Luna Colagrossi
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View article: Whole-Genome Sequencing of Adenovirus Genotypes and Clinical Implications in Pediatric Patients
Whole-Genome Sequencing of Adenovirus Genotypes and Clinical Implications in Pediatric Patients Open
Human adenoviruses (HAdV) comprise more than 100 genotypes with species-specific differences in tropism and immune response and can cause severe infections in immunocompromised patients. This study aimed to characterise the HAdV species in…
View article: Clinical manifestations and severity of COVID-19 caused by Omicron among paediatric patients aged 0–17 years in Italy
Clinical manifestations and severity of COVID-19 caused by Omicron among paediatric patients aged 0–17 years in Italy Open
View article: Viral Burden of Respiratory Syncytial Virus and Viral Coinfections as Factors Regulating Paediatric Disease Severity
Viral Burden of Respiratory Syncytial Virus and Viral Coinfections as Factors Regulating Paediatric Disease Severity Open
Background: Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections (ARIs) in children. However, the clinical impact of RSV co-infection with other respiratory viruses remains unclear. This study investigates t…
View article: Viral dynamics and factors associated with duration of COVID-19 positivity: evidence from the first-three epidemiological waves in Cameroon
Viral dynamics and factors associated with duration of COVID-19 positivity: evidence from the first-three epidemiological waves in Cameroon Open
View article: Parvovirus B19 Rebound
Parvovirus B19 Rebound Open
Human parvovirus B19 (B19V) is responsible for a wide clinical spectrum ranging from asymptomatic infection, through mild disease, up to life‐threatening one. Outbreaks are registered every 3–4 years, and a recent international alert for a…
View article: Assessing the utilization of HIV genotype resistance testing: Insight from Italian Infectious Diseases Units
Assessing the utilization of HIV genotype resistance testing: Insight from Italian Infectious Diseases Units Open
View article: A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease
A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease Open
View article: A case of Ustilago spp. infection identified by whole genome sequencing in a pediatric patient undergoing open-chest extracorporeal membrane oxygenation
A case of Ustilago spp. infection identified by whole genome sequencing in a pediatric patient undergoing open-chest extracorporeal membrane oxygenation Open
To the best of our knowledge, we presented the first case of an Ustilago spp infection in a pediatric patient undergoing ECMO, not identified by standard techniques but only by WGS performed directly on a blood sample in 5 days. Despite th…
View article: Management of low-level HIV viremia during antiretroviral therapy: Delphi consensus statement and appraisal of the evidence
Management of low-level HIV viremia during antiretroviral therapy: Delphi consensus statement and appraisal of the evidence Open
Objective While antiretroviral therapy (ART) is highly effective, detection of low levels of HIV-1 RNA in plasma is common in treated individuals. Given the uncertainties on the topic, we convened a panel of experts to consider different c…
View article: Managing low-level HIV viraemia in antiretroviral therapy: a systematic review and meta-analysis
Managing low-level HIV viraemia in antiretroviral therapy: a systematic review and meta-analysis Open
Objective HIV-1 management has advanced significantly with antiretroviral therapy (ART), yet challenges persist, including low-level HIV-1 viraemia (LLV). LLV presents a complex scenario, with varied definitions in the literature, reflecti…
View article: Whooping Cough Cases Increase in Central Italy after COVID-19 Pandemic
Whooping Cough Cases Increase in Central Italy after COVID-19 Pandemic Open
Pertussis continues to be a highly contagious respiratory infection, especially in children, with cyclical peaks of disease spread every three to five years. Here, we report relevant cases of B. pertussis infection between August 2023 and …
View article: Presence and Significance of Multiple Respiratory Viral Infections in Children Admitted to a Tertiary Pediatric Hospital in Italy
Presence and Significance of Multiple Respiratory Viral Infections in Children Admitted to a Tertiary Pediatric Hospital in Italy Open
Viral co-infections are frequently observed among children, but whether specific viral interactions enhance or diminish the severity of respiratory disease is still controversial. This study aimed to investigate the type of viral mono- and…
View article: Acute Hepatitis of Unknown Origin in Children: Analysis of 17 Cases Admitted to the Bambino Gesù Children’s Hospital in Rome
Acute Hepatitis of Unknown Origin in Children: Analysis of 17 Cases Admitted to the Bambino Gesù Children’s Hospital in Rome Open
This study described 17 cases of children admitted to the Bambino Gesù Children’s Hospital with acute hepatitis of unknown origin between mid-April and November 2022. Following the World Health Organization’s working case definition of pro…
View article: SARS-CoV-2 genomic surveillance and reliability of PCR single point mutation assay (SNPsig® SARS-CoV-2 EscapePLEX CE) for the rapid detection of variants of concern in Cameroon
SARS-CoV-2 genomic surveillance and reliability of PCR single point mutation assay (SNPsig® SARS-CoV-2 EscapePLEX CE) for the rapid detection of variants of concern in Cameroon Open
View article: PA-357 COVID-19 monitoring in Cameroon reveals men and elderly persons at risk of prolonged duration of positivity: a contribution toward Long-COVID
PA-357 COVID-19 monitoring in Cameroon reveals men and elderly persons at risk of prolonged duration of positivity: a contribution toward Long-COVID Open
Background The novel Coronavirus 2019 pandemic brings about overwhelming demographic, social, and economic damage worldwide. Evidence on disease progression (COVID-19) and viral clearance time remain limited in resource limited settings. S…
View article: PA-581 Population-based surveillance of anti-sars-cov-2 antibodies according to vaccine-status in Cameroon: evidence from the EDCTP perfect-study
PA-581 Population-based surveillance of anti-sars-cov-2 antibodies according to vaccine-status in Cameroon: evidence from the EDCTP perfect-study Open
Background Anti-SARS-CoV-2 vaccine remains a global health priority but there is scarcity of evidence on post-vaccine response from sub-Saharan Africa countries. Our objective was to assess the overall rate of SARS-CoV-2 immunity and its a…
View article: Influenza viruses circulation in a tertiary care children hospital in Rome: a comparison between 2022 and the previous 5 years
Influenza viruses circulation in a tertiary care children hospital in Rome: a comparison between 2022 and the previous 5 years Open
View article: Prevalence of Epstein-Barr Virus infection in a cohort of onco-hematologic paediatric patients
Prevalence of Epstein-Barr Virus infection in a cohort of onco-hematologic paediatric patients Open
Not available.
View article: A case of SARS-CoV-2 Omicron reinfection resulting in a significant immunity boost in a paediatric patient affected by B-cell acute lymphoblastic leukemia
A case of SARS-CoV-2 Omicron reinfection resulting in a significant immunity boost in a paediatric patient affected by B-cell acute lymphoblastic leukemia Open
View article: Performance evaluation of a new on-demand molecular test for the rapid identification of severe acute respiratory syndrome coronavirus 2 in pediatric and adult patients
Performance evaluation of a new on-demand molecular test for the rapid identification of severe acute respiratory syndrome coronavirus 2 in pediatric and adult patients Open
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has increased the need to identify additional rapid diagnostic tests for an accurate and early diagnosis of infection. Here, we evaluated the diagno…
View article: Lessons from SARS-CoV-2 Pandemics: How Restrictive Measures Impacted the Trend of Respiratory Infections in Neonates and Infants up to Three Months of Age
Lessons from SARS-CoV-2 Pandemics: How Restrictive Measures Impacted the Trend of Respiratory Infections in Neonates and Infants up to Three Months of Age Open
(1) Background: Massive social efforts to prevent the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have affected the epidemiological features of respiratory infections. (2) Methods: The study aims to …
View article: Diagnostic performance of molecular and serological tests of SARS-CoV-2 on well-characterised specimens from COVID-19 individuals: The EDCTP "PERFECT-study" protocol (RIA2020EF-3000)
Diagnostic performance of molecular and serological tests of SARS-CoV-2 on well-characterised specimens from COVID-19 individuals: The EDCTP "PERFECT-study" protocol (RIA2020EF-3000) Open
Background The SARS-CoV-2 pandemic is a global threat affecting 210 countries, with 2,177,469 confirmed cases and 6.67% case fatality rate as of April 16, 2020. In Africa, 17,243 cases have been confirmed, but many remain undiagnosed due t…
View article: Publisher Correction: Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation
Publisher Correction: Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation Open
View article: Evaluation of Safety and Immunogenicity of BNT162B2 mRNA COVID-19 Vaccine in IBD Pediatric Population with Distinct Immune Suppressive Regimens
Evaluation of Safety and Immunogenicity of BNT162B2 mRNA COVID-19 Vaccine in IBD Pediatric Population with Distinct Immune Suppressive Regimens Open
Patients affected by Inflammatory Bowel Disease (IBD) present higher risk for infection and suboptimal response upon vaccination. The immunogenicity of SARS-CoV2 vaccination is still largely unknown in adolescents or young adults affected …
View article: Perinatally Human Immunodeficiency Virus–Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity
Perinatally Human Immunodeficiency Virus–Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity Open
Background Immunization of vulnerable populations with distinct immunity often results in suboptimal immunogenicity, durability, and efficacy. Methods Safety and immunogenicity profiles of BNT162b2 messenger RNA coronavirus disease 2019 (C…
View article: Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment
Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment Open
We described the case of a patient affected by activated PI3K-kinase delta syndrome (APDS) and a long-lasting and pauci-symptomatic SARS-CoV-2 infection, treated with multiple therapeutic agents including remdesivir and SARS-CoV-2-neutrali…
View article: Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation
Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation Open
Since the start of SARS-CoV-2 pandemic, children aged ≤ 12 years have always been defined as underrepresented in terms of SARS-CoV-2 infections’ frequency and severity. By correlating SARS-CoV-2 transmission dynamics with clinical and viro…
View article: High concordance in SARSCoV-2 detection between automated (Abbott m2000) and manual (DaAn gene) RT-PCR systems: The EDCTP PERFECT-Study in Cameroon
High concordance in SARSCoV-2 detection between automated (Abbott m2000) and manual (DaAn gene) RT-PCR systems: The EDCTP PERFECT-Study in Cameroon Open
Molecular diagnosis of COVID-19 is critical to the control of the pandemic, which is a major threat to global health. Several molecular tests have been validated by WHO, but would require operational evaluation in the field to ensure their…
View article: Evidence of pediatric sepsis caused by a drug resistant <i>Lactococcus garvieae</i> contaminated platelet concentrate
Evidence of pediatric sepsis caused by a drug resistant <i>Lactococcus garvieae</i> contaminated platelet concentrate Open
Owing to an increasing number of infections in adults, Lactococcus (L.) garvieae has gained recognition as an emerging human pathogen, causing bacteraemia and septicaemia. In September 2020, four paediatric onco-hematologic patients…
View article: Safety and Long-Term Immunogenicity of BNT162b2 Vaccine in Individuals with Down Syndrome
Safety and Long-Term Immunogenicity of BNT162b2 Vaccine in Individuals with Down Syndrome Open
We aimed to evaluate the safety and immunogenicity of the BNT162b2 vaccine in young people with Down syndrome (DS), and to compare their humoral immune response with those of the healthy controls (HC). Individuals with DS and HC received t…