Michael Luu
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View article: Outcomes from Referral to Transplant for Patients with MASLD: A California Liver Network Study
Outcomes from Referral to Transplant for Patients with MASLD: A California Liver Network Study Open
Background: Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) is becoming a leading indication for liver transplantation in the United States. In this growing recipient population, the combined effects of underlying liver di…
View article: Racial and ethnic differences in valuation of life expectancy in prostate cancer treatment decision making
Racial and ethnic differences in valuation of life expectancy in prostate cancer treatment decision making Open
Background Life expectancy (LE) is essential for triage between aggressive and conservative management for all prostate cancer risk subtypes. We sought to investigate differences in how Black and Hispanic men interpret LE in treatment deci…
View article: Diagnostic Accuracy of the Oncuria-Detect Multiplex Immunoassay in Detecting Upper Tract Urothelial Carcinoma
Diagnostic Accuracy of the Oncuria-Detect Multiplex Immunoassay in Detecting Upper Tract Urothelial Carcinoma Open
Oncuria-Detect accurately identified and categorized UTUC and discriminated patients with cancer from nontumor-bearing individuals. The Oncuria-Detect test provides a rapid, accurate, and noninvasive method for detecting UTUC.
View article: Development and validation of a natural language processing system to assess quality of physician communication in prostate cancer consultations
Development and validation of a natural language processing system to assess quality of physician communication in prostate cancer consultations Open
Background AUA guidelines for shared decision making (SDM) in prostate cancer recommend discussion of five content areas in consultations: (1) cancer severity (tumor risk (TR), pathology results (PR)); (2) life expectancy (LE); (3) cancer …
View article: Correlation between clinical and pathological nodal status in hepatocellular carcinoma: identifying risk factors for lymph node metastasis via the national cancer database
Correlation between clinical and pathological nodal status in hepatocellular carcinoma: identifying risk factors for lymph node metastasis via the national cancer database Open
Tumor characteristics, patient demographics, and specific histological subtypes significantly influence the risk of pN1 in patients with resectable HCC. Given the low sensitivity of cN1, LNE should be considered for high-risk patients to i…
View article: Scoring Physician Risk Communication in Prostate Cancer Using Large Language Models
Scoring Physician Risk Communication in Prostate Cancer Using Large Language Models Open
Effective risk communication is essential to shared decision-making in prostate cancer care. However, the quality of physician communication of key tradeoffs varies widely in real-world consultations. Manual evaluation of communication is …
View article: Curative Treatment after Immunotherapy Leads to Excellent Outcomes in Patients with Hepatocellular Carcinoma
Curative Treatment after Immunotherapy Leads to Excellent Outcomes in Patients with Hepatocellular Carcinoma Open
Introduction: The high response rates observed with immunotherapy may allow downstaging to curative treatment in hepatocellular carcinoma (HCC). We aimed to investigate the factors associated with curative treatment receipt after immunothe…
View article: The nuclear transport factor IPO5 revealed as a critical mediator of male germline development
The nuclear transport factor IPO5 revealed as a critical mediator of male germline development Open
The highly conserved nuclear transport protein importin 5 (IPO5) binds cargo implicated in fundamental processes including virus and chromatin assembly, germline development, and cell signaling. It also anchors cell-specific cargo for func…
View article: Performance of the Oncuria-Detect bladder cancer test for evaluating patients presenting with haematuria: results from a real-world clinical setting
Performance of the Oncuria-Detect bladder cancer test for evaluating patients presenting with haematuria: results from a real-world clinical setting Open
The multiplex Oncuria assay identified bladder cancer with high sensitivity and NPV. Oncuria's high NPV could effectively rule out 66% of patients from requiring subsequent cystoscopy.
View article: Safety and feasibility of performing rigid bronchoscopy in the bronchoscopy suite instead of the operating room
Safety and feasibility of performing rigid bronchoscopy in the bronchoscopy suite instead of the operating room Open
Rigid bronchoscopy for the treatment of complex airway diseases, in the appropriate patient population, can be performed safely in the bronchoscopy suite.
View article: Correlation between Clinical and Pathological Nodal Status in Hepatocellular Carcinoma: Identifying Risk Factors for Lymph Node Metastasis via the National Cancer Database
Correlation between Clinical and Pathological Nodal Status in Hepatocellular Carcinoma: Identifying Risk Factors for Lymph Node Metastasis via the National Cancer Database Open
Background This study aimed to investigate the correlation between clinical nodal status (cN) and pathological nodal status (pN) in hepatocellular carcinoma (HCC) patients and to identify risk factors for lymph node metastasis (LNM) via th…
View article: Feasibility of frequent monitoring of symptoms using the PRO-CTCAE in the NRG-BR004 clinical trial
Feasibility of frequent monitoring of symptoms using the PRO-CTCAE in the NRG-BR004 clinical trial Open
Background The PRO-CTCAE Measurement System was designed to enhance the quality of the standard toxicity evaluation in clinical trials. We developed a substudy within NRG-BR004, a phase III clinical trial in patients with newly documented …
View article: Overtreatment of Prostate Cancer Among Men With Limited Longevity in the Active Surveillance Era
Overtreatment of Prostate Cancer Among Men With Limited Longevity in the Active Surveillance Era Open
Importance Men with limited life expectancy (LE) have historically been overtreated for prostate cancer despite clear guideline recommendations. With increasing use of active surveillance, it is unclear if overtreatment of men with limited…
View article: Baseline weight recovery and mortality risk in head and neck cancer
Baseline weight recovery and mortality risk in head and neck cancer Open
Background As a surrogate of malnutrition, degree of weight loss and recovery from head and neck cancer (HNC) treatment is understudied. The influence of modifiable factors that affect weight, including speech/language pathology (SLP) and …
View article: Development of a Web-Based Interactive Tool for Visualizing Breast Cancer Clinical Trial Tolerability Data
Development of a Web-Based Interactive Tool for Visualizing Breast Cancer Clinical Trial Tolerability Data Open
PURPOSE Longitudinal patient tolerability data collected as part of randomized controlled trials are often summarized in a way that loses information and does not capture the treatment experience. To address this, we developed an interacti…
View article: Impact of the Early COVID-19 Pandemic on Incidence and Outcomes of Hepatocellular Carcinoma in the United States
Impact of the Early COVID-19 Pandemic on Incidence and Outcomes of Hepatocellular Carcinoma in the United States Open
INTRODUCTION: Access to hepatocellular carcinoma (HCC) surveillance and treatments were disrupted during the coronavirus disease 2019 (COVID-19) pandemic. We aimed to characterize the impact of the pandemic on HCC incidence and mortality r…
View article: Variation in communication of side effects in prostate cancer treatment consultations
Variation in communication of side effects in prostate cancer treatment consultations Open
Background Effective communication of treatment side effects (SE) is critical for shared decision-making (SDM) in localized prostate cancer. We sought to qualitatively characterize how physicians communicate SE in consultations. Methods We…
View article: Use of Persuasive Language in Communication of Risk during Prostate Cancer Treatment Consultations
Use of Persuasive Language in Communication of Risk during Prostate Cancer Treatment Consultations Open
Background Physician treatment preference may influence how risks are communicated in prostate cancer consultations. We identified persuasive language used when describing cancer prognosis, life expectancy, and side effects in relation to …
View article: Supplementary Figure S1 from Dynamic Risk Prediction of Treatment Discontinuation Using Patient-Reported Outcomes Data in the Phase III NSABP B-35 Trial
Supplementary Figure S1 from Dynamic Risk Prediction of Treatment Discontinuation Using Patient-Reported Outcomes Data in the Phase III NSABP B-35 Trial Open
Supplementary Figure S1 shows the estimated discontinuation curve in patients treated with anastrozole and tamoxifen, along with the p-value associated with the log-rank test.
View article: Supplementary Figure S7 from Dynamic Risk Prediction of Treatment Discontinuation Using Patient-Reported Outcomes Data in the Phase III NSABP B-35 Trial
Supplementary Figure S7 from Dynamic Risk Prediction of Treatment Discontinuation Using Patient-Reported Outcomes Data in the Phase III NSABP B-35 Trial Open
Supplementary Figure S7 presents a screenshot of the web tool; the supplementary data provides instructions for utilizing the web-based treatment discontinuation predictive tool developed based on the predictive survival models.
View article: Supplementary Methods S2 from Dynamic Risk Prediction of Treatment Discontinuation Using Patient-Reported Outcomes Data in the Phase III NSABP B-35 Trial
Supplementary Methods S2 from Dynamic Risk Prediction of Treatment Discontinuation Using Patient-Reported Outcomes Data in the Phase III NSABP B-35 Trial Open
Supplementary Methods S2 provides a statistical description of the prediction error used to assess the model performance.
View article: Supplementary Table S2 from Dynamic Risk Prediction of Treatment Discontinuation Using Patient-Reported Outcomes Data in the Phase III NSABP B-35 Trial
Supplementary Table S2 from Dynamic Risk Prediction of Treatment Discontinuation Using Patient-Reported Outcomes Data in the Phase III NSABP B-35 Trial Open
Supplementary Table S2 provides information about the number of patients with missing adverse events at each timepoint for anastrozole treatment.
View article: Supplementary Figure S7 from Dynamic Risk Prediction of Treatment Discontinuation Using Patient-Reported Outcomes Data in the Phase III NSABP B-35 Trial
Supplementary Figure S7 from Dynamic Risk Prediction of Treatment Discontinuation Using Patient-Reported Outcomes Data in the Phase III NSABP B-35 Trial Open
Supplementary Figure S7 presents a screenshot of the web tool; the supplementary data provides instructions for utilizing the web-based treatment discontinuation predictive tool developed based on the predictive survival models.