Explanipedia

Monsoon differences in South Asia and East Asia during the penultimate deglaciation revealed by speleothem oxygen isotopes Open

Jingyao Zhao, Liangkang Pan, Qingming Luo, Jian Wang, Kexin Wang , et al. · 2025

Difference between the South Asian Summer Monsoon (SASM) and East Asian Summer Monsoon (EASM) is observed in modern climate variations, but remains unclear on the orbital timescales. In this study, we reconstruct the monsoon history using …

Semantic-Enhanced Feature Matching with Learnable Geometric Verification for Cross-Modal Neuron Registration Open

Lingyi Cai, Hui Gong, Qingming Luo, Anan Li · 2025

Accurately registering in-vivo two-photon and ex-vivo fluorescence micro-optical sectioning tomography images of individual neurons is critical for structure-function analysis in neuroscience. This task is profoundly challenging due to a s…

Multi-centric origins and gene flow shape the diversity of β-thalassemia mutations in Southern East Asia Open

Qianqian Zhang, Haoyang Huang, Xuan Shang, Yuhua Ye, Wei Zhang , et al. · 2025

Mouse Forebrain Region Features and Cholinergic Neurons Subtyping: Integrated Analysis with Spatial Multi-omics Open

Yujie Chen, Jiayue Meng, Dongjian Cao, Qingming Luo, Guoqing Zhang · 2025

The forebrain regions display distinct yet under-characterized gene expression patterns. In this study, we analyzed region-specific feature genes in forebrain regions and Isocortex subregions at both the transcriptomic and proteomic levels…

Lightweight Richardson-Lucy network for accelerated fluorescence microscope deconvolution Open

Xiaojun Zhao, Yanan Xiao, H.Z. Wu, Guangcai Liu, Hui Gong , et al. · 2025

Fluorescence microscopy contrast and resolution can be greatly improved through deconvolution. Deep unfolding deconvolution networks have recently received significant attention by combining the interpretability of traditional models with …

Celebrating three years of Science in One Health: shaping a transdisciplinary community Open

Han-Qing Zhao, L. A. Babiuk, Robin B. Gasser, Yvon Le Maho, Jianguo Xu , et al. · 2025

Immune Cells Mediate the Causal Pathway Linking Multisite Chronic Pain to Asthma: A Mediation Mendelian Randomization Study Open

Jie-Hai Chen, Nian-Hua Deng, Yongcheng Li, Xiao-Chun Zhu, Phillip S. Ge , et al. · 2025

Our findings revealed that MCP is significantly associated with a higher risk of asthma, which is partially mediated by immune cells.

A whole-brain male mouse atlas of long-range inputs to histaminergic neurons Open

Wenkai Lin, Xinyan Zhu, Xuemin Yu, Zhuowen Fang, Qing Xia , et al. · 2025

The precise structural and functional characteristics of input circuits targeting histaminergic neurons remain poorly understood. Here, using a rabies virus retrograde tracing system combined with fluorescence micro-optical sectioning tomo…

Fully Automated and Scalable Pipeline for Macaque Brain Registration Open

Junjie Zhuo, Z. Zhang, Chi Xiao, M. Z. Wang, Shmushkovich Bi , et al. · 2025

With the rapid development of various whole-brain ex vivo imaging technologies, there is a growing need to develop cross-modal 3D image registration methods to integrate multimodal imaging datasets. While comprehensive cross-modality regis…

A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution Open

Zhao Feng, Xiangning Li, Yue Luo, Xin Liu, Ben Long , et al. · 2025

Multi-omics studies, represented by connectomes and spatial transcriptomes, have entered the era of single-cell resolution, necessitating a reference brain atlas with spatial localization capability at the single-cell level 1–4 . However, …

Quantitative longitudinal investigation of non-alcoholic steatohepatitis in mice by photoacoustic microscopy Open

Jianshuang Wei, Ren Zhang, Ming Jiang, Lulu Gao, Ximiao Yu , et al. · 2025

Non-alcoholic steatohepatitis (NASH) is a prevalent chronic liver disease characterized by significant alterations in liver microvascular structures, leading to microcirculatory dysfunction and potentially contributing to various extrahepa…

Effect of B4C Content on the Oxidation Resistance of a B4C-SiO2–Albite/Al2O3 Coating at 900 °C Open

P.L. Chen, Qingming Luo, Haoze Wang, Huan He, Tao Liu , et al. · 2025

B4C is beneficial for forming a glassy film that is effective at impeding oxygen diffusion and improving the oxidation resistance of coatings at high temperature. The effect of B4C content on the oxidation resistance of a B4C-SiO2–Albite/A…

Autonomy, Qualification and Professionalism of the PRC Bar Open

Qingming Luo · 2025

In May 1996 the Lawyers’ Law of the People’s Republic of China (PRC) was promulgated to replace the PRC Provisional Regulations on Lawyers (hereafter referred to as the Regulations on Lawyers) in existence since 1980. The Lawyers’ Law repr…

Integrated Classification of Cortical Cells and Quantitative Projectomic Mapping Unveil Organizational Principles of Brain-Wide Connectomes at Single Cell Level Open

Yun Wang, Huilin Kou, Xiuli Kuang, Shenqin Yao, Phil Lesnar , et al. · 2025

Molecularly defined cortical cell types have recently been linked to whole neuronal morphology (WNM), particularly those characterized by whole-brain-wide projections, such as intratelencephalic (IT), extratelencephalic (ET), and corticoth…

CRISPR-based ultrasensitive multiplexed array for the detection of multiple plasma biomarkers for early Alzheimer’s disease diagnosis Open

Haiming Luo, Liding Zhang, Chenhui Yang, Xuewei Du, Hui Gong , et al. · 2025

Mild cognitive impairment (MCI) is an intermediate stage between normal cognition and dementia, with a high risk of progression to Alzheimer’s disease (AD). As an important threshold for the intervention and prevention of AD, accurate diag…

Towards Loss-Resilient Image Coding for Unstable Satellite Networks Open

Hongwei Sha, Muchen Dong, Qingming Luo, Ming‐De Lu, Hao Chen , et al. · 2025

Geostationary Earth Orbit (GEO) satellite communication demonstrates significant advantages in emergency short burst data services. However, unstable satellite networks, particularly those with frequent packet loss, present a severe challe…

The crosstalk of monocyte-neutrophil in hair follicles regulates neutrophil transepidermal migration in contact dermatitis Open

Zhan Fan, Yilun Xu, Yafang Lu, Xinlin Li, Mengli Xu , et al. · 2025

The excessive accumulation of neutrophils within the epidermis is a significant hallmark of cutaneous diseases; however, the mechanisms governing neutrophil transepidermal migration (NTEM) remain inadequately understood. In this study, we …

Label-free whole-kidney metabolic optical imaging using <i>in vivo</i> insulated cryofixation and cryo-micro-optical sectioning tomography Open

Guoqing Fan, Mingyu Tian, Huijuan Pan, Conroy Sun, Hai Gong , et al. · 2025

Cryo-imaging has the potential to obtain and visualize the metabolic state of the whole kidney without labeling. However, uneven fixation of metabolic information and incomplete organ morphology in three dimensions limit cryo-imaging appli…

Analysis of the Expression Patterns of piRNAs in Response to Microsporidian Invasion in Midgut of Workers (Apis cerana cerana) Open

Yiqiong Zhang, Mengyi Wang, Wenhua Xu, He Zang, Tizhen Yan , et al. · 2025

Piwi-interacting RNAs (piRNAs) play an essential part in transposon suppression, DNA methylation, and antiviral responses. The current understanding of the roles of piRNAs in honeybees is very limited. This study aims to analyze the expres…

Molecularly defined cellular atlas of the entire mouse brain with isotropic single-cell resolution Open

Anan Li, Mengting Zhao, Jiandong Zhou, Tao Jiang, Miao Ren , et al. · 2025

The mammalian brain comprises a vast number of neurons, exhibiting remarkable diversity in both molecular composition and spatial distribution. However, a comprehensive understanding of how these neurons are organized within the brain rema…

Single-nucleus transcriptome atlas of the basal forebrain reveals diverse ageing-related pathways Open

Jiale Chen, Qianqian Li, Bingqing Ji, Ke Zhang, Miao Ren , et al. · 2025

The basal forebrain is a critical brain region involved in various neurobiological processes, including learning, memory and attention. Basal forebrain cells undergo structural and functional changes during ageing, increasing their vulnera…

Detecting Algorithm based on the Improved YOLOv8s for a Weak Feature Defect of Aviation Clamps Open

Qingming Luo, Yi Liao · 2025

There are some weak defects on the surface of aviation clamps. Because they are very weak, it is difficult to identify them efficiently and accurately by the existing visual detecting algorithms, and the existing methods have high arithmet…

Towards Loss-Resilient Image Coding for Unstable Satellite Networks Open

Hongwei Sha, Muchen Dong, Qingming Luo, Ming‐De Lu, Hao Chen , et al. · 2025

Geostationary Earth Orbit (GEO) satellite communication demonstrates significant advantages in emergency short burst data services. However, unstable satellite networks, particularly those with frequent packet loss, present a severe challe…

Long‐range inputome of prefrontal GABAergic interneurons in the Alzheimer's disease mouse Open

Miao Ren, Yuxiao Li, Tao Jiang, Bimin Liu, Xinran Li , et al. · 2025

INTRODUCTION Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by damage to cortical circuits. However, the mechanisms underlying AD‐associated changes in long‐range circuits remain poorly understood. MET…

Light-Triggered Graphene/Black Phosphorus Heterostructure FET Platform for Ultrasensitive Detection of Alzheimer’s Disease Biomarkers at the Zeptomole Level Open

Huide Wang, Meng Qiu, Chen Wang, Liding Zhang, Ning Fan , et al. · 2025

Due to the low concentration of amyloid-beta (Aβ) in plasma and the high content of interfering factors, the conventional detection method for the quantification of Aβ still faces the problem of insufficient limit of detection (LOD). In th…

Brain-Sam: A General Automatic Sam-Based Segmentation Model for Brain Science Images Open

Shilong Zhang, Peicong Gong, Hong Zhang, Jieyu Li, Shmushkovich Bi , et al. · 2025

Optical sectioning methods in three-dimensional bioimaging Open

Jing Zhang, Wei Qiao, Rui Jin, Hongjin Li, Hui Gong , et al. · 2025

Single-Neuron Projectomes of Macaque Prefrontal Cortex Reveal Highly Refined Axon Branching and Arborization Open

Lingfeng Gou, Yanzhi Wang, Le Gao, Sang Liu, Mingli Wang , et al. · 2025

Precise Decision Energized Collaborative Strategies to Achieve High-quality and Large-scale Neuronal Reconstruction Open

Mingwei Liao, Chen Wu, Shengda Bao, Ganghua Huang, Hui Gong , et al. · 2025

The brain is the least explored organ in the human body. Brain functions are realized through a complex neural network composed of a vast number of neurons, and understanding the morphology of these neurons is base to brain studies. Howeve…

A single‐cell transcriptomic atlas of severe intrauterine adhesion Open

Siyu Xia, Wenting Ye, Jiajun Zeng, Ge Song, Yan Sun , et al. · 2024

Intrauterine adhesion (IUA) is a common endometrial disease caused by injury, leading to reproductive health issues. Current treatments have limited effectiveness, side effects, and high recurrence rates, especially, in severe cases. Howev…

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