Luwen Shi
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View article: Peer effects on appropriate antibiotic prescribing within a patient-sharing physician network in China
Peer effects on appropriate antibiotic prescribing within a patient-sharing physician network in China Open
Peer effect provides a promising solution to improve intervention efficiency by targeting influential opinion leaders and facilitate the diffusion of appropriate antibiotic prescribing.
View article: Adherence to Antibacterial Therapy and Associated Factors in Lower Respiratory Infections in War-Affected Areas: A Randomized Controlled Trial
Adherence to Antibacterial Therapy and Associated Factors in Lower Respiratory Infections in War-Affected Areas: A Randomized Controlled Trial Open
Background: Lower respiratory tract infections (LRTIs) are one of the leading causes of mortality. Pharmacist-led interventions can enhance adherence to antibiotics; the present study aims to determine adherence to the antibiotics prescrib…
View article: Assessing the risks and benefits of investigational new drugs in adult phase-I oncology trials in China, 2013–2021
Assessing the risks and benefits of investigational new drugs in adult phase-I oncology trials in China, 2013–2021 Open
Previous research shows that the benefits of phase-I oncology trials increased from 5 to 18% between 2000 and 2019 globally. However, the risk-benefit profile of phase-I trials in China is unclear. This study aims to analyze the risk-benef…
View article: Associations between clinical benefits of cancer drugs and incremental quality-adjusted life years used in reimbursement decisions in Australia, Canada, England and China: an observational study
Associations between clinical benefits of cancer drugs and incremental quality-adjusted life years used in reimbursement decisions in Australia, Canada, England and China: an observational study Open
Objectives To investigate the association between incremental quality-adjusted life years (QALYs) predicted in economic evaluations and clinical benefits assessed by the European Society for Medical Oncology-Magnitude of Clinical Benefit S…
View article: Treatment indications for antidepressants prescribed in primary health care facilities in Beijing, China
Treatment indications for antidepressants prescribed in primary health care facilities in Beijing, China Open
To examine the prevalence of treatment indications for antidepressants and assessed temporal trends in antidepressant prescribing for depression among adult patients in primary health care facilities (PHFs) in China. Descriptive study of a…
View article: Prescribing rate, healthcare utilization, and expenditure of older adults using potentially inappropriate medications in China: A nationwide cross-sectional study
Prescribing rate, healthcare utilization, and expenditure of older adults using potentially inappropriate medications in China: A nationwide cross-sectional study Open
Background: The use of potentially inappropriate medications (PIMs) is a major concern for medication safety as it may entail more harm than potential benefits for older adults. This study aimed to explore the prescribing rate, healthcare …
View article: Expedited Approval of Urgently Needed Drugs in China
Expedited Approval of Urgently Needed Drugs in China Open
This cross-sectional study evaluates the approval status and timeline and therapeutic value of urgently needed overseas drugs in China.
View article: Medicine availability and affordability for paediatric cancers, China
Medicine availability and affordability for paediatric cancers, China Open
Access to essential anticancer medicines for children remained suboptimal in China and varied across regions. Fewer than half the medicines studied had both good availability and affordability. Actions are warranted to address potential sh…
View article: Economics of first-line treatment with tislelizumab in patients with nonsquamous non-small cell lung cancer
Economics of first-line treatment with tislelizumab in patients with nonsquamous non-small cell lung cancer Open
The conclusion is that tislelizumab combination therapy is a cost-effective first-line treatment option for nsq-NSCLC patients in China.
View article: Evaluation of appropriateness of antibiotic prescribing in primary healthcare institutions in China using proxy indicator
Evaluation of appropriateness of antibiotic prescribing in primary healthcare institutions in China using proxy indicator Open
This work was supported by the National Natural Science Foundation of China (grant numbers 72374009, 81973294).
View article: Association of potentially inappropriate medications with prognosis among older patients with non-small cell lung cancer
Association of potentially inappropriate medications with prognosis among older patients with non-small cell lung cancer Open
Background Potentially inappropriate medications (PIMs) are common among older adults with cancer, but their association with overall survival (OS) among non-small cell lung cancer (NSCLC) patients remains unclear. This study aimed to inve…
View article: Evaluation of pharmacist-led medication reconciliation at county hospitals in China: A multicentre, open-label, assessor-blinded, nonrandomised controlled study
Evaluation of pharmacist-led medication reconciliation at county hospitals in China: A multicentre, open-label, assessor-blinded, nonrandomised controlled study Open
ChiCTR2100045668.
View article: Prevalence of aggressive care among patients with cancer near the end of life: a systematic review and meta-analysis
Prevalence of aggressive care among patients with cancer near the end of life: a systematic review and meta-analysis Open
National Natural Science Foundation of China (Grant No. 72274004).
View article: Economics of First-line Treatment with Tislelizumab in Patients with Nonsquamous Non-small Cell Lung Cancer: A Four-state Markov Model
Economics of First-line Treatment with Tislelizumab in Patients with Nonsquamous Non-small Cell Lung Cancer: A Four-state Markov Model Open
Background Tislelizumab combined with chemotherapy has demonstrated significant clinical benefits as a first-line treatment for patients with nonsquamous non-small cell lung cancer (nsq-NSCLC). This study aimed to evaluate its cost-effecti…
View article: Outpatient Antibiotic Prescribing Patterns in Children among Primary Healthcare Institutions in China: A Nationwide Retrospective Study, 2017–2019
Outpatient Antibiotic Prescribing Patterns in Children among Primary Healthcare Institutions in China: A Nationwide Retrospective Study, 2017–2019 Open
There is scarce evidence to demonstrate the pattern of antibiotic use in children in China. We aimed to describe antibiotic prescribing practices among children in primary healthcare institutions (PHIs) in China. We described outpatient an…
View article: Off-Label Use of Antidepressants Among Pediatric Patients in China
Off-Label Use of Antidepressants Among Pediatric Patients in China Open
View article: Associations between Clinical Benefits of Cancer Drugs and Incremental Quality-Adjusted Life Years Used in Reimbursement Decisions in Australia, Canada, England, and China: An Observational Study
Associations between Clinical Benefits of Cancer Drugs and Incremental Quality-Adjusted Life Years Used in Reimbursement Decisions in Australia, Canada, England, and China: An Observational Study Open
View article: Exploring Facilitators and Barriers to Delayed Antibiotic Prescribing in Rural Northwest China: A Qualitative Study Using the Theoretical Domains Framework and Behavior Change Wheel
Exploring Facilitators and Barriers to Delayed Antibiotic Prescribing in Rural Northwest China: A Qualitative Study Using the Theoretical Domains Framework and Behavior Change Wheel Open
Background: Antimicrobial resistance, exacerbated by antibiotic misuse, poses a global threat. Though delayed antibiotic prescribing (DAP) can mitigate antibiotic overuse, its adoption in developing nations, such as China, is limited. This…
View article: Use of suboptimal control arms in randomized clinical trials of investigational cancer drugs in China, 2016–2021: An observational study
Use of suboptimal control arms in randomized clinical trials of investigational cancer drugs in China, 2016–2021: An observational study Open
Background The use of suboptimal controls in randomized trials of new cancer drugs can produce potentially unreliable clinical efficacy results over the current standard of care and expose patients to substandard therapy. We aim to investi…
View article: Potentially inappropriate medications among older patients with Parkinson’s disease: a cross-sectional analysis of a national health insurance database in China
Potentially inappropriate medications among older patients with Parkinson’s disease: a cross-sectional analysis of a national health insurance database in China Open
View article: Evaluation of prescription review and feedback policy on rational antibiotic use in primary healthcare settings in Beijing, China: a qualitative study using the Theoretical Domains Framework and the behaviour change wheel
Evaluation of prescription review and feedback policy on rational antibiotic use in primary healthcare settings in Beijing, China: a qualitative study using the Theoretical Domains Framework and the behaviour change wheel Open
Objectives To decelerate antibiotic resistance driven by inappropriate antibiotic prescribing, a prescription review and feedback (PRF) policy is implemented in primary healthcare institutions (PHIs) in Beijing, China. However, evaluation …
View article: Sponsorship bias in published pharmacoeconomic evaluations of national reimbursement negotiation drugs in China: a systematic review
Sponsorship bias in published pharmacoeconomic evaluations of national reimbursement negotiation drugs in China: a systematic review Open
Background China’s National Reimbursement Drug List (NRDL) has become the primary route for drug reimbursement in China. More recently, the authority has made pharmacoeconomic evaluation an integral part of the application for NRDL inclusi…
View article: Thyroid dysfunction induced by immune checkpoint inhibitors and tumor progression during neoadjuvant therapy of non‑small cell lung cancer: A case report and literature review
Thyroid dysfunction induced by immune checkpoint inhibitors and tumor progression during neoadjuvant therapy of non‑small cell lung cancer: A case report and literature review Open
Immune checkpoint inhibitors (ICIs) have a demonstrable treatment response in patients with resectable non-small cell lung cancer (NSCLC). However, immune-related adverse events and tumor progression in patients administered ICIs are of gr…
View article: Appropriate use of antibiotics for acute respiratory infections at primary healthcare facilities in China: a nationwide cross-sectional study from 2017 to 2019
Appropriate use of antibiotics for acute respiratory infections at primary healthcare facilities in China: a nationwide cross-sectional study from 2017 to 2019 Open
This work was supported by the National Natural Science Foundation of China [grant number 72074007, 81973294].
View article: The impact of government reimbursement negotiation on targeted anticancer medicines use and cost in China: A cohort study based on national health insurance data
The impact of government reimbursement negotiation on targeted anticancer medicines use and cost in China: A cohort study based on national health insurance data Open
The government price negotiation and reimbursement policy improved patient access to TAMs and narrowed disparities among insurance schemes. China's approach to promoting the affordability of expensive medicines provides valuable experience…
View article: Comparisons of diabetic retinopathy events associated with glucose-lowering drugs in patients with type 2 diabetes mellitus: A network meta-analysis
Comparisons of diabetic retinopathy events associated with glucose-lowering drugs in patients with type 2 diabetes mellitus: A network meta-analysis Open
Aim: To assess the comparative effects of glucose-lowering drugs (GLDs) on the risk of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). Methods: We systematically searched Cochrane Central Register of Controlled …
View article: Statin Use and Risk of Intracerebral Hemorrhage in Chinese Population: a Target Trial Emulation Study
Statin Use and Risk of Intracerebral Hemorrhage in Chinese Population: a Target Trial Emulation Study Open
Purpose: Statin therapy has been shown to prevent major vascular events in a wide range of individuals, but the risk of intracerebral hemorrhage (ICH) from statin use is unclear.We aimed to determine the ICH risk since statin initiation fo…
View article: Evidence of clinical benefit of WHO essential anticancer medicines for children, 2011–2021
Evidence of clinical benefit of WHO essential anticancer medicines for children, 2011–2021 Open
Not applicable.
View article: Pharmacists’ Views on Unmet Needs of Patients with Cancer and Pharmaceutical Care in Specialty Pharmacy: A Qualitative Analysis
Pharmacists’ Views on Unmet Needs of Patients with Cancer and Pharmaceutical Care in Specialty Pharmacy: A Qualitative Analysis Open
Objectives This study aimed to understand the perspective of pharmacists on cancer patients’ needs and the most meaningful pharmaceutical care in specialty pharmacies. Methods Semi-structured interviews were conducted with pharmacists work…
View article: Effectiveness of hierarchical medical system policy: an interrupted time series analysis of a pilot scheme in China
Effectiveness of hierarchical medical system policy: an interrupted time series analysis of a pilot scheme in China Open
The Chinese healthcare system faces a dilemma between its hospital-centric approach to healthcare delivery and a rapidly ageing population that requires strong primary care. To improve system efficiency and continuity of care, the Hierarch…