Lei Yu
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View article: Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension
Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension Open
Refractory hypertension often involves centrally driven sympathetic augmentation. Yet effective central targets for the treatment of hypertension are still scarce. Here, the role of the histamine H4 receptor (H4R) is explored, the newest m…
View article: Regional high iron deposition is linked with cognitive impairments in peritoneal dialysis: a quantitative susceptibility mapping study
Regional high iron deposition is linked with cognitive impairments in peritoneal dialysis: a quantitative susceptibility mapping study Open
Objective Peritoneal dialysis (PD) patients demonstrate distinct iron homeostasis imbalances. However, the relationship between brain iron and cognitive impairment in this population remains poorly elucidated. Methods This study enrolled 5…
View article: (Pro)renin receptor promotes cardiomyocyte senescence via tripartite motif-containing 24-mediated stabilization of p53 in diabetic cardiomyopathy
(Pro)renin receptor promotes cardiomyocyte senescence via tripartite motif-containing 24-mediated stabilization of p53 in diabetic cardiomyopathy Open
Diabetic cardiomyopathy (DCM) is a major complication of diabetes and a leading contributor to heart failure, in which cardiomyocyte senescence plays an increasingly recognized role. However, the underlying mechanisms driving this process …
View article: Lifetime risk of incident dementia and incident mild cognitive impairment in older adults
Lifetime risk of incident dementia and incident mild cognitive impairment in older adults Open
Background and Objectives To estimate the lifetime risk of dementia and mild cognitive impairment (MCI) from age 55 to 105, accounting for competing risk of death, and to examine differences by sex and race. Methods We analyzed data from f…
View article: Computed tomography-dominant surveillance strategies for colorectal cancer: Improving early detection of recurrence
Computed tomography-dominant surveillance strategies for colorectal cancer: Improving early detection of recurrence Open
Colorectal cancer (CRC) is one of the most prevalent cancers globally, with a high recurrence rate following curative surgery, especially within the first 3 to 5 years. Post-surgical follow-up plays a vital role in detecting local and dist…
View article: Characterizing Post-Mortem Brain Molecular Taxonomy of Cognitive Resilience and Translating it to Living Humans
Characterizing Post-Mortem Brain Molecular Taxonomy of Cognitive Resilience and Translating it to Living Humans Open
Here, we define cognitive resilience as slower or faster cognitive decline after we regress out the effects of common brain neuropathologies. Its understanding could provide important insights into the biology underlying cognitive health, …
View article: Genotyping TOMM40′523 poly-T polymorphisms using whole-genome sequencing
Genotyping TOMM40′523 poly-T polymorphisms using whole-genome sequencing Open
View article: Effect and mechanism of local radiotherapy combined with immune checkpoint inhibitor in the treatment of metastatic triple negative breast cancer
Effect and mechanism of local radiotherapy combined with immune checkpoint inhibitor in the treatment of metastatic triple negative breast cancer Open
Triple negative breast cancer is highly sensitive to immunotherapy due to its high PD-L1 expression; however, many patients exhibit poor response or develop resistance. This study evaluates the efficacy and mechanism of local radiotherapy …
View article: Cognitive decline in community-dwelling older persons with primary age-related tauopathy: role of anatomical location of tangles and other co-existing brain pathologies
Cognitive decline in community-dwelling older persons with primary age-related tauopathy: role of anatomical location of tangles and other co-existing brain pathologies Open
View article: Cognitive impairment mediates the association between sarcopenic obesity and daily living ability in the frail older population
Cognitive impairment mediates the association between sarcopenic obesity and daily living ability in the frail older population Open
Sarcopenic obesity is closely related to cognitive impairment and decreased daily living ability. Sarcopenic obesity can affect daily living ability through the mediating effect of cognitive impairment. Therefore, more attention should be …
View article: Sex Differences in Associations of Lewy Body Disease with Alzheimer's Disease and Cognitive Decline
Sex Differences in Associations of Lewy Body Disease with Alzheimer's Disease and Cognitive Decline Open
Objective To investigate how sex and age at menopause influence the interplay between Alzheimer's disease (AD) and Lewy body disease (LBD) neuropathologies, and their associations with cognitive decline. Methods We analyzed data from: (1) …
View article: Timing and intraindividual variability of daytime napping and Alzheimer’s disease in older adults
Timing and intraindividual variability of daytime napping and Alzheimer’s disease in older adults Open
View article: Endovascular Management for Refractory Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt (TIPS) Creation
Endovascular Management for Refractory Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt (TIPS) Creation Open
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View article: Potential of SPHK1 as a prognostic marker and therapeutic target in colorectal cancer: insights from bioinformatics and experimental analysis
Potential of SPHK1 as a prognostic marker and therapeutic target in colorectal cancer: insights from bioinformatics and experimental analysis Open
Background: Colorectal cancer (CRC) remains a major cause of cancer-related mortality globally, primarily due to its aggressive progression and poor prognosis in many patients. Despite treatment advances, new therapeutic targets are critic…
View article: Brain Multi-Omic Subtypes of Neuroticism reveal molecular signatures linked to Alzheimer’s Disease
Brain Multi-Omic Subtypes of Neuroticism reveal molecular signatures linked to Alzheimer’s Disease Open
Importance Molecular mechanisms linking neuroticism with Alzheimer’s disease traits are unknown. Objective To identify molecular subtypes of neuroticism and examine their association with ADRD traits. Design Three ongoing cohort studies we…
View article: Reduced Complexity of Pulse Rate Is Associated With Faster Cognitive Decline in Older Adults
Reduced Complexity of Pulse Rate Is Associated With Faster Cognitive Decline in Older Adults Open
Background Cardiovascular diseases are closely linked to cognitive health. Subclinical cardiovascular functional changes, such as cardiac autonomic dysfunction, precede cardiovascular diseases and improve risk stratification. Continuous mo…
View article: Arteriolosclerosis in CNS Tissues Outside the Cerebrum and Late-Life Motor Impairment
Arteriolosclerosis in CNS Tissues Outside the Cerebrum and Late-Life Motor Impairment Open
BACKGROUND: The pathological basis underlying motor impairment in older adults is partially accounted for by Alzheimer disease and related dementias pathologies. We tested the hypothesis that arteriolosclerosis, a pathological correlate of…
View article: Genotyping TOMM40’523 Poly-T Polymorphisms Using Whole-Genome Sequencing
Genotyping TOMM40’523 Poly-T Polymorphisms Using Whole-Genome Sequencing Open
The TOMM40’523 poly-T repeat polymorphism (rs10524523), located in the TOMM40 gene and in linkage disequilibrium with APOE , has been associated with cognitive decline and Alzheimer’s disease (AD) progression. Accurate genotyping of this p…
View article: Functions and mechanisms of non-histone post-translational modifications in cancer progression
Functions and mechanisms of non-histone post-translational modifications in cancer progression Open
Protein post-translational modifications (PTMs) refer to covalent and enzymatic alterations to folded or nascent proteins during or after protein biosynthesis to alter the properties and functions of proteins. PTMs are modified in a variet…
View article: Multi-omic subtypes of Alzheimer’s dementia are differentially associated with psychological traits
Multi-omic subtypes of Alzheimer’s dementia are differentially associated with psychological traits Open
Psychological traits reflecting neuroticism, depressive symptoms, loneliness, and purpose in life are risk factors of AD dementia; however, the underlying biologic mechanisms of these associations remain largely unknown. In this study we e…
View article: Associations of social isolation with sleep duration and sleep quality in the elderly: Mediating influence of depression
Associations of social isolation with sleep duration and sleep quality in the elderly: Mediating influence of depression Open
BACKGROUND Sleep disorders are common health problems in the elderly. The effect of social isolation on sleep duration and sleep quality remains unclear in the Chinese community-dwelling elderly. AIM To explore the associations of social i…
View article: Translating the Post-Mortem Brain Multi-Omics Molecular Taxonomy of Alzheimer’s Dementia to Living Humans
Translating the Post-Mortem Brain Multi-Omics Molecular Taxonomy of Alzheimer’s Dementia to Living Humans Open
Alzheimer’s disease (AD) dementia is characterized by significant molecular and phenotypic heterogeneity, which confounds its mechanistic understanding, diagnosis, and effective treatment. In this study, we harness the most comprehensive d…
View article: Brain 5-hydroxymethylcytosine alterations are associated with Alzheimer’s disease neuropathology
Brain 5-hydroxymethylcytosine alterations are associated with Alzheimer’s disease neuropathology Open
5-hydroxymethylcytosine, also known as the sixth DNA base of the genome, plays an important role in brain aging and neurological disorders such as Alzheimer's disease. However, little is known about its genome-wide distribution and its ass…
View article: A comparative study of four physical education curricula on the developmental behavior of Chinese preschool children aged 4 to 6 years and its correlation with balance ability
A comparative study of four physical education curricula on the developmental behavior of Chinese preschool children aged 4 to 6 years and its correlation with balance ability Open
Early childhood development is important for the future developmental behavior, physical fitness, and social adaptation. The content of the physical education curriculum in kindergarten is crucial for the growth of preschool children. The …
View article: Scam susceptibility is associated with a markedly accelerated onset of Alzheimer's disease dementia
Scam susceptibility is associated with a markedly accelerated onset of Alzheimer's disease dementia Open
INTRODUCTION The association of scam susceptibility with the timing of Alzheimer's disease (AD) dementia onset is unknown. METHODS One thousand ninety‐two older adults without dementia underwent assessments of scam susceptibility and annua…
View article: Hippocampal neuronal loss and cognitive decline in LATE‐NC and ADNC among community‐dwelling older persons
Hippocampal neuronal loss and cognitive decline in LATE‐NC and ADNC among community‐dwelling older persons Open
INTRODUCTION This study investigates the inter‐related roles of hippocampal neuronal loss (HNL), limbic‐predominant age‐related TAR‐DNA binding protein of 43 kDa (TDP‐43) encephalopathy neuropathologic changes (LATE‐NC), and Alzheimer's di…
View article: Targeting glycolysis: exploring a new frontier in glioblastoma therapy
Targeting glycolysis: exploring a new frontier in glioblastoma therapy Open
Glioblastoma(GBM) is a highly malignant primary central nervous system tumor that poses a significant threat to patient survival due to its treatment resistance and rapid recurrence.Current treatment options, including maximal safe surgica…
View article: Impacts of cardiovascular risk factors and <i>APOE</i> on cognitive decline in late‐life
Impacts of cardiovascular risk factors and <i>APOE</i> on cognitive decline in late‐life Open
Background Apolipoprotein E ( APOE ) is a known genetic risk factor for dementia. Midlife cardiovascular risk factors are associated with lower cognitive performance and increased dementia risk. However, little is known whether cardiovascu…
View article: Mixed pathologies and cognitive outcomes in older persons ‘possibly’ eligible for anti‐amyloid treatment: a community‐based study
Mixed pathologies and cognitive outcomes in older persons ‘possibly’ eligible for anti‐amyloid treatment: a community‐based study Open
Background The recent approval of two anti‐amyloid antibodies, Aducanamab and Lecanamab, have set the stage for the next generation of anti‐amyloid treatments. Despite the capability of these treatments to lower Aβ brain levels, there is t…
View article: Associations between structural neuroimaging markers of Alzheimer’s risk and scam susceptibility
Associations between structural neuroimaging markers of Alzheimer’s risk and scam susceptibility Open