lignin biosynthesis and reactive oxygen species metabolism
The resistance of litchi fruit to Peronophythora litchii is associated with lignin biosynthesis and reactive oxygen species metabolism Open
View article: A ZnO-TiO2-Amygdalin nanocomposite for bone regeneration and antimicrobial activity
A ZnO-TiO2-Amygdalin nanocomposite for bone regeneration and antimicrobial activity Open
By decreasing bacterial infection and enhancing the bone repairing/healing process, nanomedicine has recently become an increasingly popular approach for addressing high infection risk and low bony reconstruction. Thus, in our study, we at…
View article: Camrelizumab combined with apatinib plus irinotecan as a second-line treatment in advanced or metastatic esophageal squamous cell carcinoma patients
Camrelizumab combined with apatinib plus irinotecan as a second-line treatment in advanced or metastatic esophageal squamous cell carcinoma patients Open
CAM combined with apatinib plus IRT as a second-line treatment exhibits acceptable efficacy and safety in advanced or metastatic ESCC patients. The model that combines clinical and radiomic features has the greatest ability to predict the …
View article: Interpretable Solutions for Multi-Physics PDEs Using T-NNGP
Interpretable Solutions for Multi-Physics PDEs Using T-NNGP Open
Multiphysics simulation aims to predict and understand interactions between multiple physical phenomena, aiding in comprehending natural processes and guiding engineering design. The system of Partial Differential Equations (PDEs) is cruci…
View article: Inhibition SIRT1 to regulate FOXP3 or RORγt can restore the balance of Treg/Th17 axis in ulcerative colitis and enhance the anti-inflammatory effect of moxibustion
Inhibition SIRT1 to regulate FOXP3 or RORγt can restore the balance of Treg/Th17 axis in ulcerative colitis and enhance the anti-inflammatory effect of moxibustion Open
Introduction Ulcerative colitis (UC) is a chronic inflammatory disease. Patients with UC typically exhibit disruption of the Treg/Th17 immune axis, but its exact mechanism is still unclear. Methods This study first analyzed RNA- seq data f…
View article: Ti6Al4V/xenogeneic bone composite promote osseointegration by recapitulating the osteogenic microenvironment
Ti6Al4V/xenogeneic bone composite promote osseointegration by recapitulating the osteogenic microenvironment Open
View article: The Resistance of Postharvest Litchi to Peronophythora Litchii is Associated with Lignin Biosynthesis and Reactive Oxygen Species Metabolism
The Resistance of Postharvest Litchi to Peronophythora Litchii is Associated with Lignin Biosynthesis and Reactive Oxygen Species Metabolism Open
View article: The combination of focal breast edema and adjacent vessel sign to assess the behavior of mass-type invasive ductal carcinoma
The combination of focal breast edema and adjacent vessel sign to assess the behavior of mass-type invasive ductal carcinoma Open
The BPS is a valuable, non-invasive biomarker for assessing the aggressiveness of M-IDC and can facilitate treatment planning.
View article: The combination of focal breast edema and adjacent vessel sign to assess the behavior of mass-type invasive ductal carcinoma
The combination of focal breast edema and adjacent vessel sign to assess the behavior of mass-type invasive ductal carcinoma Open
Objectives To investigate whether the combination of focal breast edema (FBE) and adjacent vessel sign (AVS) can provide valuable biological information for personalized treatment of patients with mass-type invasive ductal carcinoma (M-IDC…
View article: Safety and Efficacy of Rechallenge With Immune Checkpoint Inhibitors in Advanced Solid Tumor: A Systematic Review and Meta‐Analysis
Safety and Efficacy of Rechallenge With Immune Checkpoint Inhibitors in Advanced Solid Tumor: A Systematic Review and Meta‐Analysis Open
Background Immune checkpoint inhibitors (ICIs) have drastically shifted the current landscape toward a wide variety of malignancies. However, ICIs are interrupted owing immune‐related adverse events (irAEs), therapy completion, and disease…
View article: The aberrant tonsillar microbiota modulates autoimmune responses in rheumatoid arthritis
The aberrant tonsillar microbiota modulates autoimmune responses in rheumatoid arthritis Open
Palatine tonsils are the only air-contacted lymphoid organs that constantly engage in crosstalk with commensal microorganisms and serve as the first handling sites against microbial antigens. While tonsil inflammations have been implicated…
View article: Synthesized manganese oxide nanorods: Fabrication, characterization, application in cardiomyocyte protection from oxidative stress during sepsis, and evaluation of biochemical aspects of hemoglobin interaction
Synthesized manganese oxide nanorods: Fabrication, characterization, application in cardiomyocyte protection from oxidative stress during sepsis, and evaluation of biochemical aspects of hemoglobin interaction Open
Oxidative stress during sepsis could play a crucial role in the pathogenesis of several diseases, especially cardiovascular disorders. In fact, myocardial dysfunction during sepsis is caused by a number of chemicals, one of which is hydrog…
View article: An Interpretable Approach to the Solutions of High-Dimensional Partial Differential Equations
An Interpretable Approach to the Solutions of High-Dimensional Partial Differential Equations Open
In recent years, machine learning algorithms, especially deep learning, have shown promising prospects in solving Partial Differential Equations (PDEs). However, as the dimension increases, the relationship and interaction between variable…
View article: Identification of hepatitis B virus infection and integration and its oncogenic role in gastric cancer
Identification of hepatitis B virus infection and integration and its oncogenic role in gastric cancer Open
Dear Editor, Hepatitis B virus (HBV) infection has been considered an important role in hepatocellular carcinoma (HCC). However, the evidence between HBV and gastric cancer (GC) is limited.1 In this study, HBV integration is identified, fo…
View article: Epidemiological characteristics of traumatic spinal cord injuries in the intensive care unit from 2018 to 2023: a retrospective hospital-based study
Epidemiological characteristics of traumatic spinal cord injuries in the intensive care unit from 2018 to 2023: a retrospective hospital-based study Open
Falls from height and traffic accidents were the main causes of TSCIs in the ICU, especially for male patients with cervical spinal cord injuries. VTE is a frequent complication in patients with TSCI in the ICU. Age, mechanical ventilation…
View article: CTRP4/interleukin-6 receptor signaling ameliorates autoimmune encephalomyelitis by suppressing Th17 cell differentiation
CTRP4/interleukin-6 receptor signaling ameliorates autoimmune encephalomyelitis by suppressing Th17 cell differentiation Open
C1q/TNF-related protein 4 (CTRP4) is generally thought to be released extracellularly and plays a critical role in energy metabolism and protecting against sepsis. However, its physiological functions in autoimmune diseases have not been t…
View article: High-throughput sequencing unveils HBV DNA integration and its oncogenic role in gastric cancer
High-throughput sequencing unveils HBV DNA integration and its oncogenic role in gastric cancer Open
Growing evidence showed an association between hepatitis B virus (HBV) infection and gastric cancer (GC). HBV DNA integration is one of the key mechanisms contributing to hepatocellular carcinoma (HCC) development. However, the status of H…
View article: Robust Graph Meta-Learning via Manifold Calibration with Proxy Subgraphs
Robust Graph Meta-Learning via Manifold Calibration with Proxy Subgraphs Open
Graph meta-learning has become a preferable paradigm for graph-based node classification with long-tail distribution, owing to its capability of capturing the intrinsic manifold of support and query nodes. Despite the remarkable success, g…
View article: Multiple epithelioid angiosarcoma of stomach and small intestine with multiple lymph node metastases: A case report
Multiple epithelioid angiosarcoma of stomach and small intestine with multiple lymph node metastases: A case report Open
Rationale: Angiosarcoma is a mesenchymal soft tissue sarcoma with a tendency for vascular endothelial differentiation. It is highly malignant with a poor prognosis but has a low incidence. Epithelioid angiosarcoma of the gastrointestinal t…
View article: Ultrasensitive Detection of Glucose Oxidase and Alkaline Phosphatase in Milk Based on Valence Regulated Upconversion Nanoprobes
Ultrasensitive Detection of Glucose Oxidase and Alkaline Phosphatase in Milk Based on Valence Regulated Upconversion Nanoprobes Open
View article: A survey of caregiver burden for stroke survivors in non-teaching hospitals in Western China
A survey of caregiver burden for stroke survivors in non-teaching hospitals in Western China Open
The social factors that moderate stroke caregiver burden have been found to be culture- and gender-specific. We examined the factors that influence the social support and self-efficacy of caregivers of stroke survivors and the burden of ca…
View article: Serological and Molecular Characterization of Hepatitis B Virus Infection in Gastric Cancer
Serological and Molecular Characterization of Hepatitis B Virus Infection in Gastric Cancer Open
Hepatitis B virus (HBV) infection has been reported to be associated with gastric cancer (GC). Nonetheless, no study has revealed the role of HBV infection in the survival of patients with GC, and the mutation profiles of HBV-infected pati…
View article: Efficacy and safety of intermittent versus continuous dose apatinib plus docetaxel as second-line therapy in patients with advanced gastric cancer or gastroesophageal junction adenocarcinoma: a randomized controlled study
Efficacy and safety of intermittent versus continuous dose apatinib plus docetaxel as second-line therapy in patients with advanced gastric cancer or gastroesophageal junction adenocarcinoma: a randomized controlled study Open
ClinicalTrials.gov NCT03334591.
View article: A case report of esophageal metastasis from breast cancer
A case report of esophageal metastasis from breast cancer Open
Introduction: The common metastatic sites of breast carcinoma are the lymph nodes, liver, lungs and bone. Breast cancer metastasis to esophagus is a rarity with an incidence of 0.03% to 0.6%. Patient concerns: A 63-year-old woman presented…
View article: Knockdown of CENPK inhibits cell growth and facilitates apoptosis via PTEN‐PI3K‐AKT signalling pathway in gastric cancer
Knockdown of CENPK inhibits cell growth and facilitates apoptosis via PTEN‐PI3K‐AKT signalling pathway in gastric cancer Open
Previous studies have indicated that centromere protein K (CENPK) is upregulated in several cancers and related to tumorigenesis. Nevertheless, the potential function of CENPK in gastric cancer (GC) remains unknown. Here, we investigated t…
View article: CTRP4 binds to the interleukin-6 Receptor and ameliorates autoimmune encephalomyelitis by suppressing Th17 cell differentiation
CTRP4 binds to the interleukin-6 Receptor and ameliorates autoimmune encephalomyelitis by suppressing Th17 cell differentiation Open
CTRP4, a secreted protein, plays an important role in protecting against sepsis and energy metabolism; however, its physiological functions in autoimmune disease remain unknown. In this study, we demonstrate that Th17 cell-associated exper…
View article: Analysis of the Relationship Between Preoperative Arterial Oxygen Partial Pressure and Acute Kidney Injury after Surgery for Tetralogy of Fallot and Explore the Related Risk Factors
Analysis of the Relationship Between Preoperative Arterial Oxygen Partial Pressure and Acute Kidney Injury after Surgery for Tetralogy of Fallot and Explore the Related Risk Factors Open
Background: Acute kidney injury (AKI) is a severe complication of pediatric cardiothoracic surgery (CTS). It is debatable whether patients with the low preoperative arterial partial pressure of oxygen (PaO2) are more likely to develop AKI …