Lin Han
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View article: Biomimetic bilayer hydrogel coating with antithrombotic and anticalcification properties for cardiovascular tissue engineering application
Biomimetic bilayer hydrogel coating with antithrombotic and anticalcification properties for cardiovascular tissue engineering application Open
Decellularized extracellular matrix (dECM), a promising tissue engineering scaffold for cardiovascular applications, might exhibit enhanced durability when endowed with anticalcification and antithrombotic properties. Herein, we present a …
View article: Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2 <sup>+</sup> PIRB <sup>+</sup> Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis
Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2 <sup>+</sup> PIRB <sup>+</sup> Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis Open
Renal fibrosis is a critical pathological hallmark of chronic kidney disease. Although nonalcoholic fatty liver disease (NAFLD) has been implicated in kidney disease progression, its specific role and underlying mechanisms in renal fibrosi…
ISLR as a Cuproptosis-Related Predictor and Therapeutic Target in Heart Failure: A Multi-Omics and Bioinformatics Approach Open
We identified six cuproptosis-related biomarkers (HMOX2, MTSS1L, ISLR, GRB14, ARRDC3, and MEIS1) in HF. Notably, ISLR was upregulated in HF. The PPARα agonist Pirinixic acid demonstrated therapeutic potential by downregulating ISLR express…
432 Complications After Hydrocele Repair: Solving a Persistent Challenge Open
Aim Surgical intervention remains the gold-standard treatment for large or symptomatic hydroceles. Although hydrocele repair is a relatively minor procedure, complications such as haematoma and infection can have significant consequences. …
View article: Deep learning network based on high-resolution magnetic resonance vessel wall imaging combined with attention mechanism for predicting stroke recurrence in patients with symptomatic intracranial atherosclerosis
Deep learning network based on high-resolution magnetic resonance vessel wall imaging combined with attention mechanism for predicting stroke recurrence in patients with symptomatic intracranial atherosclerosis Open
The integrated model combining DL with an attention mechanism based on HR-VWI exhibits excellent performance in assessing the risk of stroke recurrence in sICAS patients. This advancement holds significant potential in assisting clinicians…
View article: Wider means worsen? Influence of QRS duration of left bundle branch block on prognosis of patients after transcatheter aortic valve replacement
Wider means worsen? Influence of QRS duration of left bundle branch block on prognosis of patients after transcatheter aortic valve replacement Open
The impact of QRS duration on postoperative LBBB and its implications for the prognosis of patients undergoing transcatheter aortic valve replacement (TAVR) remained uncertain. This study enrolled consecutive patients who underwent TAVR wi…
Association of composite dietary antioxidant index with mortality risk among adults with chronic kidney disease in NHANES Open
At present, the relationship between the intake of antioxidants in food and the mortality rate of patients with chronic kidney disease (CKD), especially the association with the mortality rate of specific causes, is not clear. This study i…
Efficacy of endoscopic radiofrequency ablation for proton pump inhibitor‐dependent gastroesophageal reflux disease: Multicenter prospective cohort study Open
Objectives To evaluate the effects of endoscopic radiofrequency ablation (RFA) on proton pump inhibitor (PPI)‐dependent gastroesophageal reflux disease (GERD) in a Chinese population, and to explore the factors associated with favorable ef…
Study on Variation of Wood Bending Properties among Trees of Taxodium Ascendens Plantation Open
In wood structural design, the modulus of elasticity (MOE) and modulus of rupture (MOR) are two key indexes of wood mechanical properties. In this study, Taxodium ascendens . Brongn plantation grown in terrestrial site were selected for th…
View article: SN 2021dbg: A Luminous Type IIP–IIL Supernova Exploding from a Massive Star with a Layered Shell
SN 2021dbg: A Luminous Type IIP–IIL Supernova Exploding from a Massive Star with a Layered Shell Open
We present extensive observations and analysis of supernova (SN) SN 2021dbg, utilizing optical photometry and spectroscopy. For approximately 385 days following the explosion, SN 2021dbg exhibited remarkable luminosity, surpassing most Typ…
The Role of Epicardial Adipose Tissue-Derived Proteins in Heart Failure with Preserved Ejection Fraction and Atrial Fibrillation: A Bioinformatics Analysis Open
This study identified EAT-derived secretory proteins as potential biomarkers for HFpEF and AF, with ITPKA and WNT9B as central hub genes. These findings offer insights into potential diagnostic and therapeutic strategies for HFpEF and AF.
CLINICAL APPLICATION OF EARLY POSTOPERATIVE NUTRITIONAL SUPPORT IN PATIENTS WITH HIGH-RISK VALVULAR HEART DISEASE Open
Background : The treatment strategy of early nutritional support after cardiac surgery has gradually been adopted. However, there are no scientific guidelines for the timing and specific programs of early nutritional support. Methods: A re…
Increased dicentric chromosome in peripheral lymphocytes is related to acute skin toxicity induced by radiotherapy in cancer patients Open
Objective: To investigate the impacts of radiotherapy (RT) on dicentric chromosomes in peripheral blood lymphocytes of cancer patients, in order to explore the relationship between dicentric chromosomes and RT-induced adverse reactions. Me…
Clinical comparative efficacy and therapeutic strategies for the Hashimoto's thyroiditis: A systematic review and network meta-analysis Open
Our analyses showed that HM alone or in combination with other treatments for patients with HT can improve the side effects of other drugs, enhance efficacy, and maybe the most effective option for treating HT. However, there still need fu…
View article: HR-MRI-based nomogram network calculator to predict stroke recurrence in high-risk non-disabling ischemic cerebrovascular events patients
HR-MRI-based nomogram network calculator to predict stroke recurrence in high-risk non-disabling ischemic cerebrovascular events patients Open
Background and objective To investigate the use of high-resolution magnetic resonance imaging (HR-MRI) to identify the characteristics of culprit plaques in intracranial arteries, and to evaluate the predictive value of the characteristics…
View article: Probing the Shock Breakout Signal of SN 2024ggi from the Transformation of Early Flash Spectroscopy
Probing the Shock Breakout Signal of SN 2024ggi from the Transformation of Early Flash Spectroscopy Open
We present early-time, hour-to-day cadence spectroscopy of the nearby Type II supernova (SN II) 2024ggi, which was discovered at a phase when the SN shock had just emerged from the red supergiant (RSG) progenitor star. Over the first few d…
Clinical Outcomes of Surgical Treatment on Myocardial Bridging in Symptomatic Patients Running Title: Surgical treatment outcomes of myocardial bridging Open
Background There is a paucity of data regarding surgical results of myocardial bridging(MB).Our study aimed to evaluate the clinical efficacy of surgical treatment including coronary artery bypass grafting (CABG) and unroofing for MB in sy…
Regulatory and Communication Shifts in Dilated Cardiomyopathy: A Multimodal Single-Cell Analysis Open
Dilated cardiomyopathy (DCM), a major cause of heart failure in young adults, is characterized by ventricular dilation and progressive heart muscle dysfunction. Cellular mechanisms driving DCM have not been elucidated despite advances in g…
Dihydroartemisinin, a potential PTGS1 inhibitor, potentiated cisplatin-induced cell death in non-small cell lung cancer through activating ROS-mediated multiple signaling pathways Open
Dihydroartemisinin (DHA) exerts an anti-tumor effect in multiple cancers, however, the molecular mechanism of DHA and whether DHA facilitates the anti-tumor efficacy of cisplatin in non-small cell lung cancer (NSCLC) are unclear. Here, we …
Inhibition of valve mesenchymal stromal cell calcium deposition by bFGF through alternative polyadenylation regulation of the CAT gene Open
Objective Calcific aortic valve disease (CAVD) is the leading cause of angina, heart failure, and death from aortic stenosis. However, the molecular mechanisms of its progression, especially the complex disease-related transcriptional regu…
Early postoperative constrictive pericarditis in China: a single-center retrospective observational study Open
Recurrent episodes of chest tightness, pleural effusion, and elevated CVP within 6 months after cardiac surgery should be considered highly suggestive of EPCP. There are few points of difference between pericarditis with thickening of the …
Risk model based on genes regulating the response of tumor cells to T-cell-mediated killing in esophageal squamous cell carcinoma Open
Immune checkpoint inhibitors (ICIs) represent a promising therapeutic approach for esophageal squamous cell carcinoma (ESCC). However, the subpopulations of ESCC patients expected to benefit from ICIs have not been clearly defined. The ant…
An interpretable machine learning model for stroke recurrence in patients with symptomatic intracranial atherosclerotic arterial stenosis Open
Background and objective Symptomatic intracranial atherosclerotic stenosis (SICAS) is the most common etiology of ischemic stroke and one of the main causes of high stroke recurrence. The recurrence of stroke is closely related to the prog…
METTL3-mediated m6A modification of OTUD1 aggravates press overload induced myocardial hypertrophy by deubiquitinating PGAM5 Open
Background: Pathological cardiac hypertrophy, a condition that contributes to heart failure, is characterized by its intricate pathogenesis. The meticulous regulation of protein function, localization, and degradation is a crucial role pla…
View article: Pulmonary and tricuspid regurgitation after Tetralogy of Fallot repair: A case report
Pulmonary and tricuspid regurgitation after Tetralogy of Fallot repair: A case report Open
BACKGROUND Tetralogy of Fallot (TOF) is one of the most common congenital heart defects, and surgery is the primary treatment. There are no precise guidelines on the treatment protocol for tricuspid regurgitation (TR) as a common complicat…
The prognosis of preoperative preemptive intubation for acute type A aortic dissection patients: a retrospective propensity score matching study Open
Preemptive pre-intubation may benefit high-risk patients with factors such as hypoxia, massive pericardial effusion, and agitation, improving the more critically AADA patients' perioperative outcomes.