Explanipedia

Correction: Endothelial AIP1 regulates vascular remodeling by suppressing NADPH Oxidase-2 Open

Jiqin Zhang, Chaofei Chen, Li Li, Huanjiao Jenny Zhou, Fenghe Li , et al. · 2025

[This corrects the article DOI: 10.3389/fphys.2018.00396.].

Merlin controls limb development and thumb formation by regulating primary cilium-hedgehog signaling Open

Shali Wu, Yan Bian, Cui Zhang, Kaixin Liu, Fuju Sun , et al. · 2025

Hedgehog (HH) signaling, transduced at the primary cilium, plays a crucial role in limb longitudinal growth and digit formation, but its involvement in thumb development has been underestimated. This study identifies Merlin (Nf2) as a crit…

Human amniotic epithelial stem cells promote cholangiocyte regeneration via Notch signaling pathway in bile duct injury Open

Zhoucheng Wang, Wenwen Ge, Xiao Tang, Jun Chen, Jinying Li , et al. · 2025

Author Correction: Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation Open

Chengyu Shi, Ying Wang, Minjie Wu, Yu Chen, Fangzhou Liu , et al. · 2024

Proteomic analysis of human Wharton’s jelly mesenchymal stem/stromal cells and human amniotic epithelial stem cells: a comparison of therapeutic potential Open

Zhen Ge, Chen Qiu, Jiayi Zhou, Zhuoheng Yang, Tuoying Jiang , et al. · 2024

Perinatal stem cells have prominent applications in cell therapy and regenerative medicine. Among them, human Wharton's jelly mesenchymal stem/stromal cells (hWJMSCs) and human amniotic epithelial stem cells (hAESCs) have been widely used.…

Epicardial transplantation of antioxidant polyurethane scaffold based human amniotic epithelial stem cell patch for myocardial infarction treatment Open

Jinying Li, Yuejun Yao, Jiayi Zhou, Zhuoheng Yang, Chen Qiu , et al. · 2024

Myocardial infarction (MI) is a leading cause of death globally. Stem cell therapy is considered a potential strategy for MI treatment. Transplantation of classic stem cells including embryonic, induced pluripotent and cardiac stem cells e…

Human Amniotic Epithelial Stem Cells Promote Colonic Recovery in Experimental Colitis via Exosomal MiR‐23a–TNFR1–NF‐κB Signaling Open

Yaohui Kou, Jinying Li, Yingyi Zhu, Jia Liu, Ruizhe Ren , et al. · 2024

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, manifests as chronic intestinal inflammation with debilitating symptoms, posing a significant burden on global healthcare. Moreover, current therapies prim…

Crosstalk between SUMOylation and other post-translational modifications in breast cancer Open

Bajin Wei, Fan Yang, Luyang Yu, Cong Qiu · 2024

Human amniotic epithelial cells alleviate ischemia-reperfusion injury of steatotic livers through mediating PAK1/AMPK-dependent autophagy Open

Xun Qiu, Hanzhi Xu, Yawen Tan, Jinying Li, Zhoucheng Wang , et al. · 2024

Biomimetic Corneal Stroma for Scarless Corneal Wound Healing via Structural Restoration and Microenvironment Modulation (Adv. Healthcare Mater. 5/2024) Open

Jian‐An Huang, Tuoying Jiang, Jinying Li, Jiqiao Qie, Xiaoyu Cheng , et al. · 2024

SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis Open

Ruizhe Ren, Sha Ding, Kefan Ma, Yuan‐Qing Jiang, Yiran Wang , et al. · 2024

BACKGROUND: Angiogenesis, which plays a critical role in embryonic development and tissue repair, is controlled by a set of angiogenic signaling pathways. As a TF (transcription factor) belonging to the basic helix-loop-helix family, HEY (…

A 3D‐Printed Dual Driving Forces Scaffold with Self‐Promoted Cell Absorption for Spinal Cord Injury Repair Open

Chen Qiu, Yuan Sun, Jinying Li, Jiayi Zhou, Yuchen Xu , et al. · 2023

Stem cells play critical roles in cell therapies and tissue engineering for nerve repair. However, achieving effective delivery of high cell density remains a challenge. Here, a novel cell delivery platform termed the hyper expansion scaff…

<i>In situ</i> beam trajectory tilt measurement based on single cavity beam position monitor Open

Jian Chen, Shanshan Cao, Luyang Yu, Longwei Lai, Renxian Yuan , et al. · 2023

In recent decades, high-gain free-electron lasers (FELs) based on linear accelerators has been successfully developed around the world. Advanced beam diagnostics and feedback technology is one of the key factors to further improve the perf…

Acetate controls endothelial-to-mesenchymal transition Open

Xiaolong Zhu, Yunyun Wang, Ioana Soaita, Heon‐Woo Lee, Hosung Bae , et al. · 2023

Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation Open

Chengyu Shi, Ying Wang, Minjie Wu, Yu Chen, Fangzhou Liu , et al. · 2022

Therapeutic Effect of Biomimetic Scaffold Loaded with Human Amniotic Epithelial Cell-Derived Neural-like Cells for Spinal Cord Injury Open

Chen Qiu, Yuan Sun, Jinying Li, Yuchen Xu, Jiayi Zhou , et al. · 2022

Spinal cord injury (SCI) results in devastating consequences for the motor and sensory function of patients due to neuronal loss and disrupted neural circuits, confronting poor prognosis and lack of effective therapies. A new therapeutic s…

Tacrolimus Causes Hypertension by Increasing Vascular Contractility via RhoA (Ras Homolog Family Member A)/ROCK (Rho-Associated Protein Kinase) Pathway in Mice Open

Xiaohua Wang, Shan Jiang, Lingyan Fei, Fang Dong, Lanyu Xie , et al. · 2022

Background: To provide tacrolimus is first-line treatment after liver and kidney transplantation. However, hypertension and nephrotoxicity are common tacrolimus side effects that limit its use. Although tacrolimus-related hypertension is w…

Repair of Retinal Degeneration by Human Amniotic Epithelial Stem Cell–Derived Photoreceptor–like Cells Open

Jinying Li, Chen Qiu, Jiayi Zhou, Yang Wei, Weixin Yuan , et al. · 2022

The loss of photoreceptors is a major event of retinal degeneration that accounts for most cases of untreatable blindness globally. To date, there are no efficient therapeutic approaches to treat this condition. In the present study, we ai…

FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis Open

Xiaolong Zhu, Cong Qiu, Yiran Wang, Yuan‐Qing Jiang, Yefeng Chen , et al. · 2022

Angiogenesis contributes fundamentally to embryonic development, tissue homeostasis, and wound healing. Basic fibroblast growth factor (FGF2) is recognized as the first proangiogenic molecule discovered, and it facilitates angiogenesis by …

ALX1-transcribed LncRNA AC132217.4 promotes osteogenesis and bone healing via IGF-AKT signaling in mesenchymal stem cells Open

Cui Zhang, Shali Wu, Erman Chen, Luyang Yu, Jinfu Wang , et al. · 2022

ALX1-transcribed LncRNA AC132217.4 Promotes Osteogenesis and Bone Healing via IGF-AKT Signaling in Mesenchymal Stem Cells Open

Cui Zhang, Shali Wu, Erman Chen, Luyang Yu, Jinfu Wang , et al. · 2022

The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) is critical for bone formation and regeneration. A high non-/delayed-union rate of fracture healing still occurs in specific populations, implying an urgent need to dis…

Hyperactivation of platelet‐derived growth factor signalling contributes to arrhythmogenesis in Brugada syndrome Open

Hongkun Wang, Lizhen Xu, Shuai Han, Xiaochen Wang, Hao Wang , et al. · 2022

We performed a comprehensive study to assess the pathogenicity of a novel transient receptor potential melastatin 4 (TRPM4) mutation and to pinpoint underlying molecular mechanisms using an induced pluripotent stem cell-derived cardiomyocy…

Human Amniotic Epithelial Stem Cell-Derived Retinal Pigment Epithelium Cells Repair Retinal Degeneration Open

Jinying Li, Chen Qiu, Yang Wei, Weixin Yuan, Jia Liu , et al. · 2021

Age-related macular degeneration (AMD), featured with dysfunction and loss of retinal pigment epithelium (RPE), is lacking efficient therapeutic approaches. According to our previous studies, human amniotic epithelial stem cells (hAESCs) m…

Programming living sensors for environment, health and biomanufacturing Open

Xinyi Wan, Behide Saltepe, Luyang Yu, Baojun Wang · 2021

Summary Synthetic biology offers new tools and capabilities of engineering cells with desired functions for example as new biosensing platforms leveraging engineered microbes. In the last two decades, bacterial cells have been programmed t…

Synthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity Open

Xinyi Wan, Filipe Pinto, Luyang Yu, Baojun Wang · 2020

Versatile tools for gene expression regulation are vital for engineering gene networks of increasing scales and complexity with bespoke responses. Here, we investigate and repurpose a ubiquitous, indirect gene regulation mechanism from nat…

Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications Open

Chen Qiu, Zhen Ge, Wenyu Cui, Luyang Yu, Jinying Li · 2020

Perinatal stem cells have been regarded as an attractive and available cell source for medical research and clinical trials in recent years. Multiple stem cell types have been identified in the human placenta. Recent advances in knowledge …

Therapeutic Effect of Human Amniotic Epithelial Cells in Rat Models of Intrauterine Adhesions Open

Xuechai Bai, Jia Liu, Weixin Yuan, Yang Liu, Wei Li , et al. · 2020

As a refractory fibrosis disease, intrauterine adhesions (IUAs) is defined as fibrosis of the physiological endometrium. Although hysteroscopic adhesiolysis is widely recommended as an effective treatment, prognosis and recurrence remain p…

p53 Protects Cells from Death at the Heatstroke Threshold Temperature Open

Lu Gong, Qinghe Zhang, Xiao Pan, Shuming Chen, Lina Yang , et al. · 2019

Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition Open

Wencao Zhao, Le Cao, Hanru Ying, Wenjuan Zhang, Dantong Li , et al. · 2019

The association of wrist circumference with hypertension in northeastern Chinese residents in comparison with other anthropometric obesity indices Open

Yongfang Li, Yuyan Liu, Jing He, Ping Ma, Luyang Yu , et al. · 2019

Background Wrist circumference (WrC) is an easily obtained measure in estimating the body frame and regional fat distribution, and has increasingly used as an obesity index. The aim of our study is to estimate the association of WrC with e…

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