Luqing Zhao
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View article: GPD1L supports glycerol-3-phosphate and triacylglycerol synthesis and promotes tumor progression in HCC
GPD1L supports glycerol-3-phosphate and triacylglycerol synthesis and promotes tumor progression in HCC Open
Background and Aims: Research on metabolic reprogramming in HCC has increased; however, studies on the metabolism of glycerolipids or interactions between different pathways remain scarce. Enzymes of the glycerol phosphate dehydrogenase (G…
View article: Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty
Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty Open
Constipation and frailty are associated with intestinal dysbiosis. This study aims to identify intestinal microbial signatures that can differentiate between constipated elders accompanied by frailty and those without frailty. We collected…
View article: The role of RNA methylation in tumor immunity and its potential in immunotherapy
The role of RNA methylation in tumor immunity and its potential in immunotherapy Open
RNA methylation, a prevalent post-transcriptional modification, has garnered considerable attention in research circles. It exerts regulatory control over diverse biological functions by modulating RNA splicing, translation, transport, and…
View article: Serum CST4 Combined with CEA, CA72-4, CA125, CA19-9 Improves the Diagnosis Value of Gastric cancer and Changes in pre-operation and post-operation
Serum CST4 Combined with CEA, CA72-4, CA125, CA19-9 Improves the Diagnosis Value of Gastric cancer and Changes in pre-operation and post-operation Open
Objective: This study aims to investigate the potential enhancement of diagnostic accuracy in gastric cancer through the combined detection of serum tumor markers (CST4, CEA, CA72-4, CA125, CA19-9). Additionally, we examine CST4 levels in …
View article: Evidence-Based Evaluation Model of Ulcerative Colitis Disease Demonstrated in Traditional Chinese Medicine Ancient Literature
Evidence-Based Evaluation Model of Ulcerative Colitis Disease Demonstrated in Traditional Chinese Medicine Ancient Literature Open
View article: Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma
Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma Open
Background and Aims Ras‐like (Ral) small guanosine triphosphatases (GTPases), RalA and RalB , are proto‐oncogenes directly downstream of Ras and cycle between the active guanosine triphosphate‐bound and inactive guanosine diphosphate‐bound…
View article: Role of gut microbiota in functional constipation
Role of gut microbiota in functional constipation Open
Functional constipation (FC) is common, yet the etiology is not clear. Accumulating evidence suggests an association between FC and abnormal gut microbiota. The relationship between the gut microbiota and the gut transit is likely bidirect…
View article: Berberine-Loaded Carboxylmethyl Chitosan Nanoparticles Ameliorate DSS-Induced Colitis and Remodel Gut Microbiota in Mice
Berberine-Loaded Carboxylmethyl Chitosan Nanoparticles Ameliorate DSS-Induced Colitis and Remodel Gut Microbiota in Mice Open
Inflammatory bowel disease (IBD) is a refractory disorder characterized by chronic and recurrent inflammation. The progression and pathogenesis of IBD is closely related to oxidative stress and irregularly high concentrations of reactive o…
View article: Bu-Zhong-Yi-Qi Granule Enhances Colonic Tight Junction Integrity via TLR4/NF-κB/MLCK Signaling Pathway in Ulcerative Colitis Rats
Bu-Zhong-Yi-Qi Granule Enhances Colonic Tight Junction Integrity via TLR4/NF-κB/MLCK Signaling Pathway in Ulcerative Colitis Rats Open
Background. Bu-zhong-yi-qi granule (BZYQ), a sort of Chinese herbal medicine, has exhibited therapeutic effects on ulcerative colitis (UC). However, the mechanism of BZYQ has not been fully clarified. This study was aimed at investigating …
View article: A Network Pharmacology‐Based Study on Irritable Bowel Syndrome Prevention and Treatment Utilizing Shenling Baizhu Powder
A Network Pharmacology‐Based Study on Irritable Bowel Syndrome Prevention and Treatment Utilizing Shenling Baizhu Powder Open
Background and Objective . Irritable bowel syndrome (IBS) is a prevalent disorder of the gastrointestinal system with complex pathogenesis. Shenling Baizhu powder (SLBZP) is a Chinese herbal compound with multicomponent and multitarget cha…
View article: The interplay between m6A modification and non-coding RNA in cancer stemness modulation: mechanisms, signaling pathways, and clinical implications
The interplay between m6A modification and non-coding RNA in cancer stemness modulation: mechanisms, signaling pathways, and clinical implications Open
Cancer stemness, mainly consisting of chemo-resistance, radio-resistance, tumorigenesis, metastasis, tumor self-renewal, cancer metabolism reprogramming, and tumor immuno-microenvironment remodeling, play crucial roles in the cancer progre…
View article: Iron Overload Impacts On Glucose And Lipid Metabolism
Iron Overload Impacts On Glucose And Lipid Metabolism Open
View article: <p>Gastro-Protective Effects of Calycosin Against Precancerous Lesions of Gastric Carcinoma in Rats</p>
Gastro-Protective Effects of Calycosin Against Precancerous Lesions of Gastric Carcinoma in Rats Open
Collectively, calycosin protected against gastric mucosal injury in part via regulation of the integrin β1/NF-κB/DARPP-32 pathway and suppressed the expression of STAT3 in PLGC. The elucidation of this effect and mechanism of calycosin in …
View article: Sini San ameliorates duodenal mucosal barrier injury and low‑grade inflammation via the CRF pathway in a rat model of functional dyspepsia
Sini San ameliorates duodenal mucosal barrier injury and low‑grade inflammation via the CRF pathway in a rat model of functional dyspepsia Open
The gut‑brain interaction is associated with impaired duodenal mucosal integrity and low‑grade inflammation, which have been proven to be important pathological mechanisms of functional dyspepsia (FD). Sini San (SNS) is a classical Chinese …
View article: Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCα‐dependent manner
Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCα‐dependent manner Open
Excessive iron increases the incidence of diabetes and worsens diabetic complications. Reciprocally, diabetes induces iron loading, partially attributable to elevated intestinal iron export according to a recent report. Herein, we show tha…
View article: Effects of Fengliao-Changweikang in Diarrhea-predominant Irritable Bowel Syndrome Rats and Its Mechanism Involving Colonic Motility
Effects of Fengliao-Changweikang in Diarrhea-predominant Irritable Bowel Syndrome Rats and Its Mechanism Involving Colonic Motility Open
FLCWK manifested curative effect in IBS-D rats by inhibiting colonic contraction. The underlying mechanisms may be related to regulatory pathway of nitric oxide/cGMP/Ca²⁺ and specific potassium channels.
View article: Effects of Hemp seed soft capsule on colonic ion transport in rats
Effects of Hemp seed soft capsule on colonic ion transport in rats Open
HSSC ameliorates constipation by increasing colonic secretion, which is mediated via the coaction of cAMP-dependent and Ca2+-dependent Cl- channels, NKCC, Na+-HCO3- cotransporte…
View article: Sini-san improves duodenal tight junction integrity in a rat model of functional dyspepsia
Sini-san improves duodenal tight junction integrity in a rat model of functional dyspepsia Open
View article: The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na<sup>+</sup>/H<sup>+</sup> exchanger 3 by ANG II
The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na<sup>+</sup>/H<sup>+</sup> exchanger 3 by ANG II Open
Na + /H + exchanger (NHE)3, a major Na + transporter in the luminal membrane of the proximal tubule, is subject to ANG II regulation in renal Na + /fluid absorption and blood pressure control. We have previously shown that inositol 1,4,5-t…
View article: Deletion of Na<sup>+</sup>/H<sup>+</sup> exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24
Deletion of Na<sup>+</sup>/H<sup>+</sup> exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24 Open
The Na + /H + exchanger regulatory factor (NHERF) family of proteins is scaffolds that orchestrate interaction of receptors and cellular proteins. Previous studies have shown that NHERF1 functions as a tumor suppressor. The goal of this st…
View article: Effect of TongXie‐YaoFang on Cl<sup>−</sup> and HCO3 - Transport in Diarrhea‐Predominant Irritable Bowel Syndrome Rats
Effect of TongXie‐YaoFang on Cl<sup>−</sup> and HCO3 - Transport in Diarrhea‐Predominant Irritable Bowel Syndrome Rats Open
TongXie‐YaoFang (TXYF) can effectively alleviate the symptoms of diarrhea‐predominant irritable bowel syndrome (D‐IBS) patients. However, the curative mechanism has not been fully clarified. The study was designed to investigate the effect…
View article: Effect of <i>Aurantii Fructus Immaturus Flavonoid</i> on the Contraction of Isolated Gastric Smooth Muscle Strips in Rats
Effect of <i>Aurantii Fructus Immaturus Flavonoid</i> on the Contraction of Isolated Gastric Smooth Muscle Strips in Rats Open
This study was designed to investigate the effect of Aurantii fructus immaturus flavonoid (AFIF) on the contraction of isolated gastric smooth muscle in rats and explore its underlying mechanisms. Isolated antral longitudinal smooth muscle…
View article: Multifunctional DDX3: dual roles in various cancer development and its related signaling pathways.
Multifunctional DDX3: dual roles in various cancer development and its related signaling pathways. Open
DEAD-box RNA helicase 3 (DDX3) is a highly conserved family member of DEAD-box protein, which is a cluster of ATP-dependent and the largest family of RNA helicase. DEAD-box family is characterized by the regulation of ATPase and helicase a…
View article: Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss
Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss Open
Diarrhea is one of the troublesome complications of diabetes, and the underlying causes of this problem are complex. Here, we investigated whether altered electrolyte transport contributes to diabetic diarrhea. We found that the expression…