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View article: Medication Patterns of Traditional Chinese Medicine for Diabetic Cardiomyopathy Based on Data Analysis and Deep Reinforcement Learning
Medication Patterns of Traditional Chinese Medicine for Diabetic Cardiomyopathy Based on Data Analysis and Deep Reinforcement Learning Open
Artificial intelligence-related technologies have been widely used in many industries, such as the Internet, finance, medical care, and education. This study is conducted in order to accurately analyze the medication patterns of diabetic c…
View article: The impact of a multidisciplinary collaboration model on nutritional support for patients undergoing retroperitoneal tumor surgery
The impact of a multidisciplinary collaboration model on nutritional support for patients undergoing retroperitoneal tumor surgery Open
View article: Association between metabolic score for insulin resistance and future stroke risk in patients with cardiovascular-kidney-metabolic syndrome stages 0–3: a longitudinal analysis based on CHARLS
Association between metabolic score for insulin resistance and future stroke risk in patients with cardiovascular-kidney-metabolic syndrome stages 0–3: a longitudinal analysis based on CHARLS Open
View article: Combination amide proton transfer imaging with diffusion-weighted imaging for differentiating tumor characteristics and assessing Ki-67 expression in soft tissue tumors
Combination amide proton transfer imaging with diffusion-weighted imaging for differentiating tumor characteristics and assessing Ki-67 expression in soft tissue tumors Open
The APT imaging and DWI can effectively differentiate between benign and malignant STTs. Combining these techniques enhances diagnostic efficiency. Furthermore, APT and ADC values show a significant correlation with tumor Ki-67 levels, whi…
View article: Prediction of blastocyst development using cleavage-stage embryo metrics and maternal age
Prediction of blastocyst development using cleavage-stage embryo metrics and maternal age Open
View article: A comprehensive benchmark of very preterm and extremely preterm infant care in Shenzhen: insights from the triple aim framework
A comprehensive benchmark of very preterm and extremely preterm infant care in Shenzhen: insights from the triple aim framework Open
View article: Let-7a-5p derived from parathyroid hormone (1–34)-preconditioned BMSCs exosomes delays the progression of osteoarthritis by promoting chondrocyte proliferation and migration
Let-7a-5p derived from parathyroid hormone (1–34)-preconditioned BMSCs exosomes delays the progression of osteoarthritis by promoting chondrocyte proliferation and migration Open
View article: Yangke powder alleviates OVA-induced allergic asthma by inhibiting the PI3K/AKT/NF-κB signaling pathway
Yangke powder alleviates OVA-induced allergic asthma by inhibiting the PI3K/AKT/NF-κB signaling pathway Open
View article: Resistin upregulates fatty acid oxidation in synoviocytes of metabolic syndrome-associated knee osteoarthritis via CAP1/PKA/CREB to promote inflammation and catabolism
Resistin upregulates fatty acid oxidation in synoviocytes of metabolic syndrome-associated knee osteoarthritis via CAP1/PKA/CREB to promote inflammation and catabolism Open
This study clarifies the mechanism by which MetS causes synovitis from a metabolic perspective and provides new ideas for further research and treatment of MetS-KOA.
View article: Metabolic Score for Insulin Resistance Is Correlated to Adipokine Disorder and Inflammatory Activity in Female Knee Osteoarthritis Patients in a Chinese Population [Corrigendum]
Metabolic Score for Insulin Resistance Is Correlated to Adipokine Disorder and Inflammatory Activity in Female Knee Osteoarthritis Patients in a Chinese Population [Corrigendum] Open
[This corrects the article DOI: 10.2147/DMSO.S249025.].
View article: Verteporfin Mitigates Isoproterenol‐Induced Myocardial Hypertrophy by Attenuating IL‐6/STAT3 in Cardiac Fibroblasts
Verteporfin Mitigates Isoproterenol‐Induced Myocardial Hypertrophy by Attenuating IL‐6/STAT3 in Cardiac Fibroblasts Open
Background: Yes‐associated protein (YAP) is a major downstream nuclear coactivator of the Hippo pathway and is activated during myocardial hypertrophy. Verteporfin, a YAP inhibitor, may serve as a potential treatment for myocardial hypertr…
View article: A novel algorithm for the detection of microsatellite instability in endometrial cancer using next‑generation sequencing data
A novel algorithm for the detection of microsatellite instability in endometrial cancer using next‑generation sequencing data Open
The molecular-based detection of microsatellite instability (MSI) in endometrial cancer is complex, due to the low sensitivity of PCR and a lack of standardization in next-generation sequencing (NGS) methods. In the present study, sequence…
View article: Human umbilical cord mesenchymal stem cells small extracellular vesicles-derived miR-370-3p inhibits cervical precancerous lesions by targeting DHCR24
Human umbilical cord mesenchymal stem cells small extracellular vesicles-derived miR-370-3p inhibits cervical precancerous lesions by targeting DHCR24 Open
Background Cervical cancer is often caused by persistent high-risk human papillomavirus (HPV) infection, causing precancerous lesions. Human umbilical cord mesenchymal stem cells-derived small extracellular vesicles (hucMSC-sEV) exhibit di…
View article: Resistin Upregulates Fatty Acid Oxidation in Synoviocytes of Metabolic Syndrome-Associated Knee Osteoarthritis via CAP1/PKA/CREB to Promote Inflammation and Catabolism
Resistin Upregulates Fatty Acid Oxidation in Synoviocytes of Metabolic Syndrome-Associated Knee Osteoarthritis via CAP1/PKA/CREB to Promote Inflammation and Catabolism Open
Background: To explore whether there were metabolism disorder which promote inflammatory and catabolic phenotype in fibroblast-like synoviocytes (FLS) from KOA patients with MetS (MetS-KOA-FLS), and the roles and mechanisim of resistin in …
View article: Delivery room resuscitation and short-term outcomes in very preterm infants: a multicenter cross-sectional study in China
Delivery room resuscitation and short-term outcomes in very preterm infants: a multicenter cross-sectional study in China Open
Objective To explore the risk factors of delivery room (DR) resuscitation and assess the association of DR resuscitation with neonatal outcomes in very preterm infants (VPIs). Methods A multicenter retrospective cross-sectional study inclu…
View article: Neonatal Resuscitation Online Registry in Shenzhen: protocol for a prospective, multicentre, open, observational cohort study
Neonatal Resuscitation Online Registry in Shenzhen: protocol for a prospective, multicentre, open, observational cohort study Open
Introduction Preterm birth complications and neonatal asphyxia are the leading causes of neonatal mortality worldwide. Surviving preterm and asphyxiated newborns can develop neurological sequelae; therefore, timely and appropriate neonatal…
View article: Effect of Day 3 cell number on the live birth rate of vitrified-warmed Day 5 single blastocyst transfer in young women
Effect of Day 3 cell number on the live birth rate of vitrified-warmed Day 5 single blastocyst transfer in young women Open
Background Previous studies have reported inconsistent results regarding blastocyst selection with a high day 3 (D3) cell number and the eventual pregnancy outcomes. Thus, in this study, the relationship between the D3 cell number and clin…
View article: Urolithin A Hijacks ERK1/2‐ULK1 Cascade to Improve CD8<sup>+</sup> T Cell Fitness for Antitumor Immunity
Urolithin A Hijacks ERK1/2‐ULK1 Cascade to Improve CD8<sup>+</sup> T Cell Fitness for Antitumor Immunity Open
According to the latest evidence, the microbial metabolite Urolithin A (UA), known for its role in promoting cellular health, modulates CD8 + T cell‐mediated antitumor activity. However, the direct target protein of UA and its underlying m…
View article: Day 2 versus day 3 embryo transfer in patients with <i>in vitro</i> fertilization and only one zygote with two pronuclei
Day 2 versus day 3 embryo transfer in patients with <i>in vitro</i> fertilization and only one zygote with two pronuclei Open
Objective This study aimed to compare the pregnancy outcomes of Day 2 (D2) fresh embryo transfer and D3 fresh embryo transfer in women with only one zygote with two pronuclei (2PN). Methods Data on 432 in vitro fertilization-embryo transfe…
View article: Beta‐Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5
Beta‐Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5 Open
Inadequate β‐cell mass and insulin secretion are essential for the development of type 2 diabetes (T2D). TNF‐α‐induced protein 8‐like 1 (Tipe1) plays a crucial role in multiple diseases, however, a specific role in T2D pathogenesis remains…
View article: Microglial glutaminase 1 mediates chronic restraint stress-induced depression-like behaviors and synaptic damages
Microglial glutaminase 1 mediates chronic restraint stress-induced depression-like behaviors and synaptic damages Open
View article: Inflammatory Factor IL1α Induces Aberrant Astrocyte Proliferation in Spinal Cord Injury Through the Grin2c/Ca2+/CaMK2b Pathway
Inflammatory Factor IL1α Induces Aberrant Astrocyte Proliferation in Spinal Cord Injury Through the Grin2c/Ca2+/CaMK2b Pathway Open
View article: High expression of P-selectin induces neutrophil extracellular traps via the PSGL-1/Syk/Ca2+/PAD4 pathway to exacerbate acute pancreatitis
High expression of P-selectin induces neutrophil extracellular traps via the PSGL-1/Syk/Ca2+/PAD4 pathway to exacerbate acute pancreatitis Open
Background Excessive neutrophil extracellular traps (NETs) is involved in the progression of acute pancreatitis (AP) but the mechanisms controlling NETs formation in AP are not fully understood. Therefore, our study sought to investigate t…
View article: Lactate-upregulated NADPH-dependent NOX4 expression via HCAR1/PI3K pathway contributes to ROS-induced osteoarthritis chondrocyte damage
Lactate-upregulated NADPH-dependent NOX4 expression via HCAR1/PI3K pathway contributes to ROS-induced osteoarthritis chondrocyte damage Open
View article: Bovine colostrum to supplement the first feeding of very preterm infants: The PreColos randomized controlled trial
Bovine colostrum to supplement the first feeding of very preterm infants: The PreColos randomized controlled trial Open
gov: NCT03085277.
View article: Zhx2 maintains islet β-cell mass and function by transcriptionally regulating Pax6
Zhx2 maintains islet β-cell mass and function by transcriptionally regulating Pax6 Open
View article: UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury
UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury Open
Activation of endogenous neural stem cells (NSCs) is greatly significant for the adult neurogenesis, which is extremely limited in the non-neurogenic spinal cord after injury. Recent evidence suggests that accumulation of protein aggregate…
View article: Genetic association of lipids and lipid-lowering drug target genes with non-alcoholic fatty liver disease
Genetic association of lipids and lipid-lowering drug target genes with non-alcoholic fatty liver disease Open
Capital's Funds for Health Improvement and Research (2022-4-4037). CAMS Innovation Fund for Medical Sciences (CIFMS, grant number: 2021-I2M-C&T-A-010).
View article: Impact of Day 3 Cell Number on the Live Birth Rate of Vitrified-Warmed Single Blastocyst Transfer
Impact of Day 3 Cell Number on the Live Birth Rate of Vitrified-Warmed Single Blastocyst Transfer Open
Background: Previous studies have reported inconsistent results regarding blastocyst selection with high cell number of day 3 (D3) and the eventual pregnancy outcomes. Thus, this study investigated the relationship between the D3 cell numb…
View article: TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis
TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis Open