Lihua Shen
YOU?
Author Swipe
View article: Levodopa/carbidopa/entacapone versus levodopa/benserazide plus pramipexole in Chinese patients with Parkinson’s disease experiencing wearing off
Levodopa/carbidopa/entacapone versus levodopa/benserazide plus pramipexole in Chinese patients with Parkinson’s disease experiencing wearing off Open
Objective To compare the efficacy and safety of direct switch from levodopa/benserazide (LB) to levodopa/carbidopa/entacapone (LCE) versus LB plus pramipexole (PPX) in Chinese patients with Parkinson’s disease (PD) experiencing wearing off…
View article: Hepcidin sustains Kupffer cell immune defense against bloodstream bacterial infection via gut-derived metabolites in mice
Hepcidin sustains Kupffer cell immune defense against bloodstream bacterial infection via gut-derived metabolites in mice Open
Bloodstream bacterial infections cause one-third of deaths from bacterial infections, and eradication of circulating bacteria is essential to prevent disseminated infections. Here, we found that hepcidin, the master regulator of systemic i…
View article: Visualization of subthalamic nucleus on susceptibility weighted imaging and the verification of accuracy by microelectrode recording
Visualization of subthalamic nucleus on susceptibility weighted imaging and the verification of accuracy by microelectrode recording Open
Objective To investigate the advantages of susceptibility weighted imaging (SWI) for visualizing the subthalamic nucleus (STN) and to verify the accuracy of this method by microelectrode recordings (MERs) and deep brain stimulation (DBS). …
View article: Caspase-1-licensed pyroptosis drives dsRNA-mediated necroptosis and dampens host defense against bacterial pneumonia
Caspase-1-licensed pyroptosis drives dsRNA-mediated necroptosis and dampens host defense against bacterial pneumonia Open
Bacterial lung infections cause severe host responses. Here, we showed that global deficiency of caspase-1 can protect against lethal pulmonary Escherichia coli infection by reducing the necroptosis of infiltrated neutrophils, which are ke…
View article: Association between deep gray matter iron deposition and clinical symptoms in Parkinson’s disease: a quantitative susceptibility mapping study
Association between deep gray matter iron deposition and clinical symptoms in Parkinson’s disease: a quantitative susceptibility mapping study Open
Purpose This study aimed to assess the association between motor and non-motor symptoms of Parkinson’s disease (PD) and iron accumulation within the deep gray matter of the brain by Quantitative Susceptibility Mapping (QSM). Methods Fifty-…
View article: Molecular phylogeny and morphology reveal a new wood-inhabiting fungal species of Conferticium (Stereaceae, Basidiomycota) from southwest China
Molecular phylogeny and morphology reveal a new wood-inhabiting fungal species of Conferticium (Stereaceae, Basidiomycota) from southwest China Open
A new wood-inhabiting fungus, Conferticium fissuratum is proposed based on morphological features and molecular phylogenetic evidence. It is characterized by the membranous basidiomata with the tuberculate hymenial surface, a monomitic hyp…
View article: Enhanced strategies for water and fertilizer management to optimize yields and promote environmental sustainability in the mechanized harvesting of ratoon rice in Southeast China
Enhanced strategies for water and fertilizer management to optimize yields and promote environmental sustainability in the mechanized harvesting of ratoon rice in Southeast China Open
Ratoon rice utilizes the axillary buds sprouting from the remaining stubble of the main crop after harvest to form panicles, enabling a second harvest. However, mechanized harvesting often resulted in damage to the rice stubbles in the rol…
View article: CircSKA3 is Associated With the Risk of Extracranial Artery Stenosis and Plaque Instability Among Ischemic Stroke Patients
CircSKA3 is Associated With the Risk of Extracranial Artery Stenosis and Plaque Instability Among Ischemic Stroke Patients Open
View article: Supine transfer test-induced changes in cardiac index predict fluid responsiveness in patients without intra-abdominal hypertension
Supine transfer test-induced changes in cardiac index predict fluid responsiveness in patients without intra-abdominal hypertension Open
Background The reversible maneuver that mimics the fluid challenge is a widely used test for evaluating volume responsiveness. However, passive leg raising (PLR) does have certain limitations. The aim of the study is to determine whether t…
View article: Applying Blockchain Technology and the Internet of Things to Improve the Data Reliability for Livestock Insurance
Applying Blockchain Technology and the Internet of Things to Improve the Data Reliability for Livestock Insurance Open
Animal husbandry is a vital sector in China’s agriculture sector, contributing to over one-third of its agricultural output, and more than 40% of farmers’ income. However, this industry is vulnerable to risks arising from production and op…
View article: Characterization of immunomodulatory factors and cells in bronchoalveolar lavage fluid for immune checkpoint inhibitor-related pneumonitis
Characterization of immunomodulatory factors and cells in bronchoalveolar lavage fluid for immune checkpoint inhibitor-related pneumonitis Open
As immune checkpoint inhibitors (ICIs) are widely used, a series of immune-related adverse events (irAEs) have been reported, including immune checkpoint inhibitor-related pneumonitis (ICI-pneumonitis). The incidence of ICI-pneumonitis is …
View article: Effects of the configurations with different organic and inorganic fertilizers on grain yield and its related physiological traits of the main and its ratoon rice crops
Effects of the configurations with different organic and inorganic fertilizers on grain yield and its related physiological traits of the main and its ratoon rice crops Open
The determination for properly combined application rate of organic and inorganic fertilizers is the key to coordinating soil nutrient supplies and rice growth demands, thereby obtaining improved economic and ecological returns in rice rat…
View article: Case Report: Treatment for steroid-refractory immune-related myocarditis with tofacitinib
Case Report: Treatment for steroid-refractory immune-related myocarditis with tofacitinib Open
Introduction Immune therapy has ushered in a new era of tumor treatment, at the expense of immune-related adverse events, including rare but fatal adverse cardiovascular events, such as myocarditis. Steroids remain the cornerstone of thera…
View article: Sequence Type 5 (ST5) as a Possible Predictor of Bacterial Persistence in Adult Patients with Methicillin-Resistant Staphylococcus aureus Pneumonia Treated with Vancomycin
Sequence Type 5 (ST5) as a Possible Predictor of Bacterial Persistence in Adult Patients with Methicillin-Resistant Staphylococcus aureus Pneumonia Treated with Vancomycin Open
Few studies have simultaneously examined the influence of clinical characteristics of patients with pneumonia, the vancomycin pharmacokinetic/pharmacodynamic (PK/PD) index, and the phenotypic and genetic characteristics of methicillin-resi…
View article: Zishen pingchan granules combined with pramipexole in the improvement of depressive symptoms in Parkinson's disease: a prospective, multicenter, randomized, double-blind, controlled clinical study
Zishen pingchan granules combined with pramipexole in the improvement of depressive symptoms in Parkinson's disease: a prospective, multicenter, randomized, double-blind, controlled clinical study Open
View article: Human Neutrophil Defensins Disrupt Liver Interendothelial Junctions and Aggravate Sepsis
Human Neutrophil Defensins Disrupt Liver Interendothelial Junctions and Aggravate Sepsis Open
Human neutrophil peptides 1-3 (HNP1-3), also known as human α-defensins, are the most abundant neutrophil granule proteins. The genes that encode HNP1-3, DEFA1/DEFA3, exhibit extensive copy number variations, which correlate well with thei…
View article: DL-3-n-butylphthalide alleviates motor disturbance by suppressing ferroptosis in a rat model of Parkinson’s disease
DL-3-n-butylphthalide alleviates motor disturbance by suppressing ferroptosis in a rat model of Parkinson’s disease Open
DL-3-n-butylphthalide (NBP)-a compound isolated from Apium graveolens seeds-is protective against brain ischemia via various mechanisms in humans and has been approved for treatment of acute ischemic stroke. NBP has shown recent potential …
View article: Changes in the Cardiac Index Induced by Unilateral Passive Leg Raising in Spontaneously Breathing Patients: A Novel Way to Assess Fluid Responsiveness
Changes in the Cardiac Index Induced by Unilateral Passive Leg Raising in Spontaneously Breathing Patients: A Novel Way to Assess Fluid Responsiveness Open
Background Evaluation of fluid responsiveness in intensive care unit (ICU) patients is crucial. This study was to determine whether changes in the cardiac index (CI) induced by a unilateral passive leg raising (PLR) test in spontaneously b…
View article: The diagnostic value of endoplasmic reticulum stress-related specific proteins GRP78 and CHOP in patients with sepsis: a diagnostic cohort study
The diagnostic value of endoplasmic reticulum stress-related specific proteins GRP78 and CHOP in patients with sepsis: a diagnostic cohort study Open
Compared with traditional inflammatory markers, ERS-related specific proteins GRP78 and CHOP have better sensitivity and specificity in the diagnosis of sepsis, which is helpful for clinicians in the diagnosis of sepsis.
View article: Changes in Cardiac Index Induced by Unilateral Passive Leg Raising: a Novel Way for Assessing Fluid Responsiveness
Changes in Cardiac Index Induced by Unilateral Passive Leg Raising: a Novel Way for Assessing Fluid Responsiveness Open
Background: To evaluate the fluid responsiveness of patients, we examined the change in cardiac index (CI) during a unilateral passive leg raising (PLR) test using the ProAQT/Pulsioflex. In addition, we compared the change of CI triggered …
View article: Methodological Considerations in N-of-1 Trials of Traditional Chinese Medicine
Methodological Considerations in N-of-1 Trials of Traditional Chinese Medicine Open
More and more scholars choose N-of-1 trials for TCM clinical research. However, the quality of the experimental designs was uneven. Accumulating more than eight years of experience in exploring the N-of-1 trials of TCM, the authors and the…
View article: A Series of N-of-1 Trials for Traditional Chinese Medicine Using a Bayesian Method: Study Rationale and Protocol
A Series of N-of-1 Trials for Traditional Chinese Medicine Using a Bayesian Method: Study Rationale and Protocol Open
Background. Our previous studies showed that N-of-1 trials could reflect the individualized characteristics of traditional Chinese medicine (TCM) syndrome differentiation with good feasibility, but the sensitivity was low. Therefore, this …
View article: The efficacy and safety of moderate aerobic exercise for patients with Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials
The efficacy and safety of moderate aerobic exercise for patients with Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials Open
Background: Exercise therapy is an important component of non-drug treatment for Parkinson’s disease (PD). However, the impact of moderate aerobic exercise on PD remains unclear. The purpose of this systematic review was to evaluate the ef…
View article: Hepcidin Decreases Rotenone-Induced α-Synuclein Accumulation via Autophagy in SH-SY5Y Cells
Hepcidin Decreases Rotenone-Induced α-Synuclein Accumulation via Autophagy in SH-SY5Y Cells Open
Parkinson's disease (PD) is a neurodegenerative disorder, and the hallmarks of this disease include iron deposition and α-synuclein (α-syn) aggregation. Hepcidin could reduce iron in the central and peripheral nervous systems. Here, we hyp…
View article: Hypoxic preconditioning enhances the differentiation of bone marrow stromal cells into mature oligodendrocytes via the mTOR/HIF‐1α/VEGF pathway in traumatic brain injury
Hypoxic preconditioning enhances the differentiation of bone marrow stromal cells into mature oligodendrocytes via the mTOR/HIF‐1α/VEGF pathway in traumatic brain injury Open
Objective Traumatic brain injury (TBI) results not only in gray matter damage, but also in severe white matter injury (WMI). Previous findings support hypoxic preconditioning (HP) could augment the efficacy of bone marrow stromal cell (BMS…
View article: Myositis-myasthenia gravis overlap syndrome complicated with myasthenia crisis and myocarditis associated with anti-programmed cell death-1 (sintilimab) therapy for lung adenocarcinoma
Myositis-myasthenia gravis overlap syndrome complicated with myasthenia crisis and myocarditis associated with anti-programmed cell death-1 (sintilimab) therapy for lung adenocarcinoma Open
Immune checkpoint inhibitors (ICIs) have improved clinical outcomes with a number of advanced malignancies. However, diverse immune-related adverse events (iRAEs) occurred with the widespread use of ICIs, some of which are rarely and life-…
View article: Therapeutic observation of electroacupuncture treatment for primary dysmenorrhea
Therapeutic observation of electroacupuncture treatment for primary dysmenorrhea Open
Objective: To observe the clinical efficacy of electroacupuncture treatment for primary dysmenorrhea. Methods: In total 75 patients with primary dysmenorrhea were randomized into electroacupuncture with point injection group (37 patients),…
View article: A Prospective Multicenter Clinical Observational Study on Vancomycin Efficiency and Safety With Therapeutic Drug Monitoring
A Prospective Multicenter Clinical Observational Study on Vancomycin Efficiency and Safety With Therapeutic Drug Monitoring Open
ChiCTR-OPC-16007920.
View article: Heterogeneity of lipidomic profiles among lung cancer subtypes of patients
Heterogeneity of lipidomic profiles among lung cancer subtypes of patients Open
Lung cancer is a leading cause of cancer‐related deaths with an increasing incidence and poor prognoses. To further understand the regulatory mechanisms of lipidomic profiles in lung cancer subtypes, we measure the profiles of plasma lipid…
View article: Incorporation of RG1 epitope concatemers into a self-adjuvanting Flagellin-L2 vaccine broaden durable protection against cutaneous challenge with diverse human papillomavirus genotypes
Incorporation of RG1 epitope concatemers into a self-adjuvanting Flagellin-L2 vaccine broaden durable protection against cutaneous challenge with diverse human papillomavirus genotypes Open
Vaccination with flagellin fused L2 multimers provided lasting (>1year) immunity without the need for an exogenous adjuvant. Inclusion of the L2 amino acid 17-38 region in such multi-HPV type fusions expanded the spectrum of protection.