Explanipedia

Understanding women’s preferences for long-acting reversible contraceptives in Gondar, Ethiopia: a discrete choice experiment Open

Ousman Ambaw, Amare Minyhun, Tsegaw Amare Baykeda, Haimanot Wubale Tewabe, Endalew Minwuye Andargie , et al. · 2025

E-Cigarette Sales to School-Uniformed Adolescents in China Open

Yang Wang, Xiaoyang Lv, Linnea Laestadius, Jeanine P. D. Guidry, Elham Mahmoudi , et al. · 2025

Importance Electronic cigarettes (e-cigarettes) are appealing to adolescents, but sale of e-cigarettes to individuals younger than 18 years is prohibited in China. The effect of school uniforms on e-cigarette sales to adolescents has not b…

Air quality targets and projected health and economic benefits in China: a modelling study (Preprint) Open

Siyuan Wang, Zhiwei Xu, Gian Luca Di Tanna, Yawen Jiang, Laura Downey , et al. · 2025

BACKGROUND Air pollution continues to pose a significant health and economic burden in China, with PM2.5 concentrations remaining six times above WHO guidelines despite recent progress. OBJECTIVE This modelling study evaluates the proje…

Economic Evaluation of a Multicomponent mHealth Intervention for Stroke Management in Rural China: Cluster-Randomized Trial With 6-Year Follow-Up Open

Bolu Yang, Enying Gong, Xingxing Chen, Jie Tan, Nicholas Peoples , et al. · 2025

Background To bridge the gap between clinical guidelines and suboptimal stroke management in rural settings, we conducted an implementation trial using evidence-based, mobile health–enabled strategies to empower primary care providers in r…

Optimization and robustness analysis of tilt and piston solving methods based on 2D interferometric image Open

Zhiqiang Gao, Xiaoyong Xu, Yu Deng, Wei Liu, Pu Zhou , et al. · 2025

Global and Regional Temporal Changes in Cross‐Country Inequalities of Site‐Specific Osteoarthritis Burden, 1990 to 2021 Open

Haowei Chen, Lei Si, David J. Hunter, Lei Zhang, Zhe‐Sheng Chen , et al. · 2025

Objective This study examined the global and regional temporal changes in cross‐country inequalities of site‐specific osteoarthritis (OA) burden from 1990 to 2021. Methods Age‐standardized years lived with disability rates (ASYRs) for site…

Multi-wavelength pump enabled spectral manipulation scalability of random Raman fiber laser Open

Yanzhao Ke, Jiangming Xu, Junrui Liang, Jun Ye, Yidong Guo , et al. · 2025

This study presents a broadband random Raman fiber laser (RRFL) with a threefold increase in wavelength coverage compared to single-wavelength pumping, along with flexible Raman gain manipulation. The system utilizes a half-open cavity con…

Residential greenspace and multiple chronic health conditions in China: a cross-sectional study Open

Siyuan Wang, Jingjie Sun, Zhiwei Xu, Gian Luca Di Tanna, Ming Sheng Chen , et al. · 2025

Our findings underscore the potential beneficial effects of residential greenness on multiple chronic conditions, with implications for urban planning, environmental policy, and community development.

Global burden of liver cancer attributable to drug use: trends from 1990 to 2021 and projections to 2040 Open

Cong Chen, Ying Zhou, Weiwei Gu, Zhuxin Gu, Pengfei Jia , et al. · 2025

The global burden of drug-induced LC has increased significantly, with notable disparities across regions and genders. High SDI regions face the fastest-growing burden, while low SDI regions experience rising mortality and morbidity. These…

Willingness to pay for assisted reproductive technologies among individuals with infertility in China Open

Chaofan Li, Hongbin Cong, Stephen Jan, Lei Si, Ling Geng , et al. · 2025

Infertility, a widely prevalent condition globally, incurs high economic burdens. Assisted reproductive technologies (ARTs) are effective treatments, but public health financing in low- and middle-income countries (LMICs) rarely covers ART…

Climate and environmental determinants of peste des petits ruminants transmission and infection risk in various wildlife suitable habitats Open

Guiping Lu, Feng Jiang, Rui Zhang, Jialong Guo, Lei Si , et al. · 2025

Multifaceted approaches to promoting the growth potential in small-for-gestational-age infants and their clinical relevance Open

Lei Si, Jing Guo, Dui Wu, Siyu Zhao, Jing Li · 2025

Objective: To investigate the multifaceted approaches to promoting growth potential in small-for-gestational-age (SGA) infants and their clinical relevance. Methods: This was a retrospective study. A total of 196 SGA infants who were born …

Health and economic benefits of improving pre‐hospital identification of stroke in Australian women: a modelling study Open

Thomas Gadsden, Lei Si, Emily Atkins, Cheryl Carcel, Xia Wang , et al. · 2025

Objective To estimate the long term gains in life years and quality‐adjusted life years (QALYs) and the cost savings that could be achieved if ischaemic stroke was identified in women with the same level of accuracy received by men, versus…

Health Economic Evaluations in Immunotherapy and Biologic Treatments for Food Allergy: A Systematic Review Open

Andrew Fong, Joshua G. Jacob, Jennifer L. P. Protudjer, Melanie Lloyd, Liz Thyer , et al. · 2025

Valuation of informal care for the old-aged with disabilities in China—a discrete choice experiment approach Open

Xinchang Zheng, Shuaizhen Chen, Fengyi Sun, Wenjing Cheng, Chen Chen , et al. · 2025

Construction of a programmed activation nanosystem based on intracellular hypoxia in cisplatin-resistant tumor cells for reversing cisplatin resistance Open

Yurong Liu, Lei Si, Yunheng Liu, Li Song, Xiaokang Zhang , et al. · 2025

Versatile Nanomaterials That Interfere with Ferroptosis in the Tumor Microenvironment Open

Yurong Liu, Yunheng Liu, Xinting Li, Song Li, Xiaokang Zhang , et al. · 2025

Ferroptosis is a type of iron-dependent programmed cell death characterized by a depletion of glutathione. Although generally less harmful to normal cells, in tumor cells, the high demand for iron ions provides conditions conducive to ferr…

Multi-pathway oxidative stress amplification via controllably targeted nanomaterials for photoimmunotherapy of tumors Open

Hang Li, Yunheng Liu, Xiaokang Zhang, Yurong Liu, Lei Si , et al. · 2025

Photoimmunotherapy, which combines phototherapy with immunotherapy, exhibits significantly improved therapeutic effects compared with mono-treatment regimens. However, its use is associated with drawbacks, such as insufficient reactive oxy…

Design of pH-Responsive Nanomaterials Based on the Tumor Microenvironment Open

Yunheng Liu, Lei Si, Yuxuan Jiang, Shaojing Jiang, Xiaokang Zhang , et al. · 2025

The metabolic activity of tumor cells leads to the acidification of the surrounding microenvironment, which provides new strategies for the application of nanotechnology in cancer therapy. Researchers have developed various types of pH-res…

Global, Regional, and National Burden of Comorbidities for Osteoarthritis and 174 Diseases, 1990–2021: A Modelling Study Based on the Global Burden of Disease Study 2021 Open

Haowei Chen, Yanqi Liu, David J. Hunter, Xiaomeng Wang, Lei Si , et al. · 2025

Cardiovascular health and economic outcomes under improved air quality in China: a modelling study Open

Siyuan Wang, Yawen Jiang, Zhiwei Xu, Gian Luca Di Tanna, Sarah Lewis , et al. · 2024

Introduction China faces the dual challenge of high air pollution and an increasing burden of cardiovascular disease (CVD). We aimed to estimate the healthcare costs associated with CVD and the quality-adjusted life years (QALYs) under sce…

Nano Acacetin Mitigates Intestinal Mucosal Injury in Sepsis Rats by Protecting Mitochondrial Function and Regulating TRX1 to Inhibit the NLRP3 Pyroptosis Pathway Open

Naxin Guo, Lei Si, P Li, Gregory Gan · 2024

AC and Nano-AC can inhibit the NLRP3/Caspase-11/GSDMD signaling pathway by upregulating TRX1 to ameliorate intestinal mucosal injury in sepsis rats, and the effect of Nano AC is more prominent.

Strengthening China’s National Essential Public Health Services Package for hypertension and diabetes care: protocol for an interrupted time series study with mixed-methods process evaluation and health economic evaluation Open

Shangzhi Xiong, Wei Jiang, Xinyi Zhang, Yongchen Wang, Chi Hu , et al. · 2024

Inequalities in health care use among patients with arthritis in China: using Andersen’s Behavioral Model Open

Jinyao Liu, Yi Tang, Pei-Yao Zheng, Mingsheng Chen, Lei Si · 2024

The costs, health and economic impact of air pollution control strategies: a systematic review Open

Siyuan Wang, Rong Song, Zhiwei Xu, Ming Sheng Chen, Gian Luca Di Tanna , et al. · 2024

Background Air pollution poses a significant threat to global public health. While broad mitigation policies exist, an understanding of the economic consequences, both in terms of health benefits and mitigation costs, remains lacking. This…

Inequalities in health care use among patients with arthritis in China: Evidence from the China Health and Retirement Longitudinal Study Open

Jinyao Liu, Mingsheng Chen, Yi Tang, Pei-Yao Zheng, Lei Si · 2024

Bakcground This study sought to assess socioeconomic-related inequalities in health care use among arthritis patients in China and to analyze factors associated with this disparity. Methods This study used data from the 2018 China Health a…

Translation and cross-cultural adaptation of Osteoporosis Knowledge Assessment Tool (OKAT) for Chinese populations in Australia Open

John Brianna Bronio, Lei Si, David Lim, Clarice Tang · 2024

Review of High-Power Continuous Wave Yb-Doped Fiber Lasers near 980 nm Open

Shangde Zhou, Jianqiu Cao, Maoni Chen, Zefeng Wang, Lei Si , et al. · 2024

In this paper, the development of a high-power continuous wave (CW) fiber laser near 980 nm is reviewed. This review is focused primary on the power evolution resulting from the designation of Yb-doped fibers, which is important in the sup…

Evaluation of the impact of weak end feedback on the SBS threshold in high-power narrow-linewidth fiber amplifiers Open

Wei Li, Yu Deng, Qi Chen, Yisha Chen, Pengfei Ma , et al. · 2024

In this work, we quantitatively investigate the SBS threshold in high-power narrow-linewidth fiber amplifiers seeded with phase-modulated single-frequency lasers in presence of weak end feedback. The impacts of the end feedback and spectra…

Cost-Effectiveness of Salt Substitute and Salt Supply Restriction in Eldercare Facilities Open

Xiaozhen Lai, Yifang Yuan, Hongxia Wang, Ruijuan Zhang, Qianku Qiao , et al. · 2024

Importance Salt substitution has been reported to be a cost-saving sodium reduction strategy that has not yet been replicated in different contexts. Objective To estimate the cost-effectiveness of sodium reduction strategies within the DEC…

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