Luquan Zheng
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View article: Targeting GJB4 to inhibit tumor growth and induce ferroptosis in pancreatic cancer
Targeting GJB4 to inhibit tumor growth and induce ferroptosis in pancreatic cancer Open
Background Pancreatic cancer (PC) is a highly malignant type of cancer characterized by poor prognosis and high mortality rate. The role of gap junction protein beta 4 (GJB4) in PC has been scarcely reported. Therefore, the aim of this stu…
View article: Tanshinone IIA reduces tubulointerstitial fibrosis by suppressing GSDMD-mediated pyroptosis
Tanshinone IIA reduces tubulointerstitial fibrosis by suppressing GSDMD-mediated pyroptosis Open
Tan IIA may mitigate GSDMD-mediated pyroptosis in renal tubular epithelial cells (RTECs) and reduce kidney fibrosis, highlighting its potential as a therapeutic strategy to prevent the progression of kidney disease after ureteral obstructi…
View article: A set of urinary peptides can predict early renal damage in primary hypertension
A set of urinary peptides can predict early renal damage in primary hypertension Open
Objectives: Renal diseases caused by primary hypertension (HTN) are often asymptomatic without sensitive markers for early diagnosis and prediction, easily progressing to severe and irreversible renal damage in patients with clinical manif…
View article: Steroidogenic factor 1 promotes cuproptosis in renal tubular epithelial cells during acute kidney injury
Steroidogenic factor 1 promotes cuproptosis in renal tubular epithelial cells during acute kidney injury Open
Programmed cell death of renal tubular epithelial cells (RTECs) is the main pathophysiological mechanism of acute kidney injury (AKI). Copper-induced death is a newly discovered form of programmed cell death, mainly attributed to fatty acy…
View article: A classifier based on 273 urinary peptides predicts early renal damage in primary hypertension
A classifier based on 273 urinary peptides predicts early renal damage in primary hypertension Open
Objectives: Renal diseases caused by primary hypertension (HTN) are often asymptomatic without sensitive markers for early diagnosis and prediction, easily progressing to severe and irreversible renal damage in patients with clinical manif…
View article: Ginsenoside Rb1 ameliorates renal tubular epithelial cells ferroptosis in AKI
Ginsenoside Rb1 ameliorates renal tubular epithelial cells ferroptosis in AKI Open
Acute kidney injury (AKI) is mainly caused by ischemia-reperfusion (I/R), with high clinical mortality since there is a lack of definite and effective drug intervention except for renal replacement therapy. Previous research emphasized tha…
View article: Eosinophilic Granulomatosis With Polyangiitis Presenting With Oral Granuloma as the Initial Symptom: A Case Report
Eosinophilic Granulomatosis With Polyangiitis Presenting With Oral Granuloma as the Initial Symptom: A Case Report Open
Antineutrophil cytoplasmic antibody associated vasculitis includes granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis (EGPA), and microscopic polyangiitis. While EGPA has no specific symptoms, it usually presen…
View article: Long Non-coding RNA MEG3 Promotes Renal Tubular Epithelial Cell Pyroptosis by Regulating the miR-18a-3p/GSDMD Pathway in Lipopolysaccharide-Induced Acute Kidney Injury
Long Non-coding RNA MEG3 Promotes Renal Tubular Epithelial Cell Pyroptosis by Regulating the miR-18a-3p/GSDMD Pathway in Lipopolysaccharide-Induced Acute Kidney Injury Open
Background and Objective: Acute kidney injury (AKI) is a complication of sepsis. Pyroptosis of gasdermin D (GSDMD)-mediated tubular epithelial cells (TECs) play important roles in pathogenesis of sepsis-associated AKI. Long non-coding RNA …
View article: Risk factors and prognosis for COVID-19-induced acute kidney injury: a meta-analysis
Risk factors and prognosis for COVID-19-induced acute kidney injury: a meta-analysis Open
Objective To analyse the incidence, risk factors and impact of acute kidney injury (AKI) on the prognosis of patients with COVID-19. Design Meta-analysis. Data sources PubMed, Embase, CNKI and MedRxiv of Systematic Reviews from 1 January 2…
View article: Membranous nephropathy and thymoma in a patient with ankylosing spondylitis
Membranous nephropathy and thymoma in a patient with ankylosing spondylitis Open
Rationale: We report a rare case with ankylosing spondylitis (AS), thymoma, and membranous glomerulonephritis. The pathogenic mechanisms of these 3 diseases may be associated with each other. Here, we discuss the course of diagnosis and tr…