Liang Tong
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View article: Molecular basis for the recognition of low-frequency polyadenylation signals by mPSF
Molecular basis for the recognition of low-frequency polyadenylation signals by mPSF Open
The 3′-end cleavage and polyadenylation of pre-mRNAs is dependent on a key hexanucleotide motif known as the polyadenylation signal (PAS). The PAS hexamer is recognized by the mammalian polyadenylation specificity factor (mPSF). AAUAAA is …
View article: Acupuncture modulates the microbiota-gut-brain axis: a new strategy for Parkinson’s disease treatment
Acupuncture modulates the microbiota-gut-brain axis: a new strategy for Parkinson’s disease treatment Open
Parkinson’s disease is a relatively common neurodegenerative disorder in clinical practice, and its prevalence is increasing worldwide. It not only causes patients to have movement disorders such as tremors and delayed initiation but also …
View article: SUMO2 promotes histone pre-mRNA processing by stabilizing histone locus body interactions and facilitating U7 snRNP assembly
SUMO2 promotes histone pre-mRNA processing by stabilizing histone locus body interactions and facilitating U7 snRNP assembly Open
Histone mRNAs are the only nonpolyadenylated mRNAs in eukaryotic cells and require specialized processing in the histone locus body (HLB), a nuclear body where essential processing factors, including the U7 snRNP, are concentrated. Recent …
View article: Molecular basis for the interaction between Saccharomyces cerevisiae Rtt103 and the Rat1-Rai1 complex
Molecular basis for the interaction between Saccharomyces cerevisiae Rtt103 and the Rat1-Rai1 complex Open
The Rat1 5'-3' exoribonuclease together with its partner Rai1 have important roles in Saccharomyces cerevisiae RNA polymerase II transcription termination. Rtt103 copurifies with Rat1-Rai1 in S. cerevisiae, but its mechanism of interaction…
View article: The L-lactate dehydrogenases of <i>Pseudomonas aeruginosa</i> are conditionally regulated but both contribute to survival during macrophage infection
The L-lactate dehydrogenases of <i>Pseudomonas aeruginosa</i> are conditionally regulated but both contribute to survival during macrophage infection Open
Pseudomonas aeruginosa is an opportunistic pathogen that thrives in environments associated with human activity, including soil and water altered by agriculture or pollution. Because L-lactate is a significant product of plant and animal m…
View article: Research on coal-rock identification method and data augmentation algorithm of comprehensive working face based on FL-Segformer
Research on coal-rock identification method and data augmentation algorithm of comprehensive working face based on FL-Segformer Open
Coal-rock interface identification technology was pivotal in automatically adjusting the shearer’s cutting drum during coal mining. However, it also served as a technical bottleneck hindering the advancement of intelligent coal mining. Thi…
View article: The L-lactate dehydrogenases of<i>Pseudomonas aeruginosa</i>are conditionally regulated but both contribute to survival during macrophage infection
The L-lactate dehydrogenases of<i>Pseudomonas aeruginosa</i>are conditionally regulated but both contribute to survival during macrophage infection Open
Pseudomonas aeruginosa is an opportunistic pathogen that thrives in environments associated with human activity, including soil and water altered by agriculture or pollution. Because L-lactate is a significant product of plant and animal m…
View article: CFD Simulation and ANN Prediction of Hydrogen Leakage and Diffusion Behavior in a Hydrogen Refuelling Station
CFD Simulation and ANN Prediction of Hydrogen Leakage and Diffusion Behavior in a Hydrogen Refuelling Station Open
Hydrogen refueling station (HRS) is an essential part of the infrastructure for promoting the hydrogen economy. Since hydrogen is a flammable and explosive gas, hydrogen released from high‐pressure hydrogen storage equipment in HRS will li…
View article: Characterization of the SF3B1–SUGP1 interface reveals how numerous cancer mutations cause mRNA missplicing
Characterization of the SF3B1–SUGP1 interface reveals how numerous cancer mutations cause mRNA missplicing Open
The spliceosomal gene SF3B1 is frequently mutated in cancer. While it is known that SF3B1 hotspot mutations lead to loss of splicing factor SUGP1 from spliceosomes, the cancer-relevant SF3B1–SUGP1 interaction has not been characterized. To…
View article: In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome
In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome Open
U7 snRNP is a multisubunit endonuclease required for 3′ end processing of metazoan replication-dependent histone pre-mRNAs. In contrast to the spliceosomal snRNPs, U7 snRNP lacks the Sm subunits D1 and D2 and instead contains two related p…
View article: Strength deterioration and energy dissipation characteristics of cemented backfill with different gangue particle size distributions
Strength deterioration and energy dissipation characteristics of cemented backfill with different gangue particle size distributions Open
The particle size distribution of gangue is an important factor affecting the strength of backfill body. To uncover the strength deterioration law and energy dissipation characteristics of cemented backfill with different gangue particle s…
View article: <i>In vitro</i>methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome
<i>In vitro</i>methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome Open
U7 snRNP is a multi-subunit endonuclease required for 3’ end processing of metazoan replication-dependent histone pre-mRNAs. In contrast to the spliceosomal snRNPs, U7 snRNP lacks the Sm subunits D1 and D2 and instead contains two related …
View article: Supplementary Figure from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
Supplementary Figure from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open
Supplementary Figure from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
View article: Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open
Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
View article: Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open
Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
View article: Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open
Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
View article: Supplementary Figure from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
Supplementary Figure from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open
Supplementary Figure from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
View article: Data from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
Data from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open
Low-intensity maintenance therapy with 6-mercaptopurine (6-MP) limits the occurrence of acute lymphoblastic leukemia (ALL) relapse and is central to the success of multiagent chemotherapy protocols. Activating mutations in the 5′-nucleotid…
View article: Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open
Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
View article: Data from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
Data from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia Open
Low-intensity maintenance therapy with 6-mercaptopurine (6-MP) limits the occurrence of acute lymphoblastic leukemia (ALL) relapse and is central to the success of multiagent chemotherapy protocols. Activating mutations in the 5′-nucleotid…
View article: Creation of Thermal Response Ordered Mesostructure Polymer Particles Using Diblock Copolymers via 3D Confined Self‐Assembly
Creation of Thermal Response Ordered Mesostructure Polymer Particles Using Diblock Copolymers via 3D Confined Self‐Assembly Open
Front Cover: In article 2200402 by Teruaki Hayakawa and co-workers, submicronsized particles with ordered mesostructure features are created via 3D confined self-assembly of poly(2,2,2-trifluoroethyl methacrylate)-b-poly(2-vinyl pyridine).…