Luxia Chen
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View article: Effective response to high-frequency and prolonged dupilumab therapy in severe refractory bullous pemphigoid: A case study
Effective response to high-frequency and prolonged dupilumab therapy in severe refractory bullous pemphigoid: A case study Open
Bullous pemphigoid (BP) is an autoimmune blistering disorder primarily affecting elderly individuals, with its incidence increasing with age. Standard treatments, such as glucocorticoids and immunosuppressive agents, are generally effectiv…
View article: Case Report: Successful treatment of refractory synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome and palmoplantar pustulosis with ustekinumab
Case Report: Successful treatment of refractory synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome and palmoplantar pustulosis with ustekinumab Open
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic inflammatory disease mainly manifested as skin and osteoarticular lesions. We describe a male patient with SAPHO syndrome who exhibited primary palm…
View article: A novel sandwich technique of minimally invasive surgery for corneal perforation
A novel sandwich technique of minimally invasive surgery for corneal perforation Open
View article: Comparative Efficacy of 3% Diquafosol Sodium Eye Drops in Dry Eye Patients Across Age Groups: a Propensity Score-Matched Longitudinal Study
Comparative Efficacy of 3% Diquafosol Sodium Eye Drops in Dry Eye Patients Across Age Groups: a Propensity Score-Matched Longitudinal Study Open
This study aimed to evaluate the efficacy of 3% diquafosol sodium eye drops in treating dry eye disease (DED) across different age groups using a propensity score-matched longitudinal design. Participants were divided into younger (< 40 ye…
View article: Adenosine and Its Receptors in the Pathogenesis and Treatment of Inflammatory Skin Diseases
Adenosine and Its Receptors in the Pathogenesis and Treatment of Inflammatory Skin Diseases Open
Inflammatory skin diseases highlight inflammation as a central driver of skin pathologies, involving a multiplicity of mediators and cell types, including immune and non-immune cells. Adenosine, a ubiquitous endogenous immune modulator, ge…
View article: Adenosine, bridging chronic inflammation and tumor growth
Adenosine, bridging chronic inflammation and tumor growth Open
Adenosine (Ado) is a well-known immunosuppressive agent that may be released or generated extracellularly by cells, via degrading ATP by the sequential actions of the ectonucleotides CD39 and CD73. During inflammation Ado is produced by le…
View article: The variability of judicial decisions in the stem cell industry in China
The variability of judicial decisions in the stem cell industry in China Open
View article: A composite hydrogel membrane with shape and water retention for corneal tissue engineering
A composite hydrogel membrane with shape and water retention for corneal tissue engineering Open
Tissue engineering (TE) cornea is one of the most potential alternatives to the shortage of corneal donors in cornea transplantation. Sodium alginate (SA) hydrogel is commonly used as scaffold in TE. Herein, we present an approach to const…
View article: The Impact of the Type and Abundance of Urban Blue Space on House Prices: A Case Study of Eight Megacities in China
The Impact of the Type and Abundance of Urban Blue Space on House Prices: A Case Study of Eight Megacities in China Open
Urban blue spaces (UBS) have been shown to provide a multitude of cultural ecosystem services to urban residents, while also having a considerable impact on the surrounding community’s house prices. However, the impact of different types o…
View article: Guidelines for mouse and human DC functional assays
Guidelines for mouse and human DC functional assays Open
This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state‐of‐the‐art protocols for the preparation, phenotype analysis by flow cytometry, generation, fluorescence microscopy, and functional …
View article: Comprehensive Transcriptome Analysis of Patients With Keratoconus Highlights the Regulation of Immune Responses and Inflammatory Processes
Comprehensive Transcriptome Analysis of Patients With Keratoconus Highlights the Regulation of Immune Responses and Inflammatory Processes Open
Keratoconus (KTCN), characterized by the steeper curvature of the cornea and the thinner central corneal thickness, was a degenerative corneal ectasia with ambiguous etiology and mechanism. We aim to reveal underlying pathological mechanis…
View article: HPV58 E7 Protein Expression Profile in Cervical Cancer and CIN with Immunohistochemistry
HPV58 E7 Protein Expression Profile in Cervical Cancer and CIN with Immunohistochemistry Open
Background: The persistent infection of high-risk human papillomavirus (HR-HPV) is one of the most common causes of cervical cancer worldwide, and HPV type 58 (HPV58) is the third most common HPV type in eastern Asia. The E7 oncopro…
View article: Integrative Analysis of Genes Associated With Cancer Stem Cell Characteristics via Stemness Indices Combined With Multi-Omics Data in Liver Cancer
Integrative Analysis of Genes Associated With Cancer Stem Cell Characteristics via Stemness Indices Combined With Multi-Omics Data in Liver Cancer Open
BackgroundLiver cancer (LC) is one of the most prevalent malignancies with a high morbidity and mortality. Cancer stem cells (CSCs) are capable of tumorigenicity, self-renewal and long-term survival. However, the relationship between LC an…
View article: The Differential Expression of Cytokines and Growth Factors After SMILE Compared With FS-LASIK in Rabbits
The Differential Expression of Cytokines and Growth Factors After SMILE Compared With FS-LASIK in Rabbits Open
SMILE could induce significantly less acute inflammation than FS-LASIK in the cornea and aqueous humor. The differential expression of TGF-β1 and BFGF between two procedures until 1 month might contribute to the post-SMILE delayed recovery…
View article: HPV E7 inhibits cell pyroptosis by promoting TRIM21-mediated degradation and ubiquitination of the IFI16 inflammasome
HPV E7 inhibits cell pyroptosis by promoting TRIM21-mediated degradation and ubiquitination of the IFI16 inflammasome Open
Human papillomavirus (HPV) is a DNA virus that causes sexually transmitted infections. The HPV oncoprotein E7 plays a critical role in the regulation of host immunity to promote the immune escape of HPV and the occurrence of cervical cance…
View article: Induction of co-inhibitory molecule CTLA-4 by human papillomavirus E7 protein through downregulation of histone methyltransferase JHDM1B expression
Induction of co-inhibitory molecule CTLA-4 by human papillomavirus E7 protein through downregulation of histone methyltransferase JHDM1B expression Open
Human papillomavirus causes various skin diseases and even cancer. Unfortunately, the host immune system often fails to generate effective responses against HPV infection due to the ability of HPV to evade immune-mediated eradication, alth…
View article: Assessment of p16 expression and HPV infection in adenoid cystic carcinoma of the lacrimal gland.
Assessment of p16 expression and HPV infection in adenoid cystic carcinoma of the lacrimal gland. Open
In summary, p16 overexpression was cell-type dependent in ACCs in the lacrimal gland, while HPV infection was negative. P16 overexpression was unrelated to HPV infection. The mechanism of p16 overexpression needs to be further investigated…
View article: Comparative Study of Xenobiotic-free Media for the Cultivation of Human Corneal Epithelial Stem Cells
Comparative Study of Xenobiotic-free Media for the Cultivation of Human Corneal Epithelial Stem Cells Open
View article: Different Regions of Amniotic Membrane Denuded with EDTA or Thermolysin Equally Support the in vitro Expansion of Limbal Stem/progenitor Cells
Different Regions of Amniotic Membrane Denuded with EDTA or Thermolysin Equally Support the in vitro Expansion of Limbal Stem/progenitor Cells Open
View article: Comparative Study of Xenobiotic-Free Media for the Cultivation of Human Limbal Epithelial Stem/Progenitor Cells
Comparative Study of Xenobiotic-Free Media for the Cultivation of Human Limbal Epithelial Stem/Progenitor Cells Open
The culture of human limbal epithelial stem/progenitor cells (LSCs) in the presence of animal components poses the risk of cross-species contamination in clinical applications. We quantitatively compared different xenobiotic-free culture m…
View article: Vasculogenic mimicry is a major feature and novel predictor of poor prognosis in patients with orbital rhabdomyosarcoma
Vasculogenic mimicry is a major feature and novel predictor of poor prognosis in patients with orbital rhabdomyosarcoma Open
Vasculogenic mimicry (VM) is a key developmental program, frequently activated during cancer invasion and metastasis. The aim of the present study was to evaluate the role of VM in orbital rhabdomyosarcoma (RMS), the correlation between VM…
View article: Epithelial Thinning in Limbal Stem Cell Deficiency
Epithelial Thinning in Limbal Stem Cell Deficiency Open
Both corneal and limbal epithelia become progressively thinner in LSCD. Epithelial thickness could be used as a diagnostic measure of LSCD.
View article: Limbal Basal Cell Density Decreases in Limbal Stem Cell Deficiency
Limbal Basal Cell Density Decreases in Limbal Stem Cell Deficiency Open
Basal cell density in both central cornea and limbus decreases in LSCD. Limbal stem cells (LSCs) are affected globally and basal cell density could be used as a parameter to measure LSC function at the early stages of the disease process.